{"id":"https://openalex.org/W1990297217","doi":"https://doi.org/10.1097/shk.0b013e318219ff2a","title":"Hypoxia-Inducible Factor 1\u03b1 Regulates the Expression of the Mitochondrial ATPase Inhibitor Protein (IF1) in Rat Liver","display_name":"Hypoxia-Inducible Factor 1\u03b1 Regulates the Expression of the Mitochondrial ATPase Inhibitor Protein (IF1) in Rat Liver","publication_year":2011,"publication_date":"2011-03-16","ids":{"openalex":"https://openalex.org/W1990297217","doi":"https://doi.org/10.1097/shk.0b013e318219ff2a","mag":"1990297217","pmid":"https://pubmed.ncbi.nlm.nih.gov/21412184"},"language":"en","primary_location":{"id":"doi:10.1097/shk.0b013e318219ff2a","doi":"https://doi.org/10.1097/shk.0b013e318219ff2a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/shk.0b013e318219ff2a","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042619302","display_name":"Li\u2010Ju Huang","orcid":"https://orcid.org/0000-0002-3134-8590","observed_orcids":["https://orcid.org/0000-0002-3134-8590"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Li-Ju Huang","raw_affiliation_strings":["Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan","Graduate Institute of Medicine and \u2020Department of Respiratory Therapy, Kaohsiung Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Graduate Institute of Medicine and \u2020Department of Respiratory Therapy, Kaohsiung Medical University","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032910889","display_name":"I\u2010Chun Chuang","orcid":"https://orcid.org/0000-0001-7156-4936","observed_orcids":["https://orcid.org/0000-0001-7156-4936"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"I-Chun Chuang","raw_affiliation_strings":["Department of Respiratory Therapy, Kaohsiung Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Therapy, Kaohsiung Medical University","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044048847","display_name":"Huei\u2010Ping Dong","orcid":"https://orcid.org/0000-0001-8555-5539","observed_orcids":["https://orcid.org/0000-0001-8555-5539"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huei-Ping Dong","raw_affiliation_strings":["School of Medicine and Health Sciences, Foo-Yin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Health Sciences, Foo-Yin University","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101820890","display_name":"Rei\u2010Cheng Yang","orcid":"https://orcid.org/0000-0001-6116-260X","observed_orcids":["https://orcid.org/0000-0001-6116-260X"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I2802587341","display_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","ror":"https://ror.org/02xmkec90","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802587341"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Rei-Cheng Yang","raw_affiliation_strings":["Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan","Department of Pediatrics, Kaohsiung Medical University Hospital","Department of Pediatrics, Kaohsiung Medical University Hospital; and","Graduate Institute of Medicine and \u2020Department of Respiratory Therapy, Kaohsiung Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Department of Pediatrics, Kaohsiung Medical University Hospital","institution_ids":["https://openalex.org/I2802587341"]},{"raw_affiliation_string":"Department of Pediatrics, Kaohsiung Medical University Hospital; and","institution_ids":["https://openalex.org/I2802587341"]},{"raw_affiliation_string":"Graduate Institute of Medicine and \u2020Department of Respiratory Therapy, Kaohsiung Medical University","institution_ids":["https://openalex.org/I152743029"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042619302","https://openalex.org/A5101820890"],"corresponding_institution_ids":["https://openalex.org/I152743029","https://openalex.org/I2802587341"],"apc_list":null,"apc_paid":null,"fwci":0.535,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.59906194,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"36","issue":"1","first_page":"90","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.31049999594688416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.31049999594688416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.25999999046325684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0997999981045723,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.9599999785423279},{"id":"https://openalex.org/keywords/if1","display_name":"IF1","score":0.8399999737739563},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.46399998664855957},{"id":"https://openalex.org/keywords/bioenergetic-failure","display_name":"bioenergetic failure","score":0.9210000038146973},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.7979999780654907},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.6079999804496765},{"id":"https://openalex.org/keywords/cobalt-chloride","display_name":"cobalt chloride","score":0.777999997138977},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.8569999933242798},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.7419999837875366},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7430092096328735},{"id":"https://openalex.org/C2781142959","wikidata":"https://www.wikidata.org/wiki/Q6033825","display_name":"Inhibitor