{"id":"https://openalex.org/W1990387892","doi":"https://doi.org/10.1163/156856297x00542","title":"Detection of specific plasma proteins on surfaces by immunospecific adhesion of dyed polystyrene beads","display_name":"Detection of specific plasma proteins on surfaces by immunospecific adhesion of dyed polystyrene beads","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W1990387892","doi":"https://doi.org/10.1163/156856297x00542","mag":"1990387892","pmid":"https://pubmed.ncbi.nlm.nih.gov/8933287"},"language":"en","primary_location":{"id":"doi:10.1163/156856297x00542","doi":"https://doi.org/10.1163/156856297x00542","is_oa":false,"landing_page_url":"https://doi.org/10.1163/156856297x00542","pdf_url":null,"source":{"id":"https://openalex.org/S150667925","display_name":"Journal of Biomaterials Science Polymer Edition","issn_l":"0920-5063","issn":["0920-5063","1568-5624"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomaterials Science, Polymer Edition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001770998","display_name":"Evgenia Mandrusov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Mandrusov","raw_affiliation_strings":["a    1Artificial Organs Research Laboratory. Department of Chemical Engineering, Material Science, and Mining Engineering, Columbia University. New York City. NY 10027, USA","1Artificial Organs Research Laboratory. Department of Chemical Engineering, Material Science, and Mining Engineering, Columbia University. New York City. NY 10027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a    1Artificial Organs Research Laboratory. Department of Chemical Engineering, Material Science, and Mining Engineering, Columbia University. New York City. NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"1Artificial Organs Research Laboratory. Department of Chemical Engineering, Material Science, and Mining Engineering, Columbia University. New York City. NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066898494","display_name":"Leo Vroman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Vroman","raw_affiliation_strings":["b    1Artificial Organs Research Laboratory. Department of Chemical Engineering, Material Science, and Mining Engineering, Columbia University. New York City. NY 10027, USA","1Artificial Organs Research Laboratory. Department of Chemical Engineering, Material Science, and Mining Engineering, Columbia University. New York City. NY 10027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b    1Artificial Organs Research Laboratory. Department of Chemical Engineering, Material Science, and Mining Engineering, Columbia University. New York City. NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"1Artificial Organs Research Laboratory. Department of Chemical Engineering, Material Science, and Mining Engineering, Columbia University. New York City. NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008427380","display_name":"Edward F. Leonard","orcid":"https://orcid.org/0000-0001-8860-8536","observed_orcids":["https://orcid.org/0000-0001-8860-8536"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.F. Leonard","raw_affiliation_strings":["c    1Artificial Organs Research Laboratory. Department of Chemical Engineering, Material Science, and Mining Engineering, Columbia University. New York City. NY 10027, USA","1Artificial Organs Research Laboratory. Department of Chemical Engineering, Material Science, and Mining Engineering, Columbia University. New York City. NY 10027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"c    1Artificial Organs Research Laboratory. Department of Chemical Engineering, Material Science, and Mining Engineering, Columbia University. New York City. NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"1Artificial Organs Research Laboratory. Department of Chemical Engineering, Material Science, and Mining Engineering, Columbia University. New York City. NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":1.2954,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.74508349,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":"1","first_page":"1","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-protein-adsorption","display_name":"plasma protein adsorption","score":0.8939999938011169},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.8790000081062317},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.9929999709129333},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":1.0},{"id":"https://openalex.org/keywords/high-molecular-weight-kininogen","display_name":"high molecular weight kininogen","score":0.9990000128746033},{"id":"https://openalex.org/keywords/langmuir-isotherm","display_name":"Langmuir isotherm","score":0.9110000133514404},{"id":"https://openalex.org/keywords/biomaterial-surfaces","display_name":"biomaterial surfaces","score":0.7910000085830688},{"id":"https://openalex.org/keywords/surface-staining","display_name":"surface staining","score":0.5180000066757202},{"id":"https://openalex.org/keywords/plasma-dilution","display_name":"plasma dilution","score":0.6330000162124634},{"id":"https://openalex.org/keywords/flow-separation","display_name":"flow separation","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.7214193940162659},{"id":"https://openalex.org/C2777922577","wikidata":"https://www.wikidata.org/wiki/Q146243","display_name":"Polystyrene","level":3,"score":0.673344612121582},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.6050472259521484},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5638726353645325},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5626923441886902},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.537082850933075},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.5250425338745117},{"id":"https://openalex.org/C115958267","wikidata":"https://www.wikidata.org/wiki/Q464196","display_name":"Langmuir","level":3,"score":0.48433077335357666},{"id":"https://openalex.org/C88001094","wikidata":"https://www.wikidata.org/wiki/Q7251453","display_name":"Protein