{"id":"https://openalex.org/W1990165054","doi":"https://doi.org/10.1016/s0924-9338(13)77429-7","title":"2848 \u2013 Second Generation Antipsychotic-Induced Weight Alteration","display_name":"2848 \u2013 Second Generation Antipsychotic-Induced Weight Alteration","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W1990165054","doi":"https://doi.org/10.1016/s0924-9338(13)77429-7","mag":"1990165054"},"language":"en","primary_location":{"id":"doi:10.1016/s0924-9338(13)77429-7","doi":"https://doi.org/10.1016/s0924-9338(13)77429-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0924-9338(13)77429-7","pdf_url":null,"source":{"id":"https://openalex.org/S87202501","display_name":"European Psychiatry","issn_l":"0924-9338","issn":["0924-9338","1778-3585"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113547026","display_name":"N. Ron Wan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162743","display_name":"Hospital S\u00e3o Paulo","ror":"https://ror.org/050z9fj14","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210162743"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"N. Ron Wan","raw_affiliation_strings":["S\u00e3o Luis Hospital, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S\u00e3o Luis Hospital, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210162743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009382389","display_name":"A. Silva","orcid":"https://orcid.org/0000-0002-7612-7193","observed_orcids":["https://orcid.org/0000-0002-7612-7193"]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I2800288331"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"A. Silva","raw_affiliation_strings":["Albert Einstein Hospital, S\u00e3o Paulo, Brazil","Albert Einstein#N#          Hospital, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein Hospital, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800288331"]},{"raw_affiliation_string":"Albert Einstein#N#          Hospital, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800288331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055775111","display_name":"Maria de Lourdes Rabelo Pequeno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I2800288331"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M.d.L. Pequeno","raw_affiliation_strings":["Albert Einstein Hospital, S\u00e3o Paulo, Brazil","Albert Einstein#N#          Hospital, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein Hospital, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800288331"]},{"raw_affiliation_string":"Albert Einstein#N#          Hospital, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800288331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103447046","display_name":"Javier Ropero Pel\u00e1ez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71715416","display_name":"Universidade Federal do ABC","ror":"https://ror.org/028kg9j04","country_code":"BR","type":"education","lineage":["https://openalex.org/I71715416"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"J. Ropero Pel\u00e1ez","raw_affiliation_strings":["UFABC, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UFABC, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I71715416"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. Gon\u00e7alves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I2800288331"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"J. Gon\u00e7alves","raw_affiliation_strings":["Albert Einstein Hospital, S\u00e3o Paulo, Brazil","Albert Einstein#N#          Hospital, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein Hospital, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800288331"]},{"raw_affiliation_string":"Albert Einstein#N#          Hospital, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800288331"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061101022","display_name":"S. Taniguchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Taniguchi","raw_affiliation_strings":["Basics Sciences, Albert Einstein Hospital, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basics Sciences, Albert Einstein Hospital, S\u00e3o Paulo, Brazil","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10263","display_name":"Eating Disorders and Behaviors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antipsychotic-induced-weight-gain","display_name":"antipsychotic-induced weight gain","score":0.9520000219345093},{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.9190000295639038},{"id":"https://openalex.org/keywords/olanzapine","display_name":"olanzapine","score":0.9210000038146973},{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":1.0},{"id":"https://openalex.org/keywords/risperidone","display_name":"risperidone","score":1.0},{"id":"https://openalex.org/keywords/haloperidol","display_name":"haloperidol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/typical-antipsychotics","display_name":"typical antipsychotics","score":0.7789999842643738},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.781000018119812},{"id":"https://openalex.org/keywords/psychosis","display_name":"psychosis","score":0.7680000066757202},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9049999713897705},{"id":"https://openalex.org/keywords/drug-induced-weight-gain","display_name":"drug-induced weight