{"id":"https://openalex.org/W1990326036","doi":"https://doi.org/10.1016/s0022-3468(99)90372-x","title":"Epithelio-mesenchymal interactions in the developing mouse pancreas: Morphogenesis of the adult architecture","display_name":"Epithelio-mesenchymal interactions in the developing mouse pancreas: Morphogenesis of the adult architecture","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W1990326036","doi":"https://doi.org/10.1016/s0022-3468(99)90372-x","mag":"1990326036","pmid":"https://pubmed.ncbi.nlm.nih.gov/10359180"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-3468(99)90372-x","doi":"https://doi.org/10.1016/s0022-3468(99)90372-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-3468(99)90372-x","pdf_url":null,"source":{"id":"https://openalex.org/S39924113","display_name":"Journal of Pediatric Surgery","issn_l":"0022-3468","issn":["0022-3468","1531-5037"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0022-3468(99)90372-x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023565483","display_name":"Michael I. Rose","orcid":"https://orcid.org/0000-0002-3320-8479","observed_orcids":["https://orcid.org/0000-0002-3320-8479"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael I. Rose","raw_affiliation_strings":["Department of Surgery, New York University Medical Center, NY 10016, USA","Laboratory of Developmental Biology and Repair, Department of Surgery, New York University Medical Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, New York University Medical Center, NY 10016, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Laboratory of Developmental Biology and Repair, Department of Surgery, New York University Medical Center, New York, New York, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109037134","display_name":"Christopher A. Crisera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher A. Crisera","raw_affiliation_strings":["Laboratory of Developmental Biology and Repair, Department of Surgery, New York University Medical Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Developmental Biology and Repair, Department of Surgery, New York University Medical Center, New York, New York, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074127477","display_name":"Kari L. Colen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kari L. Colen","raw_affiliation_strings":["Laboratory of Developmental Biology and Repair, Department of Surgery, New York University Medical Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Developmental Biology and Repair, Department of Surgery, New York University Medical Center, New York, New York, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102784271","display_name":"Patrick R. Connelly","orcid":"https://orcid.org/0000-0002-8410-4207","observed_orcids":["https://orcid.org/0000-0002-8410-4207"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick R. Connelly","raw_affiliation_strings":["Laboratory of Developmental Biology and Repair, Department of Surgery, New York University Medical Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Developmental Biology and Repair, Department of Surgery, New York University Medical Center, New York, New York, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005728573","display_name":"Michael Thornton Longaker","orcid":"https://orcid.org/0000-0003-1430-8914","observed_orcids":["https://orcid.org/0000-0003-1430-8914"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael T. Longaker","raw_affiliation_strings":["Laboratory of Developmental Biology and Repair, Department of Surgery, New York University Medical Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Developmental Biology and Repair, Department of Surgery, New York University Medical Center, New York, New York, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044556352","display_name":"George K. Gittes","orcid":"https://orcid.org/0000-0002-1374-6640","observed_orcids":["https://orcid.org/0000-0002-1374-6640"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George K. Gittes","raw_affiliation_strings":["Laboratory of Developmental Biology and Repair, Department of Surgery, New York University Medical Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Developmental Biology and Repair, Department of Surgery, New York University Medical Center, New York, New York, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044556352"],"corresponding_institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":{"value":4430,"currency":"USD","value_usd":4430},"fwci":1.7537,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.83979857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"34","issue":"5","first_page":"774","last_page":"780"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreas-development","display_name":"pancreatic development","score":0.7739999890327454},{"id":"https://openalex.org/keywords/mouse-embryo","display_name":"mouse embryo","score":0.5199999809265137},{"id":"https://openalex.org/keywords/acinar-cell-differentiation","display_name":"acinar differentiation","score":0.921999990940094},{"id":"https://openalex.org/keywords/mesenchyme","display_name":"mesenchyme","score":0.7210000157356262},{"id":"https://openalex.org/keywords/pancreatic-morphogenesis","display_name":"pancreatic morphogenesis","score":0.6499999761581421},{"id":"https://openalex.org/keywords/organ-culture","display_name":"organ culture","score":0.6940000057220459},{"id":"https://openalex.org/keywords/extrinsic-signaling","display_name":"extrinsic