{"id":"https://openalex.org/W1990315839","doi":"https://doi.org/10.1152/physiol.00002.2006","title":"Insulin Vesicle Release: Walk, Kiss, Pause \u2026 Then Run","display_name":"Insulin Vesicle Release: Walk, Kiss, Pause \u2026 Then Run","publication_year":2006,"publication_date":"2006-05-19","ids":{"openalex":"https://openalex.org/W1990315839","doi":"https://doi.org/10.1152/physiol.00002.2006","mag":"1990315839","pmid":"https://pubmed.ncbi.nlm.nih.gov/16714477"},"language":"en","primary_location":{"id":"doi:10.1152/physiol.00002.2006","doi":"https://doi.org/10.1152/physiol.00002.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.00002.2006","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015737554","display_name":"Guy A. Rutter","orcid":"https://orcid.org/0000-0001-6360-0343","observed_orcids":["https://orcid.org/0000-0001-6360-0343"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Guy A. Rutter","raw_affiliation_strings":["Department of Biochemistry, School of Medical Sciences, University Walk University of Bristol, Bristol","Department of Cell Biology, Division of Medicine, Imperial College, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Medical Sciences, University Walk University of Bristol, Bristol","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"Department of Cell Biology, Division of Medicine, Imperial College, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110602573","display_name":"Elaine V. Hill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elaine V. Hill","raw_affiliation_strings":["Department of Biochemistry, School of Medical Sciences, University Walk University of Bristol, Bristol"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Medical Sciences, University Walk University of Bristol, Bristol","institution_ids":["https://openalex.org/I36234482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3159,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.24028777,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"3","first_page":"189","last_page":"196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.02539999969303608,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.8679999709129333},{"id":"https://openalex.org/keywords/kiss-and-run","display_name":"kiss-and-run","score":0.8709999918937683},{"id":"https://openalex.org/keywords/exocytosis","display_name":"exocytosis","score":0.843999981880188},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.746999979019165},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.8510000109672546},{"id":"https://openalex.org/keywords/vesicle-fusion","display_name":"vesicle fusion","score":0.7049999833106995},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9200000166893005}],"concepts":[{"id":"https://openalex.org/C109929346","wikidata":"https://www.wikidata.org/wiki/Q17093083","display_name":"KISS (TNC)","level":2,"score":0.7291577458381653},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.593390941619873},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.47558844089508057},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41229814291000366},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40734031796455383},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3787076771259308},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3634200692176819},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3506680428981781},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2568471133708954},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.19962507486343384},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17331141233444214},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0679197609424591},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022142","descriptor_name":"Secretory Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/physiol.00002.2006","doi":"https://doi.org/10.1152/physiol.00002.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.00002.2006","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},{"id":"pmid:16714477","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16714477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology (Bethesda, Md.