{"id":"https://openalex.org/W1990349042","doi":"https://doi.org/10.1136/adc.43.229.316","title":"Fatal haemolytic-uraemic syndrome in two sibs.","display_name":"Fatal haemolytic-uraemic syndrome in two sibs.","publication_year":1968,"publication_date":"1968-06-01","ids":{"openalex":"https://openalex.org/W1990349042","doi":"https://doi.org/10.1136/adc.43.229.316","mag":"1990349042","pmid":"https://pubmed.ncbi.nlm.nih.gov/5652708","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2019973"},"language":"en","primary_location":{"id":"doi:10.1136/adc.43.229.316","doi":"https://doi.org/10.1136/adc.43.229.316","is_oa":true,"landing_page_url":"https://doi.org/10.1136/adc.43.229.316","pdf_url":"https://adc.bmj.com/content/archdischild/43/229/316.full.pdf","source":{"id":"https://openalex.org/S207294652","display_name":"Archives of Disease in Childhood","issn_l":"0003-9888","issn":["0003-9888","1468-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Disease in Childhood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://adc.bmj.com/content/archdischild/43/229/316.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000772509","display_name":"P. P. Anthony","orcid":"https://orcid.org/0009-0008-1681-8583","observed_orcids":["https://orcid.org/0009-0008-1681-8583"]},"institutions":[{"id":"https://openalex.org/I4210131790","display_name":"Central Middlesex Hospital","ror":"https://ror.org/03mq8zc85","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800484787","https://openalex.org/I4210131790"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. P. Anthony","raw_affiliation_strings":["From the Departments of Histopathology and Paediatrics, Central Middlesex Hospital, London N.W.1O"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Histopathology and Paediatrics, Central Middlesex Hospital, London N.W.1O","institution_ids":["https://openalex.org/I4210131790"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111589429","display_name":"A Kaplan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131790","display_name":"Central Middlesex Hospital","ror":"https://ror.org/03mq8zc85","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800484787","https://openalex.org/I4210131790"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. B. Kaplan","raw_affiliation_strings":["From the Departments of Histopathology and Paediatrics, Central Middlesex Hospital, London N.W.1O"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Histopathology and Paediatrics, Central Middlesex Hospital, London N.W.1O","institution_ids":["https://openalex.org/I4210131790"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210131790"],"apc_list":null,"apc_paid":null,"fwci":1.3275,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.78766573,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"43","issue":"229","first_page":"316","last_page":"318"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemolytic-uremic-syndrome","display_name":"hemolytic uremic syndrome","score":0.949999988079071},{"id":"https://openalex.org/keywords/familial-occurrence","display_name":"familial occurrence","score":0.8349999785423279},{"id":"https://openalex.org/keywords/siblings","display_name":"siblings","score":0.8840000033378601},{"id":"https://openalex.org/keywords/neonatal-onset","display_name":"neonatal onset","score":0.8080000281333923},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9160000085830688},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9860000014305115},{"id":"https://openalex.org/keywords/necrotizing-glomerulonephritis","display_name":"necrotizing glomerulonephritis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6570000052452087},{"id":"https://openalex.org/keywords/stillbirth","display_name":"stillbirth","score":0.4749999940395355},{"id":"https://openalex.org/keywords/antepartum-hemorrhage","display_name":"antepartum hemorrhage","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9508156776428223},{"id":"https://openalex.org/C2908570841","wikidata":"https://www.wikidata.org/wiki/Q162266","display_name":"Haemolytic-uraemic syndrome","level":4,"score":0.8216781616210938},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4275050163269043},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3763757348060608},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000743","descriptor_name":"Anemia, Hemolytic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000743","descriptor_name":"Anemia, Hemolytic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000743","descriptor_name":"Anemia, Hemolytic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007232","descriptor_name":"Infant, Newborn, Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D014511","descriptor_name":"Uremia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D014511","descriptor_name":"Uremia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014511","descriptor_name":"Uremia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1136/adc.43.229.316","doi":"https://doi.org/10.1136/adc.43.229.316","is_oa":true,"landing_page_url":"https://doi.org/10.1136/adc.43.229.316","pdf_url":"https://adc.bmj.com/content/archdischild/43/229/316.full.pdf","source":{"id":"https://openalex.org/S207294652","display_name":"Archives of Disease in Childhood","issn_l":"0003-9888","issn":["0003-9888","1468-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Disease in