{"id":"https://openalex.org/W1990307702","doi":"https://doi.org/10.1016/j.jneuroim.2007.06.003","title":"Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis","display_name":"Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis","publication_year":2007,"publication_date":"2007-06-29","ids":{"openalex":"https://openalex.org/W1990307702","doi":"https://doi.org/10.1016/j.jneuroim.2007.06.003","mag":"1990307702","pmid":"https://pubmed.ncbi.nlm.nih.gov/17602759"},"language":"en","primary_location":{"id":"doi:10.1016/j.jneuroim.2007.06.003","doi":"https://doi.org/10.1016/j.jneuroim.2007.06.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jneuroim.2007.06.003","pdf_url":null,"source":{"id":"https://openalex.org/S137419829","display_name":"Journal of Neuroimmunology","issn_l":"0165-5728","issn":["0165-5728","1872-8421"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroimmunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075596287","display_name":"Bianca Weinstock\u2010Guttman","orcid":"https://orcid.org/0000-0001-6732-151X","observed_orcids":["https://orcid.org/0000-0001-6732-151X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bianca Weinstock-Guttman","raw_affiliation_strings":["Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079130521","display_name":"Robert Zivadinov","orcid":"https://orcid.org/0000-0002-7799-1485","observed_orcids":["https://orcid.org/0000-0002-7799-1485"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Zivadinov","raw_affiliation_strings":["Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State, University of New York, Buffalo, NY, 14203, United States","Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State, University of New York, Buffalo, NY, 14203, United States","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007879818","display_name":"Miriam Tama\u00f1o\u2010Blanco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miriam Tama\u00f1o-Blanco","raw_affiliation_strings":["Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY 14260-1200, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY 14260-1200, United States","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063090227","display_name":"Nadir G. Abdelrahman","orcid":"https://orcid.org/0000-0003-3858-3064","observed_orcids":["https://orcid.org/0000-0003-3858-3064"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadir Abdelrahman","raw_affiliation_strings":["Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State, University of New York, Buffalo, NY, 14203, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State, University of New York, Buffalo, NY, 14203, United States","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001358429","display_name":"Darlene Badgett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darlene Badgett","raw_affiliation_strings":["Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY 14260-1200, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY 14260-1200, United States","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102812979","display_name":"Jackie Durfee","orcid":"https://orcid.org/0000-0002-9571-975X","observed_orcids":["https://orcid.org/0000-0002-9571-975X"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jackie Durfee","raw_affiliation_strings":["Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State, University of New York, Buffalo, NY, 14203, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State, University of New York, Buffalo, NY, 14203, United States","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110158606","display_name":"Sara M. Hussein","orcid":"https://orcid.org/0009-0004-8539-4981","observed_orcids":["https://orcid.org/0009-0004-8539-4981"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Hussein","raw_affiliation_strings":["Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State, University of New York, Buffalo, NY, 14203, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State, University of New York, Buffalo, NY, 14203, United States","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030482942","display_name":"Joan Feichter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joan Feichter","raw_affiliation_strings":["Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088591117","display_name":"Kara Patrick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kara Patrick","raw_affiliation_strings":["Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033147621","display_name":"Ralph H. B. Benedict","orcid":"https://orcid.org/0000-0002-2080-3631","observed_orcids":["https://orcid.org/0000-0002-2080-3631"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralph Benedict","raw_affiliation_strings":["Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002609733","display_name":"Murali Krishna Ramanathan","orcid":"https://orcid.org/0000-0002-9943-150X","observed_orcids":["https://orcid.org/0000-0002-9943-150X"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Murali Ramanathan","raw_affiliation_strings":["Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY 14260-1200, United States","Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY 14260-1200, United States","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002609733"],"corresponding_institution_ids":["https://openalex.org/I63190737"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":4.4137,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.94182447,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"188","issue":"1-2","first_page":"167","last_page":"174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9760000109672546},{"id":"https://openalex.org/keywords/white-matter-volume","display_name":"white matter volume","score":0.9829999804496765},{"id":"https://openalex.org/keywords/contrast-enhancing-lesions","display_name":"contrast-enhancing lesions","score":0.8090000152587891},{"id":"https://openalex.org/keywords/normal-appearing-white-matter","display_name":"normal-appearing white matter","score":0.9049999713897705},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.7409999966621399},{"id":"https://openalex.org/keywords/bdnf-val66met-polymorphism","display_name":"BDNF Val66Met polymorphism","score":0.9210000038146973},{"id":"https://openalex.org/keywords/magnetization-transfer-ratio","display_name":"magnetization transfer ratio","score":0.8159999847412109},{"id":"https://openalex.org/keywords/diffusion-weighted-imaging","display_name":"diffusion-weighted imaging","score":0.5569999814033508},{"id":"https://openalex.org/keywords/grey-matter-volume","display_name":"gray matter volume","score":0.5490000247955322},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C2778163459","wikidata":"https://www.wikidata.org/wiki/Q7375573","display_name":"rs6265","level":5,"score":0.8322938680648804},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6415258646011353},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5621992945671082},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4838382303714752},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47180214524269104},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.4366685152053833},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.4232412874698639},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36546996235847473},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.33837854862213135},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068556","descriptor_name":"Interferon beta-1a","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jneuroim.2007.06.003","doi":"https://doi.org/10.1016/j.jneuroim.2007.06.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jneuroim.2007.06.003","pdf_url":null,"source":{"id":"https://openalex.org/S137419829","display_name":"Journal of Neuroimmunology","issn_l":"0165-5728","issn":["0165-5728","1872-8421"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroimmunology","raw_type":"journal-article"},{"id":"pmid:17602759","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17602759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroimmunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W31370813","https://openalex.org/W37545008","https://openalex.org/W54608552","https://openalex.org/W1921871464","https://openalex.org/W1977175874","https://openalex.org/W2007156391","https://openalex.org/W2013373204","https://openalex.org/W2015502121","https://openalex.org/W2018048616","https://openalex.org/W2028942474","https://openalex.org/W2030806405","https://openalex.org/W2047245436","https://openalex.org/W2052644075","https://openalex.org/W2058360762","https://openalex.org/W2067962939","https://openalex.org/W2074989312","https://openalex.org/W2085281197","https://openalex.org/W2094544368","https://openalex.org/W2105209479","https://openalex.org/W2113012066","https://openalex.org/W2120819751","https://openalex.org/W2130417276","https://openalex.org/W2133005541","https://openalex.org/W2147273136","https://openalex.org/W2169515058","https://openalex.org/W2325038063","https://openalex.org/W2325735106"],"related_works":["https://openalex.org/W2077357002","https://openalex.org/W2047245436","https://openalex.org/W2015502121","https://openalex.org/W4281704418","https://openalex.org/W2043186547","https://openalex.org/W3092120107","https://openalex.org/W2948369897","https://openalex.org/W3164711745","https://openalex.org/W4408411154","https://openalex.org/W4417335289"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}