{"id":"https://openalex.org/W1990201357","doi":"https://doi.org/10.1097/mao.0000000000000251","title":"Ototoxicity of Gentian Violet on the Guinea Pig Cochlea","display_name":"Ototoxicity of Gentian Violet on the Guinea Pig Cochlea","publication_year":2014,"publication_date":"2014-03-11","ids":{"openalex":"https://openalex.org/W1990201357","doi":"https://doi.org/10.1097/mao.0000000000000251","mag":"1990201357","pmid":"https://pubmed.ncbi.nlm.nih.gov/24622028"},"language":"en","primary_location":{"id":"doi:10.1097/mao.0000000000000251","doi":"https://doi.org/10.1097/mao.0000000000000251","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mao.0000000000000251","pdf_url":null,"source":{"id":"https://openalex.org/S19176856","display_name":"Otology & Neurotology","issn_l":"1531-7129","issn":["1531-7129","1537-4505"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otology &amp; Neurotology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111971909","display_name":"Hitomi Higuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]},{"id":"https://openalex.org/I4210092114","display_name":"Fukuoka University Hospital","ror":"https://ror.org/00d3mr981","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210092114"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hitomi Higuchi","raw_affiliation_strings":["*Department of Otolaryngology, School of Medicine, Fukuoka University; \u2020Department of Pharmacy, and \u2021Department of Clinical Laboratory, Fukuoka University Hospital; and \u00a7Department of Otolaryngology, Nishi Fukuoka Hospital, Fukuoka, Japan","Fukuoka University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Otolaryngology, School of Medicine, Fukuoka University; \u2020Department of Pharmacy, and \u2021Department of Clinical Laboratory, Fukuoka University Hospital; and \u00a7Department of Otolaryngology, Nishi Fukuoka Hospital, Fukuoka, Japan","institution_ids":["https://openalex.org/I31784960","https://openalex.org/I4210092114"]},{"raw_affiliation_string":"Fukuoka University","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058620579","display_name":"Takafumi Yamano","orcid":"https://orcid.org/0000-0002-3929-9359","observed_orcids":["https://orcid.org/0000-0002-3929-9359"]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takafumi Yamano","raw_affiliation_strings":["Department of Otolaryngology, School of Medicine, Fukuoka University","Fukuoka University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, School of Medicine, Fukuoka University","institution_ids":["https://openalex.org/I31784960"]},{"raw_affiliation_string":"Fukuoka University","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025282879","display_name":"Hisamitsu Takase","orcid":"https://orcid.org/0009-0009-4232-6803","observed_orcids":["https://orcid.org/0009-0009-4232-6803"]},"institutions":[{"id":"https://openalex.org/I4210092114","display_name":"Fukuoka University Hospital","ror":"https://ror.org/00d3mr981","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210092114"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisamitsu Takase","raw_affiliation_strings":["Department of Pharmacy, and \u2021Department of Clinical Laboratory, Fukuoka University Hospital","Department of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, and \u2021Department of Clinical Laboratory, Fukuoka University Hospital","institution_ids":["https://openalex.org/I4210092114"]},{"raw_affiliation_string":"Department of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000010510","display_name":"Hisae Yoshimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisae Yoshimura","raw_affiliation_strings":["Fukuoka University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fukuoka University","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101450929","display_name":"Takashi Nakagawa","orcid":"https://orcid.org/0000-0002-3198-639X","observed_orcids":["https://orcid.org/0000-0002-3198-639X"]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takashi Nakagawa","raw_affiliation_strings":["Department of Otolaryngology, School of Medicine, Fukuoka University","Fukuoka University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, School of Medicine, Fukuoka University","institution_ids":["https://openalex.org/I31784960"]},{"raw_affiliation_string":"Fukuoka