{"id":"https://openalex.org/W1990363400","doi":"https://doi.org/10.1089/dna.2008.0732","title":"Association of Matrix Metalloproteinases-9 Gene Polymorphisms with Genetic Susceptibility to Esophageal Squamous Cell Carcinoma","display_name":"Association of Matrix Metalloproteinases-9 Gene Polymorphisms with Genetic Susceptibility to Esophageal Squamous Cell Carcinoma","publication_year":2008,"publication_date":"2008-08-04","ids":{"openalex":"https://openalex.org/W1990363400","doi":"https://doi.org/10.1089/dna.2008.0732","mag":"1990363400","pmid":"https://pubmed.ncbi.nlm.nih.gov/18680431"},"language":"en","primary_location":{"id":"doi:10.1089/dna.2008.0732","doi":"https://doi.org/10.1089/dna.2008.0732","is_oa":false,"landing_page_url":"https://doi.org/10.1089/dna.2008.0732","pdf_url":null,"source":{"id":"https://openalex.org/S97146013","display_name":"DNA and Cell Biology","issn_l":"1044-5498","issn":["1044-5498","1557-7430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA and Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101911234","display_name":"Jin Wu","orcid":"https://orcid.org/0000-0002-7924-2613","observed_orcids":["https://orcid.org/0000-0002-7924-2613"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Wu","raw_affiliation_strings":["Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Zhang","raw_affiliation_strings":["Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006695497","display_name":"Hao Luo","orcid":"https://orcid.org/0000-0001-5463-9852","observed_orcids":["https://orcid.org/0000-0001-5463-9852"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Luo","raw_affiliation_strings":["Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044966199","display_name":"Zhendong Zhu","orcid":"https://orcid.org/0000-0002-6867-0591","observed_orcids":["https://orcid.org/0000-0002-6867-0591"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhendong Zhu","raw_affiliation_strings":["Department of Histology and Embryology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048108638","display_name":"Cong\u2010Hai Zhang","orcid":"https://orcid.org/0000-0001-9796-4911","observed_orcids":["https://orcid.org/0000-0001-9796-4911"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Conghai Zhang","raw_affiliation_strings":["Department of Morphology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048663245","display_name":"Yiping Hou","orcid":"https://orcid.org/0000-0003-4254-2388","observed_orcids":["https://orcid.org/0000-0003-4254-2388"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiping Hou","raw_affiliation_strings":["Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4782,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.83889627,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"27","issue":"10","first_page":"553","last_page":"557"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.5038999915122986,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.5038999915122986,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.4675000011920929,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9470000267028809},{"id":"https://openalex.org/keywords/mmp-9-gene-polymorphism","display_name":"MMP-9 gene polymorphism","score":0.9350000023841858},{"id":"https://openalex.org/keywords/esophageal-squamous-cell-carcinoma","display_name":"esophageal squamous cell carcinoma","score":0.9739999771118164},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9760000109672546},{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.8050000071525574},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.6079999804496765},{"id":"https://openalex.org/keywords/chinese-population","display_name":"Chinese population","score":0.7099999785423279},{"id":"https://openalex.org/keywords/tumor-invasion-and-metastasis","display_name":"tumor invasion and metastasis","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.8642311096191406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8164151906967163},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7508096098899841},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6470280289649963},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5534480214118958},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5065237283706665},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.4361114203929901},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42496517300605774},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40964648127555847},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3633335828781128},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3472195267677307},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07498887181282043},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/dna.2008.0732","doi":"https://doi.org/10.1089/dna.2008.0732","is_oa":false,"landing_page_url":"https://doi.org/10.1089/dna.2008.0732","pdf_url":null,"source":{"id":"https://openalex.org/S97146013","display_name":"DNA