signaling","score":0.6420000195503235},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.9836071729660034},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6399731636047363},{"id":"https://openalex.org/C28483552","wikidata":"https://www.wikidata.org/wiki/Q3634161","display_name":"Organ culture","level":3,"score":0.6350617408752441},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.629921555519104},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.5698491334915161},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.5134907364845276},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5112133026123047},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.5100844502449036},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.46094924211502075},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4504287838935852},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3717181980609894},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2867961525917053},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27323681116104126},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2665242850780487},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08649709820747375},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07255947589874268}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-3468(99)90372-x","doi":"https://doi.org/10.1016/s0022-3468(99)90372-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-3468(99)90372-x","pdf_url":null,"source":{"id":"https://openalex.org/S39924113","display_name":"Journal of Pediatric Surgery","issn_l":"0022-3468","issn":["0022-3468","1531-5037"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Surgery","raw_type":"journal-article"},{"id":"pmid:10359180","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10359180","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric surgery","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0022-3468(99)90372-x","doi":"https://doi.org/10.1016/s0022-3468(99)90372-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-3468(99)90372-x","pdf_url":null,"source":{"id":"https://openalex.org/S39924113","display_name":"Journal of Pediatric Surgery","issn_l":"0022-3468","issn":["0022-3468","1531-5037"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1485586274","https://openalex.org/W1830287761","https://openalex.org/W1844743435","https://openalex.org/W1984631007","https://openalex.org/W2014277977","https://openalex.org/W2023445515","https://openalex.org/W2033045615","https://openalex.org/W2035015033","https://openalex.org/W2037728573","https://openalex.org/W2039140546","https://openalex.org/W2048994813","https://openalex.org/W2058782310","https://openalex.org/W2082944236","https://openalex.org/W2087052700","https://openalex.org/W2103600075","https://openalex.org/W2121562333","https://openalex.org/W2142986021","https://openalex.org/W2151005088","https://openalex.org/W2159128174","https://openalex.org/W2405679123","https://openalex.org/W2409978037","https://openalex.org/W2417045254"],"related_works":["https://openalex.org/W2103600075","https://openalex.org/W2023445515","https://openalex.org/W2003095227","https://openalex.org/W2890479916","https://openalex.org/W2133154776","https://openalex.org/W207400167","https://openalex.org/W2023223175","https://openalex.org/W1984631007","https://openalex.org/W2115802523","https://openalex.org/W2115148843"],"abstract_inverted_index":{"BACKGROUND/PURPOSE:":[0],"The":[1,20,76,116,161],"mammalian":[2,195],"pancreas":[3,196],"is":[4,26,31],"thought":[5],"to":[6,33,81,121,135,167],"develop":[7],"through":[8],"a":[9,40,79],"complex":[10],"interaction":[11,25],"between":[12,102,145],"the":[13,17,48,68,96,99,103,124,131,146,149,164,170,188,193],"budding":[14],"epithelium":[15,106,147],"and":[16,63,93,107,112,139,148,159,175,210],"surrounding":[18],"mesenchyme.":[19],"exact":[21],"nature":[22],"of":[23,29,35,42,163,172,177],"this":[24],"unclear.":[27],"Most":[28],"what":[30],"known":[32],"date":[34],"these":[36,52,83],"interactions":[37,101,191],"comes":[38],"from":[39],"series":[41],"organ":[43,64,91],"culture":[44,61,94],"experiments":[45,54],"done":[46],"in":[47,73,141,192],"late":[49],"1960s.":[50],"Nevertheless,":[51],"important":[53,180,214],"may":[55,151,197],"have":[56,198],"been":[57],"confounded":[58],"by":[59],"less-defined":[60],"media":[62],"dissection":[65,92],"techniques,":[66],"because":[67],"results":[69],"are":[70],"not":[71,129],"reproducible":[72],"our":[74],"hands.":[75],"authors":[77,97,117],"undertook":[78],"study":[80],"reexplore":[82],"basic":[84,100,189],"epithelio-mesenchymal":[85,190],"interactions.":[86],"METHODS:":[87],"Using":[88],"previously":[89],"described":[90],"techniques":[95],"examined":[98],"embryonic":[104],"pancreatic":[105,126,208],"its":[108],"mesenchyme":[109,150,165,178],"with":[110,169],"histological":[111],"immunohistological":[113],"techniques.":[114],"RESULTS:":[115],"found":[118],"that,":[119],"contrary":[120],"previous":[122],"reports,":[123],"earliest":[125],"anlage":[127],"did":[128],"possess":[130],"intrinsic":[132],"signaling":[133],"necessary":[134,153,205],"support":[136],"normal":[137,157],"growth":[138,158],"differentiation":[140],"vitro.":[142],"Intimate":[143],"contact":[144],"be":[152],"until":[154],"E11.5":[155],"for":[156,181,206,215],"differentiation.":[160,183,217],"age":[162],"seemed":[166],"correlate":[168],"degree":[171],"acinar":[173,182,216],"differentiation,":[174,209],"proximity":[176],"was":[179],"CONCLUSIONS:":[184],"Previous":[185],"investigations":[186],"into":[187],"developing":[194],"had":[199],"confounding":[200],"factors.":[201],"Extrinsic":[202],"signals":[203],"seem":[204],"complete":[207],"mesenchymal":[211],"factors":[212],"appear":[213]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}