adsorption","level":3,"score":0.4701267182826996},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.4167901575565338},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3934205174446106},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3672722578048706},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.36407071352005005},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.29877421259880066},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12196359038352966},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11266398429870605},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000267","descriptor_name":"Tissue Adhesions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000327","descriptor_name":"Adsorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002021","descriptor_name":"Buffers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007704","descriptor_name":"Kininogens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011137","descriptor_name":"Polystyrenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011137","descriptor_name":"Polystyrenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1163/156856297x00542","doi":"https://doi.org/10.1163/156856297x00542","is_oa":false,"landing_page_url":"https://doi.org/10.1163/156856297x00542","pdf_url":null,"source":{"id":"https://openalex.org/S150667925","display_name":"Journal of Biomaterials Science Polymer Edition","issn_l":"0920-5063","issn":["0920-5063","1568-5624"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomaterials Science, Polymer Edition","raw_type":"journal-article"},{"id":"pmid:8933287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8933287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomaterials science. Polymer edition","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","score":0.6000000238418579,"display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3767466036","display_name":null,"funder_award_id":"HL 44535","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8744480497","display_name":"PLASMA PROTEIN REACTIONS IN SEPARATED FLOWS","funder_award_id":"5r01hl044535-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W142037237","https://openalex.org/W1531917249","https://openalex.org/W1966459783","https://openalex.org/W1968486149","https://openalex.org/W1971277463","https://openalex.org/W1979249968","https://openalex.org/W1983325490","https://openalex.org/W1983933457","https://openalex.org/W1984082275","https://openalex.org/W1985049569","https://openalex.org/W2013754942","https://openalex.org/W2021789067","https://openalex.org/W2022144393","https://openalex.org/W2022865031","https://openalex.org/W2024424463","https://openalex.org/W2027034049","https://openalex.org/W2028210989","https://openalex.org/W2035799618","https://openalex.org/W2040898500","https://openalex.org/W2048411143","https://openalex.org/W2051247565","https://openalex.org/W2051900389","https://openalex.org/W2057097706","https://openalex.org/W2061084809","https://openalex.org/W2068201768","https://openalex.org/W2068688585","https://openalex.org/W2076782834","https://openalex.org/W2091703206","https://openalex.org/W2128635872","https://openalex.org/W2143007110","https://openalex.org/W2164176490","https://openalex.org/W2338341558","https://openalex.org/W2418477959","https://openalex.org/W2432443528","https://openalex.org/W2475067738"],"related_works":["https://openalex.org/W1966459783","https://openalex.org/W2991991682","https://openalex.org/W1985049569","https://openalex.org/W2412004627","https://openalex.org/W2043070859","https://openalex.org/W7096563998","https://openalex.org/W2417410162","https://openalex.org/W2020063827","https://openalex.org/W2908637073","https://openalex.org/W3129270130"],"abstract_inverted_index":{"This":[0,180],"paper":[1],"describes":[2],"and":[3,36,65,102,109],"evaluates":[4],"a":[5,63,143,158],"method":[6,92,126,188],"for":[7,97,189],"quantifying":[8],"the":[9,29,74,80,85,90,129,136,164,169,174,177,183,186],"amounts":[10],"of":[11,32,47,55,76,131,138,145,149,152,171,176,185,193],"specific":[12,77,194],"plasma":[13,146,154,198],"proteins":[14,195],"adsorbed":[15,196],"to":[16,72,83,112],"biomaterial":[17],"surfaces.":[18,86],"In":[19],"particular,":[20],"it":[21],"demonstrates":[22],"that":[23,27,104],"macroscopic":[24],"images":[25],"('stains'),":[26],"assess":[28],"spatial":[30,191],"distribution":[31],"albumin,":[33,98],"IgG,":[34],"fibrinogen,":[35],"HMK":[37,117],"(high":[38],"molecular":[39],"weight":[40],"kininogen),":[41],"can":[42],"be":[43],"obtained":[44,88],"over":[45],"areas":[46],"at":[48,173],"least":[49],"12":[50],"cm2":[51],"using":[52],"immunospecific":[53],"adhesion":[54],"dyed":[56],"polystyrene":[57],"beads.":[58],"Stain":[59],"intensities,":[60],"measured":[61],"with":[62,89],"scanner":[64],"an":[66,132],"image":[67],"analysis":[68],"system,":[69],"were":[70,110],"found":[71],"quantify":[73],"amount":[75],"protein":[78,95],"in":[79,135,199],"solution":[81],"used":[82],"coat":[84],"Results":[87],"proposed":[91,125,187],"produced":[93,161],"single":[94],"isotherms":[96],"immunoglobulin":[99],"G":[100],"(IgG)":[101],"fibrinogen":[103,139,150,172],"followed":[105],"Langmuir-like":[106,121],"adsorption":[107,122,137],"behavior":[108],"similar":[111],"previously":[113],"published":[114],"isotherms.":[115],"The":[116,124],"isotherm":[118],"also":[119,127],"exhibited":[120],"behavior.":[123],"detected":[128],"presence":[130],"expected":[133],"maximum":[134],"onto":[140,155],"glass":[141,156],"as":[142,166,168],"function":[144],"dilution.":[147],"Adsorption":[148],"out":[151],"6.4%":[153],"from":[157,197],"separated":[159,178],"flow":[160],"results":[162],"indicating":[163],"quantity":[165],"well":[167],"location":[170],"boundary":[175],"region.":[179],"result":[181],"confirmed":[182],"utility":[184],"detecting":[190],"distributions":[192],"practical":[200],"devices.":[201]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}