{"id":"https://openalex.org/W1990355368","doi":"https://doi.org/10.1021/jm00161a032","title":"9,11-Epoxy-9-homo-14-oxaprosta-5-enoic acid derivatives. Novel inhibitors of fatty acid cyclooxygenase","display_name":"9,11-Epoxy-9-homo-14-oxaprosta-5-enoic acid derivatives. Novel inhibitors of fatty acid cyclooxygenase","publication_year":1986,"publication_date":"1986-11-01","ids":{"openalex":"https://openalex.org/W1990355368","doi":"https://doi.org/10.1021/jm00161a032","mag":"1990355368","pmid":"https://pubmed.ncbi.nlm.nih.gov/3097316"},"language":"en","primary_location":{"id":"doi:10.1021/jm00161a032","doi":"https://doi.org/10.1021/jm00161a032","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm00161a032","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111790339","display_name":"Steven E. Hall","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven E. Hall","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111589452","display_name":"Wen Ching Han","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen Ching Han","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078574353","display_name":"Martin F. Haslanger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin F. Haslanger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005857440","display_name":"Don N. Harris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Don N. Harris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076079312","display_name":"Martin L. Ogletree","orcid":"https://orcid.org/0000-0001-5142-1276","observed_orcids":["https://orcid.org/0000-0001-5142-1276"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin L. Ogletree","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.0747,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.74324324,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"29","issue":"11","first_page":"2335","last_page":"2347"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.796999990940094},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.6600000262260437},{"id":"https://openalex.org/keywords/sudden-death","display_name":"sudden death","score":0.5260000228881836},{"id":"https://openalex.org/keywords/bronchoconstriction","display_name":"bronchoconstriction","score":0.9390000104904175},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8545966744422913},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.8435144424438477},{"id":"https://openalex.org/C24961977","wikidata":"https://www.wikidata.org/wiki/Q225972","display_name":"Bicyclic molecule","level":2,"score":0.7039499282836914},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.6768491864204407},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5955148339271545},{"id":"https://openalex.org/C2780407432","wikidata":"https://www.wikidata.org/wiki/Q103230","display_name":"Ether","level":2,"score":0.5571700930595398},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.5097503066062927},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.5030261874198914},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.49610385298728943},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.47828707098960876},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3447624444961548},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19865605235099792},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09776997566223145},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.06330731511116028},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011465","descriptor_name":"Prostaglandins, Synthetic","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011465","descriptor_name":"Prostaglandins, Synthetic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm00161a032","doi":"https://doi.org/10.1021/jm00161a032","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm00161a032","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:3097316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3097316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2949512016","https://openalex.org/W2063945321","https://openalex.org/W1989862805","https://openalex.org/W1987650891","https://openalex.org/W2099495189","https://openalex.org/W2061702749","https://openalex.org/W2314700348","https://openalex.org/W2508881731","https://openalex.org/W2093673061","https://openalex.org/W2050926317"],"abstract_inverted_index":{"A":[0],"novel":[1],"bicyclic":[2],"prostaglandin":[3],"analogue,":[4],"[1R-[l":[5],"alpha,2":[6],"beta":[7],"(5Z),3":[8],"beta,4":[9],"alpha]]-7-[3-[(hexyloxy)methyl]-":[10],"7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic":[11],"acid":[12,24,53],"(1),":[13],"and":[14,83],"cogeners":[15],"were":[16],"found":[17],"to":[18],"be":[19],"potent":[20,46,66],"inhibitors":[21],"of":[22,33,57],"fatty":[23],"cyclooxygenase.":[25],"Compound":[26,61],"1":[27,41,62],"was":[28,38,42,63],"the":[29,78,87],"only":[30],"stereoisomer":[31],"out":[32],"eight":[34],"possible":[35],"structures":[36],"that":[37],"active.":[39],"Ether":[40],"20":[43],"times":[44],"more":[45,65],"than":[47,67],"indomethacin":[48],"(IND)":[49],"in":[50,69,71,77,86],"inhibiting":[51],"arachidonic":[52],"(AA)":[54],"induced":[55],"aggregation":[56],"human":[58],"platelet-rich":[59],"plasma.":[60],"also":[64],"IND":[68],"several":[70],"vivo":[72],"assays,":[73],"AA-induced":[74,84],"sudden":[75],"death":[76],"conscious":[79],"mouse":[80],"(2":[81],"times)":[82],"bronchoconstriction":[85],"anesthetized":[88],"guinea":[89],"pig":[90],"(16-45":[91],"times).":[92]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}