{"id":"https://openalex.org/W1990263121","doi":"https://doi.org/10.1001/archinternmed.2009.229","title":"Drugs With Anticholinergic Properties, Cognitive Decline, and Dementia in an Elderly General Population","display_name":"Drugs With Anticholinergic Properties, Cognitive Decline, and Dementia in an Elderly General Population","publication_year":2009,"publication_date":"2009-07-27","ids":{"openalex":"https://openalex.org/W1990263121","doi":"https://doi.org/10.1001/archinternmed.2009.229","mag":"1990263121","pmid":"https://pubmed.ncbi.nlm.nih.gov/19636034"},"language":"en","primary_location":{"id":"doi:10.1001/archinternmed.2009.229","doi":"https://doi.org/10.1001/archinternmed.2009.229","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archinternmed.2009.229","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://inserm.hal.science/inserm-00415864/document","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068708409","display_name":"Isabelle Carri\u00e8re","orcid":"https://orcid.org/0000-0002-3617-0752","observed_orcids":["https://orcid.org/0000-0002-3617-0752"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387153574","display_name":"Universit\u00e9 Montpellier 1","ror":"https://ror.org/0227fbx80","country_code":null,"type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387153574"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Isabelle Carri\u00e8re","raw_affiliation_strings":["Inserm, U888, Universit\u00e9 Montpellier 1, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, U888, Universit\u00e9 Montpellier 1, Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387153574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020558306","display_name":"Annie Fourrier\u2010R\u00e9glat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405256745","display_name":"Universit\u00e9 Bordeaux Segalen","ror":"https://ror.org/04gbzm373","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530","https://openalex.org/I4405256745"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Annie Fourrier-Reglat","raw_affiliation_strings":[", Bordeaux","Inserm U657, Univ Bordeaux 2, Bordeaux"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", Bordeaux","institution_ids":[]},{"raw_affiliation_string":"Inserm U657, Univ Bordeaux 2, Bordeaux","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405256745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048761069","display_name":"Jean\u2010Fran\u00e7ois Dartigues","orcid":"https://orcid.org/0000-0001-9482-5529","observed_orcids":["https://orcid.org/0000-0001-9482-5529"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Fran\u00e7ois Dartigues","raw_affiliation_strings":["Inserm, U897, Univ Bordeaux"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, U897, Univ Bordeaux","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082923927","display_name":"Olivier Rouaud","orcid":"https://orcid.org/0000-0001-9767-8421","observed_orcids":["https://orcid.org/0000-0001-9767-8421"]},"institutions":[{"id":"https://openalex.org/I4210116240","display_name":"CHU Dijon Bourgogne","ror":"https://ror.org/0377z4z10","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210116240"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Rouaud","raw_affiliation_strings":["Department of Neurology, CHU Dijon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, CHU Dijon","institution_ids":["https://openalex.org/I4210116240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055524428","display_name":"Florence Pasquier","orcid":"https://orcid.org/0000-0001-9880-9788","observed_orcids":["https://orcid.org/0000-0001-9880-9788"]},"institutions":[{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Florence Pasquier","raw_affiliation_strings":["Department of Neurology, CHU Lille"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, CHU Lille","institution_ids":["https://openalex.org/I3018718406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075011135","display_name":"Karen A. Ritchie","orcid":"https://orcid.org/0000-0002-0688-8982","observed_orcids":["https://orcid.org/0000-0002-0688-8982"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4387153574","display_name":"Universit\u00e9 Montpellier 1","ror":"https://ror.org/0227fbx80","country_code":null,"type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387153574"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Karen Ritchie","raw_affiliation_strings":["Inserm, U888, Montpellier, F-34093 France ;","Univ Montpellier 1, Montpellier, F-34000 France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, U888, Montpellier, F-34093 France ;","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Univ Montpellier 1, Montpellier, F-34000 France","institution_ids":["https://openalex.org/I19894307","https://openalex.org/I4387153574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009296549","display_name":"Marie\u2010Laure Ancelin","orcid":"https://orcid.org/0000-0002-1149-4320","observed_orcids":["https://orcid.org/0000-0002-1149-4320"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Laure Ancelin","raw_affiliation_strings":["French