protein","level":3,"score":0.5407256484031677},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.49292755126953125},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4770978093147278},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46677011251449585},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.4566747844219208},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.43721142411231995},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.43028926849365234},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.42914944887161255},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4282572269439697},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.42822641134262085},{"id":"https://openalex.org/C2909350873","wikidata":"https://www.wikidata.org/wiki/Q104598479","display_name":"Hypoxia-Inducible Factor 1","level":4,"score":0.42398035526275635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.422111451625824},{"id":"https://openalex.org/C160450060","wikidata":"https://www.wikidata.org/wiki/Q104598479","display_name":"Hypoxia-inducible factors","level":3,"score":0.421045184135437},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4186054766178131},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39937394857406616},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1479465365409851},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14763063192367554},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13817241787910461},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09628000855445862},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000097795","descriptor_name":"ATPase Inhibitory Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003035","descriptor_name":"Cobalt","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/shk.0b013e318219ff2a","doi":"https://doi.org/10.1097/shk.0b013e318219ff2a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/shk.0b013e318219ff2a","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},{"id":"pmid:21412184","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21412184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock (Augusta, Ga.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W68821243","https://openalex.org/W183275956","https://openalex.org/W1972421865","https://openalex.org/W1979109569","https://openalex.org/W1988290050","https://openalex.org/W1992969522","https://openalex.org/W1998258084","https://openalex.org/W2004108198","https://openalex.org/W2008946188","https://openalex.org/W2012987669","https://openalex.org/W2017398866","https://openalex.org/W2028732531","https://openalex.org/W2029619625","https://openalex.org/W2031658313","https://openalex.org/W2031679095","https://openalex.org/W2033562848","https://openalex.org/W2034454063","https://openalex.org/W2035433014","https://openalex.org/W2036007746","https://openalex.org/W2049166204","https://openalex.org/W2072839085","https://openalex.org/W2079056831","https://openalex.org/W2091555220","https://openalex.org/W2093361250","https://openalex.org/W2096283154","https://openalex.org/W2102277066","https://openalex.org/W2148194696","https://openalex.org/W2161705855","https://openalex.org/W2416173255","https://openalex.org/W2466885468"],"related_works":["https://openalex.org/W20029513","https://openalex.org/W2068508309","https://openalex.org/W2033562848","https://openalex.org/W7074070674","https://openalex.org/W2099087409","https://openalex.org/W1998258084","https://openalex.org/W2611386094","https://openalex.org/W3000951314","https://openalex.org/W4393220081","https://openalex.org/W4413306646"],"abstract_inverted_index":{"A":[0],"growing":[1],"number":[2],"of":[3,16,29,56,61,75,105,118,124,166,179],"reports":[4],"indicate":[5],"that":[6,26,87,99,193],"bioenergetic":[7,46],"failure":[8,19,47],"plays":[9],"a":[10,84,103,198],"crucial":[11,199],"role":[12,200],"in":[13,48,94,114,121,160,176,201,206],"the":[14,27,45,49,54,57,73,91,138,172,177,190,194],"development":[15],"multiple":[17],"organ":[18],"during":[20,51],"sepsis.":[21,95],"Our":[22],"previous":[23],"results":[24,97,187],"showed":[25,98],"suppression":[28],"IF1":[30,62,76,108,134,154,203],"(mitochondrial":[31],"ATPase":[32],"inhibitor":[33],"protein)":[34],"expression":[35,78,110,168,205],"and":[36,53,79,107,143,152],"subsequent":[37],"elevated":[38],"mitochondrial":[39,173],"F(o)F\u2081-ATPase":[40,174],"activity":[41,175],"might":[42,63,196],"contribute":[43],"to":[44,147,170],"liver":[50,117],"sepsis,":[52],"influence":[55],"decreased":[58,159],"transcriptional":[59],"level":[60],"be":[64],"an":[65],"important":[66],"factor.":[67],"In":[68,184],"this":[69],"study,":[70],"we":[71],"investigated":[72],"interaction":[74],"protein":[77,135,155,204],"hypoxia-inducible":[80],"factor":[81,86],"1":[82],"(HIF-1),":[83],"transcription":[85],"is":[88],"correlated":[89],"with":[90],"inflammatory":[92],"status":[93],"The":[96],"nuclear":[100],"HIF-1\u03b1":[101,125,140,150,167],"protein,":[102],"subunit":[104],"HIF-1,":[106],"mRNA":[109],"were":[111,145,157],"coincidently":[112],"reduced":[113],"late":[115,207],"septic":[116,208],"rats.":[119],"Furthermore,":[120],"vitro,":[122],"overexpression":[123],"by":[126],"hypoxia":[127],"or":[128],"CoCl\u2082":[129],"(HIF-1\u03b1":[130],"activator)":[131],"treatment":[132],"augmented":[133],"levels.":[136],"On":[137],"contrary,":[139],"antisense":[141],"oligonucleotide":[142],"siRNA":[144],"used":[146],"specifically":[148],"downregulate":[149],"expression,":[151],"then":[153],"levels":[156],"significantly":[158],"clone":[161],"9":[162],"cells.":[163],"Meanwhile,":[164],"downregulation":[165],"led":[169],"elevate":[171],"presence":[178],"Bis-Tris":[180],"buffer":[181],"(pH":[182],"6.5).":[183],"conclusion,":[185],"these":[186],"suggested":[188],"for":[189],"first":[191],"time":[192],"HIF-1":[195],"play":[197],"regulating":[202],"liver.":[209]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}