{"id":"https://openalex.org/W1990278379","doi":"https://doi.org/10.1021/jp036009f","title":"Solution Conformations of Wild-Type and Mutated Bak BH3 Peptides via Dynamical Conformational Sampling and Implication to Their Binding to Antiapoptotic Bcl-2 Proteins","display_name":"Solution Conformations of Wild-Type and Mutated Bak BH3 Peptides via Dynamical Conformational Sampling and Implication to Their Binding to Antiapoptotic Bcl-2 Proteins","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W1990278379","doi":"https://doi.org/10.1021/jp036009f","mag":"1990278379"},"language":"en","primary_location":{"id":"doi:10.1021/jp036009f","doi":"https://doi.org/10.1021/jp036009f","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp036009f","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012092064","display_name":"Chao\u2010Yie Yang","orcid":"https://orcid.org/0000-0002-5445-0109","observed_orcids":["https://orcid.org/0000-0002-5445-0109"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chao-Yie Yang","raw_affiliation_strings":["Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109-0934, and Laboratory of Medicinal Chemistry, National Cancer Institute, FCRDC, Building 376, Room 207, Fredrick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109-0934, and Laboratory of Medicinal Chemistry, National Cancer Institute, FCRDC, Building 376, Room 207, Fredrick, Maryland 21702","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I27837315","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061886518","display_name":"Zaneta Nikolovska\u2010Coleska","orcid":"https://orcid.org/0000-0001-6688-4206","observed_orcids":["https://orcid.org/0000-0001-6688-4206"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zaneta Nikolovska-Coleska","raw_affiliation_strings":["Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109-0934, and Laboratory of Medicinal Chemistry, National Cancer Institute, FCRDC, Building 376, Room 207, Fredrick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109-0934, and Laboratory of Medicinal Chemistry, National Cancer Institute, FCRDC, Building 376, Room 207, Fredrick, Maryland 21702","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I27837315","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100432772","display_name":"Peng Li","orcid":"https://orcid.org/0000-0003-2030-1807","observed_orcids":["https://orcid.org/0000-0003-2030-1807","https://orcid.org/0009-0006-3632-5079"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Li","raw_affiliation_strings":["Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109-0934, and Laboratory of Medicinal Chemistry, National Cancer Institute, FCRDC, Building 376, Room 207, Fredrick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109-0934, and Laboratory of Medicinal Chemistry, National Cancer Institute, FCRDC, Building 376, Room 207, Fredrick, Maryland 21702","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I27837315","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083036570","display_name":"Peter P. Roller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Roller","raw_affiliation_strings":["Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109-0934, and Laboratory of Medicinal Chemistry, National Cancer Institute, FCRDC, Building 376, Room 207, Fredrick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109-0934, and Laboratory of Medicinal Chemistry, National Cancer Institute, FCRDC, Building 376, Room 207, Fredrick, Maryland 21702","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I27837315","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073754378","display_name":"Shaomeng Wang","orcid":"https://orcid.org/0000-0002-8782-6950","observed_orcids":["https://orcid.org/0000-0002-8782-6950"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaomeng Wang","raw_affiliation_strings":["Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109-0934, and Laboratory of Medicinal Chemistry, National Cancer Institute, FCRDC, Building 376, Room 207, Fredrick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109-0934, and Laboratory of Medicinal Chemistry, National Cancer Institute, FCRDC, Building 376, Room 207, Fredrick, Maryland 21702","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I27837315","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.09519918,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"108","issue":"4","first_page":"1467","last_page":"1477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.8500000238418579},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9380000233650208},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.6800000071525574},{"id":"https://openalex.org/keywords/apoptosis-regulation","display_name":"apoptosis regulation","score":0.6710000038146973},{"id":"https://openalex.org/keywords/solution-conformation","display_name":"solution conformation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/helical-structure","display_name":"helical conformation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/peptide-protein-binding-affinity","display_name":"peptide-protein binding