{"id":"https://openalex.org/W1990361085","doi":"https://doi.org/10.1080/01635581.2014.916320","title":"Suppression by Geraniol of the Growth of A549 Human Lung Adenocarcinoma Cells and Inhibition of the Mevalonate Pathway in Culture and In Vivo: Potential Use in Cancer Chemotherapy","display_name":"Suppression by Geraniol of the Growth of A549 Human Lung Adenocarcinoma Cells and Inhibition of the Mevalonate Pathway in Culture and In Vivo: Potential Use in Cancer Chemotherapy","publication_year":2014,"publication_date":"2014-05-29","ids":{"openalex":"https://openalex.org/W1990361085","doi":"https://doi.org/10.1080/01635581.2014.916320","mag":"1990361085","pmid":"https://pubmed.ncbi.nlm.nih.gov/24875281"},"language":"en","primary_location":{"id":"doi:10.1080/01635581.2014.916320","doi":"https://doi.org/10.1080/01635581.2014.916320","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01635581.2014.916320","pdf_url":null,"source":{"id":"https://openalex.org/S105083709","display_name":"Nutrition and Cancer","issn_l":"0163-5581","issn":["0163-5581","1532-7914"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319847","host_organization_name":"Routledge","host_organization_lineage":["https://openalex.org/P4310319847","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Routledge","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition and Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11336/32290","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003063988","display_name":"Marianela Galle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210138160","display_name":"Centro Cient\u00edfico Tecnol\u00f3gico - La Plata","ror":"https://ror.org/03qan4b12","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Marianela Galle","raw_affiliation_strings":["a Instituto de Investigaciones Bioqu\u00edmicas de La Plata, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Centro Cient\u00edfico Tecnol\u00f3gico , Universidad Nacional de La Plata , Facultad de Cs. M\u00e9dicas , La Plata , Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Instituto de Investigaciones Bioqu\u00edmicas de La Plata, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Centro Cient\u00edfico Tecnol\u00f3gico , Universidad Nacional de La Plata , Facultad de Cs. M\u00e9dicas , La Plata , Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210138160","https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058641625","display_name":"Rosana Crespo","orcid":"https://orcid.org/0000-0003-2455-5951","observed_orcids":["https://orcid.org/0000-0003-2455-5951"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210138160","display_name":"Centro Cient\u00edfico Tecnol\u00f3gico - La Plata","ror":"https://ror.org/03qan4b12","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Rosana Crespo","raw_affiliation_strings":["Instituto de Investigaciones Bioqu\u00edmicas de La Plata, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Centro Cient\u00edfico Tecnol\u00f3gico, Universidad Nacional de La Plata, Facultad de Cs. M\u00e9dicas, La Plata, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Bioqu\u00edmicas de La Plata, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Centro Cient\u00edfico Tecnol\u00f3gico, Universidad Nacional de La Plata, Facultad de Cs. M\u00e9dicas, La Plata, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210138160","https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046008089","display_name":"Boris Rodenak\u2010Kladniew","orcid":"https://orcid.org/0000-0001-6963-0690","observed_orcids":["https://orcid.org/0000-0001-6963-0690"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210138160","display_name":"Centro Cient\u00edfico Tecnol\u00f3gico - La Plata","ror":"https://ror.org/03qan4b12","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Boris Rodenak Kladniew","raw_affiliation_strings":["Instituto de Investigaciones Bioqu\u00edmicas de La Plata, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Centro Cient\u00edfico Tecnol\u00f3gico, Universidad Nacional de La Plata, Facultad de Cs. M\u00e9dicas, La Plata, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Bioqu\u00edmicas de La Plata, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Centro Cient\u00edfico Tecnol\u00f3gico, Universidad Nacional de La Plata, Facultad de Cs. M\u00e9dicas, La Plata, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210138160","https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sandra Montero Villegas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210138160","display_name":"Centro Cient\u00edfico Tecnol\u00f3gico - La Plata","ror":"https://ror.org/03qan4b12","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Sandra Montero Villegas","raw_affiliation_strings":["Instituto de Investigaciones Bioqu\u00edmicas de La Plata, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Centro Cient\u00edfico Tecnol\u00f3gico, Universidad Nacional de La Plata, Facultad de Cs. M\u00e9dicas, La Plata, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Bioqu\u00edmicas de La Plata, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Centro Cient\u00edfico Tecnol\u00f3gico, Universidad Nacional de La Plata, Facultad de Cs. M\u00e9dicas, La Plata, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210138160","https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110068261","display_name":"M\u00f3nica Patricia