{"id":"https://openalex.org/W1990323979","doi":"https://doi.org/10.1002/cncr.25068","title":"A prospective cohort study defining utilities using time trade\u2010offs and the Euroqol\u20105D to assess the impact of cancer\u2010related lymphedema","display_name":"A prospective cohort study defining utilities using time trade\u2010offs and the Euroqol\u20105D to assess the impact of cancer\u2010related lymphedema","publication_year":2010,"publication_date":"2010-04-30","ids":{"openalex":"https://openalex.org/W1990323979","doi":"https://doi.org/10.1002/cncr.25068","mag":"1990323979","pmid":"https://pubmed.ncbi.nlm.nih.gov/20564063","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3855404"},"language":"en","primary_location":{"id":"doi:10.1002/cncr.25068","doi":"https://doi.org/10.1002/cncr.25068","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cncr.25068","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3855404","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089254242","display_name":"Andrea Lynne Cheville","orcid":"https://orcid.org/0000-0001-7668-6115","observed_orcids":["https://orcid.org/0000-0001-7668-6115"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea L. Cheville","raw_affiliation_strings":["Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota 55905, USA. cheville.andrea@mayo.edu","Department of Physical Medicine & Rehabilitation Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota 55905, USA. cheville.andrea@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Physical Medicine & Rehabilitation Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078907925","display_name":"Mously Almoza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mously Almoza","raw_affiliation_strings":["Department of Physical Medicine and Rehabilitation, New York Presbyterian Hospital Columbia and Cornell, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, New York Presbyterian Hospital Columbia and Cornell, New York, New York","institution_ids":["https://openalex.org/I1340179700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078999773","display_name":"Janice N. Courmier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janice N. Courmier","raw_affiliation_strings":["Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017760808","display_name":"Jeffrey R. Basford","orcid":"https://orcid.org/0000-0001-7200-7760","observed_orcids":["https://orcid.org/0000-0001-7200-7760"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey R. Basford","raw_affiliation_strings":["Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota","Department of Physical Medicine & Rehabilitation Mayo Clinic Rochester Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Physical Medicine & Rehabilitation Mayo Clinic Rochester Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":8.9501,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.9721254,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"116","issue":"15","first_page":"3722","last_page":"3731"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.046799998730421066,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-related-lymphedema","display_name":"cancer-related lymphedema","score":0.9850000143051147},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.7820000052452087},{"id":"https://openalex.org/keywords/time-trade-off","display_name":"time trade-off","score":0.7049999833106995},{"id":"https://openalex.org/keywords/euroqol-5d","display_name":"EuroQol-5D","score":0.8529999852180481},{"id":"https://openalex.org/keywords/utility-estimation","display_name":"utility estimation","score":0.6769999861717224},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8569999933242798},{"id":"https://openalex.org/keywords/upper-limb-lymphedema","display_name":"upper limb lymphedema","score":0.8740000128746033},{"id":"https://openalex.org/keywords/lower-limb-lymphedema","display_name":"lower limb lymphedema","score":0.9729999899864197},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C2781392513","wikidata":"https://www.wikidata.org/wiki/Q916398","display_name":"Lymphedema","level":4,"score":0.9636985063552856},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9382270574569702},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6546004414558411},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.6062471270561218},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5634745955467224},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5276604890823364},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4653834402561188},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.4576607346534729},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3237249255180359},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.305109441280365},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008209","descriptor_name":"Lymphedema","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008209","descriptor_name":"Lymphedema","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008209","descriptor_name":"Lymphedema","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018434","descriptor_name":"Sickness Impact Profile","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019057","descriptor_name":"Quality-Adjusted Life