affinity","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.8060577511787415},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.7068887948989868},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.6284403800964355},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6260721683502197},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5385332107543945},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5131105184555054},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4991743564605713},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.46364063024520874},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4586188793182373},{"id":"https://openalex.org/C57711820","wikidata":"https://www.wikidata.org/wiki/Q310425","display_name":"C-terminus","level":3,"score":0.4291055500507355},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.41328197717666626},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3606022894382477},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3319740295410156},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28925424814224243},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16699647903442383},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/jp036009f","doi":"https://doi.org/10.1021/jp036009f","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp036009f","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","score":0.6200000047683716,"display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1963667773","https://openalex.org/W1964412608","https://openalex.org/W1964617786","https://openalex.org/W1966743338","https://openalex.org/W1967936523","https://openalex.org/W1968673134","https://openalex.org/W1968780760","https://openalex.org/W1973060931","https://openalex.org/W1976499671","https://openalex.org/W1976720365","https://openalex.org/W1978002329","https://openalex.org/W1980837484","https://openalex.org/W2008708467","https://openalex.org/W2014985938","https://openalex.org/W2018221677","https://openalex.org/W2032518125","https://openalex.org/W2038910312","https://openalex.org/W2044601459","https://openalex.org/W2050347763","https://openalex.org/W2067174909","https://openalex.org/W2069594391","https://openalex.org/W2071490032","https://openalex.org/W2087877138","https://openalex.org/W2093381148","https://openalex.org/W2106140689","https://openalex.org/W2106799894","https://openalex.org/W2110562802","https://openalex.org/W2122199548","https://openalex.org/W2125673422","https://openalex.org/W2135579845","https://openalex.org/W2141920771","https://openalex.org/W2162166182","https://openalex.org/W2165948287","https://openalex.org/W4294326239","https://openalex.org/W4318445412"],"related_works":["https://openalex.org/W2236541693","https://openalex.org/W2156133707","https://openalex.org/W2766448961","https://openalex.org/W2049587744","https://openalex.org/W2109193476","https://openalex.org/W2039108630","https://openalex.org/W2770396502","https://openalex.org/W2007141443","https://openalex.org/W2106799894","https://openalex.org/W4286685934"],"abstract_inverted_index":{"The":[0],"BH3":[1,31,50,104,274],"(Bcl-2":[2],"homology":[3],"3)":[4],"domain":[5,32],"of":[6,10,19,33,80,101,166,197,203,218,230,259,270,305,322,325],"the":[7,17,30,34,41,58,98,127,144,156,173,195,200,204,210,215,219,222,235,241,248,254,267,282,295,302,306,313,326,331,338],"Bcl-2":[8,44],"family":[9],"proteins":[11,43],"plays":[12],"a":[13,53,71,83,90,115,131,137,148,186,228,260],"critical":[14],"role":[15],"in":[16,57,63,75,112,171,253],"regulation":[18],"programmed":[20],"cell":[21],"death,":[22],"or":[23,185,190],"apoptosis.":[24],"A":[25],"16-residue":[26],"peptide":[27,51,105,129,249],"derived":[28],"from":[29],"proapoptotic":[35],"protein":[36],"Bak":[37,49,103,128,169,205,237,273,297],"potently":[38],"binds":[39],"to":[40,181,193,234,276,319,337,346],"antiapoptotic":[42],"and":[45,85,147,221,284,289],"Bcl-xL.":[46,320,347],"While":[47],"this":[48,94,102],"adopts":[52],"well-defined":[54,86],"helical":[55,73,134,141,153,303,334],"conformation":[56,74,88],"experimental":[59],"NMR":[60],"solution":[61,87,99,201,216,250],"structure":[62,135],"complex":[64],"with":[65,136],"Bcl-xL,":[66],"it":[67],"does":[68,244],"not":[69,245,312],"adopt":[70],"stable":[72,84,139,150,333],"water.":[76],"Experimental":[77],"structural":[78],"determination":[79],"peptides":[81,275,307],"without":[82],"remains":[89],"difficult":[91],"task.":[92],"In":[93,239],"paper,":[95],"we":[96,160,264],"investigated":[97],"conformations":[100,202,217,251,324],"through":[106],"extensive":[107,163],"molecular":[108],"dynamics":[109],"(MD)":[110],"simulations":[111,124,165],"water":[113],"using":[114],"recently":[116],"developed":[117],"self-guided":[118],"MD":[119],"simulation":[120],"(SGMD)":[121],"method.":[122],"Our":[123],"showed":[125],"that":[126,209,281,301,330],"exhibits":[130],"partially":[132],"formed":[133],"fairly":[138],"6-residue":[140],"segment":[142,154,335],"at":[143,155,176],"N":[145,339],"terminus":[146,340],"less":[149,292],"approximately":[151],"4-residue":[152],"C":[157],"terminus.":[158],"Additionally,":[159],"also":[161],"performed":[162],"SGMD":[164],"two":[167],"mutated":[168,180],"peptides,":[170],"which":[172],"arginine":[174],"residue":[175,188],"position":[177],"5":[178],"is":[179,308],"either":[182],"an":[183,309],"alanine":[184],"glycine":[187],"(R5A":[189],"R5G":[191,211,283],"mutant)":[192],"investigate":[194],"influence":[196],"mutation":[198,212,243],"on":[199],"peptide.":[206,238],"We":[207,279],"found":[208,280],"greatly":[213,342],"affects":[214],"peptide,":[220,298],"overall":[223],"helix":[224],"ratio":[225,304],"decreases":[226],"by":[227],"factor":[229,315],"2":[231],"as":[232],"compared":[233],"wild-type":[236,296],"contrast,":[240],"R5A":[242,285,327],"affect":[246],"significantly":[247],"observed":[252],"wild":[255],"type.":[256],"By":[257],"use":[258],"fluorescence-polarization-based":[261],"binding":[262,268,318,345],"assay,":[263],"quantitatively":[265],"determined":[266],"affinities":[269],"these":[271],"three":[272],"Bcl-xL":[277],"protein.":[278],"mutants":[286],"are":[287],"24":[288],"6":[290],"times":[291],"potent":[293],"than":[294],"respectively,":[299],"suggesting":[300],"important":[310],"but":[311],"only":[314],"for":[316],"their":[317],"Analysis":[321],"representative":[323],"mutant":[328],"suggested":[329],"relatively":[332],"close":[336],"may":[341],"facilitate":[343],"its":[344]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}