{"id":"https://openalex.org/W1990356197","doi":"https://doi.org/10.1002/jmv.1890150404","title":"Absence of detectable hepatitis B virus DNA in sera and liver of chimpanzees with non\u2010A, non\u2010B hepatitis","display_name":"Absence of detectable hepatitis B virus DNA in sera and liver of chimpanzees with non\u2010A, non\u2010B hepatitis","publication_year":1985,"publication_date":"1985-08-01","ids":{"openalex":"https://openalex.org/W1990356197","doi":"https://doi.org/10.1002/jmv.1890150404","mag":"1990356197","pmid":"https://pubmed.ncbi.nlm.nih.gov/3920354"},"language":"en","primary_location":{"id":"doi:10.1002/jmv.1890150404","doi":"https://doi.org/10.1002/jmv.1890150404","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jmv.1890150404","pdf_url":null,"source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110015982","display_name":"S. H. Yap","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279838","display_name":"Organon (Netherlands)","ror":"https://ror.org/02388np20","country_code":"NL","type":"company","lineage":["https://openalex.org/I4405279838"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"S. H. Yap","raw_affiliation_strings":["Division of Gastrointestinal and Liver Diseases, Department of Medicine, St. Radboud University Hospital, Nijmegen Organon Scientific Development Group, Oss, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastrointestinal and Liver Diseases, Department of Medicine, St. Radboud University Hospital, Nijmegen Organon Scientific Development Group, Oss, The Netherlands","institution_ids":["https://openalex.org/I4405279838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063071650","display_name":"J. A. Heilings","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279838","display_name":"Organon (Netherlands)","ror":"https://ror.org/02388np20","country_code":"NL","type":"company","lineage":["https://openalex.org/I4405279838"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. A. Heilings","raw_affiliation_strings":["St. Radboud University Hospital, Nijmegen Organon Scientific Development Group, Oss, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Radboud University Hospital, Nijmegen Organon Scientific Development Group, Oss, The Netherlands","institution_ids":["https://openalex.org/I4405279838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090583614","display_name":"P. J. M. Rijntjes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279838","display_name":"Organon (Netherlands)","ror":"https://ror.org/02388np20","country_code":"NL","type":"company","lineage":["https://openalex.org/I4405279838"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P. J. M. Rijntjes","raw_affiliation_strings":["Division of Gastrointestinal and Liver Diseases, Department of Medicine, St. Radboud University Hospital, Nijmegen Organon Scientific Development Group, Oss, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastrointestinal and Liver Diseases, Department of Medicine, St. Radboud University Hospital, Nijmegen Organon Scientific Development Group, Oss, The Netherlands","institution_ids":["https://openalex.org/I4405279838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113575375","display_name":"Anton M. van Loon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279838","display_name":"Organon (Netherlands)","ror":"https://ror.org/02388np20","country_code":"NL","type":"company","lineage":["https://openalex.org/I4405279838"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. M. van Loon","raw_affiliation_strings":["Department of Medical Microbiology, St. Radboud University Hospital, Nijmegen Organon Scientific Development Group, Oss, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, St. Radboud University Hospital, Nijmegen Organon Scientific Development Group, Oss, The Netherlands","institution_ids":["https://openalex.org/I4405279838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027469839","display_name":"Willem Duermeyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279838","display_name":"Organon (Netherlands)","ror":"https://ror.org/02388np20","country_code":"NL","type":"company","lineage":["https://openalex.org/I4405279838"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"W. Duermeyer","raw_affiliation_strings":["St. Radboud University Hospital, Nijmegen Organon Scientific Development Group, Oss, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Radboud University Hospital, Nijmegen Organon Scientific Development Group, Oss, The Netherlands","institution_ids":["https://openalex.org/I4405279838"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025745222","display_name":"R. Stute","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Stute","raw_affiliation_strings":["Blutbank Saarland, 6600 Saarbru\u0308cken, Federal Republic of Germany","Blutbank Saarland, 6600 Saarbr\u00fccken, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blutbank Saarland, 6600 Saarbru\u0308cken, Federal Republic of Germany","institution_ids":[]},{"raw_affiliation_string":"Blutbank Saarland, 6600 Saarbr\u00fccken, Federal Republic of Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110015982"],"corresponding_institution_ids":["https://openalex.org/I4405279838"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":0.3181,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.596209,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"15","issue":"4","first_page":"343","last_page":"350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.16030000150203705,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12025","display_name":"Hepatitis Viruses Studies and Epidemiology","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-a-non-b-hepatitis","display_name":"non-A non-B hepatitis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9399999976158142},{"id":"https://openalex.org/keywords/chimpanzees","display_name":"chimpanzees","score":0.859000027179718},{"id":"https://openalex.org/keywords/hbv-dna","display_name":"HBV DNA","score":0.44600000977516174},{"id":"https://openalex.org/keywords/post-transfusion-hepatitis","display_name":"post-transfusion