and Cell Biology","issn_l":"1044-5498","issn":["1044-5498","1557-7430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA and Cell Biology","raw_type":"journal-article"},{"id":"pmid:18680431","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18680431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA and cell biology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306650","display_name":"China Medical Board","ror":"https://ror.org/02jpa9x52"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1503337666","https://openalex.org/W1806896498","https://openalex.org/W1820069114","https://openalex.org/W1971653050","https://openalex.org/W1983609115","https://openalex.org/W1988517229","https://openalex.org/W1994971225","https://openalex.org/W2015865893","https://openalex.org/W2020206029","https://openalex.org/W2027275036","https://openalex.org/W2040143851","https://openalex.org/W2043703193","https://openalex.org/W2046091872","https://openalex.org/W2054704516","https://openalex.org/W2069118847","https://openalex.org/W2077142428","https://openalex.org/W2082812095","https://openalex.org/W2083878136","https://openalex.org/W2091429519","https://openalex.org/W2093512107","https://openalex.org/W2097540122","https://openalex.org/W2098323713","https://openalex.org/W2128049766","https://openalex.org/W2133794263","https://openalex.org/W2149110775","https://openalex.org/W2157425429","https://openalex.org/W2159845139","https://openalex.org/W2159954806","https://openalex.org/W2162030705","https://openalex.org/W2164313608","https://openalex.org/W3168182028"],"related_works":["https://openalex.org/W2355892166","https://openalex.org/W2419164148","https://openalex.org/W2136531119","https://openalex.org/W7098444206","https://openalex.org/W3200571212","https://openalex.org/W4306777405","https://openalex.org/W2402935195","https://openalex.org/W2090904374","https://openalex.org/W2598261676","https://openalex.org/W992427625"],"abstract_inverted_index":{"Matrix":[0],"metalloproteinases-9":[1],"(MMP-9)":[2],"plays":[3],"important":[4],"roles":[5],"in":[6,17,21,67,75,196],"tumor":[7],"invasion":[8],"and":[9,33,59,78,90,135,164],"metastasis":[10],"by":[11],"degrading":[12],"extracellular":[13],"matrix":[14],"components.":[15],"Variations":[16],"the":[18,22,53,56,63,76,85,108,146,153,171,179],"DNA":[19],"sequence":[20],"MMP-9":[23,29,57,86,161,183],"gene":[24,87,184],"may":[25,36,187],"lead":[26],"to":[27,41,189],"altered":[28],"production":[30],"and/or":[31],"activity,":[32],"so":[34],"this":[35,49],"modulate":[37],"an":[38],"individual's":[39],"susceptibility":[40],"esophageal":[42],"squamous":[43],"cell":[44],"carcinoma":[45],"(ESCC).":[46],"To":[47],"test":[48],"hypothesis,":[50],"we":[51],"investigated":[52],"association":[54],"of":[55,65,81,84,103,149,155,173],"polymorphisms":[58,163],"their":[60],"haplotypes":[61,143],"with":[62,98,107,125,170],"risk":[64,102,148,172,192],"ESCC":[66,104,150,195],"a":[68,99,190,197],"Chinese":[69,198],"population.":[70,199],"There":[71],"were":[72,96],"significant":[73],"differences":[74],"genotype":[77],"allele":[79],"distribution":[80],"P574R":[82,93,162,185],"polymorphism":[83,186],"among":[88],"cases":[89],"controls.":[91],"The":[92],"GG":[94],"genotypes":[95,110],"associated":[97,169],"significantly":[100,168],"increased":[101],"as":[105],"compared":[106],"CC":[109],"(odds":[111],"ratio":[112],"[OR]":[113],"=":[114,122,130,138],"4.08;":[115],"95%":[116,132,140],"confidence":[117],"interval":[118],"[CI]:":[119],"1.58-10.52;":[120],"p":[121],"0.00).":[123],"Compared":[124],"279R-574P":[126],"haplotype,":[127],"279R-574R":[128,156],"(OR":[129,137],"3.52;":[131],"CI:":[133,141],"1.99-6.25)":[134],"279Q-574P":[136],"2.16;":[139],"1.07-4.35)":[142],"can":[144],"increase":[145],"onset":[147],"statistically,":[151],"but":[152],"role":[154],"haplotype":[157,166],"is":[158],"more":[159],"obvious.":[160],"P574R-R279Q":[165],"are":[167],"ESCC.":[174],"Our":[175],"study":[176],"shows":[177],"for":[178,194],"first":[180],"time":[181],"that":[182],"contribute":[188],"genetic":[191],"factor":[193]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
