{"id":"https://openalex.org/W1990237397","doi":"https://doi.org/10.1016/j.bone.2012.02.235","title":"Acute moderate and severe hypo- and hyperthermia down-regulate gene expression of molecular chaperones and inflammatory cytokines in osteoblast cells","display_name":"Acute moderate and severe hypo- and hyperthermia down-regulate gene expression of molecular chaperones and inflammatory cytokines in osteoblast cells","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W1990237397","doi":"https://doi.org/10.1016/j.bone.2012.02.235","mag":"1990237397"},"language":"en","primary_location":{"id":"doi:10.1016/j.bone.2012.02.235","doi":"https://doi.org/10.1016/j.bone.2012.02.235","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bone.2012.02.235","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001456635","display_name":"Aisha Mohd Din","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.D. Aisha\u204e","raw_affiliation_strings":["Faculty of Medicine, Institute of Medical Molecular Biotechnology, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Institute of Medical Molecular Biotechnology, Malaysia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056975732","display_name":"\u041c. \u042e. \u041a\u0430\u043f\u0438\u0442\u043e\u043d\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0001-6055-3123","observed_orcids":["https://orcid.org/0000-0001-6055-3123"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Kapitonova","raw_affiliation_strings":["Faculty of Medicine, Institute of Medical Molecular Biotechnology, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Institute of Medical Molecular Biotechnology, Malaysia","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"M.N.K. Nor-Ashikin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.N.K. Nor-Ashikin","raw_affiliation_strings":["Faculty of Medicine, Institute of Medical Molecular Biotechnology, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Institute of Medical Molecular Biotechnology, Malaysia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035489724","display_name":"A. R. Sharaniza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A.R. Sharaniza","raw_affiliation_strings":["Faculty of Medicine, Institute of Medical Molecular Biotechnology, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Institute of Medical Molecular Biotechnology, Malaysia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012812036","display_name":"Hapizah Mohd Nawawi","orcid":"https://orcid.org/0000-0003-4462-8484","observed_orcids":["https://orcid.org/0000-0003-4462-8484","https://orcid.org/0009-0002-5871-405X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Nawawi","raw_affiliation_strings":["Faculty of Medicine, Center for Pathology Diagnostic and Research Laboratories, Sungai Buloh, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Center for Pathology Diagnostic and Research Laboratories, Sungai Buloh, Malaysia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033044540","display_name":"Gabriele Ruth Anisah Froemming","orcid":"https://orcid.org/0000-0002-5931-1968","observed_orcids":["https://orcid.org/0000-0002-5931-1968"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G.R.A. Froemming","raw_affiliation_strings":["Faculty of Medicine, Institute of Medical Molecular Biotechnology, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Institute of Medical Molecular Biotechnology, Malaysia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3960,"currency":"USD","value_usd":3960},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07470027,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"50","issue":null,"first_page":"S81","last_page":"S81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.04270000010728836,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.03620000183582306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypothermia","display_name":"hypothermia","score":0.7919999957084656},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/heat-shock","display_name":"heat shock","score":0.46799999475479126},{"id":"https://openalex.org/keywords/molecular-chaperones","display_name":"molecular chaperones","score":0.9580000042915344},{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.8629999756813049},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9440000057220459},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6830000281333923},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.9760000109672546},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.7578941583633423},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.49993085861206055},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4973202049732208},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.48642826080322266},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4546135663986206},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4283478260040283},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.41855859756469727},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40795886516571045},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.375093549489975},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3341884911060333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28250306844711304},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2640220522880554},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21002471446990967},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1267375648021698},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0321994423866272}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bone.2012.02.235","doi":"https://doi.org/10.1016/j.bone.2012.02.235","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bone.2012.02.235","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.44999998807907104}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4379052364","https://openalex.org/W2416795054","https://openalex.org/W2392126385","https://openalex.org/W1992848314","https://openalex.org/W3039146159","https://openalex.org/W2571013527","https://openalex.org/W2015667478","https://openalex.org/W1955721074","https://openalex.org/W4206781811","https://openalex.org/W2011724047"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
