{"id":"https://openalex.org/W1990252243","doi":"https://doi.org/10.1073/pnas.95.13.7760","title":"Antisense oligonucleotides against \u03b1 1E reduce R-type calcium currents in cerebellar granule cells","display_name":"Antisense oligonucleotides against \u03b1 1E reduce R-type calcium currents in cerebellar granule cells","publication_year":1998,"publication_date":"1998-06-23","ids":{"openalex":"https://openalex.org/W1990252243","doi":"https://doi.org/10.1073/pnas.95.13.7760","mag":"1990252243","pmid":"https://pubmed.ncbi.nlm.nih.gov/9636224","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/22749"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.95.13.7760","doi":"https://doi.org/10.1073/pnas.95.13.7760","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.95.13.7760","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC22749","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014493479","display_name":"Erika S. Piedras-Renter\u0131\u0301a","orcid":"https://orcid.org/0000-0001-7983-585X","observed_orcids":["https://orcid.org/0000-0001-7983-585X"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erika S. Piedras-Renter\u00eda","raw_affiliation_strings":["Department of Molecular and Cellular Physiology, Beckman Center, Stanford University Medical Center, Stanford, California 94305","Department of Molecular and Cellular Physiology Beckman Center Stanford University Medical Center Stanford, California 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Physiology, Beckman Center, Stanford University Medical Center, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306"]},{"raw_affiliation_string":"Department of Molecular and Cellular Physiology Beckman Center Stanford University Medical Center Stanford, California 94305, USA","institution_ids":["https://openalex.org/I4210137306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028006387","display_name":"Richard W. Tsien","orcid":"https://orcid.org/0000-0001-7428-9722","observed_orcids":["https://orcid.org/0000-0001-7428-9722"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard W. Tsien","raw_affiliation_strings":["Department of Molecular and Cellular Physiology, Beckman Center, Stanford University Medical Center, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Physiology, Beckman Center, Stanford University Medical Center, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210137306"],"apc_list":null,"apc_paid":null,"fwci":4.3001,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.95148909,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"95","issue":"13","first_page":"7760","last_page":"7765"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha1e-subunit","display_name":"alpha1E subunit","score":0.9399999976158142},{"id":"https://openalex.org/keywords/cerebellar-granule-cells","display_name":"cerebellar granule cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.9800000190734863},{"id":"https://openalex.org/keywords/high-voltage-activated-calcium-channels","display_name":"high-voltage-activated calcium channels","score":0.8299999833106995},{"id":"https://openalex.org/keywords/alpha1a-subunit","display_name":"alpha1A subunit","score":0.968999981880188},{"id":"https://openalex.org/keywords/voltage-gated-calcium-channels","display_name":"voltage-gated calcium channels","score":0.6579999923706055},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C143141573","wikidata":"https://www.wikidata.org/wiki/Q7450971","display_name":"Sense (electronics)","level":2,"score":0.6963736414909363},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.6678161025047302},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5509830117225647},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5417107343673706},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.5405709743499756},{"id":"https://openalex.org/C49760210","wikidata":"https://www.wikidata.org/wiki/Q5596727","display_name":"Granule (geology)","level":2,"score":0.4959898889064789},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38875219225883484},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3330226242542267},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2865888476371765},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.20428374409675598},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20158705115318298},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1893705427646637},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10226619243621826},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013873","descriptor_name":"Thionucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.95.13.7760","doi":"https://doi.org/10.1073/pnas.95.13.7760","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.95.13.7760","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:190401","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC22749","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:22749","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/22749","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