{"id":"https://openalex.org/W1990396337","doi":"https://doi.org/10.1016/j.ymben.2009.11.002","title":"Rational design and construction of an efficient E. coli for production of diapolycopendioic acid","display_name":"Rational design and construction of an efficient E. coli for production of diapolycopendioic acid","publication_year":2009,"publication_date":"2009-11-27","ids":{"openalex":"https://openalex.org/W1990396337","doi":"https://doi.org/10.1016/j.ymben.2009.11.002","mag":"1990396337","pmid":"https://pubmed.ncbi.nlm.nih.gov/19944775","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2875070"},"language":"en","primary_location":{"id":"doi:10.1016/j.ymben.2009.11.002","doi":"https://doi.org/10.1016/j.ymben.2009.11.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ymben.2009.11.002","pdf_url":null,"source":{"id":"https://openalex.org/S173328182","display_name":"Metabolic Engineering","issn_l":"1096-7176","issn":["1096-7176","1096-7184"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic Engineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2875070/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009144438","display_name":"Pornkamol Unrean","orcid":"https://orcid.org/0000-0001-5447-826X","observed_orcids":["https://orcid.org/0000-0001-5447-826X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pornkamol Unrean","raw_affiliation_strings":["Department of Chemical Engineering and Materials Science, and BioTechnology Institute, University of Minnesota, 240 Gortner Laboratory, 1479 Gortner Ave, St. Paul, MN 55108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering and Materials Science, and BioTechnology Institute, University of Minnesota, 240 Gortner Laboratory, 1479 Gortner Ave, St. Paul, MN 55108, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022468384","display_name":"Cong T. Trinh","orcid":"https://orcid.org/0000-0002-8362-725X","observed_orcids":["https://orcid.org/0000-0002-8362-725X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cong T. Trinh","raw_affiliation_strings":["Department of Chemical Engineering and Materials Science, and BioTechnology Institute, University of Minnesota, 240 Gortner Laboratory, 1479 Gortner Ave, St. Paul, MN 55108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering and Materials Science, and BioTechnology Institute, University of Minnesota, 240 Gortner Laboratory, 1479 Gortner Ave, St. Paul, MN 55108, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005698632","display_name":"Friedrich Srienc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Friedrich Srienc","raw_affiliation_strings":["Department of Chemical Engineering and Materials Science, and BioTechnology Institute, University of Minnesota, 240 Gortner Laboratory, 1479 Gortner Ave, St. Paul, MN 55108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering and Materials Science, and BioTechnology Institute, University of Minnesota, 240 Gortner Laboratory, 1479 Gortner Ave, St. Paul, MN 55108, USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005698632"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":2.0379,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.86212032,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"12","issue":"2","first_page":"112","last_page":"122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carotenoid-biosynthesis","display_name":"carotenoid biosynthesis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8889999985694885},{"id":"https://openalex.org/keywords/elementary-mode-analysis","display_name":"elementary mode analysis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/metabolic-network-model","display_name":"metabolic network model","score":0.5450000166893005},{"id":"https://openalex.org/keywords/secondary-metabolite-production","display_name":"secondary metabolite production","score":0.8970000147819519},{"id":"https://openalex.org/keywords/gene-deletion","display_name":"gene deletion","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C28781525","wikidata":"https://www.wikidata.org/wiki/Q191907","display_name":"Carotenoid","level":2,"score":0.816747784614563},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7319833040237427},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6616005301475525},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.6391800045967102},{"id":"https://openalex.org/C77957584","wikidata":"https://www.wikidata.org/wiki/Q1133550","display_name":"Gene knockout","level":3,"score":0.6091381907463074},{"id":"https://openalex.org/C2776436953","wikidata":"https://www.wikidata.org/wiki/Q5163215","display_name":"Consistency (knowledge bases)","level":2,"score":0.5461645126342773},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5389827489852905},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.5336637496948242},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5050097107887268},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.5040015578269958},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5020811557769775},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4723854064941406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45246222615242004},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.4414314925670624},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2379060685634613},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21917802095413208},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.10696536302566528},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002338","descriptor_name":"Carotenoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ymben.2009.11.002","doi":"https://doi.org/10.1016/j.ymben.2009.11.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ymben.2009.11.002","pdf_url":null,"source":{"id":"https://openalex.org/S173328182","display_name":"Metabolic Engineering","issn_l":"1096-7176","issn":["1096-7176","1096-7184"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic Engineering","raw_type":"journal-article"},{"id":"pmid:19944775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19944775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic engineering","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2875070","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2875070/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Metab Eng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2875070","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2875070/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Metab Eng","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7278183070","display_name":"Design and Construction of Efficient Reaction Networks","funder_award_id":"R01GM077529","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320320909","display_name":"Keio University","ror":"https://ror.org/02kn6nx58"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W40033085","https://openalex.org/W1512810258","https://openalex.org/W1758395617","https://openalex.org/W1797516342","https://openalex.org/W1802630246","https://openalex.org/W1964491374","https://openalex.org/W2000236735","https://openalex.org/W2020942708","https://openalex.org/W2028681077","https://openalex.org/W2052247409","https://openalex.org/W2056305771","https://openalex.org/W2062042850","https://openalex.org/W2062873229","https://openalex.org/W2072042166","https://openalex.org/W2077927477","https://openalex.org/W2083693802","https://openalex.org/W2090098817","https://openalex.org/W2094315333","https://openalex.org/W2094399313","https://openalex.org/W2108078368","https://openalex.org/W2111967267","https://openalex.org/W2116735729","https://openalex.org/W2118323536","https://openalex.org/W2118885986","https://openalex.org/W2143626957","https://openalex.org/W4243243349"],"related_works":["https://openalex.org/W2028681077","https://openalex.org/W2159724748","https://openalex.org/W1961707331","https://openalex.org/W2051420223","https://openalex.org/W4240878561","https://openalex.org/W2792021592","https://openalex.org/W3026462627","https://openalex.org/W2061195384","https://openalex.org/W2125901288","https://openalex.org/W1730769032"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}