{"id":"https://openalex.org/W1990217898","doi":"https://doi.org/10.1046/j.1365-2125.1997.00609.x","title":"Pharmacokinetics of \u03b2\u2010adrenoceptor blockers in obese and normal volunteers","display_name":"Pharmacokinetics of \u03b2\u2010adrenoceptor blockers in obese and normal volunteers","publication_year":1997,"publication_date":"1997-06-01","ids":{"openalex":"https://openalex.org/W1990217898","doi":"https://doi.org/10.1046/j.1365-2125.1997.00609.x","mag":"1990217898","pmid":"https://pubmed.ncbi.nlm.nih.gov/9205815","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2042788"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2125.1997.00609.x","doi":"https://doi.org/10.1046/j.1365-2125.1997.00609.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2125.1997.00609.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2125.1997.00609.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2125.1997.00609.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069509986","display_name":"GEORGES CHEYMOL","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Georges Cheymol","raw_affiliation_strings":["Service de Pharmacologie, H\u00f4pital St Antoine, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Pharmacologie, H\u00f4pital St Antoine, Paris, France","institution_ids":["https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111680324","display_name":"Jean\u2010Marie Poirier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean\u2010Marie Poirier","raw_affiliation_strings":["Service de Pharmacologie, Ho\u0302pital St Antoine, Paris, France,","Service de Pharmacologie, H\u00f4pital St Antoine, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Pharmacologie, Ho\u0302pital St Antoine, Paris, France,","institution_ids":["https://openalex.org/I4210102928"]},{"raw_affiliation_string":"Service de Pharmacologie, H\u00f4pital St Antoine, Paris, France","institution_ids":["https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109942787","display_name":"Pierre\u2010Alain Carrupt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Pierre\u2010Alain Carrupt","raw_affiliation_strings":["Institut de Chimie The\u0301rapeutique, Ecole de Pharmacie, Universite\u0301 de Lausanne, Switzerland,","Institut de Chimie th\u00e9rapeutique, Ecole de Pharmacie, Universit\u00e9 de Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Chimie The\u0301rapeutique, Ecole de Pharmacie, Universite\u0301 de Lausanne, Switzerland,","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Institut de Chimie th\u00e9rapeutique, Ecole de Pharmacie, Universit\u00e9 de Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080796605","display_name":"Bernard Testa","orcid":"https://orcid.org/0000-0002-3218-4612","observed_orcids":["https://orcid.org/0000-0002-3218-4612"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Bernard Testa","raw_affiliation_strings":["Institut de Chimie The\u0301rapeutique, Ecole de Pharmacie, Universite\u0301 de Lausanne, Switzerland,","Institut de Chimie th\u00e9rapeutique, Ecole de Pharmacie, Universit\u00e9 de Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Chimie The\u0301rapeutique, Ecole de Pharmacie, Universite\u0301 de Lausanne, Switzerland,","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Institut de Chimie th\u00e9rapeutique, Ecole de Pharmacie, Universit\u00e9 de Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028759234","display_name":"JACQUES WEISSENBURGER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jacques Weissenburger","raw_affiliation_strings":["Service de Pharmacologie, Ho\u0302pital St Antoine, Paris, France,","Service de Pharmacologie, H\u00f4pital St Antoine, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Pharmacologie, Ho\u0302pital St Antoine, Paris, France,","institution_ids":["https://openalex.org/I4210102928"]},{"raw_affiliation_string":"Service de Pharmacologie, H\u00f4pital St Antoine, Paris, France","institution_ids":["https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112196751","display_name":"Jean\u2010Claude Levron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137982388","display_name":"Janssen (Belgium)","ror":"https://ror.org/04yzcpd71","country_code":"BE","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I137982388"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean\u2010Claude Levron","raw_affiliation_strings":["Janssen Research Foundation, Val de Reuil, France, Beerse, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research Foundation, Val de Reuil, France, Beerse, Belgium","institution_ids":["https://openalex.org/I137982388"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022136918","display_name":"Eric Snoeck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137982388","display_name":"Janssen (Belgium)","ror":"https://ror.org/04yzcpd71","country_code":"BE","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I137982388"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Eric Snoeck","raw_affiliation_strings":["Janssen Research Foundation, Val de Reuil, France, Beerse, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research Foundation, Val de