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":96,"referenced_works":["https://openalex.org/W138403972","https://openalex.org/W1576213701","https://openalex.org/W1876043561","https://openalex.org/W1894223650","https://openalex.org/W1963181827","https://openalex.org/W1969914617","https://openalex.org/W1979153662","https://openalex.org/W1980301773","https://openalex.org/W1981344194","https://openalex.org/W1984903682","https://openalex.org/W1988165332","https://openalex.org/W1988851345","https://openalex.org/W2004564781","https://openalex.org/W2010116142","https://openalex.org/W2016266703","https://openalex.org/W2017427555","https://openalex.org/W2017701987","https://openalex.org/W2018757497","https://openalex.org/W2020027514","https://openalex.org/W2022294768","https://openalex.org/W2022975427","https://openalex.org/W2024301716","https://openalex.org/W2028083111","https://openalex.org/W2029371986","https://openalex.org/W2033004791","https://openalex.org/W2033302376","https://openalex.org/W2034713205","https://openalex.org/W2038351958","https://openalex.org/W2038874191","https://openalex.org/W2039210066","https://openalex.org/W2039825580","https://openalex.org/W2041028158","https://openalex.org/W2041513765","https://openalex.org/W2041777802","https://openalex.org/W2043466785","https://openalex.org/W2044162798","https://openalex.org/W2047604959","https://openalex.org/W2049043048","https://openalex.org/W2049418438","https://openalex.org/W2054363543","https://openalex.org/W2055258092","https://openalex.org/W2057895011","https://openalex.org/W2059775037","https://openalex.org/W2060046982","https://openalex.org/W2068524200","https://openalex.org/W2070449068","https://openalex.org/W2080730085","https://openalex.org/W2082879781","https://openalex.org/W2084619807","https://openalex.org/W2085680244","https://openalex.org/W2090963425","https://openalex.org/W2092327340","https://openalex.org/W2095341074","https://openalex.org/W2096526911","https://openalex.org/W2096575464","https://openalex.org/W2096910934","https://openalex.org/W2103188904","https://openalex.org/W2104214122","https://openalex.org/W2104272621","https://openalex.org/W2104622496","https://openalex.org/W2106268887","https://openalex.org/W2111301709","https://openalex.org/W2113544353","https://openalex.org/W2113613483","https://openalex.org/W2114041992","https://openalex.org/W2123878072","https://openalex.org/W2126384224","https://openalex.org/W2128115766","https://openalex.org/W2128167237","https://openalex.org/W2129963016","https://openalex.org/W2130250468","https://openalex.org/W2133260492","https://openalex.org/W2133768969","https://openalex.org/W2136207368","https://openalex.org/W2137087583","https://openalex.org/W2140192657","https://openalex.org/W2142777783","https://openalex.org/W2144924187","https://openalex.org/W2145824107","https://openalex.org/W2146933899","https://openalex.org/W2147594695","https://openalex.org/W2151297568","https://openalex.org/W2155766648","https://openalex.org/W2156189210","https://openalex.org/W2157920366","https://openalex.org/W2160905895","https://openalex.org/W2161127226","https://openalex.org/W2161231472","https://openalex.org/W2162324890","https://openalex.org/W2164606836","https://openalex.org/W2165577641","https://openalex.org/W2167921865","https://openalex.org/W2168632142","https://openalex.org/W2339049224","https://openalex.org/W2412090302","https://openalex.org/W4245176134"],"related_works":["https://openalex.org/W2120828690","https://openalex.org/W2094982559","https://openalex.org/W2161127226","https://openalex.org/W2106268887","https://openalex.org/W2102289204","https://openalex.org/W7097798970","https://openalex.org/W1989079625","https://openalex.org/W1662787424","https://openalex.org/W2168148059","https://openalex.org/W2070449068"],"abstract_inverted_index":{"The":[0],"mechanisms":[1,44,55],"by":[2],"which":[3,100],"insulin-containing":[4],"dense":[5],"core":[6],"secretory":[7],"vesicles":[8,92],"approach":[9],"and":[10,53,84],"finally":[11],"fuse":[12],"with":[13,111,119],"the":[14,30,42,50,54,75,112],"plasma":[15,76,113],"membrane":[16,77,114],"are":[17],"of":[18,29,103],"considerable":[19],"current":[20],"interest:":[21],"defects":[22],"in":[23,46,95,99],"these":[24,57],"processes":[25],"may":[26,58,93,115],"be":[27,59],"one":[28],"contributing":[31],"factors":[32],"to":[33,65],"Type":[34],"2":[35],"diabetes.":[36],"In":[37],"this":[38],"review,":[39],"we":[40],"discuss":[41],"molecular":[43],"involved":[45],"vesicle":[47,72],"trafficking":[48],"within":[49],"pancreatic":[51],"beta-cell":[52],"whereby":[56],"regulated.":[60],"We":[61,89],"then":[62],"go":[63],"on":[64],"describe":[66],"recent":[67],"evidence":[68],"that":[69,71,91,105],"suggests":[70],"fusion":[73],"at":[74],"is":[78],"a":[79,96,101],"partly":[80],"reversible":[81],"process":[82],"(\"kiss":[83],"run\"":[85],"or":[86],"\"cavity":[87],"recapture\").":[88],"propose":[90],"participate":[94],"exo-endocytotic":[97],"cycle":[98],"proportion":[102],"those":[104],"have":[106],"already":[107],"undergone":[108],"an":[109],"interaction":[110],"exchange":[116],"exocytotic":[117],"machinery":[118],"maturing":[120],"vesicles.":[121]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