Polo","orcid":"https://orcid.org/0000-0001-8422-1019","observed_orcids":["https://orcid.org/0000-0001-8422-1019"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210138160","display_name":"Centro Cient\u00edfico Tecnol\u00f3gico - La Plata","ror":"https://ror.org/03qan4b12","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"M\u00f3nica Polo","raw_affiliation_strings":["Instituto de Investigaciones Bioqu\u00edmicas de La Plata, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Centro Cient\u00edfico Tecnol\u00f3gico, Universidad Nacional de La Plata, Facultad de Cs. M\u00e9dicas, La Plata, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Bioqu\u00edmicas de La Plata, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Centro Cient\u00edfico Tecnol\u00f3gico, Universidad Nacional de La Plata, Facultad de Cs. M\u00e9dicas, La Plata, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210138160","https://openalex.org/I874386039"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102250571","display_name":"Margarita Mar\u00eda Garc\u00eda de Bravo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210138160","display_name":"Centro Cient\u00edfico Tecnol\u00f3gico - La Plata","ror":"https://ror.org/03qan4b12","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Margarita G. de Bravo","raw_affiliation_strings":["Instituto de Investigaciones Bioqu\u00edmicas de La Plata, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Centro Cient\u00edfico Tecnol\u00f3gico, Universidad Nacional de La Plata, Facultad de Cs. M\u00e9dicas, La Plata, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Bioqu\u00edmicas de La Plata, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Centro Cient\u00edfico Tecnol\u00f3gico, Universidad Nacional de La Plata, Facultad de Cs. M\u00e9dicas, La Plata, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210138160","https://openalex.org/I874386039"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003063988"],"corresponding_institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210138160","https://openalex.org/I874386039"],"apc_list":null,"apc_paid":null,"fwci":0.9191,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.7058716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"66","issue":"5","first_page":"888","last_page":"895"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.5088000297546387,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.5088000297546387,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.12160000205039978,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.09510000050067902,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/geraniol","display_name":"geraniol","score":1.0},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/mevalonate-pathway","display_name":"mevalonate pathway","score":0.9950000047683716},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cholesterogenesis","display_name":"cholesterogenesis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cholesterolemia","display_name":"cholesterolemia","score":0.8989999890327454},{"id":"https://openalex.org/keywords/ras-proteins","display_name":"Ras proteins","score":0.8640000224113464},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7689999938011169},{"id":"https://openalex.org/keywords/essential-oils","display_name":"essential oils","score":0.703000009059906},{"id":"https://openalex.org/keywords/cancer-chemotherapy","display_name":"cancer chemotherapy","score":0.6100000143051147},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7757353782653809},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.7308081388473511},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7039499282836914},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6263257265090942},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.5765203237533569},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5686661005020142},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4678512215614319},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4463481307029724},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42788177728652954},{"id":"https://openalex.org/C2778240251","wikidata":"https://www.wikidata.org/wiki/Q410836","display_name":"Geraniol","level":3,"score":0.42120561003685},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4135757088661194},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35535314679145813},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3373678922653198},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.09060809016227722},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.05145862698554993},{"id":"https://openalex.org/C2777278459","wikidata":"https://www.wikidata.org/wiki/Q170885","display_name":"Essential oil","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000080462","descriptor_name":"Acyclic Monoterpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006903","descriptor_name":"Hydroxymethylglutaryl CoA Reductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006903","descriptor_name":"Hydroxymethylglutaryl CoA Reductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008798","descriptor_name":"Mevalonic Acid","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008798","descriptor_name":"Mevalonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/01635581.2014.916320","doi":"https://doi.org/10.1080/01635581.2014.916320","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01635581.2014.916320","pdf_url":null,"source":{"id":"https://openalex.org/S105083709","display_name":"Nutrition and