{"id":"https://openalex.org/W1990212010","doi":"https://doi.org/10.1074/jbc.m110.134262","title":"Tyrosines in the Carboxyl Terminus Regulate Syk Kinase Activity and Function","display_name":"Tyrosines in the Carboxyl Terminus Regulate Syk Kinase Activity and Function","publication_year":2010,"publication_date":"2010-06-17","ids":{"openalex":"https://openalex.org/W1990212010","doi":"https://doi.org/10.1074/jbc.m110.134262","mag":"1990212010","pmid":"https://pubmed.ncbi.nlm.nih.gov/20554527","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2924109"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m110.134262","doi":"https://doi.org/10.1074/jbc.m110.134262","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.134262","pdf_url":"http://www.jbc.org/article/S0021925820596294/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820596294/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103218173","display_name":"Rodrigo Orlandini de Castro","orcid":"https://orcid.org/0000-0001-6146-3760","observed_orcids":["https://orcid.org/0000-0001-6146-3760"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Rodrigo O. de Castro","raw_affiliation_strings":["Receptors and Signal Transduction Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA","Department of Cell and Molecular Biology and Pathogenic Bioagents, Faculdade de Medicina de Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeirao Preto, S\u00e3o Paulo 14049-900, Brazil","Receptors and Signal Transduction Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptors and Signal Transduction Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]},{"raw_affiliation_string":"Department of Cell and Molecular Biology and Pathogenic Bioagents, Faculdade de Medicina de Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeirao Preto, S\u00e3o Paulo 14049-900, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Receptors and Signal Transduction Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100390010","display_name":"Juan Zhang","orcid":"https://orcid.org/0000-0001-6241-7176","observed_orcids":["https://orcid.org/0000-0001-6241-7176"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Zhang","raw_affiliation_strings":["Receptors and Signal Transduction Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptors and Signal Transduction Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019294126","display_name":"Maria C\u00e9lia Jamur","orcid":"https://orcid.org/0000-0001-7065-8543","observed_orcids":["https://orcid.org/0000-0001-7065-8543"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria C. Jamur","raw_affiliation_strings":["Department of Cell and Molecular Biology and Pathogenic Bioagents, Faculdade de Medicina de Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeirao Preto, S\u00e3o Paulo 14049-900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology and Pathogenic Bioagents, Faculdade de Medicina de Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeirao Preto, S\u00e3o Paulo 14049-900, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066964916","display_name":"Constance Oliver","orcid":"https://orcid.org/0000-0002-8633-4612","observed_orcids":["https://orcid.org/0000-0002-8633-4612"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Constance Oliver","raw_affiliation_strings":["Department of Cell and Molecular Biology and Pathogenic Bioagents, Faculdade de Medicina de Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeirao Preto, S\u00e3o Paulo 14049-900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology and Pathogenic Bioagents, Faculdade de Medicina de Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeirao Preto, S\u00e3o Paulo 14049-900, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108352806","display_name":"Reuben P. Siraganian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Reuben P. Siraganian","raw_affiliation_strings":["Receptors and Signal Transduction Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptors and Signal Transduction Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108352806"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.7857,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.83709416,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"285","issue":"34","first_page":"26674","last_page":"26684"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.6255000233650208,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.6255000233650208,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.08860000222921371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.07670000195503235,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/syk","display_name":"Syk","score":0.9409999847412109},{"id":"https://openalex.org/keywords/itam-signaling","display_name":"ITAM