{"id":"https://openalex.org/W1990308647","doi":"https://doi.org/10.7322/abcs.v36i3.59","title":"Diabetes melito: hiperglicemia cr\u00f4nica e suas complica\u00e7\u00f5es","display_name":"Diabetes melito: hiperglicemia cr\u00f4nica e suas complica\u00e7\u00f5es","publication_year":2011,"publication_date":"2011-12-20","ids":{"openalex":"https://openalex.org/W1990308647","doi":"https://doi.org/10.7322/abcs.v36i3.59","mag":"1990308647"},"language":"pt","primary_location":{"id":"doi:10.7322/abcs.v36i3.59","doi":"https://doi.org/10.7322/abcs.v36i3.59","is_oa":true,"landing_page_url":"https://doi.org/10.7322/abcs.v36i3.59","pdf_url":"https://www.portalnepas.org.br/abcs/article/download/59/58","source":{"id":"https://openalex.org/S4210173510","display_name":"Arquivos Brasileiros de Ci\u00eancias da Sa\u00fade","issn_l":"1983-2451","issn":["1983-2451","2358-0747"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Ci\u00eancias da Sa\u00fade","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.portalnepas.org.br/abcs/article/download/59/58","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038919613","display_name":"Leandro Tadeu Ferreira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143330","display_name":"Faculdade de Medicina do ABC","ror":"https://ror.org/047s7ag77","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210143330"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Leandro Tadeu Ferreira","raw_affiliation_strings":["Laborat\u00f3rio de Escrita Cient\u00edfica, Disciplina de Fisiologia, Faculdade de Medicina do ABC (FMABC) \u2013 Santo Andr\u00e9 (SP), Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Escrita Cient\u00edfica, Disciplina de Fisiologia, Faculdade de Medicina do ABC (FMABC) \u2013 Santo Andr\u00e9 (SP), Brasil","institution_ids":["https://openalex.org/I4210143330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049741990","display_name":"Israel Hideo Saviolli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143330","display_name":"Faculdade de Medicina do ABC","ror":"https://ror.org/047s7ag77","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210143330"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Israel Hideo Saviolli","raw_affiliation_strings":["Laborat\u00f3rio de Escrita Cient\u00edfica, Disciplina de Fisiologia, Faculdade de Medicina do ABC (FMABC) \u2013 Santo Andr\u00e9 (SP), Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Escrita Cient\u00edfica, Disciplina de Fisiologia, Faculdade de Medicina do ABC (FMABC) \u2013 Santo Andr\u00e9 (SP), Brasil","institution_ids":["https://openalex.org/I4210143330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043239993","display_name":"V\u00edtor Engr\u00e1cia Valenti","orcid":"https://orcid.org/0000-0001-7477-3805","observed_orcids":["https://orcid.org/0000-0001-7477-3805"]},"institutions":[{"id":"https://openalex.org/I4210143330","display_name":"Faculdade de Medicina do ABC","ror":"https://ror.org/047s7ag77","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210143330"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vitor Engr\u00e1cia Valenti","raw_affiliation_strings":["Laborat\u00f3rio de Escrita Cient\u00edfica, Disciplina de Fisiologia, Faculdade de Medicina do ABC (FMABC) \u2013 Santo Andr\u00e9 (SP), Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Escrita Cient\u00edfica, Disciplina de Fisiologia, Faculdade de Medicina do ABC (FMABC) \u2013 Santo Andr\u00e9 (SP), Brasil","institution_ids":["https://openalex.org/I4210143330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004317326","display_name":"Lu\u00edz Carlos de Abreu","orcid":"https://orcid.org/0000-0002-7618-2109","observed_orcids":["https://orcid.org/0000-0002-7618-2109"]},"institutions":[{"id":"https://openalex.org/I4210143330","display_name":"Faculdade de Medicina do ABC","ror":"https://ror.org/047s7ag77","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210143330"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luiz Carlos de Abreu","raw_affiliation_strings":["Laborat\u00f3rio de Escrita Cient\u00edfica, Disciplina de Fisiologia, Faculdade de Medicina do ABC (FMABC) \u2013 Santo Andr\u00e9 (SP), Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Escrita Cient\u00edfica, Disciplina de Fisiologia, Faculdade de Medicina do ABC (FMABC) \u2013 Santo Andr\u00e9 (SP), Brasil","institution_ids":["https://openalex.org/I4210143330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210143330"],"apc_list":null,"apc_paid":null,"fwci":0.6162,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.69721624,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"36","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.5605000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.5605000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.35109999775886536,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.04740000143647194,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9789999723434448},{"id":"https://openalex.org/keywords/chronic-hyperglycemia","display_name":"chronic hyperglycemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/diabetes-complications","display_name":"diabetes complications","score":0.8399999737739563},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.9779999852180481},{"id":"https://openalex.org/keywords/macrovascular-complications","display_name":"macrovascular complications","score":0.7850000262260437},{"id":"https://openalex.org/keywords/microvascular-complications","display_name":"microvascular complications","score":0.8700000047683716},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.7519999742507935},{"id":"https://openalex.org/keywords/diabetic-neuropathy","display_name":"diabetic neuropathy","score":0.9470000267028809},{"id":"https://openalex.org/keywords/diabetic-eye-disease","display_name":"diabetic eye disease","score":0.6019999980926514},{"id":"https://openalex.org/keywords/ketosis","display_name":"ketosis","score":0.5849999785423279},{"id":"https://openalex.org/keywords/metabolic-acidosis","display_name":"metabolic acidosis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.6510000228881836},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":0.5809999704360962},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.40700000524520874},{"id":"https://openalex.org/keywords/polyol-pathway","display_name":"polyol pathway","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8360776901245117},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5246144533157349},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.40628260374069214},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2564738988876343}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.7322/abcs.v36i3.59","doi":"https://doi.org/10.7322/abcs.v36i3.59","is_oa":true,"landing_page_url":"https://doi.org/10.7322/abcs.v36i3.59","pdf_url":"https://www.portalnepas.org.br/abcs/article/download/59/58","source":{"id":"https://openalex.org/S4210173510","display_name":"Arquivos Brasileiros de Ci\u00eancias da Sa\u00fade","issn_l":"1983-2451","issn":["1983-2451","2358-0747"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Ci\u00eancias da Sa\u00fade","raw_type":"journal-article"},{"id":"mag:2188322589","doi":null,"is_oa":false,"landing_page_url":"http://files.bvs.br/upload/S/1983-2451/2011/v36n3/a2664.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.7322/abcs.v36i3.59","doi":"https://doi.org/10.7322/abcs.v36i3.59","is_oa":true,"landing_page_url":"https://doi.org/10.7322/abcs.v36i3.59","pdf_url":"https://www.portalnepas.org.br/abcs/article/download/59/58","source":{"id":"https://openalex.org/S4210173510","display_name":"Arquivos Brasileiros de Ci\u00eancias da Sa\u00fade","issn_l":"1983-2451","issn":["1983-2451","2358-0747"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Ci\u00eancias da Sa\u00fade","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990308647.pdf","grobid_xml":"https://content.openalex.org/works/W1990308647.