University","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112164175","display_name":"Tetsuo Morizono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096923","display_name":"Fukuoka Hospital","ror":"https://ror.org/00vv7qz60","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210096923","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuo Morizono","raw_affiliation_strings":["Department of Otolaryngology, Nishi Fukuoka Hospital, Fukuoka, Japan","Nishifukuoka Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Nishi Fukuoka Hospital, Fukuoka, Japan","institution_ids":["https://openalex.org/I4210096923"]},{"raw_affiliation_string":"Nishifukuoka Hospital","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5058620579","https://openalex.org/A5101450929","https://openalex.org/A5111971909"],"corresponding_institution_ids":["https://openalex.org/I31784960","https://openalex.org/I4210092114"],"apc_list":null,"apc_paid":null,"fwci":0.3696,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.54222792,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"35","issue":"4","first_page":"743","last_page":"747"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10861","display_name":"Ear Surgery and Otitis Media","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crystal-violet","display_name":"crystal violet","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ototoxicity","display_name":"ototoxicity","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cochlea","display_name":"cochlea","score":0.6420000195503235},{"id":"https://openalex.org/keywords/middle-ear","display_name":"middle ear","score":0.7179999947547913},{"id":"https://openalex.org/keywords/compound-action-potential","display_name":"compound action potential","score":0.6809999942779541},{"id":"https://openalex.org/keywords/auditory-nerve","display_name":"auditory nerve","score":0.847000002861023},{"id":"https://openalex.org/keywords/temporal-bone-histopathology","display_name":"temporal bone histopathology","score":0.8169999718666077},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.6620000004768372},{"id":"https://openalex.org/keywords/antifungal-activity","display_name":"antifungal activity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.871999979019165},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7785916328430176},{"id":"https://openalex.org/C2778534666","wikidata":"https://www.wikidata.org/wiki/Q1351381","display_name":"Ototoxicity","level":4,"score":0.6648614406585693},{"id":"https://openalex.org/C2777846895","wikidata":"https://www.wikidata.org/wiki/Q501553","display_name":"Middle ear","level":2,"score":0.5643437504768372},{"id":"https://openalex.org/C2779812621","wikidata":"https://www.wikidata.org/wiki/Q258328","display_name":"Ear canal","level":2,"score":0.5533341765403748},{"id":"https://openalex.org/C2780130748","wikidata":"https://www.wikidata.org/wiki/Q317857","display_name":"Cochlea","level":2,"score":0.4900745153427124},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.42224428057670593},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.262726366519928},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1972523033618927},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.0},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000160","descriptor_name":"Vestibulocochlear Nerve Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000160","descriptor_name":"Vestibulocochlear Nerve Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000161","descriptor_name":"Acoustic Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D001309","descriptor_name":"Auditory Threshold","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005072","descriptor_name":"Evoked Potentials, Auditory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005840","descriptor_name":"Gentian Violet","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005840","descriptor_name":"Gentian Violet","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013701","descriptor_name":"Temporal Bone","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015169","descriptor_name":"Colony