{"id":"https://openalex.org/W1990187192","doi":"https://doi.org/10.1007/s002280050100","title":"Stereoselective pharmacokinetics of mefloquine in young children","display_name":"Stereoselective pharmacokinetics of mefloquine in young children","publication_year":1996,"publication_date":"1996-05-14","ids":{"openalex":"https://openalex.org/W1990187192","doi":"https://doi.org/10.1007/s002280050100","mag":"1990187192","pmid":"https://pubmed.ncbi.nlm.nih.gov/8737767"},"language":"en","primary_location":{"id":"doi:10.1007/s002280050100","doi":"https://doi.org/10.1007/s002280050100","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s002280050100","pdf_url":null,"source":{"id":"https://openalex.org/S31780008","display_name":"European Journal of Clinical Pharmacology","issn_l":"0031-6970","issn":["0031-6970","1432-1041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024659165","display_name":"A. Bourahla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A. Bourahla","raw_affiliation_strings":["H\u00f4pital Pitie Salpetriere Service Pharmacie 47, Paris, France","H\u00f4pital Pitie Salpetriere Service Pharmacie 47, boulevard de l\u2032h\u00f4pital F-75651 Paris Cedex 13, France, , FR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Pitie Salpetriere Service Pharmacie 47, Paris, France","institution_ids":["https://openalex.org/I4210121705"]},{"raw_affiliation_string":"H\u00f4pital Pitie Salpetriere Service Pharmacie 47, boulevard de l\u2032h\u00f4pital F-75651 Paris Cedex 13, France, , FR","institution_ids":["https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062035781","display_name":"Corinne Martin\u2010Chouly","orcid":"https://orcid.org/0000-0001-7493-0612","observed_orcids":["https://orcid.org/0000-0001-7493-0612"]},"institutions":[{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Martin","raw_affiliation_strings":["H\u00f4pital Pitie Salpetriere Service Pharmacie 47, boulevard de l\u2032h\u00f4pital F-75651 Paris Cedex 13, France, , FR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Pitie Salpetriere Service Pharmacie 47, boulevard de l\u2032h\u00f4pital F-75651 Paris Cedex 13, France, , FR","institution_ids":["https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113590871","display_name":"Fran\ufffdois Gimenez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F. Gimenez","raw_affiliation_strings":["H\u00f4pital Pitie Salpetriere Service Pharmacie 47, boulevard de l\u2032h\u00f4pital F-75651 Paris Cedex 13, France, , FR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Pitie Salpetriere Service Pharmacie 47, boulevard de l\u2032h\u00f4pital F-75651 Paris Cedex 13, France, , FR","institution_ids":["https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021384306","display_name":"V. Singhasivanon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"V. Singhasivanon","raw_affiliation_strings":["Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, , TH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, , TH","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111497880","display_name":"P. Attanath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"P. Attanath","raw_affiliation_strings":["Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, , TH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, , TH","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046493870","display_name":"A. Sabchearon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"A. Sabchearon","raw_affiliation_strings":["Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, , TH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, , TH","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009005885","display_name":"Tan Chongsuphajaisiddhi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"T. Chongsuphajaisiddhi","raw_affiliation_strings":["Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, , TH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, , TH","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071030872","display_name":"Robert Farinotti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Farinotti","raw_affiliation_strings":["Facult\u00e9 de Pharmacie, Pharmacie Clinique, Chatenay Malabry, France, , FR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facult\u00e9 de Pharmacie, Pharmacie Clinique, Chatenay Malabry, France, , FR","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":null,"fwci":0.2552,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.41235309,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"50","issue":"3","first_page":"241","last_page":"244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.4490000009536743,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.4490000009536743,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.22460000216960907,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.2125999927520752,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mefloquine","display_name":"mefloquine","score":1.0},{"id":"https://openalex.org/keywords/stereoselective-pharmacokinetics","display_name":"stereoselective pharmacokinetics","score":0.9539999961853027},{"id":"https://openalex.org/keywords/enantiomers","display_name":"enantiomers","score":0.871999979019165},{"id":"https://openalex.org/keywords/falciparum-malaria","display_name":"falciparum malaria","score":0.8209999799728394},{"id":"https://openalex.org/keywords/young-children","display_name":"young children","score":0.6549999713897705},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.8019999861717224},{"id":"https://openalex.org/keywords/plasma-half-life","display_name":"plasma half-life","score":0.5460000038146973},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.9819999933242798},{"id":"https://openalex.org/keywords/clearance","display_name":"clearance","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C2777199930","wikidata":"https://www.wikidata.org/wiki/Q736270","display_name":"Mefloquine","level":4,"score":0.9709935784339905},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.9256432056427002},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.7375864386558533},{"id":"https://openalex.org/C181647583","wikidata":"https://www.wikidata.org/wiki/Q903429","display_name":"Stereoselectivity","level":3,"score":0.6809594035148621},{"id":"https://openalex.org/C139254425","wikidata":"https://www.wikidata.org/wiki/Q1332167","display_name":"Volume of distribution","level":3,"score":0.6445872187614441},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6257251501083374},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.597506046295166},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5196398496627808},{"id":"https://openalex.org/C2777035104","wikidata":"https://www.wikidata.org/wiki/Q421072","display_name":"Pyrimethamine","level":4,"score":0.5152223706245422},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.41137272119522095},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.3154459595680237},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2960769534111023},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.16429215669631958},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08696717023849487},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05576172471046448},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013785","descriptor_name":"Thailand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015767","descriptor_name":"Mefloquine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D015767","descriptor_name":"Mefloquine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s002280050100","doi":"https://doi.org/10.1007/s002280050100","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s002280050100","pdf_url":null,"source":{"id":"https://openalex.org/S31780008","display_name":"European Journal of Clinical Pharmacology","issn_l":"0031-6970","issn":["0031-6970","1432-1041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:8737767","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8737767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of clinical pharmacology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W47752255","https://openalex.org/W1967043268","https://openalex.org/W1983988243","https://openalex.org/W2000054877","https://openalex.org/W2012908210","https://openalex.org/W2020096923","https://openalex.org/W2027560783","https://openalex.org/W2051263087","https://openalex.org/W2059814420","https://openalex.org/W2088027386","https://openalex.org/W2092995729","https://openalex.org/W2327294852"],"related_works":["https://openalex.org/W1983988243","https://openalex.org/W2012908210","https://openalex.org/W2327294852","https://openalex.org/W2213699572","https://openalex.org/W2021904328","https://openalex.org/W2148235165","https://openalex.org/W2136333952","https://openalex.org/W2510756521","https://openalex.org/W7216272618","https://openalex.org/W119786142"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}