Reuil, France, Beerse, Belgium","institution_ids":["https://openalex.org/I137982388"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5069509986"],"corresponding_institution_ids":["https://openalex.org/I4210102928"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":0.4775,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":{"value":0.54628225,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"43","issue":"6","first_page":"563","last_page":"570"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.05380000174045563,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.030400000512599945,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.9580000042915344},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9900000095367432},{"id":"https://openalex.org/keywords/lipophilic-drugs","display_name":"lipophilic drugs","score":0.8579999804496765},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.8579999804496765},{"id":"https://openalex.org/keywords/labetalol","display_name":"labetalol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nebivolol","display_name":"nebivolol","score":1.0},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.7379999756813049},{"id":"https://openalex.org/keywords/lipophilicity","display_name":"lipophilicity","score":0.796999990940094},{"id":"https://openalex.org/keywords/ionization-constants","display_name":"ionization constants","score":0.7649999856948853},{"id":"https://openalex.org/keywords/body-fat-distribution","display_name":"body fat distribution","score":0.7360000014305115},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.3709999918937683},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8234922885894775},{"id":"https://openalex.org/C2779670145","wikidata":"https://www.wikidata.org/wiki/Q412515","display_name":"Bisoprolol","level":3,"score":0.707595705986023},{"id":"https://openalex.org/C2776525901","wikidata":"https://www.wikidata.org/wiki/Q411325","display_name":"Atenolol","level":3,"score":0.677152156829834},{"id":"https://openalex.org/C201399114","wikidata":"https://www.wikidata.org/wiki/Q898401","display_name":"Lipophilicity","level":2,"score":0.6108432412147522},{"id":"https://openalex.org/C2777962398","wikidata":"https://www.wikidata.org/wiki/Q958087","display_name":"Labetalol","level":3,"score":0.582819402217865},{"id":"https://openalex.org/C139254425","wikidata":"https://www.wikidata.org/wiki/Q1332167","display_name":"Volume of distribution","level":3,"score":0.5674413442611694},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5184944868087769},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.49752119183540344},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4889337122440338},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44497784972190857},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.4115754961967468},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39649415016174316},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39610469341278076},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.2043376863002777},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.17296040058135986},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.06631976366043091}],"mesh":[{"descriptor_ui":"D000068577","descriptor_name":"Nebivolol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001578","descriptor_name":"Benzopyrans","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001578","descriptor_name":"Benzopyrans","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001578","descriptor_name":"Benzopyrans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001578","descriptor_name":"Benzopyrans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001774","descriptor_name":"Blood Chemical Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004983","descriptor_name":"Ethanolamines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004983","descriptor_name":"Ethanolamines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004983","descriptor_name":"Ethanolamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004983","descriptor_name":"Ethanolamines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007741","descriptor_name":"Labetalol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007741","descriptor_name":"Labetalol","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D007741","descriptor_name":"Labetalol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007741","descriptor_name":"Labetalol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013015","descriptor_name":"Sotalol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013015","descriptor_name":"Sotalol","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013015","descriptor_name":"Sotalol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017298","descriptor_name":"Bisoprolol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017298","descriptor_name":"Bisoprolol","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D017298","descriptor_name":"Bisoprolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1046/j.1365-2125.1997.00609.x","doi":"https://doi.org/10.1046/j.1365-2125.1997.00609.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2125.1997.00609.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2125.1997.00609.