Institute of Health and Medical Research > > > >  >  >"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"French Institute of Health and Medical Research > > > >  >  >","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.0617,"has_fulltext":true,"cited_by_count":367,"citation_normalized_percentile":{"value":0.98646924,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"169","issue":"14","first_page":"1317","last_page":"1317"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.2515000104904175,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anticholinergic-drugs","display_name":"anticholinergic agents","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.996999979019165},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7879999876022339},{"id":"https://openalex.org/keywords/community-dwelling-elderly","display_name":"community-dwelling older adults","score":0.8230000138282776},{"id":"https://openalex.org/keywords/verbal-fluency","display_name":"verbal fluency","score":0.8849999904632568},{"id":"https://openalex.org/keywords/visual-memory","display_name":"visual memory","score":0.9819999933242798},{"id":"https://openalex.org/keywords/executive-function","display_name":"executive function","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9509999752044678},{"id":"https://openalex.org/keywords/hormone-therapy","display_name":"hormone therapy","score":0.968999981880188},{"id":"https://openalex.org/keywords/medication-discontinuation","display_name":"drug discontinuation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.628000020980835},{"id":"https://openalex.org/keywords/polypharmacy","display_name":"polypharmacy","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C2778689640","wikidata":"https://www.wikidata.org/wiki/Q113259","display_name":"Anticholinergic","level":2,"score":0.9101045727729797},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7291935086250305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6711792945861816},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.6168422698974609},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5690127611160278},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5577784776687622},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49445676803588867},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4731929302215576},{"id":"https://openalex.org/C2910745098","wikidata":"https://www.wikidata.org/wiki/Q113259","display_name":"Anticholinergic agents","level":3,"score":0.47219857573509216},{"id":"https://openalex.org/C2776332859","wikidata":"https://www.wikidata.org/wiki/Q411887","display_name":"Rivastigmine","level":5,"score":0.46982431411743164},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4495410621166229},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42887893319129944},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3808929920196533},{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.261801540851593},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1187584400177002},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018680","descriptor_name":"Cholinergic Antagonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018680","descriptor_name":"Cholinergic Antagonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018680","descriptor_name":"Cholinergic Antagonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1001/archinternmed.2009.229","doi":"https://doi.org/10.1001/archinternmed.2009.229","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archinternmed.2009.229","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:19636034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19636034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of internal medicine","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:inserm-00415864v1","doi":null,"is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-00415864","pdf_url":"https://inserm.hal.science/inserm-00415864/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archives of Internal Medicine -New Series-, 2009, 169 (14), pp.1317-24. &#x27E8;10.1001/archinternmed.2009.229&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2933398","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2933398","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arch Intern Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:HAL:inserm-00415864v1","doi":null,"is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-00415864","pdf_url":"https://inserm.hal.science/inserm-00415864/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archives of Internal Medicine -New Series-, 2009, 169 (14), pp.1317-24. &#x27E8;10.1001/archinternmed.2009.229&#x27E9;","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990263121.pdf","grobid_xml":"https://content.openalex.org/works/W1990263121.