gain","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C2776619155","wikidata":"https://www.wikidata.org/wiki/Q201872","display_name":"Olanzapine","level":3,"score":0.9258522987365723},{"id":"https://openalex.org/C2780057945","wikidata":"https://www.wikidata.org/wiki/Q412443","display_name":"Risperidone","level":3,"score":0.8828171491622925},{"id":"https://openalex.org/C2780864610","wikidata":"https://www.wikidata.org/wiki/Q221361","display_name":"Clozapine","level":3,"score":0.8317815661430359},{"id":"https://openalex.org/C2780948584","wikidata":"https://www.wikidata.org/wiki/Q251347","display_name":"Haloperidol","level":3,"score":0.7946373224258423},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.6473023891448975},{"id":"https://openalex.org/C2776921671","wikidata":"https://www.wikidata.org/wiki/Q758295","display_name":"Atypical antipsychotic","level":4,"score":0.5271722078323364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5174939632415771},{"id":"https://openalex.org/C2780320433","wikidata":"https://www.wikidata.org/wiki/Q3403879","display_name":"Weight gain","level":3,"score":0.5144855976104736},{"id":"https://openalex.org/C2781353949","wikidata":"https://www.wikidata.org/wiki/Q3271533","display_name":"Dopamine antagonist","level":4,"score":0.5008950233459473},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.49181249737739563},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.40027835965156555},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.380287766456604},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.36068210005760193},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3441256880760193},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.28556668758392334},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.05959996581077576}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0924-9338(13)77429-7","doi":"https://doi.org/10.1016/s0924-9338(13)77429-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0924-9338(13)77429-7","pdf_url":null,"source":{"id":"https://openalex.org/S87202501","display_name":"European Psychiatry","issn_l":"0924-9338","issn":["0924-9338","1778-3585"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Psychiatry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W177521965","https://openalex.org/W1975087639","https://openalex.org/W2062250724","https://openalex.org/W2338902003","https://openalex.org/W2045659791","https://openalex.org/W2000771821","https://openalex.org/W2398003649","https://openalex.org/W2080648851","https://openalex.org/W1993842704","https://openalex.org/W2076034178"],"abstract_inverted_index":{"Introduction:":[0],"Atypical":[1],"antipsychotics":[2],"are":[3],"frequently":[4],"associated":[5],"with":[6,35,51,66,132,271],"increased":[7],"risk":[8],"of":[9,38,58,117,120,152,157,189,197,200,275],"weight":[10,109,119,159,191,266],"gain":[11],"as":[12,70,90],"side":[13],"effect.":[14],"Objective:":[15],"To":[16],"compare":[17],"body":[18,108,118,158,190,265],"weigh":[19],"alteration":[20],"in":[21,45,149,161],"psychotic":[22,52],"disorder":[23],"patients":[24,34,106,128],"undergoing":[25],"atypical":[26,67],"neuroleptics":[27,68,92],"therapy.":[28],"Methods:":[29],"This":[30],"study":[31],"included":[32],"37":[33],"mean":[36,110],"age":[37],"35,14":[39],"\u00b1":[40,101,113,122,135,140,146,165,171,177,184,204,209,214,220,232,237,242,248],"1,57":[41],"years":[42],"old,":[43],"enrolled":[44],"a":[46],"public":[47],"mental":[48],"health":[49],"service":[50],"disorders":[53],"related":[54],"to":[55,264],"the":[56,105,150,195,198],"use":[57],"illicit":[59],"drugs":[60],"and":[61,79,104,143,182,218,246,257],"schizophrenia.":[62],"Results:":[63],"Patients":[64],"treated":[65],"such":[69],"olanzapine":[71,133],"(11)":[72],"0,28":[73],"mg/kg/day,":[74,83,89],"clozapine":[75,138,181,217,245,256],"(7)":[76],"1,56":[77],"mg/kg/day":[78],"risperidone":[80,144,258],"(10)":[81],"0,031":[82],"were":[84,163,230],"evaluated.":[85],"Haloperidol":[86],"(9)":[87],"0,072":[88],"typical":[91],"was":[93,99,111,125,202],"also":[94],"studied.":[95],"Neuroleptics\u2019":[96],"treatment":[97],"period":[98,199],"126,97":[100],"20,93":[102],"days":[103],"inicial":[107],"67,63":[112],"2,13":[114],"kg.":[115],"Increase":[116,188],"1,79":[121],"0,72":[123],"kg":[124,142,148],"observed":[126],"for":[127,168,174,180,186,206,211,216,222,234,239,244,250],"receiving":[129],"haloperidol,":[130,169,207,235,254],"compared":[131],"10,37":[134],"1,74":[136],"kg,":[137],"3,6":[139],"2,10":[141],"1,21":[145],"0,90":[147,215],"end":[151,196],"evaluation":[153],"period.":[154],"These":[155,224],"increase":[156],"calculated":[160],"g/day":[162,167,173,179],"31,68":[164],"1,83":[166],"99,54":[170],"25,55":[172],"olanzapine,":[175,212,240,255],"27,44":[176],"13,35":[178],"13,11":[183],"1,40g/day":[185],"risperidone.":[187,223,251],"index":[192],"(BWI)":[193],"at":[194],"analysis":[201],"0,66":[203],"0,25":[205],"3,59":[208],"0,63":[210],"1,52":[213],"0,40":[219],"0,35":[221],"BWI":[225],"increases":[226],"identified":[227],"per":[228],"day":[229],"0,011":[231,241],"0,0038":[233],"0,034":[236],"0,0085":[238],"0,0057":[243],"0,0039":[247],"0,0055":[249],"Conclusions:":[252],"Although":[253],"act":[259,270],"blocking":[260],"serotonin":[261],"receptors":[262],"conducting":[263],"gain,":[267],"they":[268],"probably":[269],"different":[272],"intensity":[273],"degree":[274],"blockage.":[276]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}