Count, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015834","descriptor_name":"Cochlear Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D015834","descriptor_name":"Cochlear Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/mao.0000000000000251","doi":"https://doi.org/10.1097/mao.0000000000000251","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mao.0000000000000251","pdf_url":null,"source":{"id":"https://openalex.org/S19176856","display_name":"Otology & Neurotology","issn_l":"1531-7129","issn":["1531-7129","1537-4505"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otology &amp; Neurotology","raw_type":"journal-article"},{"id":"pmid:24622028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24622028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W98299236","https://openalex.org/W182412409","https://openalex.org/W1966901877","https://openalex.org/W1993790933","https://openalex.org/W2003454297","https://openalex.org/W2017043624","https://openalex.org/W2034748829","https://openalex.org/W2058192280","https://openalex.org/W2061858795","https://openalex.org/W2062644444","https://openalex.org/W2086776599","https://openalex.org/W2091483266","https://openalex.org/W2091769739","https://openalex.org/W2171503588","https://openalex.org/W2200702576","https://openalex.org/W2415891654"],"related_works":["https://openalex.org/W2164352821","https://openalex.org/W2052157152","https://openalex.org/W2062644444","https://openalex.org/W2799028160","https://openalex.org/W2355938842","https://openalex.org/W2041121535","https://openalex.org/W2356652933","https://openalex.org/W2562569039","https://openalex.org/W2204718008","https://openalex.org/W2099193400"],"abstract_inverted_index":{"PURPOSE:":[0],"Gentian":[1],"violet":[2],"(GV)":[3],"is":[4,27,256],"an":[5,235],"antimicrobial":[6],"and":[7,78,86,89,93,116,154,176,200,220,241,244],"antifungal":[8,221],"agent":[9],"that":[10],"has":[11,217],"been":[12],"used":[13],"widely":[14],"to":[15,28,228],"treat":[16],"intractable":[17],"discharge":[18],"in":[19,37,54,58,141,169,188,238,251],"the":[20,32,38,55,68,101,142,170,189,209,229,246,252],"ear.":[21,40],"The":[22,63,121],"purpose":[23],"of":[24,35,67,84,124,157,198,211,248],"this":[25,249],"report":[26],"warn":[29],"clinicians":[30],"about":[31],"ototoxic":[33,236],"effect":[34,237],"GV":[36,44,73,125,135,164,196,216,233],"middle":[39,64,190,253],"MATERIALS":[41],"AND":[42],"METHODS:":[43],"ototoxicity":[45],"was":[46,126,186],"evaluated":[47,127],"by":[48],"measuring":[49],"compound":[50],"action":[51],"potentials":[52],"(CAPs)":[53],"VIIIth":[56],"nerve":[57],"adult":[59],"Hartley":[60],"guinea":[61],"pigs.":[62],"ear":[65,191,231,254],"cavities":[66],"animals":[69],"were":[70,80,99,104,111,202],"filled":[71],"with":[72,208],"solution":[74,136,165],"(0.5%":[75],"or":[76],"0.13%),":[77],"CAPs":[79],"measured":[81],"after":[82],"intervals":[83],"5":[85],"30":[87,146],"minutes":[88],"1,":[90],"2,":[91],"6,":[92],"24":[94,160],"hours.":[95,161,181],"After":[96],"all":[97,205],"measurements":[98],"completed,":[100],"temporal":[102],"bones":[103],"harvested":[105],"for":[106],"histopathologic":[107],"evaluation.":[108],"Celloidin-embedded":[109],"specimens":[110],"cut":[112],"into":[113],"20-\u03bcm":[114],"slices":[115],"examined":[117],"using":[118,128],"light":[119],"microscopy.":[120],"bacteriostatic":[122],"activity":[123],"a":[129,138,148,239],"disk-diffusion":[130],"assay.":[131],"RESULTS:":[132],"A":[133,162],"0.5%":[134],"produced":[137],"mild":[139,167],"elevation":[140,168,178],"CAP":[143,158,171],"threshold":[144,172],"at":[145,151,159,173,179,193],"minutes,":[147],"greater":[149],"reduction":[150],"1":[152],"hour,":[153],"complete":[155],"abolishment":[156],"0.13%":[163,199],"caused":[166],"2":[174],"hours":[175],"severe":[177],"6":[180,194],"Massive":[182],"new":[183],"bone":[184],"formation":[185],"found":[187],"cavity":[192,255],"weeks.":[195],"concentrations":[197],"0.06%":[201],"effective":[203],"against":[204],"bacteria":[206],"tested,":[207],"exception":[210],"Pseudomonas":[212],"aeruginosa.":[213],"CONCLUSIONS:":[214],"Although":[215],"marked":[218],"antibacterial":[219],"activities,":[222],"its":[223],"use":[224,247],"should":[225],"be":[226],"limited":[227],"external":[230],"canal.":[232],"exerts":[234],"concentration-":[240],"time-dependent":[242],"manner,":[243],"so":[245],"drug":[250],"not":[257],"recommended.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