:9636224","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9636224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:190401","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC22749","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1488629111","https://openalex.org/W1578096869","https://openalex.org/W1616459298","https://openalex.org/W1755201723","https://openalex.org/W1818781363","https://openalex.org/W1828854785","https://openalex.org/W1965772541","https://openalex.org/W1968124094","https://openalex.org/W1973868940","https://openalex.org/W1974015977","https://openalex.org/W1983635763","https://openalex.org/W1988323645","https://openalex.org/W1990072811","https://openalex.org/W1995654174","https://openalex.org/W2005168527","https://openalex.org/W2020352263","https://openalex.org/W2030034009","https://openalex.org/W2032114328","https://openalex.org/W2035198661","https://openalex.org/W2036937904","https://openalex.org/W2052006707","https://openalex.org/W2061056399","https://openalex.org/W2062944755","https://openalex.org/W2063370119","https://openalex.org/W2068116440","https://openalex.org/W2070344212","https://openalex.org/W2074797643","https://openalex.org/W2075162730","https://openalex.org/W2075654108","https://openalex.org/W2082299946","https://openalex.org/W2084165595","https://openalex.org/W2090157435","https://openalex.org/W2112520934","https://openalex.org/W2128487067","https://openalex.org/W2129749682","https://openalex.org/W2131545381","https://openalex.org/W2131921751","https://openalex.org/W2134902160","https://openalex.org/W2140318655","https://openalex.org/W2146263938","https://openalex.org/W2169929759","https://openalex.org/W2172530119","https://openalex.org/W2415021190","https://openalex.org/W2416491965","https://openalex.org/W2416575026","https://openalex.org/W3025655743","https://openalex.org/W4214868137","https://openalex.org/W4300784327","https://openalex.org/W4301356103"],"related_works":["https://openalex.org/W2063370119","https://openalex.org/W2121365228","https://openalex.org/W1946405761","https://openalex.org/W2164235945","https://openalex.org/W7099895825","https://openalex.org/W2166171095","https://openalex.org/W2020352263","https://openalex.org/W59880249","https://openalex.org/W7100798459","https://openalex.org/W1488629111"],"abstract_inverted_index":{"Many":[0],"neurons":[1,86],"of":[2,39,79,170,180,184,236,240],"the":[3,26,29,36,47,57,77,120,135,155,171,178,185,212,232,237,244],"central":[4],"nervous":[5],"system":[6],"display":[7],"multiple":[8],"high":[9,245],"voltage-activated":[10,246],"Ca2+":[11,52],"currents,":[12],"pharmacologically":[13],"classified":[14],"as":[15],"L-,":[16],"N-,":[17],"P-,":[18],"Q-,":[19],"and":[20,98,191,205],"R-type.":[21],"Of":[22],"these":[23],"current":[24,81,123,156,187,200,226,248],"types,":[25],"R-type":[27,40,58,80,122,199,247],"is":[28,46,227],"least":[30],"understood.":[31],"The":[32,168],"leading":[33],"candidate":[34],"for":[35],"molecular":[37],"correlate":[38],"currents":[41,53,220],"in":[42,61,82,87,108,119,134,154,160,182,223,249],"cerebellar":[43,84,250],"granule":[44,85,251],"cells":[45,163],"alpha1E":[48,74,112,172],"subunit,":[49],"which":[50,224],"yields":[51],"very":[54],"similar":[55],"to":[56,138],"when":[59],"expressed":[60],"heterologous":[62],"systems.":[63],"As":[64],"a":[65,116],"complementary":[66],"approach,":[67],"we":[68],"tested":[69],"whether":[70],"antisense":[71,94,113,173,190,214],"oligonucleotides":[72,97,174,193],"against":[73,194],"could":[75],"decrease":[76,118],"expression":[78,157,201],"rat":[83],"culture.":[88],"Cells":[89],"were":[90,103,158],"supplemented":[91],"with":[92,111],"either":[93],"or":[95],"sense":[96,161,192],"whole-cell":[99],"patch":[100],"clamp":[101],"recordings":[102],"obtained":[104],"after":[105],"6-8":[106],"days":[107],"vitro.":[109],"Incubation":[110],"oligonucleotide":[114,215],"caused":[115],"52.5%":[117],"peak":[121],"density,":[124],"from":[125],"-10":[126],"+/-":[127,140,165,203,207],"0.6":[128],"picoamperes/picofarad":[129],"(pA/pF)":[130],"(n":[131,143],"=":[132,144],"6)":[133],"untreated":[136],"controls":[137],"-4.8":[139],"0.8":[141],"pA/pF":[142],"11)":[145],"(P":[146],"<":[147],"0.01).":[148],"In":[149],"contrast,":[150],"no":[151],"significant":[152],"changes":[153],"seen":[159],"oligonucleotide-treated":[162],"(-11.3":[164],"3.2":[166],"pA/pF).":[167],"specificity":[169],"was":[175],"supported":[176],"by":[177],"lack":[179],"change":[181],"estimates":[183],"P/Q":[186,225],"amplitude.":[188],"Furthermore,":[189],"alpha1A":[195,213],"did":[196],"not":[197],"affect":[198],"(-11.5":[202],"1.7":[204,208],"-11.7":[206],"pA/pF,":[209],"respectively),":[210],"whereas":[211],"significantly":[216],"reduced":[217],"whole":[218],"cell":[219],"under":[221],"conditions":[222],"dominant.":[228],"Our":[229],"results":[230],"support":[231,243],"hypothesis":[233],"that":[234],"members":[235],"E":[238],"class":[239],"alpha1":[241],"subunits":[242],"cells.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
