{"id":"https://openalex.org/W1990292046","doi":"https://doi.org/10.1116/1.3694833","title":"Externally triggered on-demand drug release and deep tumor penetration","display_name":"Externally triggered on-demand drug release and deep tumor penetration","publication_year":2012,"publication_date":"2012-03-01","ids":{"openalex":"https://openalex.org/W1990292046","doi":"https://doi.org/10.1116/1.3694833","mag":"1990292046"},"language":"en","primary_location":{"id":"doi:10.1116/1.3694833","doi":"https://doi.org/10.1116/1.3694833","is_oa":false,"landing_page_url":"https://doi.org/10.1116/1.3694833","pdf_url":null,"source":{"id":"https://openalex.org/S4210235835","display_name":"Journal of Vacuum Science & Technology B Nanotechnology and Microelectronics Materials Processing Measurement and Phenomena","issn_l":"2166-2746","issn":["2166-2746","2166-2754"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Vacuum Science &amp; Technology B, Nanotechnology and Microelectronics: Materials, Processing, Measurement, and Phenomena","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088709270","display_name":"Seong Deok Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seong Deok Kong","raw_affiliation_strings":["Materials Science & Engineering , UC, San Diego, La Jolla, California 92093\u20130411"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Materials Science & Engineering , UC, San Diego, La Jolla, California 92093\u20130411","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041054598","display_name":"Weizhou Zhang","orcid":"https://orcid.org/0000-0002-8236-0346","observed_orcids":["https://orcid.org/0000-0002-8236-0346"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weizhou Zhang","raw_affiliation_strings":["School of Medicine Department of Pharmacology, , UC, San Diego, La Jolla, California 92093\u20130636"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine Department of Pharmacology, , UC, San Diego, La Jolla, California 92093\u20130636","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100700141","display_name":"Jun Hee Lee","orcid":"https://orcid.org/0000-0001-5121-244X","observed_orcids":["https://orcid.org/0000-0001-5121-244X","https://orcid.org/0000-0003-4303-6735","https://orcid.org/0000-0002-6935-9439"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Hee Lee","raw_affiliation_strings":["School of Medicine Department of Pharmacology, , UC, San Diego, La Jolla, California 92093\u20130636"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine Department of Pharmacology, , UC, San Diego, La Jolla, California 92093\u20130636","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101541349","display_name":"Chulmin Choi","orcid":"https://orcid.org/0000-0002-9805-5231","observed_orcids":["https://orcid.org/0000-0002-9805-5231"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chulmin Choi","raw_affiliation_strings":["Materials Science & Engineering , UC, San Diego, La Jolla, California 92093\u20130411"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Materials Science & Engineering , UC, San Diego, La Jolla, California 92093\u20130411","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032433022","display_name":"Jirapon Khamwannah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jirapon Khamwannah","raw_affiliation_strings":["Materials Science & Engineering , UC, San Diego, La Jolla, California 92093\u20130411"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Materials Science & Engineering , UC, San Diego, La Jolla, California 92093\u20130411","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056315342","display_name":"Michael Karin","orcid":"https://orcid.org/0000-0002-2758-6473","observed_orcids":["https://orcid.org/0000-0002-2758-6473"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Karin","raw_affiliation_strings":["School of Medicine Department of Pharmacology, , UC, San Diego, La Jolla, California 92093\u20130636"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine Department of Pharmacology, , UC, San Diego, La Jolla, California 92093\u20130636","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103456723","display_name":"Sungho Jin","orcid":"https://orcid.org/0000-0001-6022-9729","observed_orcids":["https://orcid.org/0000-0001-6022-9729"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sungho Jin","raw_affiliation_strings":["Department of Mechanical & Aerospace Engineering and Materials Science & Engineering, UC, San Diego, La Jolla, California 92093\u20130411"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical & Aerospace Engineering and Materials Science & Engineering, UC, San Diego, La Jolla, California 92093\u20130411","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":0.2593,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.50516432,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"30","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12405","display_name":"Characterization and Applications of Magnetic Nanoparticles","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/magnetic-nanoparticles","display_name":"magnetic