{"id":"https://openalex.org/W1990378159","doi":"https://doi.org/10.1167/iovs.11-8361","title":"Regulation of Lysyl Oxidase-like 1 ( LOXL1 ) and Elastin-Related Genes by Pathogenic Factors Associated with Pseudoexfoliation Syndrome","display_name":"Regulation of Lysyl Oxidase-like 1 ( LOXL1 ) and Elastin-Related Genes by Pathogenic Factors Associated with Pseudoexfoliation Syndrome","publication_year":2011,"publication_date":"2011-09-25","ids":{"openalex":"https://openalex.org/W1990378159","doi":"https://doi.org/10.1167/iovs.11-8361","mag":"1990378159","pmid":"https://pubmed.ncbi.nlm.nih.gov/21948647"},"language":"en","primary_location":{"id":"doi:10.1167/iovs.11-8361","doi":"https://doi.org/10.1167/iovs.11-8361","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.11-8361","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028810073","display_name":"Matthias Zenkel","orcid":"https://orcid.org/0000-0003-0141-120X","observed_orcids":["https://orcid.org/0000-0003-0141-120X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthias Zenkel","raw_affiliation_strings":["From the Departments of Ophthalmology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Ophthalmology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064849166","display_name":"Anita Krysta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anita Krysta","raw_affiliation_strings":["From the Departments of Ophthalmology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Ophthalmology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011573420","display_name":"Francesca Pasutto","orcid":"https://orcid.org/0000-0002-0026-5362","observed_orcids":["https://orcid.org/0000-0002-0026-5362"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Francesca Pasutto","raw_affiliation_strings":["Human Genetics, University of Erlangen-N\u00fcrnberg, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genetics, University of Erlangen-N\u00fcrnberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111997470","display_name":"Anselm G M Juenemann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anselm Juenemann","raw_affiliation_strings":["From the Departments of Ophthalmology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Ophthalmology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111589543","display_name":"Friedrich Eduard Kruse","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Friedrich E. Kruse","raw_affiliation_strings":["From the Departments of Ophthalmology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Ophthalmology and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021747244","display_name":"Ursula M. Schl\u00f6tzer-Schrehardt","orcid":"https://orcid.org/0000-0001-8423-7395","observed_orcids":["https://orcid.org/0000-0001-8423-7395"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ursula Schl\u00f6tzer-Schrehardt","raw_affiliation_strings":["From the Departments of Ophthalmology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Ophthalmology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":5.2163,"has_fulltext":false,"cited_by_count":97,"citation_normalized_percentile":{"value":0.95197478,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"52","issue":"11","first_page":"8488","last_page":"8488"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.039400000125169754,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":0.02539999969303608,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudoexfoliation-syndrome","display_name":"pseudoexfoliation syndrome","score":0.9490000009536743},{"id":"https://openalex.org/keywords/pseudoexfoliation-glaucoma","display_name":"pseudoexfoliation glaucoma","score":0.9399999976158142},{"id":"https://openalex.org/keywords/loxl1","display_name":"LOXL1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/elastic-fibers","display_name":"elastic fibers","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8240000009536743},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ultraviolet-radiation","display_name":"ultraviolet radiation","score":0.871999979019165},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9850000143051147},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tenon-s-capsule-fibroblasts","display_name":"Tenon's capsule fibroblasts","score":0.9480000138282776},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.8663300275802612},{"id":"https://openalex.org/C2779541357","wikidata":"https://www.wikidata.org/wiki/Q3824795","display_name":"Pseudoexfoliation syndrome","level":3,"score":0.8593610525131226},{"id":"https://openalex.org/C193143273","wikidata":"https://www.wikidata.org/wiki/Q419389","display_name":"Lysyl oxidase","level":3,"score":0.7313429117202759},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6224416494369507},{"id":"https://openalex.org/C2780028357","wikidata":"https://www.wikidata.org/wiki/Q259817","display_name":"Elastic fiber","level":2,"score":0.6012853980064392},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4961324632167816},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4399508237838745},{"id":"https://openalex.org/C2908569227","wikidata":"https://www.wikidata.org/wiki/Q3824795","display_name":"Pseudoexfoliation","level":3,"score":0.4291667640209198},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41966748237609863},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21924346685409546},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21389883756637573},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.21122148633003235},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2104611098766327},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.1591927409172058},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.07229098677635193},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000594","descriptor_name":"Amino