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1847168837","https://openalex.org/W1965868118","https://openalex.org/W1968996734","https://openalex.org/W1978172876","https://openalex.org/W1992268087","https://openalex.org/W1997677647","https://openalex.org/W1999771234","https://openalex.org/W2000555003","https://openalex.org/W2001917448","https://openalex.org/W2004602458","https://openalex.org/W2008453699","https://openalex.org/W2009631046","https://openalex.org/W2010301326","https://openalex.org/W2028779253","https://openalex.org/W2030802886","https://openalex.org/W2032752614","https://openalex.org/W2039398668","https://openalex.org/W2044589919","https://openalex.org/W2051274997","https://openalex.org/W2051350612","https://openalex.org/W2059901490","https://openalex.org/W2066558048","https://openalex.org/W2070495958","https://openalex.org/W2080265469","https://openalex.org/W2087574663","https://openalex.org/W2092246656","https://openalex.org/W2100039954","https://openalex.org/W2101037478","https://openalex.org/W2101435235","https://openalex.org/W2105020753","https://openalex.org/W2112778345","https://openalex.org/W2120890203","https://openalex.org/W2126292472","https://openalex.org/W2130920183","https://openalex.org/W2133900227","https://openalex.org/W2138988922","https://openalex.org/W2153016796","https://openalex.org/W2155658041","https://openalex.org/W2168335347","https://openalex.org/W2334077207","https://openalex.org/W2602374858","https://openalex.org/W3022868799","https://openalex.org/W4232886441"],"related_works":["https://openalex.org/W3129153696","https://openalex.org/W2074232386","https://openalex.org/W2465790833","https://openalex.org/W124780977","https://openalex.org/W2392306180","https://openalex.org/W2806153698","https://openalex.org/W2025924280","https://openalex.org/W2356131690","https://openalex.org/W2399544616","https://openalex.org/W1672029851"],"abstract_inverted_index":{"BACKGROUND:":[0],"Despite":[1],"the":[2,14,71,204,227,274],"high":[3,281],"intake":[4],"of":[5,50,68,70,87,178,200,229,266],"medications":[6],"with":[7,133,257],"anticholinergic":[8,53,74,88,125,163,188,230,241,253,267],"properties":[9],"by":[10],"community-dwelling":[11],"elderly":[12,270,276],"persons,":[13],"effects":[15],"on":[16],"cognitive":[17,114,179,248,285],"decline":[18,94,134,180,249],"and":[19,30,52,59,61,111,143,165,250,277],"dementia":[20,202],"have":[21],"rarely":[22],"been":[23],"evaluated.":[24],"METHODS:":[25],"Participants":[26],"were":[27,55,158,243],"4128":[28],"women":[29,84,122,161],"2784":[31],"men":[32],"65":[33],"years":[34,63,97],"or":[35,169],"older":[36],"from":[37,42],"a":[38,145,258],"population-based":[39],"cohort":[40],"recruited":[41],"3":[43],"French":[44],"cities.":[45],"Cognitive":[46],"performance,":[47],"clinical":[48],"diagnosis":[49],"dementia,":[51],"use":[54,76,86,164,228],"evaluated":[56],"at":[57,77,90,244,280],"baseline":[58,91],"2":[60],"4":[62,96],"later.":[64],"RESULTS:":[65],"A":[66,172],"total":[67],"7.5%":[69],"participants":[72],"reported":[73],"drug":[75],"baseline.":[78],"Multivariate-adjusted":[79],"logistic":[80],"regression":[81],"indicated":[82],"that":[83],"reporting":[85],"drugs":[89,189,231,242,268],"showed":[92],"greater":[93],"over":[95,203],"in":[98,112,135,148,160,211,223,269,273,278],"verbal":[99],"fluency":[100],"scores":[101],"(odds":[102],"ratio":[103,215],"[OR],":[104],"1.41;":[105],"95%":[106,118,140,153,218,234],"confidence":[107],"interval":[108],"[CI],":[109],"1.11-1.79)":[110],"global":[113],"functioning":[115],"(OR,":[116,138,151],"1.22;":[117],"CI,":[119,141,154,219,235],"0.96-1.55)":[120],"than":[121],"not":[123,191,222],"using":[124],"drugs.":[126],"In":[127],"men,":[128],"an":[129],"association":[130],"was":[131,181,208,255],"found":[132],"visual":[136],"memory":[137],"1.63;":[139],"1.08-2.47)":[142],"to":[144,174],"lesser":[146],"extent":[147],"executive":[149],"function":[150],"1.47;":[152],"0.89-2.44).":[155],"Notable":[156],"interactions":[157],"observed":[159,182],"between":[162],"age,":[166],"apolipoprotein":[167],"E,":[168],"hormone":[170],"therapy.":[171],"1.4-":[173],"2-fold":[175],"higher":[176],"risk":[177,199,246,283],"for":[183,192,247,284],"those":[184,193,224],"who":[185,194,225],"continuously":[186],"used":[187],"but":[190,221],"had":[195],"discontinued":[196,226],"use.":[197],"The":[198],"incident":[201],"4-year":[205],"follow-up":[206],"period":[207],"also":[209],"increased":[210,245],"continuous":[212],"users":[213],"(hazard":[214],"[HR],":[216],"1.65;":[217],"1.00-2.73)":[220],"(HR,":[232],"1.28;":[233],"0.59-2.76).":[236],"CONCLUSIONS:":[237],"Elderly":[238],"people":[239],"taking":[240],"dementia.":[251],"Discontinuing":[252],"treatment":[254],"associated":[256],"decreased":[259],"risk.":[260],"Physicians":[261],"should":[262],"carefully":[263],"consider":[264],"prescription":[265],"people,":[271],"especially":[272],"very":[275],"persons":[279],"genetic":[282],"disorder.":[286]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":38},{"year":2020,"cited_by_count":35},{"year":2019,"cited_by_count":32},{"year":2018,"cited_by_count":28},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":21},{"year":2015,"cited_by_count":30},{"year":2014,"cited_by_count":29},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":24}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