nanoparticles","score":0.9110000133514404},{"id":"https://openalex.org/keywords/on-demand-drug-release","display_name":"on-demand drug release","score":0.925000011920929},{"id":"https://openalex.org/keywords/tumor-penetration","display_name":"tumor penetration","score":0.6700000166893005},{"id":"https://openalex.org/keywords/controlled-drug-delivery","display_name":"controlled drug delivery","score":0.6769999861717224},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tumor-cell-growth-inhibition","display_name":"tumor cell growth inhibition","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C204399865","wikidata":"https://www.wikidata.org/wiki/Q17157402","display_name":"Nanocapsules","level":3,"score":0.9470406770706177},{"id":"https://openalex.org/C87023908","wikidata":"https://www.wikidata.org/wiki/Q3870166","display_name":"Magnetic nanoparticles","level":3,"score":0.7102488875389099},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6578563451766968},{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.6471759080886841},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6118359565734863},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6117833852767944},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5432137846946716},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5126966238021851},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.4793142080307007},{"id":"https://openalex.org/C115260700","wikidata":"https://www.wikidata.org/wiki/Q11408","display_name":"Magnetic field","level":2,"score":0.4539782702922821},{"id":"https://openalex.org/C3018146709","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Anticancer drug","level":3,"score":0.4465826451778412},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3583683967590332},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.11920881271362305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07779213786125183},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06313067674636841},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1116/1.3694833","doi":"https://doi.org/10.1116/1.3694833","is_oa":false,"landing_page_url":"https://doi.org/10.1116/1.3694833","pdf_url":null,"source":{"id":"https://openalex.org/S4210235835","display_name":"Journal of Vacuum Science & Technology B Nanotechnology and Microelectronics Materials Processing Measurement and Phenomena","issn_l":"2166-2746","issn":["2166-2746","2166-2754"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Vacuum Science &amp; Technology B, Nanotechnology and Microelectronics: Materials, Processing, Measurement, and Phenomena","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1593844282","https://openalex.org/W1965308710","https://openalex.org/W1972530499","https://openalex.org/W1974824262","https://openalex.org/W1976601933","https://openalex.org/W1979716619","https://openalex.org/W2004334950","https://openalex.org/W2012295039","https://openalex.org/W2013984845","https://openalex.org/W2028344537","https://openalex.org/W2029255146","https://openalex.org/W2038369700","https://openalex.org/W2049296888","https://openalex.org/W2054063883","https://openalex.org/W2055180419","https://openalex.org/W2056691086","https://openalex.org/W2090637305","https://openalex.org/W2091753857","https://openalex.org/W2124998760","https://openalex.org/W2130211871","https://openalex.org/W2153552284","https://openalex.org/W2157914600","https://openalex.org/W2316001945","https://openalex.org/W2322771948","https://openalex.org/W4231516524"],"related_works":["https://openalex.org/W2156267868","https://openalex.org/W2998407704","https://openalex.org/W2008773225","https://openalex.org/W2021225601","https://openalex.org/W2167111958","https://openalex.org/W7047910598","https://openalex.org/W2153123089","https://openalex.org/W2335813846","https://openalex.org/W7171727990","https://openalex.org/W2033489615"],"abstract_inverted_index":{"Hollow-sphere-shaped":[0],"nanocapsules":[1,24,87],"containing":[2],"intentionally":[3],"inserted":[4],"magnetic":[5,14,19,49,71],"nanoparticles":[6,72],"and":[7,30,70],"predefined":[8],"anticancer":[9,39],"drugs":[10],"provide":[11],"a":[12,32],"powerful":[13],"vector":[15],"under":[16],"moderate":[17],"gradient":[18],"fields.":[20],"They":[21],"enable":[22],"the":[23,28,38,43,67,86],"to":[25],"penetrate":[26],"into":[27],"tumors":[29],"allow":[31],"controlled":[33],"on-off":[34],"switchable":[35],"release":[36],"of":[37],"drug":[40,53,68],"cargo":[41],"inside":[42],"tunors":[44],"by":[45],"remotely":[46],"applied":[47],"RF":[48],"field.":[50],"This":[51],"smart":[52],"delivery":[54],"system,":[55],"which":[56],"can":[57,73],"also":[58],"be":[59,75],"made":[60],"imageable,":[61],"is":[62],"compact":[63],"in":[64,90],"geometry":[65],"because":[66],"molecules":[69],"all":[74],"self-contained":[76],"within":[77],"\u223c150":[78],"nm":[79],"capsules.":[80],"In":[81],"vitro":[82],"results":[83],"indicate":[84],"that":[85],"are":[88],"effective":[89],"reducing":[91],"tumor":[92],"cell":[93],"growth.":[94]},"counts_by_year":[{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}