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:9205815","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9205815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Clinical Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:2042788","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2042788/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"},{"id":"pmh:oai:iris.unil.ch:iris/76277","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/76277","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:serval.unil.ch:BIB_1715","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_1715","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"British Journal of Clinical Pharmacology, vol. 43, no. 6, pp. 563-570","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:unige.ch:aou:unige:10559","doi":null,"is_oa":false,"landing_page_url":"https://archive-ouverte.unige.ch/unige:10559","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0306-5251","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:unige.ch:unige:10559","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:10559","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0306-5251","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1046/j.1365-2125.1997.00609.x","doi":"https://doi.org/10.1046/j.1365-2125.1997.00609.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2125.1997.00609.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2125.1997.00609.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990217898.pdf","grobid_xml":"https://content.openalex.org/works/W1990217898.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W123433672","https://openalex.org/W1965107401","https://openalex.org/W2067312325"],"related_works":["https://openalex.org/W2415437695","https://openalex.org/W2027387528","https://openalex.org/W2060691076","https://openalex.org/W2036659204","https://openalex.org/W2044493603","https://openalex.org/W2107564745","https://openalex.org/W2112493339","https://openalex.org/W1967418493","https://openalex.org/W3119101435","https://openalex.org/W4315628917"],"abstract_inverted_index":{"AIMS:":[0],"Obesity":[1],"can":[2],"modify":[3],"the":[4,29,71,84,135,184,205,263,296],"pharmacokinetics":[5,30],"of":[6,31,46,81,83,96,112,125,177,204,262,298],"lipophilic":[7,32,194],"drugs.":[8],"As":[9],"beta-adrenoceptor":[10,33,87,126,179,247],"blockers":[11,34,127,248],"(BB)":[12],"are":[13],"often":[14],"prescribed":[15],"for":[16,134,237],"obese":[17,36,42,153,169,240,282,290],"patients":[18,154,291],"suffering":[19],"from":[20],"hypertension":[21],"or":[22,269],"coronary":[23],"heart":[24],"disease,":[25],"this":[26],"study":[27],"compares":[28],"in":[35,70,152,156,168,280,289,308],"and":[37,54,105,122,175,197,210,239,283,301],"control":[38],"subjects.":[39,285],"METHODS:":[40],"Nine":[41],"(157":[43],"+/-":[44,52,60,65],"24%":[45],"ideal":[47],"body":[48,163],"weight":[49,164],"(IBW)":[50],"mean":[51],"s.d.)":[53],"nine":[55],"non-obese":[56],"healthy":[57],"volunteers":[58],"(98":[59],"10%":[61],"IBW),":[62],"aged":[63],"32":[64],"9":[66],"years,":[67],"were":[68,74,115,128,138,242],"included":[69],"study.":[72],"Subjects":[73],"randomly":[75],"given":[76],"a":[77,143,146,192,198],"single":[78],"i.v.":[79],"infusion":[80],"one":[82,200],"following":[85],"racemic":[86],"blockers,":[88],"whose":[89],"doses":[90],"(expressed":[91],"as":[92],"base":[93],"per":[94,161],"kg":[95,162],"IBW)":[97],"were:":[98],"propranolol":[99],"(0.108":[100],"mg),":[101],"labetalol":[102],"(0.99":[103],"mg)":[104],"nebivolol":[106],"(0.073":[107],"mg).":[108],"The":[109,119,131,171,202,233],"plasma":[110],"concentrations":[111],"unchanged":[113],"drugs":[114,137,207,264],"measured":[116],"by":[117,182,295],"h.p.l.c.":[118],"ionisation":[120],"constants":[121],"lipophilicity":[123,176],"parameters":[124],"assessed.":[129],"RESULTS:":[130],"pharmacokinetic":[132],"data":[133],"three":[136],"qualitatively":[139],"similar.":[140,244],"There":[141],"was":[142,165,180,208],"trend":[144],"towards":[145],"greater":[147],"total":[148],"distribution":[149,220,288],"volume":[150],"(Vss)":[151],"than":[155,255],"controls.":[157],"However,":[158],"Vss":[159,174,203],"expressed":[160],"slightly":[166],"smaller":[167],"patients.":[170],"relationship":[172],"between":[173],"five":[178,206],"studied":[181],"combining":[183],"current":[185],"results":[186],"with":[187,191,218,229,306],"those":[188],"previously":[189],"obtained":[190],"moderately":[193],"drug":[195],"(bisoprolol)":[196],"hydrophilic":[199],"(sotalol).":[201],"positively":[209],"well-correlated":[211],"(r2":[212],"=":[213],"0.90;":[214],"P":[215],"<":[216],"0.01)":[217],"their":[219,230,277],"coefficient":[221],"at":[222,272],"pH":[223,274],"7.4":[224],"(log":[225],"D7.4),":[226],"but":[227],"not":[228],"partition":[231],"coefficients.":[232],"linear":[234],"regression":[235],"coefficients":[236],"lean":[238,257,284,309],"subjects":[241],"very":[243],"CONCLUSIONS:":[245],"Lipophilic":[246],"seem":[249],"to":[250,276],"diffuse":[251],"less":[252],"into":[253,256],"adipose":[254],"tissues.":[258,310],"All":[259],"electrical":[260],"forms":[261],"(i.e.":[265],"cations,":[266],"neutral":[267],"forms,":[268],"zwitterions)":[270],"present":[271],"physiological":[273],"contribute":[275],"tissue":[278,287],"distribution,":[279],"both":[281],"Their":[286],"could":[292],"be":[293],"restricted":[294],"sum":[297],"hydrophobic":[299],"forces":[300],"hydrogen":[302],"bonds":[303],"they":[304],"elicit":[305],"macromolecules":[307]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}