{"id":"https://openalex.org/W1990376003","doi":"https://doi.org/10.1371/journal.pone.0048224","title":"Disruption of the Human Gut Microbiota following Norovirus Infection","display_name":"Disruption of the Human Gut Microbiota following Norovirus Infection","publication_year":2012,"publication_date":"2012-10-30","ids":{"openalex":"https://openalex.org/W1990376003","doi":"https://doi.org/10.1371/journal.pone.0048224","mag":"1990376003","pmid":"https://pubmed.ncbi.nlm.nih.gov/23118957"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0048224","doi":"https://doi.org/10.1371/journal.pone.0048224","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0048224","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048224&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048224&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030704403","display_name":"Adam M. Nelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adam M. Nelson","raw_affiliation_strings":["Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA. nelso222@gmail.com","Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, Michigan, United States of America","Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA. nelso222@gmail.com","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039480482","display_name":"Seth T. Walk","orcid":"https://orcid.org/0000-0001-6891-8537","observed_orcids":["https://orcid.org/0000-0001-6891-8537"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth T. Walk","raw_affiliation_strings":["Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003449441","display_name":"Stefan Taube","orcid":"https://orcid.org/0000-0002-9159-3651","observed_orcids":["https://orcid.org/0000-0002-9159-3651"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Taube","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051998945","display_name":"Mami Taniuchi","orcid":"https://orcid.org/0000-0002-7559-1998","observed_orcids":["https://orcid.org/0000-0002-7559-1998"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mami Taniuchi","raw_affiliation_strings":["Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007061685","display_name":"Eric R. Houpt","orcid":"https://orcid.org/0000-0003-1085-1354","observed_orcids":["https://orcid.org/0000-0003-1085-1354"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric R. Houpt","raw_affiliation_strings":["Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032714357","display_name":"Christiane E. Wobus","orcid":"https://orcid.org/0000-0001-5286-0924","observed_orcids":["https://orcid.org/0000-0001-5286-0924"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christiane E. Wobus","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049294221","display_name":"Vincent Bensan Young","orcid":"https://orcid.org/0000-0003-3687-2364","observed_orcids":["https://orcid.org/0000-0003-3687-2364"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent B. Young","raw_affiliation_strings":["Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, Michigan, United States of America","Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5030704403"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.7881,"has_fulltext":true,"cited_by_count":127,"citation_normalized_percentile":{"value":0.91258847,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"7","issue":"10","first_page":"e48224","last_page":"e48224"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.796999990940094},{"id":"https://openalex.org/keywords/norovirus-infection","display_name":"norovirus infection","score":0.8679999709129333},{"id":"https://openalex.org/keywords/microbiota-disruption","display_name":"microbiota disruption","score":0.7820000052452087},{"id":"https://openalex.org/keywords/proteobacteria","display_name":"Proteobacteria","score":0.9010000228881836},{"id":"https://openalex.org/keywords/bacteroidetes","display_name":"Bacteroidetes","score":0.9359999895095825},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ribotyping","display_name":"ribotyping","score":0.6959999799728394},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.9739999771118164},{"id":"https://openalex.org/keywords/intestinal-infection","display_name":"intestinal infection","score":0.628000020980835},{"id":"https://openalex.org/keywords/stool-microbiota","display_name":"stool microbiome","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C2778750513","wikidata":"https://www.wikidata.org/wiki/Q1142751","display_name":"Norovirus","level":3,"score":0.9171134233474731},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7941067814826965},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7476663589477539},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.7119373083114624},{"id":"https://openalex.org/C2779676784","wikidata":"https://www.wikidata.org/wiki/Q130999","display_name":"Proteobacteria","level":4,"score":0.5930086374282837},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.5836279988288879},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3492947220802307},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3259413540363312},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2877836525440216},{"id":"https://openalex.org/C42062724","wikidata":"https://www.wikidata.org/wiki/Q1209205","display_name":"16S ribosomal RNA","level":3,"score":0.18620818853378296},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.15972772240638733},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14563587307929993},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14456644654273987}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005759","descriptor_name":"Gastroenteritis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005759","descriptor_name":"Gastroenteritis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005759","descriptor_name":"Gastroenteritis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017250","descriptor_name":"Caliciviridae Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D017250","descriptor_name":"Caliciviridae Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D017250","descriptor_name":"Caliciviridae Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D029322","descriptor_name":"Norovirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029322","descriptor_name":"Norovirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029322","descriptor_name":"Norovirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D041963","descriptor_name":"Bacteroidetes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D041963","descriptor_name":"Bacteroidetes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D041963","descriptor_name":"Bacteroidetes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D041963","descriptor_name":"Bacteroidetes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D041963","descriptor_name":"Bacteroidetes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D041963","descriptor_name":"Bacteroidetes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058889","descriptor_name":"Molecular Typing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058889","descriptor_name":"Molecular Typing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058889","descriptor_name":"Molecular Typing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0048224","doi":"https://doi.org/10.1371/journal.pone.0048224","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0048224","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048224&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:23118957","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23118957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3484122","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3484122","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.771.7226","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.771.7226","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a7/d2/pone.0048224.PMC3484122.