signaling","score":0.8029999732971191},{"id":"https://openalex.org/keywords/fcepsilonri","display_name":"Fc\u03b5RI","score":0.8479999899864197},{"id":"https://openalex.org/keywords/mast-cell-degranulation","display_name":"mast cell degranulation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/autophosphorylation","display_name":"autophosphorylation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/kinase-activation","display_name":"kinase activation","score":0.6430000066757202},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/mapk-phosphorylation","display_name":"MAPK phosphorylation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/zap-70","display_name":"ZAP-70","score":0.8700000047683716},{"id":"https://openalex.org/keywords/immunoreceptor-signaling","display_name":"immunoreceptor signaling","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C35174551","wikidata":"https://www.wikidata.org/wiki/Q7660502","display_name":"Syk","level":4,"score":0.9911855459213257},{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.8966283798217773},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6945250630378723},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.6211385726928711},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5681731700897217},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.560196042060852},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5202478170394897},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.48394113779067993},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47108137607574463},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43796294927597046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3735042214393616},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3631824851036072},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3449748754501343}],"mesh":[{"descriptor_ui":"D000072377","descriptor_name":"Syk Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1074/jbc.m110.134262","doi":"https://doi.org/10.1074/jbc.m110.134262","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.134262","pdf_url":"http://www.jbc.org/article/S0021925820596294/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2163485","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2924109","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2924109","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2924109","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:20554527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20554527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:www.producao.usp.br:BDPI/23811","doi":null,"is_oa":false,"landing_page_url":"http://producao.usp.br/handle/BDPI/23811","pdf_url":null,"source":{"id":"https://openalex.org/S4306401373","display_name":"Scientific Electronic Library Online (S\u00e3o Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2982035970","host_organization_name":"Costa Rican Department of Social Security","host_organization_lineage":["https://openalex.org/I2982035970"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m110.134262","doi":"https://doi.org/10.1074/jbc.m110.134262","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.134262","pdf_url":"http://www.jbc.org/article/S0021925820596294/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990212010.pdf","grobid_xml":"https://content.openalex.org/works/W1990212010.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W106796798","https://openalex.org/W136542906","https://openalex.org/W1484096248","https://openalex.org/W1519260014","https://openalex.org/W1576212058","https://openalex.org/W1583957430","https://openalex.org/W1594086146","https://openalex.org/W1621875089","https://openalex.org/W1787674222","https://openalex.org/W1817073110","https://openalex.org/W1871691509","https://openalex.org/W1886292263","https://openalex.org/W1967758178","https://openalex.org/W1972869861","https://openalex.org/W1974555059","https://openalex.org/W1977128317","https://openalex.org/W1980388991","https://openalex.org/W1988222207","https://openalex.org/W1997634231","https://openalex.org/W2001669425","https://openalex.org/W2005857763","https://openalex.org/W2013050167","https://openalex.org/W2015082452","https://openalex.org/W2015791855","https://openalex.org/W2017025637","https://openalex.org/W2019064446","https://openalex.org/W2022772131","https://openalex.org/W2024939178","https://openalex.org/W2032056136","https://openalex.org/W2032391169","https://openalex.org/W2040691054","https://openalex.org/W2041055214","https://openalex.org/W2052561585","https://openalex.org/W2053340262","https://openalex.org/W2053972865","https://openalex.org/W2061851471","https://openalex.org/W2067884008","https://openalex.org/W2069028742","https://openalex.org/W2074436812","https://openalex.org/W2077206820","https://openalex.org/W2081170890","https://openalex.org/W2089783130","https://openalex.org/W2090863009","https://openalex.org/W2095152292","https://openalex.org/W2096160200","https://openalex.org/W2099519675","https://openalex.org/W2101304953","https://openalex.org/W2103450164","https://openalex.org/W2105342114","https://openalex.org/W2108173194","https://openalex.org/W2119778247","https://openalex.org/W2129941617","https://openalex.org/W2140887407","https://openalex.org/W2141297227","https://openalex.org/W2147576834","https://openalex.org/W2152450698","https://openalex.org/W2156802525","https://openalex.org/W2157307070","https://openalex.org/W2157383269","https://openalex.org/W2158093352","https://openalex.org/W2164829133","https://openalex.org/W2166126152","https://openalex.org/W2168181266","https://openalex.org/W2168746872","https://openalex.org/W2399303500"],"related_works":["https://openalex.org/W135919367","https://openalex.org/W1817073110","https://openalex.org/W2065702591","https://openalex.org/W1974934658","https://openalex.org/W2005857763","https://openalex.org/W1886292263","https://openalex.org/W7096414251","https://openalex.org/W2030884423","https://openalex.org/W2081170890","https://openalex.org/W2067674272"],"abstract_inverted_index":{"The":[0,16],"Syk":[1,19,79,110,127,146,157,188,213,235],"tyrosine":[2,130,228],"kinase":[3,164,179,201,273],"family":[4],"plays":[5],"an":[6,38,167,217],"essential":[7],"role":[8,70,251,269],"in":[9,33,74,89,199,208,252,262,270],"immunoreceptor":[10],"tyrosine-based":[11],"activation":[12,103,106],"motif":[13],"(ITAM)":[14],"signaling.":[15],"binding":[17,143],"of":[18,24,40,43,52,64,71,115,136,144,185,205,212,241,277],"to":[20,85,147,151,216,220],"tyrosine-phosphorylated":[21],"ITAM":[22,149],"subunits":[23],"immunoreceptors,":[25],"such":[26],"as":[27,133],"FcepsilonRI":[28],"on":[29,226],"mast":[30,91],"cells,":[31,124],"results":[32,257],"a":[34,134,267],"conformational":[35,46],"change,":[36],"with":[37,80,107,112],"increase":[39],"enzymatic":[41],"activity":[42,165,180,274],"Syk.":[44,278],"This":[45,155],"change":[47],"exposes":[48],"the":[49,69,108,125,178,182,193,198,209,242,249,263,272],"COOH-terminal":[50,210],"tail":[51,264],"Syk,":[53],"which":[54,224],"has":[55],"three":[56,82],"conserved":[57],"Tyr":[58,83],"residues":[59,73],"(Tyr-623,":[60],"Tyr-624,":[61],"and":[62,77,104,119,181,275],"Tyr-625":[63,247],"rat":[65],"Syk).":[66],"To":[67],"understand":[68],"these":[72,81,206,253,256,260],"signaling,":[75],"wild-type":[76],"mutant":[78],"mutated":[84,109,126,145,156,187,236],"Phe":[86],"was":[87,94,128,141,174,195],"expressed":[88],"Syk-deficient":[90],"cells.":[92],"There":[93],"decreased":[95,191],"FcepsilonRI-induced":[96],"degranulation,":[97],"nuclear":[98],"factor":[99],"for":[100,230],"T":[101],"cell":[102],"NFkappaB":[105],"together":[111],"reduced":[113,142,163],"phosphorylation":[114],"MAP":[116],"kinases":[117,229],"p38":[118],"p42/44":[120],"ERK.":[121],"In":[122,138,233],"non-stimulated":[123,159],"more":[129],"phosphorylated":[131,148],"predominantly":[132],"result":[135],"autophosphorylation.":[137],"vitro,":[139],"there":[140],"due":[150],"this":[152,186],"increased":[153],"phosphorylation.":[154],"from":[158],"cells":[160],"had":[161,248],"significantly":[162],"toward":[166],"exogenous":[168],"substrate,":[169],"whereas":[170],"its":[171,221],"autophosphorylation":[172,183],"capacity":[173,184],"not":[175],"affected.":[176],"However,":[177],"were":[189],"dramatically":[190],"when":[192],"protein":[194],"dephosphorylated":[196],"before":[197],"vitro":[200],"reaction.":[202],"Furthermore,":[203],"mutation":[204],"tyrosines":[207,261],"region":[211,265],"transforms":[214],"it":[215],"enzyme,":[218],"similar":[219],"homolog":[222],"ZAP-70,":[223],"depends":[225],"other":[227],"optimal":[231],"activation.":[232],"testing":[234],"singly":[237],"at":[238],"each":[239],"one":[240],"tyrosines,":[243],"Tyr-624":[244],"but":[245],"especially":[246],"major":[250],"reactions.":[254],"Therefore,":[255],"indicate":[258],"that":[259],"play":[266],"critical":[268],"regulating":[271],"function":[276]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