Childhood","raw_type":"journal-article"},{"id":"pmid:5652708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5652708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of disease in childhood","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2019973","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2019973/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arch Dis Child","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1136/adc.43.229.316","doi":"https://doi.org/10.1136/adc.43.229.316","is_oa":true,"landing_page_url":"https://doi.org/10.1136/adc.43.229.316","pdf_url":"https://adc.bmj.com/content/archdischild/43/229/316.full.pdf","source":{"id":"https://openalex.org/S207294652","display_name":"Archives of Disease in Childhood","issn_l":"0003-9888","issn":["0003-9888","1468-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Disease in Childhood","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990349042.pdf","grobid_xml":"https://content.openalex.org/works/W1990349042.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1511124696","https://openalex.org/W1987914982","https://openalex.org/W2012163748","https://openalex.org/W2054984010","https://openalex.org/W2064865139","https://openalex.org/W2069085234","https://openalex.org/W2082862564","https://openalex.org/W2108909871","https://openalex.org/W2145619203","https://openalex.org/W2152555686","https://openalex.org/W2225522108","https://openalex.org/W2499618630","https://openalex.org/W6607987446","https://openalex.org/W6686122368"],"related_works":["https://openalex.org/W2064865139","https://openalex.org/W2000466296","https://openalex.org/W1987914982","https://openalex.org/W372496137","https://openalex.org/W2409643165","https://openalex.org/W2050534818","https://openalex.org/W1988557698","https://openalex.org/W154637457","https://openalex.org/W2030354551","https://openalex.org/W2761928211"],"abstract_inverted_index":{"The":[0],"first":[1,119,197],"clear":[2],"account":[3],"of":[4,29,73,128,169,173,178,193,233,248,268],"this":[5],"syndrome":[6,36,181],"was":[7,190,201,228,261,285],"published":[8],"by":[9,39,135],"Gasser":[10],"et":[11,79,139],"al.":[12,140],"(1955),":[13],"who":[14,131,252],"gave":[15],"it":[16],"its":[17],"name.Since":[18],"then":[19],"some":[20],"200":[21],"cases":[22,86,144,165],"have":[23,96],"been":[24,98,111],"reported":[25],"from":[26],"all":[27,288],"parts":[28],"the":[30,56,71,118,180,184,206,219,246,282],"world":[31],"(Piel":[32],"and":[33,51,82,93,114,175,255,271,281,300],"Phibbs,":[34],"1966).The":[35],"is":[37,277],"characterized":[38],"non-immune,":[40],"Coombs":[41],"negative,":[42],"haemolytic":[43],"anaemia,":[44],"with":[45,63,245],"bizarre":[46],"red":[47],"cells,":[48],"variable":[49],"thrombocytopenia,":[50],"acute":[52],"renal":[53],"failure.At":[54],"necropsy":[55,225],"main":[57],"findings":[58],"are":[59,267,272,303],"necrotizing":[60],"glomerular":[61],"lesions":[62],"fibrinous":[64],"capillary":[65],"thromboses.The":[66],"aetiology":[67],"remains":[68,253],"obscure,":[69],"though":[70],"occurrence":[72],"a":[74,83,122,126,152,249],"viral-like,":[75],"prodromal":[76],"illness":[77],"(Gianantonio":[78],"al.,":[80],"1964)":[81],"tendency":[84],"for":[85],"to":[87,120,161],"occur":[88],"in":[89,125,145,166,176,183,203,223,242,263,287],"groups":[90],"(McLean,":[91],"Jones,":[92],"Sutherland,":[94],"1966)":[95],"both":[97,177],"noted.Despite":[99],"intensive":[100],"research,":[101],"however,":[102],"no":[103,226],"viral,":[104],"bacterial,":[105],"or":[106],"toxic":[107],"agent":[108],"has":[109,158],"yet":[110],"convincingly":[112],"demonstrated.Campbell":[113],"Carre":[115],"(1965)":[116],"were":[117,132,294],"report":[121],"familial":[123],"incidence":[124],"pair":[127],"monozygotic":[129],"twins":[130],"also":[133],"affected":[134],"idiopathic":[136],"hyperlipaemia.Recently":[137],"Hagge":[138],"(1967)":[141],"added":[142],"two":[143,163],"sibs":[146],"without":[147],"hyperlipaemia.The":[148],"possibility,":[149],"therefore,":[150],"that":[151],"genetic":[153],"factor":[154],"may":[155],"be":[156],"involved":[157],"prompted":[159],"us":[160],"record":[162],"further":[164],"sibs,":[167],"neither":[168],"whom":[170,179],"showed":[171],"evidence":[172,232],"hyperlipaemia":[174],"developed":[182],"neonatal":[185],"period.":[186],"Case":[187],"ReportsThe":[188],"mother":[189],"21":[191],"years":[192],"age":[194],"when":[195],"her":[196,289],"child":[198,258],"(Case":[199,259],"1)":[200],"bom":[202,262],"January":[204],"1962.In":[205],"same":[207],"year":[208],"she":[209],"became":[210],"pregnant":[211],"again,":[212],"but":[213],"an":[214],"antepartum":[215],"haemor-":[216],"rhage":[217],"at":[218,240],"33rd":[220],"week":[221],"resulted":[222],"stillbirth.At":[224],"abnormality":[227],"found":[229],"other":[230],"than":[231],"intra-":[234],"uterine":[235],"asphyxia.Her":[236],"third":[237],"pregnancy":[238],"ended":[239],"term":[241],"July":[243],"1964,":[244],"delivery":[247],"healthy":[250],"infant":[251],"alive":[254],"well.The":[256],"fourth":[257],"2)":[260],"September":[264],"1965.Both":[265],"parents":[266],"Irish":[269],"descent":[270],"unrelated.The":[273],"mother's":[274],"blood":[275,291],"group":[276,292],"A":[278],"Rhesus":[279],"positive,":[280],"Wassermann":[283],"reaction":[284],"negative":[286],"pregnancies.Atypical":[290],"antibodies":[293],"never":[295],"demonstrated.The":[296],"past,":[297],"per-":[298],"sonal,":[299],"family":[301],"histories":[302],"non-contributory.":[304]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}