Cancer","issn_l":"0163-5581","issn":["0163-5581","1532-7914"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319847","host_organization_name":"Routledge","host_organization_lineage":["https://openalex.org/P4310319847","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Routledge","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition and Cancer","raw_type":"journal-article"},{"id":"pmid:24875281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24875281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition and cancer","raw_type":"Journal Article"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/32290","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/32290","pdf_url":null,"source":{"id":"https://openalex.org/S4306402455","display_name":"CONICET Digital (CONICET)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210148385","host_organization_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","host_organization_lineage":["https://openalex.org/I4210148385"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:ri.conicet.gov.ar:11336/32290","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/32290","pdf_url":null,"source":{"id":"https://openalex.org/S4306402455","display_name":"CONICET Digital (CONICET)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210148385","host_organization_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","host_organization_lineage":["https://openalex.org/I4210148385"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320322227","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929"},{"id":"https://openalex.org/F4320334832","display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/03stxzb56"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W16482145","https://openalex.org/W140715057","https://openalex.org/W1499006142","https://openalex.org/W1629660124","https://openalex.org/W1870436667","https://openalex.org/W1878812720","https://openalex.org/W1920904246","https://openalex.org/W1967825083","https://openalex.org/W2012605209","https://openalex.org/W2019761140","https://openalex.org/W2034378607","https://openalex.org/W2037243061","https://openalex.org/W2052432585","https://openalex.org/W2057466768","https://openalex.org/W2066814742","https://openalex.org/W2070732640","https://openalex.org/W2071124826","https://openalex.org/W2074047945","https://openalex.org/W2085680350","https://openalex.org/W2096527204","https://openalex.org/W2109031404","https://openalex.org/W2114918609","https://openalex.org/W2123781894","https://openalex.org/W2128635872","https://openalex.org/W2136240474","https://openalex.org/W2140118120","https://openalex.org/W2168260178","https://openalex.org/W2168526937","https://openalex.org/W2168812832","https://openalex.org/W2169270120","https://openalex.org/W2184786725","https://openalex.org/W2225386332"],"related_works":["https://openalex.org/W1629660124","https://openalex.org/W1875691087","https://openalex.org/W3159468716","https://openalex.org/W2019409384","https://openalex.org/W190689301","https://openalex.org/W586597035","https://openalex.org/W2136240474","https://openalex.org/W2293421874","https://openalex.org/W2042296503","https://openalex.org/W7098256515"],"abstract_inverted_index":{"Geraniol":[0],"(G)-a":[1],"natural":[2],"compound":[3],"present":[4],"in":[5,32,50,52,56,58,64,94,104,118,128,147,169,174],"the":[6,24,43,111,132,142,156],"essential":[7],"oils":[8],"of":[9,23,45,88,100,113,134,144],"many":[10],"aromatic":[11],"plants-has":[12],"attracted":[13],"interest":[14],"for":[15,193],"its":[16],"potential":[17],"antitumor":[18,185],"effects.":[19],"The":[20],"molecular":[21],"mechanisms":[22],"growth":[25,86,93],"inhibition":[26,87],"and":[27,55,73,84,91,126,166,187],"apoptosis":[28,168],"induced":[29],"by":[30],"G":[31,46,80,109,145,182],"cancer":[33,194],"cells,":[34],"however,":[35],"remain":[36],"unclear.":[37],"In":[38],"this":[39,148],"study,":[40],"we":[41,179],"investigated":[42],"effects":[44],"on":[47],"cell":[48,164],"proliferation":[49,165],"culture":[51],"A549":[53,89,170],"cells":[54,62,90],"vivo":[57,95,105],"those":[59],"same":[60],"tumor":[61,92],"implanted":[63],"nude":[65],"mice":[66],"fed":[67],"diets":[68],"supplemented":[69],"with":[70,97,124],"25,":[71],"50,":[72],"75":[74],"mmol":[75],"G/kg.":[76],"We":[77],"demonstrated":[78],"that":[79,108,141,181],"caused":[81],"a":[82,120,190],"dose-":[83],"time-dependent":[85],"along":[96,123],"an":[98],"induction":[99],"apoptosis.":[101],"Moreover,":[102],"further":[103],"assays":[106],"indicated":[107],"decreased":[110],"levels":[112],"3-hydroxymethylglutarylcoenzyme-A":[114],"reductase-the":[115],"rate-limiting":[116],"enzyme":[117],"cholesterogenesis-in":[119],"dose-dependent":[121],"manner":[122],"cholesterogenesis":[125],"cholesterolemia":[127],"addition":[129],"to":[130,152,163],"reducing":[131],"amount":[133],"membrane-bound":[135],"Ras":[136],"protein.":[137],"These":[138],"results":[139],"showed":[140],"doses":[143],"used":[146],"work,":[149],"though":[150],"nontoxic":[151],"animals,":[153],"clearly":[154],"inhibited":[155],"mevalonate":[157],"pathway,":[158],"which":[159],"is":[160],"closely":[161],"linked":[162],"increased":[167],"tumors,":[171],"but":[172],"not":[173],"normal":[175],"mouse-liver":[176],"cells.":[177],"Accordingly,":[178],"suggest":[180],"displays":[183],"significant":[184],"activity":[186],"should":[188],"be":[189],"promising":[191],"candidate":[192],"chemotherapy.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}