{"id":"https://openalex.org/W1990387942","doi":"https://doi.org/10.1158/1538-7445.am2011-3245","title":"Abstract 3245: Novel anticancer agents \u2013 lead discovery and optimization","display_name":"Abstract 3245: Novel anticancer agents \u2013 lead discovery and optimization","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W1990387942","doi":"https://doi.org/10.1158/1538-7445.am2011-3245","mag":"1990387942"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-3245","doi":"https://doi.org/10.1158/1538-7445.am2011-3245","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-3245","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112121273","display_name":"Liping Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liping Meng","raw_affiliation_strings":["1University of California, Davis, Sacramento, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, Davis, Sacramento, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004207565","display_name":"Don-Hong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Don-Hong Wang","raw_affiliation_strings":["1University of California, Davis, Sacramento, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, Davis, Sacramento, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026305465","display_name":"Chun\u2010Yi Wu","orcid":"https://orcid.org/0000-0003-2642-0380","observed_orcids":["https://orcid.org/0000-0003-2642-0380"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chun-Yi Wu","raw_affiliation_strings":["1University of California, Davis, Sacramento, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, Davis, Sacramento, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016566536","display_name":"Kit S. Lam","orcid":"https://orcid.org/0000-0002-3076-6969","observed_orcids":["https://orcid.org/0000-0002-3076-6969"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kit S. Lam","raw_affiliation_strings":["1University of California, Davis, Sacramento, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, Davis, Sacramento, CA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"3245","last_page":"3245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.09529999643564224,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.9710000157356262},{"id":"https://openalex.org/keywords/lead-identification","display_name":"lead compound identification","score":0.8259999752044678},{"id":"https://openalex.org/keywords/m13-phage-display","display_name":"M13 phage display","score":0.8149999976158142},{"id":"https://openalex.org/keywords/eif5b","display_name":"eIF5B","score":0.9679999947547913},{"id":"https://openalex.org/keywords/eukaryotic-translation-initiation-factors","display_name":"eukaryotic translation initiation factors","score":0.7960000038146973},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.6100000143051147},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8399999737739563},{"id":"https://openalex.org/keywords/lead-optimization","display_name":"lead optimization","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.69573974609375},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.6775254607200623},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5221907496452332},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5173484683036804},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4558370113372803},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.41446322202682495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3916208744049072},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3507479429244995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33795422315597534},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3028985261917114},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1982041597366333},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.1612759828567505},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14934641122817993},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-3245","doi":"https://doi.org/10.1158/1538-7445.am2011-3245","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-3245","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1908179051","https://openalex.org/W2784995797","https://openalex.org/W2156144208","https://openalex.org/W2318004921","https://openalex.org/W2378779803","https://openalex.org/W4294670707","https://openalex.org/W2429618429","https://openalex.org/W7166843555","https://openalex.org/W2407060086","https://openalex.org/W6960171585"],"abstract_inverted_index":{"Abstract":[0],"Though":[1],"cancer":[2,16,51],"chemotherapy":[3],"helps":[4],"in":[5,23,27,146],"successful":[6],"treating":[7],"some":[8,63,126],"types":[9],"of":[10,45,49,75,163,171,191,196],"solid":[11],"tumors,":[12],"lymphomas,":[13],"and":[14,47,54,105,120,144,148,166,177],"leukemias,":[15],"is":[17,34],"still":[18],"responsible":[19],"for":[20,200],"about":[21],"one":[22],"every":[24],"four":[25],"deaths":[26],"the":[28,43,140,161,192,197],"United":[29],"States":[30],"nowadays.":[31],"Thus,":[32],"it":[33],"urgent":[35],"to":[36,41,56,100,115,129],"develop":[37],"novel":[38,71,172],"anticancer":[39,67],"agents":[40],"overcome":[42],"problems":[44],"toxicity":[46],"resistance":[48],"existing":[50],"chemotherapeutic":[52],"agents,":[53],"eventually":[55,149],"cure":[57],"cancer.":[58],"Recently":[59],"we":[60],"have":[61,174],"found":[62],"lead":[64,154],"compounds":[65,97,127],"possessing":[66],"effects":[68],"through":[69],"a":[70,83,132],"ultra-high-throughput":[72],"multiplex":[73],"screening":[74],"OBOC":[76],"(one-bead-one-compound)":[77],"small":[78],"molecule":[79],"combinatorial":[80],"library":[81,90],"against":[82],"M13":[84],"phage":[85],"display":[86],"cDNA":[87],"expression":[88],"proteome":[89],"derived":[91],"from":[92,112],"T-lymphoma":[93],"Jurkat":[94,103],"cell.":[95],"These":[96],"were":[98],"able":[99],"kill":[101],"both":[102],"cells":[104,108],"HepG2":[106],"hepatocarcinoma":[107],"with":[109],"IC50s":[110],"ranging":[111],"15":[113],"\u00b5M":[114],"80":[116],"\u00b5M.":[117],"Further":[118],"biopanning":[119],"pull":[121],"down":[122],"results":[123],"showed":[124],"that":[125],"bounded":[128],"EIF5B":[130],"\u2013":[131],"eukaryotic":[133],"translation":[134,142],"imitation":[135],"factor,":[136],"which":[137],"might":[138],"inhibit":[139],"cellular":[141],"initiation":[143],"result":[145],"apoptosis":[147],"cause":[150],"cell":[151],"death.":[152],"The":[153],"optimization":[155],"was":[156],"carried":[157],"out":[158],"by":[159],"using":[160],"method":[162],"\u201cmethyl":[164],"walking\u201d":[165],"\u201cdeletion":[167],"studies\u201d.":[168],"A":[169],"series":[170],"derivatives":[173],"been":[175],"synthesized":[176],"structure-activity":[178],"relationship":[179],"will":[180],"be":[181],"investigated.":[182],"Citation":[183],"Format:":[184],"{Authors}.":[185],"{Abstract":[186],"title}":[187],"[abstract].":[188],"In:":[189],"Proceedings":[190],"102nd":[193],"Annual":[194],"Meeting":[195],"American":[198],"Association":[199],"Cancer":[201,211],"Research;":[202],"2011":[203],"Apr":[204],"2-6;":[205],"Orlando,":[206],"FL.":[207],"Philadelphia":[208],"(PA):":[209],"AACR;":[210],"Res":[212],"2011;71(8":[213],"Suppl):Abstract":[214],"nr":[215],"3245.":[216],"doi:10.1158/1538-7445.AM2011-3245":[217]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}