hepatitis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/blood-donor-screening","display_name":"blood donor screening","score":0.7279999852180481},{"id":"https://openalex.org/keywords/hepatitis-b-surface-antigen","display_name":"hepatitis B surface antigen","score":0.6380000114440918},{"id":"https://openalex.org/keywords/virus-transmission","display_name":"virus transmission","score":0.3790000081062317},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7812639474868774},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.7309925556182861},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.6879013180732727},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.6553870439529419},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.6013914942741394},{"id":"https://openalex.org/C2780617729","wikidata":"https://www.wikidata.org/wiki/Q1356878","display_name":"Hepadnaviridae","level":4,"score":0.5211668014526367},{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.49267011880874634},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4562552869319916},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4539567828178406},{"id":"https://openalex.org/C2908737250","wikidata":"https://www.wikidata.org/wiki/Q327281","display_name":"Hepatitis D virus","level":5,"score":0.4434690773487091},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4375782310962677},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4333825707435608},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.41142213344573975},{"id":"https://openalex.org/C2775876817","wikidata":"https://www.wikidata.org/wiki/Q157661","display_name":"Hepatitis A","level":3,"score":0.4113801121711731},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36625388264656067}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002679","descriptor_name":"Pan troglodytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006525","descriptor_name":"Hepatitis, Viral, Human","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014766","descriptor_name":"Viremia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jmv.1890150404","doi":"https://doi.org/10.1002/jmv.1890150404","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jmv.1890150404","pdf_url":null,"source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},{"id":"pmid:3920354","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3920354","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical virology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W171739121","https://openalex.org/W1965839057","https://openalex.org/W2002451611","https://openalex.org/W2027379295","https://openalex.org/W2028082957","https://openalex.org/W2029987769","https://openalex.org/W2039618199","https://openalex.org/W2049562406","https://openalex.org/W2058071436","https://openalex.org/W2063450941","https://openalex.org/W2083583256","https://openalex.org/W2108036191","https://openalex.org/W3210414919"],"related_works":["https://openalex.org/W2058071436","https://openalex.org/W2053702072","https://openalex.org/W2022878150","https://openalex.org/W2333434124","https://openalex.org/W2003887562","https://openalex.org/W2084232809","https://openalex.org/W2050887493","https://openalex.org/W2071323188","https://openalex.org/W2340277112","https://openalex.org/W2027379295"],"abstract_inverted_index":{"The":[0,150],"risk":[1,25],"of":[2,11,26,43,49,92,105,125,216,224,231],"hepatitis":[3,15,36,45,55,69,74,88,117,126,195,234],"B":[4,16,127],"infections":[5],"has":[6],"been":[7,60,143],"reduced":[8],"by":[9,96,108,162,179,189],"screening":[10],"blood":[12],"donors":[13],"for":[14,40,221],"surface":[17],"antigen":[18],"(HBsAg).":[19],"However,":[20],"recipients":[21],"remain":[22],"at":[23],"significant":[24],"developing":[27],"post-transfusion":[28,44],"hepatitis.":[29,149],"Studies":[30],"have":[31,57,142],"shown":[32,144,188],"that":[33,66,114,141],"non-A,":[34,53,67,86,115,147,193],"non-B":[35,54,68,87,116,148,194],"virus(es)":[37],"are":[38],"responsible":[39],"the":[41,90,174,217],"majority":[42],"infections.":[46],"In":[47,130],"spite":[48],"many":[50,71],"efforts,":[51],"these":[52],"viruses":[56],"not":[58],"yet":[59],"identified.":[61],"Epidemiological":[62],"studies,":[63],"however,":[64],"suggest":[65],"shares":[70],"features":[72],"with":[73,85,98,137,173,233],"B.":[75],"Recently,":[76],"Wands":[77],"et":[78,197],"al":[79],"[1982]":[80],"showed,":[81],"in":[82,205],"chimpanzees":[83,134,201,218],"infected":[84,172],"agents,":[89],"presence":[91],"antigenemia":[93],"or":[94,237],"viremia":[95],"radioimmunoassay":[97],"monoclonal":[99],"antibodies":[100],"directed":[101],"toward":[102],"distinct":[103,123],"determinants":[104],"HBsAg":[106],"and":[107,182,210],"molecular":[109],"hybridization":[110],"analysis.":[111],"They":[112],"suggested":[113],"agents":[118,140],"may":[119],"be":[120],"related,":[121],"but":[122],"variant(s)":[124],"virus":[128],"(HBV).":[129],"this":[131],"study,":[132],"five":[133],"were":[135,153],"inoculated":[136],"three":[138],"different":[139],"to":[145,191],"transmit":[146,192],"following":[151],"inocula":[152],"used":[154],"(I)":[155],"a":[156,170,184,203],"factor":[157],"VIII":[158],"preparation":[159],"kindly":[160,177],"provided":[161,178],"D.W.":[163],"Bradley,":[164],"(II)":[165],"acute":[166],"phase":[167],"serum":[168,186],"from":[169],"chimpanzee":[171,241],"F":[175],"strain":[176],"A.J.":[180],"Zuckerman,":[181],"(III)":[183],"DS-antigen":[185],"previously":[187],"us":[190],"[Duermeyer":[196],"al,":[198],"1983].":[199],"All":[200],"developed":[202,242],"rise":[204],"transaminase":[206],"levels":[207],"between":[208],"8":[209],"10":[211],"weeks":[212],"after":[213],"inoculation.":[214],"None":[215],"was":[219,229],"positive":[220],"any":[222],"markers":[223],"HBV":[225],"infection.":[226],"No":[227],"evidence":[228],"obtained":[230],"infection":[232],"A,":[235],"cytomegalovirus,":[236],"Epstein-Barr":[238],"virus.":[239],"One":[240],"chronic":[243],"liver":[244],"disease.(ABSTRACT":[245],"TRUNCATED":[246],"AT":[247],"250":[248],"WORDS)":[249]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}