Acid Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004549","descriptor_name":"Elastin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017889","descriptor_name":"Exfoliation Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D058475","descriptor_name":"Tenon Capsule","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1167/iovs.11-8361","doi":"https://doi.org/10.1167/iovs.11-8361","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.11-8361","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},{"id":"pmid:21948647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21948647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W129621858","https://openalex.org/W182898172","https://openalex.org/W191434561","https://openalex.org/W1499500424","https://openalex.org/W1812782019","https://openalex.org/W1938683170","https://openalex.org/W1967551315","https://openalex.org/W1969074359","https://openalex.org/W1975875223","https://openalex.org/W1979283960","https://openalex.org/W1980852716","https://openalex.org/W1983746019","https://openalex.org/W1984229896","https://openalex.org/W1985564676","https://openalex.org/W1990709104","https://openalex.org/W1991722827","https://openalex.org/W2013222907","https://openalex.org/W2019002861","https://openalex.org/W2020852548","https://openalex.org/W2027829019","https://openalex.org/W2030407045","https://openalex.org/W2037524363","https://openalex.org/W2043243292","https://openalex.org/W2054183860","https://openalex.org/W2055525598","https://openalex.org/W2056103427","https://openalex.org/W2064314555","https://openalex.org/W2065015419","https://openalex.org/W2072504158","https://openalex.org/W2075011735","https://openalex.org/W2085224134","https://openalex.org/W2087221895","https://openalex.org/W2103382626","https://openalex.org/W2122019433","https://openalex.org/W2126736296","https://openalex.org/W2134336527","https://openalex.org/W2153902624","https://openalex.org/W2159541446","https://openalex.org/W2168918955","https://openalex.org/W2172262731","https://openalex.org/W2320447672","https://openalex.org/W2320976765","https://openalex.org/W2400056527","https://openalex.org/W2407258021","https://openalex.org/W3023110197"],"related_works":["https://openalex.org/W2056103427","https://openalex.org/W2030407045","https://openalex.org/W2020852548","https://openalex.org/W2192645316","https://openalex.org/W3006630598","https://openalex.org/W103643423","https://openalex.org/W1968933624","https://openalex.org/W2026807076","https://openalex.org/W2343721705","https://openalex.org/W6996161770"],"abstract_inverted_index":{"PURPOSE:":[0],"Pseudoexfoliation":[1],"(PEX)":[2],"syndrome/glaucoma":[3],"is":[4,17],"a":[5,130],"complex,":[6],"late-onset":[7],"disorder":[8],"of":[9,35,40,48,57,95,100,119,136,144,150,160,176,192,210,245],"the":[10,20,33,36,46,54,93,142,203,207,213,225,242],"elastic":[11,98,139,151,163],"fiber":[12,164],"system.":[13],"Strong":[14],"genetic":[15,229],"risk":[16],"conferred":[18],"by":[19,107],"lysyl":[21],"oxidase-like":[22],"1":[23],"(LOXL1)":[24],"gene,":[25],"but":[26,212],"additional":[27],"comodulating":[28],"factors":[29,52],"are":[30],"necessary":[31],"for":[32],"manifestation":[34],"disease.":[37],"The":[38,222],"aim":[39],"this":[41],"study":[42],"was":[43,146,197],"to":[44,76,148],"analyze":[45],"effect":[47,143],"various":[49],"PEX-associated":[50],"pathogenic":[51],"on":[53,181],"genotype-correlated":[55],"expression":[56,94,134,191],"LOXL1":[58,72,96,137,161,193],"and":[59,70,97,103,114,127,138,154,162,166,185,189,195,230,236],"elastin-related":[60],"genes.":[61],"METHODS:":[62],"Cultured":[63],"human":[64],"Tenon's":[65],"capsule":[66],"fibroblasts":[67,120],"with":[68,121,173,183,206],"high-":[69],"low-risk":[71,208],"haplotypes":[73],"were":[74,105,217],"exposed":[75],"transforming":[77],"growth":[78],"factor":[79],"(TGF)-\u03b21,":[80],"interleukin":[81],"(IL)-6,":[82],"homocysteine,":[83],"oxidative":[84,123,186,237],"stress,":[85,124,238],"hypoxia,":[86],"or":[87],"ultraviolet":[88],"(UV)":[89],"radiation.":[90],"Changes":[91],"in":[92,133,200,241],"constituents":[99],"PEX":[101,246],"material":[102],"TGF-\u03b21":[104,184,235],"assessed":[106],"quantitative":[108],"real-time":[109],"PCR,":[110],"Western":[111],"blotting,":[112],"immunohistochemistry,":[113],"electron":[115,155],"microscopy.":[116],"RESULTS:":[117],"Treatment":[118],"TGF-\u03b21,":[122],"UV":[125],"light,":[126],"hypoxia":[128],"induced":[129],"significant":[131],"increase":[132],"levels":[135],"proteins,":[140],"whereas":[141],"IL-6":[145],"limited":[147],"induction":[149],"constituents.":[152],"Immunohistochemistry":[153],"microscopy":[156],"confirmed":[157],"an":[158],"upregulation":[159],"proteins":[165],"their":[167],"assembly":[168],"into":[169,178],"extracellular":[170],"microfibrillar":[171],"networks":[172],"focal":[174],"aggregation":[175],"microfibrils":[177],"PEX-like":[179],"fibrils":[180],"stimulation":[182],"stress.":[187],"Basal":[188],"stimulated":[190],"mRNA":[194],"protein":[196],"slightly":[198],"decreased":[199],"cells":[201],"carrying":[202],"high-risk":[204],"compared":[205],"haplotype":[209],"LOXL1,":[211],"differences":[214],"between":[215],"groups":[216],"statistically":[218],"not":[219],"significant.":[220],"CONCLUSIONS:":[221],"findings":[223],"support":[224],"notion":[226],"that":[227],"both":[228],"nongenetic":[231],"fibrogenic":[232],"factors,":[233],"particularly":[234],"may":[239],"cooperate":[240],"stable":[243],"accumulation":[244],"aggregates.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}