{"id":"https://openalex.org/W1990303386","doi":"https://doi.org/10.1006/bbrc.1998.9391","title":"Intracellular Expression of the Anti-erbB-2 sFv N29 Fails to Accomplish Efficient Target Modulation","display_name":"Intracellular Expression of the Anti-erbB-2 sFv N29 Fails to Accomplish Efficient Target Modulation","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W1990303386","doi":"https://doi.org/10.1006/bbrc.1998.9391","mag":"1990303386","pmid":"https://pubmed.ncbi.nlm.nih.gov/9784409"},"language":"en","primary_location":{"id":"doi:10.1006/bbrc.1998.9391","doi":"https://doi.org/10.1006/bbrc.1998.9391","is_oa":false,"landing_page_url":"https://doi.org/10.1006/bbrc.1998.9391","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112088399","display_name":"Jon E. Grim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon E. Grim","raw_affiliation_strings":["Gene Therapy Program, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA","Gene Therapy Program, University of Alabama at Birmingham, Birmingham, Alabama, 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Therapy Program, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Gene Therapy Program, University of Alabama at Birmingham, Birmingham, Alabama, 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017208495","display_name":"Gene P. Siegal","orcid":"https://orcid.org/0000-0003-3857-3368","observed_orcids":["https://orcid.org/0000-0003-3857-3368"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gene P. Siegal","raw_affiliation_strings":["Departments of Pathology, Cell Biology and Surgery, University of Alabama at Birmingham, Birmingham, Alabama, 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, Cell Biology and Surgery, University of Alabama at Birmingham, Birmingham, Alabama, 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009816072","display_name":"Ronald David Alvarez","orcid":"https://orcid.org/0000-0002-0933-5398","observed_orcids":["https://orcid.org/0000-0002-0933-5398"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald D. Alvarez","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110108800","display_name":"David T. Curiel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Curiel","raw_affiliation_strings":["Departments of Pathology, Cell Biology and Surgery, University of Alabama at Birmingham, Birmingham, Alabama, 35294","Gene Therapy Program, University of Alabama at Birmingham, Birmingham, Alabama, 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, Cell Biology and Surgery, University of Alabama at Birmingham, Birmingham, Alabama, 35294","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Gene Therapy Program, University of Alabama at Birmingham, Birmingham, Alabama, 35294","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":0.7225,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.70052667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"250","issue":"3","first_page":"699","last_page":"703"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.19089999794960022,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.7870000004768372},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.8019999861717224},{"id":"https://openalex.org/keywords/er-retention","display_name":"endoplasmic reticulum retention","score":0.8690000176429749},{"id":"https://openalex.org/keywords/protein-downregulation","display_name":"protein downregulation","score":0.7059999704360962},{"id":"https://openalex.org/keywords/epitope-specificity","display_name":"epitope specificity","score":0.5809999704360962},{"id":"https://openalex.org/keywords/antitumor-cytotoxicity","display_name":"tumor cytotoxicity","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C2779251935","wikidata":"https://www.wikidata.org/wiki/Q5385089","display_name":"ErbB","level":3,"score":0.7116812467575073},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6872433423995972},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6824061274528503},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6281677484512329},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.531082808971405},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.47595688700675964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4465215802192688},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3836906850337982},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33152520656585693},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.29009783267974854},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14373236894607544}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/bbrc.1998.9391","doi":"https://doi.org/10.1006/bbrc.1998.9391","is_oa":false,"landing_page_url":"https://doi.org/10.1006/bbrc.1998.9391","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:9784409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9784409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.41999998688697815}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1710078530","display_name":null,"funder_award_id":"R01 CA72532","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2447325798","display_name":"GENE THERAPY FOR OVARIAN CANCER","funder_award_id":"5r01ca068245-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2638392201","display_name":null,"funder_award_id":"R01 CA 68245","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3162682850","display_name":"SFV MEDIATED ONCOGENE KNOCKOUT FOR CHEMOSENSITIZATION","funder_award_id":"5r01ca072532-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W827183970","https://openalex.org/W1490624051","https://openalex.org/W1537158757","https://openalex.org/W1549258100","https://openalex.org/W1595135214","https://openalex.org/W1598571431","https://openalex.org/W1669656365","https://openalex.org/W1836091192","https://openalex.org/W1932604536","https://openalex.org/W1966204321","https://openalex.org/W1974203712","https://openalex.org/W1977958044","https://openalex.org/W1988377672","https://openalex.org/W1994410348","https://openalex.org/W2008024194","https://openalex.org/W2010036724","https://openalex.org/W2016296831","https://openalex.org/W2040142253","https://openalex.org/W2042455517","https://openalex.org/W2054070431","https://openalex.org/W2054858544","https://openalex.org/W2056558465","https://openalex.org/W2080431132","https://openalex.org/W2092132445","https://openalex.org/W2092612993","https://openalex.org/W2092977161","https://openalex.org/W2123184189","https://openalex.org/W2146447599","https://openalex.org/W2161221562","https://openalex.org/W2175687390","https://openalex.org/W2246949741","https://openalex.org/W2395794062","https://openalex.org/W2417789568","https://openalex.org/W2474494464","https://openalex.org/W2474771385"],"related_works":["https://openalex.org/W2246949741","https://openalex.org/W1490624051","https://openalex.org/W133355765","https://openalex.org/W2050314327","https://openalex.org/W2122102674","https://openalex.org/W2022647282","https://openalex.org/W2008024194","https://openalex.org/W2092132445","https://openalex.org/W307403642","https://openalex.org/W1990943199"],"abstract_inverted_index":null,"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
