{"id":"https://openalex.org/W1990205652","doi":"https://doi.org/10.1016/s0021-5198(19)52541-0","title":"THE ROLE OF NORADRENERGIC AND SEROTONERGIC SYSTEMS IN THE HIPPOCAMPAL KINDLING EFFECT","display_name":"THE ROLE OF NORADRENERGIC AND SEROTONERGIC SYSTEMS IN THE HIPPOCAMPAL KINDLING EFFECT","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W1990205652","doi":"https://doi.org/10.1016/s0021-5198(19)52541-0","mag":"1990205652","pmid":"https://pubmed.ncbi.nlm.nih.gov/6876524"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-5198(19)52541-0","doi":"https://doi.org/10.1016/s0021-5198(19)52541-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-5198(19)52541-0","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1016/s0021-5198(19)52541-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112659639","display_name":"Hiroaki Araki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki ARAKI","raw_affiliation_strings":["Department of Pharmacology, Research Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama 330, Japan","Department of Pharmacology, Research Laboratories, Taisho Pharmaceutical Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Research Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama 330, Japan","institution_ids":["https://openalex.org/I144245601"]},{"raw_affiliation_string":"Department of Pharmacology, Research Laboratories, Taisho Pharmaceutical Co., Ltd","institution_ids":["https://openalex.org/I144245601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111532471","display_name":"Hironaka Aihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hironaka AIHARA","raw_affiliation_strings":["Department of Pharmacology, Research Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama 330, Japan","Department of Pharmacology, Research Laboratories, Taisho Pharmaceutical Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Research Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama 330, Japan","institution_ids":["https://openalex.org/I144245601"]},{"raw_affiliation_string":"Department of Pharmacology, Research Laboratories, Taisho Pharmaceutical Co., Ltd","institution_ids":["https://openalex.org/I144245601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103495213","display_name":"Shigenori Watanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigenori WATANABE","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka 812, Japan","Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062700753","display_name":"Hisashi Ohta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisashi OHTA","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka 812, Japan","Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103284548","display_name":"Tsuneyuki Yamamoto","orcid":"https://orcid.org/0000-0001-5365-5842","observed_orcids":["https://orcid.org/0000-0001-5365-5842"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuneyuki YAMAMOTO","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka 812, Japan","Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110192300","display_name":"Showa Ueki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Showa UEKI","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka 812, Japan","Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1204,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.90862783,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"33","issue":"1","first_page":"57","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hippocampal-kindling","display_name":"hippocampal kindling","score":0.949999988079071},{"id":"https://openalex.org/keywords/amygdala-kindling","display_name":"amygdala kindling","score":0.9879999756813049},{"id":"https://openalex.org/keywords/noradrenergic-system","display_name":"noradrenergic system","score":0.953000009059906},{"id":"https://openalex.org/keywords/serotonergic-system","display_name":"serotonergic system","score":0.9729999899864197},{"id":"https://openalex.org/keywords/norepinephrine-depletion","display_name":"norepinephrine depletion","score":0.6850000023841858},{"id":"https://openalex.org/keywords/seizure-generation","display_name":"seizure generation","score":0.4580000042915344},{"id":"https://openalex.org/keywords/convulsions","display_name":"convulsions","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C100691959","wikidata":"https://www.wikidata.org/wiki/Q6410625","display_name":"Kindling","level":3,"score":0.872116208076477},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.8266427516937256},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.7653694152832031},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6425971984863281},{"id":"https://openalex.org/C32610206","wikidata":"https://www.wikidata.org/wiki/Q5298804","display_name":"Dorsal raphe nucleus","level":5,"score":0.5345029234886169},{"id":"https://openalex.org/C2777615928","wikidata":"https://www.wikidata.org/wiki/Q26261774","display_name":"Raphe","level":5,"score":0.5060564875602722},{"id":"https://openalex.org/C2777865548","wikidata":"https://www.wikidata.org/wiki/Q2061493","display_name":"Raphe nuclei","level":5,"score":0.47656014561653137},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3799232840538025},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3496231436729431},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.2569197416305542},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25140100717544556},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18936660885810852},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.17425119876861572},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.046286702156066895}],"mesh":[{"descriptor_ui":"D000679","descriptor_name":"Amygdala","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007696","descriptor_name":"Kindling, Neurologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0021-5198(19)52541-0","doi":"https://doi.org/10.1016/s0021-5198(19)52541-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-5198(19)52541-0","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},{"id":"doi:10.1254/jjp.33.57","doi":"https://doi.org/10.1254/jjp.33.57","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jjp.33.57","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Japanese Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:6876524","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6876524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-5198(19)52541-0","doi":"https://doi.org/10.1016/s0021-5198(19)52541-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-5198(19)52541-0","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W57541883","https://openalex.org/W1498891976","https://openalex.org/W1966977187","https://openalex.org/W1968050456","https://openalex.org/W1969063676","https://openalex.org/W1970569351","https://openalex.org/W1975966847","https://openalex.org/W1987349053","https://openalex.org/W1998049300","https://openalex.org/W2018865339","https://openalex.org/W2019884656","https://openalex.org/W2024227780","https://openalex.org/W2037917157","https://openalex.org/W2046508400","https://openalex.org/W2052573649","https://openalex.org/W2059205656","https://openalex.org/W2059626613","https://openalex.org/W2064765037","https://openalex.org/W2066856808","https://openalex.org/W2068019023","https://openalex.org/W2072281981","https://openalex.org/W2082317157","https://openalex.org/W2082724832","https://openalex.org/W2096722650","https://openalex.org/W2167324562","https://openalex.org/W2330221404","https://openalex.org/W2409568686","https://openalex.org/W2500684935"],"related_works":["https://openalex.org/W1966702494","https://openalex.org/W2049215227","https://openalex.org/W2084907450","https://openalex.org/W2088313708","https://openalex.org/W3101044260","https://openalex.org/W2059205656","https://openalex.org/W7197190634","https://openalex.org/W7197102803","https://openalex.org/W2004849989","https://openalex.org/W1966977187"],"abstract_inverted_index":{"The":[0,32],"role":[1,92],"of":[2,12,27,42,74,96],"the":[3,6,10,25,39,72,84,94,97,101],"noradrenergic":[4],"and":[5,14,29,61,77,100,106],"serotonergic":[7],"systems":[8],"in":[9,38,93,104],"development":[11,95],"hippocampal":[13,28,76,105],"amygdaloid":[15,30,78,107],"kindling":[16],"was":[17,36],"studied.":[18],"Dorsal":[19],"noradrenaline":[20,45,53,86],"bundle":[21,54,87],"lesions":[22,65],"markedly":[23],"facilitated":[24],"formation":[26,73],"kindling.":[31,43,79,108],"most":[33],"significant":[34],"facilitation":[35],"observed":[37],"earliest":[40],"phase":[41],"Cortical":[44],"content":[46],"decreased":[47],"by":[48],"about":[49],"70%":[50],"after":[51],"dorsal":[52,60,85],"lesions.":[55],"Midbrain":[56],"raphe":[57,63],"nuclei":[58],"(both":[59],"medial":[62],"nuclei)":[64],"did":[66],"not":[67],"have":[68],"any":[69],"effect":[70],"on":[71],"both":[75],"These":[80],"results":[81],"indicate":[82],"that":[83],"system":[88],"plays":[89],"an":[90],"inhibitory":[91],"seizure":[98],"discharges":[99],"behavioral":[102],"convulsions":[103]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}