Years","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/cncr.25068","doi":"https://doi.org/10.1002/cncr.25068","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cncr.25068","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:20564063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20564063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2840455","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3855404","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3855404","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3855404","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2840455","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3855404","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3825399106","display_name":"Mayo Clinic Center for Translational Science Activities","funder_award_id":"KL2RR024151","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W14104846","https://openalex.org/W172882491","https://openalex.org/W1483076316","https://openalex.org/W1513342725","https://openalex.org/W1963655754","https://openalex.org/W1964921635","https://openalex.org/W1969898741","https://openalex.org/W1970520417","https://openalex.org/W1993464791","https://openalex.org/W1997249866","https://openalex.org/W1998261797","https://openalex.org/W2000057619","https://openalex.org/W2001326794","https://openalex.org/W2036400031","https://openalex.org/W2056884670","https://openalex.org/W2064936613","https://openalex.org/W2065745847","https://openalex.org/W2081567869","https://openalex.org/W2096782143","https://openalex.org/W2097576519","https://openalex.org/W2101713088","https://openalex.org/W2112446953","https://openalex.org/W2115077526","https://openalex.org/W2124966064","https://openalex.org/W2127097154","https://openalex.org/W2130036154","https://openalex.org/W2130232389","https://openalex.org/W2130554465","https://openalex.org/W2141453541","https://openalex.org/W2143425425","https://openalex.org/W2149658846","https://openalex.org/W2155835844","https://openalex.org/W2156017061","https://openalex.org/W2157146861","https://openalex.org/W2222337716","https://openalex.org/W2260962818","https://openalex.org/W2264626425","https://openalex.org/W2330798353","https://openalex.org/W2411939478"],"related_works":["https://openalex.org/W1980823078","https://openalex.org/W6960063085","https://openalex.org/W4310486264","https://openalex.org/W2317198888","https://openalex.org/W4367307047","https://openalex.org/W7172541292","https://openalex.org/W7001980840","https://openalex.org/W2989749509","https://openalex.org/W2337113920","https://openalex.org/W2236034591"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"devastating":[2],"impact":[3],"of":[4,10,15,26,65,104,112,199,223],"lymphedema":[5,47,57,69,73,98,108,151,170,209,225],"on":[6],"cancer":[7,113,118,180],"survivors'":[8],"quality":[9],"life":[11],"has":[12],"prompted":[13],"consideration":[14],"several":[16],"changes":[17],"in":[18,89,164,196],"medical":[19],"and":[20,48,59,82,97,119,141,153,174,213,221],"surgical":[21],"care.":[22],"Unfortunately,":[23],"our":[24],"understanding":[25],"the":[27,83,197,219],"benefits":[28],"gained":[29],"from":[30],"these":[31],"approaches":[32],"relative":[33],"to":[34,43],"their":[35],"cost":[36],"remains":[37],"limited.":[38],"This":[39],"study":[40],"was":[41],"designed":[42],"estimate":[44],"utilities":[45,51,194,202],"for":[46,93,205,218],"characterize":[49],"how":[50],"differ":[52],"between":[53],"subgroups":[54],"defined":[55],"by":[56],"etiology":[58],"distribution.":[60],"METHODS:":[61],"A":[62],"consecutive":[63],"sample":[64],"236":[66],"subjects":[67],"with":[68,116,149,166,207],"seen":[70],"at":[71],"a":[72,77,110],"clinic":[74],"completed":[75],"both":[76],"time":[78],"trade-off":[79],"(TTO)":[80],"exercise":[81],"Euroqol":[84,131,142,175,186],"5D.":[85],"Responses":[86],"were":[87,127,162],"adjusted":[88,185],"multivariate":[90],"regression":[91],"models":[92],"demographic":[94],"factors,":[95],"comorbidities,":[96],"severity/location.":[99],"RESULTS:":[100],"Most":[101],"participants":[102],"(167":[103],"236,":[105],"71%)":[106],"had":[107,183],"as":[109],"consequence":[111],"treatment;":[114],"123":[115],"breast":[117],"upper":[120],"extremity":[121,169],"involvement.":[122],"Mean":[123],"TTO":[124,135],"utility":[125,160],"estimates":[126],"consistently":[128],"higher":[129,208],"than":[130],"5D":[132,143,187],"estimates.":[133],"Unadjusted":[134],"(0.85;":[136],"standard":[137],"deviation":[138],"[SD],":[139],"0.21)":[140],"(0.76;":[144],"SD,":[145,172,177,190],"0.18)":[146],"scores":[147,161,188],"diminished":[148],"increasing":[150],"stage":[152],"patient":[154],"body":[155],"mass":[156],"index":[157],"(BMI).":[158],"Adjusted":[159],"lowest":[163],"patients":[165,181,206],"cancer-related":[167,214,224],"lower":[168,184],"(TTO=0.82;":[171],"0.04":[173],"5D=0.80;":[176],"0.03).":[178],"Breast":[179],"also":[182],"(0.80;":[189],"0.02).":[191],"CONCLUSIONS:":[192],"Lymphedema-associated":[193],"are":[195,203,226],"range":[198],"0.80.":[200],"Lower":[201],"observed":[204],"stages,":[210],"elevated":[211],"BMI,":[212],"lymphedema.":[215],"Greater":[216],"expenditures":[217],"prevention":[220],"treatment":[222],"warranted.":[227]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}