{"id":"https://openalex.org/W1990265446","doi":"https://doi.org/10.1002/jps.20070","title":"Human Skin Permeation and Partition: General Linear Free\u2010Energy Relationship Analyses","display_name":"Human Skin Permeation and Partition: General Linear Free\u2010Energy Relationship Analyses","publication_year":2004,"publication_date":"2004-03-29","ids":{"openalex":"https://openalex.org/W1990265446","doi":"https://doi.org/10.1002/jps.20070","mag":"1990265446","pmid":"https://pubmed.ncbi.nlm.nih.gov/15124209"},"language":"en","primary_location":{"id":"doi:10.1002/jps.20070","doi":"https://doi.org/10.1002/jps.20070","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.20070","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1990265446"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012093239","display_name":"Michael H. Abraham","orcid":"https://orcid.org/0000-0002-4579-8621","observed_orcids":["https://orcid.org/0000-0002-4579-8621","https://orcid.org/0000-0001-6363-2521"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Michael H. Abraham","raw_affiliation_strings":["Department of Chemistry, University College London, 20 Gordon Street, London WC1H OAJ, United Kingdom. m.h.abraham@ucl.ac.uk","Department of Chemistry, University College London, 20 Gordon Street, London, WC1H OAJ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University College London, 20 Gordon Street, London WC1H OAJ, United Kingdom. m.h.abraham@ucl.ac.uk","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Department of Chemistry, University College London, 20 Gordon Street, London, WC1H OAJ, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071447672","display_name":"Filomena E. L. Martins","orcid":"https://orcid.org/0000-0003-4189-1228","observed_orcids":["https://orcid.org/0000-0003-4189-1228"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Filomena Martins","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Faculty of Sciences, University of Lisboa, CECUL, CQB, Edificio C8, Campo Grande 1749\u2010016, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Faculty of Sciences, University of Lisboa, CECUL, CQB, Edificio C8, Campo Grande 1749\u2010016, Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012093239"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":null,"fwci":8.1345,"has_fulltext":false,"cited_by_count":212,"citation_normalized_percentile":{"value":0.98983482,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"93","issue":"6","first_page":"1508","last_page":"1523"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.07530000060796738,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skin-permeation","display_name":"skin permeation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/permeability-coefficient","display_name":"permeability coefficient","score":0.7630000114440918},{"id":"https://openalex.org/keywords/abraham-descriptors","display_name":"Abraham descriptors","score":0.7310000061988831},{"id":"https://openalex.org/keywords/free-energy-relationships","display_name":"free energy relationships","score":0.7519999742507935},{"id":"https://openalex.org/keywords/hydrogen-bond-basicity","display_name":"hydrogen-bond basicity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/temperature-dependence","display_name":"temperature dependence","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C192552737","wikidata":"https://www.wikidata.org/wiki/Q898797","display_name":"Partition coefficient","level":2,"score":0.8403612375259399},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.8363492488861084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.759878396987915},{"id":"https://openalex.org/C2778370115","wikidata":"https://www.wikidata.org/wiki/Q2038676","display_name":"Stratum corneum","level":2,"score":0.5704811215400696},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.5127845406532288},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.49978065490722656},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.4940105080604553},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4576396942138672},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.1592535674571991},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09289214015007019},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012869","descriptor_name":"Skin Absorption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012869","descriptor_name":"Skin Absorption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1002/jps.20070","doi":"https://doi.org/10.1002/jps.20070","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.20070","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:15124209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15124209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmaceutical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.910.4104","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.910.4104","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Filomena_Martins3/publication/8581737_Human_skin_permeation_and_partition_general_linear_free-energy_relationship_analyses/links/5446ea8d0cf22b3c14e0b793.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.928.755","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.928.755","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Filomena_Martins3/publication/8581737_Human_skin_permeation_and_partition_general_linear_free-energy_relationship_analyses/links/5446ea8d0cf22b3c14e0b793.pdf?origin%3Dpublication_detail","raw_type":"text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:35553","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/35553/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JOURNAL OF PHARMACEUTICAL SCIENCES , 93 (6) pp. 1508-1523. (2004)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W18265906","https://openalex.org/W133901956","https://openalex.org/W174346363","https://openalex.org/W306918910","https://openalex.org/W344089625","https://openalex.org/W1501864094","https://openalex.org/W1520834681","https://openalex.org/W1544311753","https://openalex.org/W1561210178","https://openalex.org/W1568499110","https://openalex.org/W1584401858","https://openalex.org/W1587900694","https://openalex.org/W1594382975","https://openalex.org/W1890739221","https://openalex.org/W1963589634","https://openalex.org/W1971643336","https://openalex.org/W1976372018","https://openalex.org/W1978060458","https://openalex.org/W1981432419","https://openalex.org/W1983355645","https://openalex.org/W1988601069","https://openalex.org/W1992215820","https://openalex.org/W1993296121","https://openalex.org/W1998682680","https://openalex.org/W1999610960","https://openalex.org/W2002377386","https://openalex.org/W2004462262","https://openalex.org/W2008876775","https://openalex.org/W2009983903","https://openalex.org/W2013048000","https://openalex.org/W2017693902","https://openalex.org/W2019428704","https://openalex.org/W2020052928","https://openalex.org/W2020737146","https://openalex.org/W2031627294","https://openalex.org/W2039309216","https://openalex.org/W2044078572","https://openalex.org/W2047048974","https://openalex.org/W2049189738","https://openalex.org/W2055368553","https://openalex.org/W2059092103","https://openalex.org/W2063752165","https://openalex.org/W2063816876","https://openalex.org/W2064757248","https://openalex.org/W2068491399","https://openalex.org/W2070676754","https://openalex.org/W2077535359","https://openalex.org/W2080541742","https://openalex.org/W2080919381","https://openalex.org/W2086364016","https://openalex.org/W2089621094","https://openalex.org/W2096850608","https://openalex.org/W2106192138","https://openalex.org/W2110771669","https://openalex.org/W2118984839","https://openalex.org/W2133271116","https://openalex.org/W2141095211","https://openalex.org/W2150933325","https://openalex.org/W2151702186","https://openalex.org/W2159642794","https://openalex.org/W2160754546","https://openalex.org/W2163763334","https://openalex.org/W2167307830","https://openalex.org/W2170850345","https://openalex.org/W2171141505","https://openalex.org/W2171893580","https://openalex.org/W2172187417","https://openalex.org/W2266861214","https://openalex.org/W2269539447"],"related_works":["https://openalex.org/W2590165942","https://openalex.org/W2063752165","https://openalex.org/W2075051989","https://openalex.org/W4387035689","https://openalex.org/W176583632","https://openalex.org/W141715706","https://openalex.org/W1544311753","https://openalex.org/W2410430866","https://openalex.org/W2266861214"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}