{"id":"https://openalex.org/W1990207675","doi":"https://doi.org/10.1002/ijc.2910470325","title":"Differential role of transforming growth factor\u2010\u03b1 in two human colon\u2010carcinoma cell lines","display_name":"Differential role of transforming growth factor\u2010\u03b1 in two human colon\u2010carcinoma cell lines","publication_year":1991,"publication_date":"1991-02-01","ids":{"openalex":"https://openalex.org/W1990207675","doi":"https://doi.org/10.1002/ijc.2910470325","mag":"1990207675","pmid":"https://pubmed.ncbi.nlm.nih.gov/1993555"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.2910470325","doi":"https://doi.org/10.1002/ijc.2910470325","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910470325","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111609445","display_name":"Linda F. Watkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda F. Watkins","raw_affiliation_strings":["Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030","Department of Pharmacology, Baylor College of Medicine, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Pharmacology, Baylor College of Medicine, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044801311","display_name":"Alan E. Levine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan E. Levine","raw_affiliation_strings":["Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044801311"],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":2.6344,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.90767499,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":"3","first_page":"455","last_page":"460"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transforming-growth-factor-alpha","display_name":"transforming growth factor-alpha","score":0.9900000095367432},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.8050000071525574},{"id":"https://openalex.org/keywords/autocrine-growth","display_name":"autocrine growth","score":0.4690000116825104},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.8019999861717224},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.6830000281333923},{"id":"https://openalex.org/keywords/antibody-mediated-growth-inhibition","display_name":"antibody-mediated growth inhibition","score":0.42399999499320984},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.8722933530807495},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.7333780527114868},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.7143762707710266},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.695587694644928},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6145968437194824},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5708264708518982},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5633012652397156},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5092116594314575},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.49849581718444824},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.49266988039016724},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48414191603660583},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45873844623565674},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4163265824317932},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.41507527232170105},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3755109906196594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3518655002117157},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34878939390182495},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2148534059524536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12103623151779175},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10617786645889282},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.2910470325","doi":"https://doi.org/10.1002/ijc.2910470325","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910470325","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:1993555","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1993555","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5919670368","display_name":"AUTOCRINE ROLE OF TRANSFORMING GROWTH FACTOR","funder_award_id":"R01CA049127","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W126219881","https://openalex.org/W1494997792","https://openalex.org/W1538064596","https://openalex.org/W1553513611","https://openalex.org/W1555502876","https://openalex.org/W1568217878","https://openalex.org/W1585975755","https://openalex.org/W1865083834","https://openalex.org/W1970852573","https://openalex.org/W1972167965","https://openalex.org/W1998329643","https://openalex.org/W2010178768","https://openalex.org/W2043179867","https://openalex.org/W2043813981","https://openalex.org/W2045453475","https://openalex.org/W2046756969","https://openalex.org/W2054012934","https://openalex.org/W2059810045","https://openalex.org/W2060485107","https://openalex.org/W2070617849","https://openalex.org/W2092087857","https://openalex.org/W2093582829","https://openalex.org/W2100048123","https://openalex.org/W2137115652","https://openalex.org/W2144910592","https://openalex.org/W2165534710","https://openalex.org/W2169434055"],"related_works":["https://openalex.org/W2163185599","https://openalex.org/W1514367239","https://openalex.org/W2070617849","https://openalex.org/W2072690765","https://openalex.org/W2440589633","https://openalex.org/W1990445373","https://openalex.org/W2104036338","https://openalex.org/W2100048123","https://openalex.org/W2144910592","https://openalex.org/W2011105692"],"abstract_inverted_index":{"Antibodies":[0],"to":[1,12,78,109,114,119],"epidermal-growth-factor":[2],"receptor":[3,70,98],"(EGF)":[4],"and":[5,31,42,81,99],"transforming":[6],"growth":[7,21,128,162],"factor-alpha":[8],"(TGF-alpha)":[9],"were":[10,117],"used":[11],"determine":[13],"the":[14,20,29,53,58,65,74,79,88,96,103,115,120,136,146,150,161],"role":[15,159],"of":[16,22,40,46,76,87,112,163],"endogenous":[17],"TGF-alpha":[18,41,113,141,147],"in":[19,106,142,160],"2":[23],"human":[24],"colon-carcinoma":[25,34],"cell":[26,35,84,90,123,138],"lines.":[27,85],"Both":[28],"GEO":[30,66,80,89,137],"HCT":[32,54,82,121,151],"116":[33,55,83,122,152],"lines":[36],"secrete":[37],"similar":[38,44],"levels":[39],"have":[43],"numbers":[45],"low-affinity":[47],"binding":[48,61,75,111],"sites":[49],"for":[50],"EGF.":[51],"However,":[52],"cells":[56,153],"lack":[57],"high-affinity":[59],"EGF":[60],"site":[62],"present":[63],"on":[64,127],"cells.":[67,165],"The":[68],"anti-EGF":[69,97],"antibodies":[71],"effectively":[72],"blocked":[73],"125I-EGF":[77],"Growth":[86],"line":[91,139],"was":[92,129],"inhibited":[93],"50-80%":[94],"by":[95,149],"anti-TGF-alpha":[100],"antibodies.":[101],"When":[102],"same":[104],"antibodies,":[105],"sufficient":[107],"amounts":[108],"block":[110],"cells,":[116],"added":[118],"line,":[124],"no":[125],"effect":[126],"seen.":[130],"These":[131],"results":[132],"suggest":[133],"that":[134],"while":[135],"utilizes":[140],"an":[143],"autocrine":[144],"manner,":[145],"secreted":[148],"apparently":[154],"does":[155],"not":[156],"play":[157],"a":[158],"these":[164]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}