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1971221760","https://openalex.org/W1981763566","https://openalex.org/W1983997496","https://openalex.org/W1985268373","https://openalex.org/W1997563123","https://openalex.org/W2003796408","https://openalex.org/W2011419421","https://openalex.org/W2022737570","https://openalex.org/W2031308308","https://openalex.org/W2042780431","https://openalex.org/W2046012846","https://openalex.org/W2051078320","https://openalex.org/W2052947442","https://openalex.org/W2059158127","https://openalex.org/W2075690391","https://openalex.org/W2086965486","https://openalex.org/W2087762661","https://openalex.org/W2093960743","https://openalex.org/W2106690885","https://openalex.org/W2119392136","https://openalex.org/W2133264020","https://openalex.org/W2138969187","https://openalex.org/W2155163346","https://openalex.org/W2157373537","https://openalex.org/W2159820101","https://openalex.org/W2162954653","https://openalex.org/W2167048587","https://openalex.org/W2168118750","https://openalex.org/W2169971427","https://openalex.org/W2471605942","https://openalex.org/W2520432709","https://openalex.org/W2616284082","https://openalex.org/W4205718468"],"related_works":["https://openalex.org/W2188322589","https://openalex.org/W3208662012","https://openalex.org/W1576189985","https://openalex.org/W2943485815","https://openalex.org/W2896783427","https://openalex.org/W4285491701","https://openalex.org/W4391874434","https://openalex.org/W1860581162","https://openalex.org/W7204597686","https://openalex.org/W7003014353"],"abstract_inverted_index":{"Introdu\u00e7\u00e3o:":[0],"O":[1,25],"termo":[2],"diabetes":[3,26,35,51],"melito":[4,27],"descreve":[5],"uma":[6],"desordem":[7],"metab\u00f3lica":[8],"de":[9,17,73,102,115,141,151,170,204,234],"m\u00faltipla":[10],"etiologia,":[11],"caracterizado":[12],"por":[13,107,186],"hiperglicemia":[14,41,96,223],"cr\u00f4nica":[15,42,179],"decorrente":[16],"defeitos":[18],"na":[19,160],"secre\u00e7\u00e3o":[20,114],"e/ou":[21],"a\u00e7\u00e3o":[22],"da":[23,66,165,188,198,222],"insulina.":[24],"\u00e9":[28,43,144,176],"classificado":[29],"em":[30,146],"tipo":[31],"1":[32],"e":[33,37,61,78,87,92,122,130,169,206,219,228],"2,":[34],"gestacional":[36],"outros":[38],"tipos.":[39],"A":[40,95,110,149,192,214],"o":[44],"fator":[45],"prim\u00e1rio":[46],"desencadeador":[47],"das":[48,58,216],"complica\u00e7\u00f5es":[49,59,108],"do":[50,75,124,167,200,209,236],"melito.":[52],"Objetivo:":[53],"Descrever":[54],"os":[55],"mecanismos":[56,225],"fisiopatol\u00f3gicos":[57],"cr\u00f4nicas":[60],"dos":[62,100],"dist\u00farbios":[63],"metab\u00f3licos":[64],"decorrentes":[65,221],"hiperglicemia.":[67],"M\u00e9todos:":[68],"Foram":[69],"consultadas":[70],"as":[71],"bases":[72],"dados":[74],"SciELO,":[76],"Lilacs":[77],"Medline.":[79],"As":[80],"consultas":[81],"inclu\u00edram":[82],"artigos":[83],"registrados":[84],"entre":[85],"1999":[86],"2010,":[88],"nas":[89],"l\u00ednguas":[90],"portuguesa":[91],"inglesa.":[93],"Resultados:":[94],"promove":[97],"a":[98,113,177,183,196,202,207,232],"forma\u00e7\u00e3o":[99],"produtos":[101],"glica\u00e7\u00e3o":[103],"avan\u00e7ada":[104],"(AGEs),":[105],"respons\u00e1veis":[106],"macrovasculares.":[109],"insulinopenia":[111],"estimula":[112],"horm\u00f4nios":[116],"contrainsul\u00ednicos":[117],"como":[118],"glucagon,":[119],"cortisol,":[120],"catecolaminas":[121],"horm\u00f4nio":[123],"crescimento.":[125],"Iniciam-se":[126],"processos":[127],"catab\u00f3licos":[128],"(lip\u00f3lise":[129],"prote\u00f3lise).":[131],"\u00c1cidos":[132],"graxos":[133],"s\u00e3o":[134,163],"captados":[135],"pelas":[136],"c\u00e9lulas":[137],"hep\u00e1ticas.":[138],"Ocorre":[139],"s\u00edntese":[140,203],"acetil-Coa":[142],"que":[143,181,230],"convertida":[145],"corpos":[147,152],"cet\u00f4nicos.":[148],"reten\u00e7\u00e3o":[150],"cet\u00f4nicos":[153],"no":[154],"plasma":[155],"provoca":[156],"acidose":[157],"metab\u00f3lica.":[158],"Altera\u00e7\u00f5es":[159],"fisiologia":[161],"ocular":[162],"derivadas":[164],"opacifica\u00e7\u00e3o":[166],"cristalino":[168],"modifica\u00e7\u00f5es":[171],"vasculares":[172],"retinianas.":[173],"Nefropatia":[174],"diab\u00e9tica":[175,194],"complica\u00e7\u00e3o":[178],"microvascular":[180],"compromete":[182],"fun\u00e7\u00e3o":[184],"renal":[185],"aumento":[187],"membrana":[189],"basal":[190],"glomerular.":[191],"neuropatia":[193],"envolve":[195],"ativa\u00e7\u00e3o":[197],"via":[199],"poliol,":[201],"AGEs":[205],"redu\u00e7\u00e3o":[208],"fluxo":[210],"sangu\u00edneo":[211],"neural.":[212],"Conclus\u00e3o:":[213],"patog\u00eanese":[215],"altera\u00e7\u00f5es":[217],"fisiol\u00f3gicas":[218],"metab\u00f3licas":[220],"compreende":[224],"fisiol\u00f3gicos,":[226],"biol\u00f3gicos":[227],"bioqu\u00edmicos":[229],"afetam":[231],"qualidade":[233],"vida":[235],"organismo.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":18},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}