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:32073c0367154269bdd1a499b1698ef3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/32073c0367154269bdd1a499b1698ef3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 10, p e48224 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/118079","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Disruption_of_the_Human_Gut_Microbiota_following_Norovirus_Infection__/118079","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0048224","doi":"https://doi.org/10.1371/journal.pone.0048224","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0048224","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048224&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7400000095367432}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3903617685","display_name":null,"funder_award_id":"U01AI075396","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G902668629","display_name":null,"funder_award_id":"5 U01 AI075396","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309652","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990376003.pdf","grobid_xml":"https://content.openalex.org/works/W1990376003.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W105760296","https://openalex.org/W1487811474","https://openalex.org/W1525234204","https://openalex.org/W1527298303","https://openalex.org/W1716783468","https://openalex.org/W1963562551","https://openalex.org/W1974577714","https://openalex.org/W1984974981","https://openalex.org/W1985684734","https://openalex.org/W1987051219","https://openalex.org/W1987184081","https://openalex.org/W1992174684","https://openalex.org/W1998990856","https://openalex.org/W2011581147","https://openalex.org/W2012289680","https://openalex.org/W2026074634","https://openalex.org/W2030842783","https://openalex.org/W2037673292","https://openalex.org/W2040896401","https://openalex.org/W2041341409","https://openalex.org/W2048093113","https://openalex.org/W2050939953","https://openalex.org/W2053593613","https://openalex.org/W2055040162","https://openalex.org/W2056091951","https://openalex.org/W2059521692","https://openalex.org/W2064201279","https://openalex.org/W2069894149","https://openalex.org/W2075869595","https://openalex.org/W2095655760","https://openalex.org/W2097875133","https://openalex.org/W2099119185","https://openalex.org/W2099329670","https://openalex.org/W2100259805","https://openalex.org/W2102729801","https://openalex.org/W2108718991","https://openalex.org/W2111054935","https://openalex.org/W2114455930","https://openalex.org/W2123812491","https://openalex.org/W2128591134","https://openalex.org/W2128769815","https://openalex.org/W2129029652","https://openalex.org/W2131186249","https://openalex.org/W2136957224","https://openalex.org/W2143775010","https://openalex.org/W2149717767","https://openalex.org/W2151028255","https://openalex.org/W2156080241","https://openalex.org/W2157800726","https://openalex.org/W2159111033","https://openalex.org/W2160672581","https://openalex.org/W2164846935","https://openalex.org/W4250467159"],"related_works":["https://openalex.org/W2353498255","https://openalex.org/W2158937766","https://openalex.org/W2347463849","https://openalex.org/W2436036196","https://openalex.org/W2380870509","https://openalex.org/W4386134360","https://openalex.org/W4220674773","https://openalex.org/W2735197665","https://openalex.org/W2102979443","https://openalex.org/W2484476310"],"abstract_inverted_index":{"The":[0],"gut":[1,51,188],"microbiota,":[2],"the":[3,10,21,50,56,64,75,119],"collection":[4],"of":[5,20,27,55,93,108,132],"all":[6],"bacterial":[7],"members":[8],"in":[9,17,67,77,87,114,121],"intestinal":[11,33],"tract,":[12],"plays":[13],"a":[14,25,91,99,111,126,197],"key":[15],"role":[16],"health.":[18],"Disruption":[19],"indigenous":[22],"microbiota":[23,66,76,102,199],"by":[24,104,163],"variety":[26],"stressors,":[28],"including":[29],"antibiotic":[30],"therapy":[31],"and":[32,110,142,147,170,203],"infections,":[34],"is":[35],"associated":[36],"with":[37,47],"multiple":[38],"health":[39,212],"problems.":[40],"We":[41,135],"sought":[42],"to":[43,62,125,177],"determine":[44],"if":[45],"infection":[46],"Norovirus":[48,201],"disrupts":[49],"microbiota.":[52],"Barcoded":[53],"pyrosequencing":[54],"16S":[57],"rRNA-encoding":[58],"gene":[59],"was":[60,123],"used":[61],"characterize":[63],"stool":[65],"Norovirus-infected":[68,140],"human":[69],"patients":[70,80,94,141,195],"(n":[71,81,95],"=":[72,82,96],"38).":[73],"While":[74],"most":[78],"infected":[79],"31)":[83],"resembled":[84],"that":[85,193],"seen":[86],"uninfected":[88],"healthy":[89],"controls,":[90],"minority":[92],"7)":[97],"possessed":[98,157],"significantly":[100,175],"altered":[101],"characterized":[103,143],"reduced":[105],"relative":[106],"numbers":[107],"Bacteriodetes":[109],"corresponding":[112],"increase":[113,120],"Proteobacteria.":[115],"In":[116],"these":[117],"patients,":[118],"Proteobacteria":[122,172],"due":[124],"single":[127],"operational":[128],"taxonomic":[129],"unit":[130],"(OTU)":[131],"Escherichia":[133],"coli.":[134],"cultured":[136],"E.":[137,165],"coli":[138,166],"from":[139],"them":[144],"using":[145],"PCR-ribotyping":[146],"virulence":[148,159],"factor":[149],"analysis.":[150],"Multiple":[151],"ribotypes":[152],"were":[153,173],"encountered,":[154],"but":[155],"none":[156],"typical":[158],"factors":[160],"commonly":[161],"carried":[162],"enteropathogenic":[164],"strains.":[167],"Microbiota":[168],"disruption":[169],"elevated":[171,208],"not":[174],"correlated":[176],"patient":[178],"age,":[179],"gender,":[180],"sampling":[181],"time":[182],"following":[183,200],"illness":[184],"onset,":[185],"or":[186],"overall":[187],"inflammation.":[189],"These":[190],"results":[191],"demonstrate":[192],"some":[194],"have":[196],"disrupted":[198],"infection,":[202],"therefore":[204],"may":[205],"be":[206],"at":[207],"risk":[209],"for":[210],"long-term":[211],"complications.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}