{"id":"https://openalex.org/W1990155580","doi":"https://doi.org/10.1016/j.jasms.2005.02.005","title":"Quantitative analysis of the low molecular weight serum proteome using 18O stable isotope labeling in a lung tumor xenograft mouse model","display_name":"Quantitative analysis of the low molecular weight serum proteome using 18O stable isotope labeling in a lung tumor xenograft mouse model","publication_year":2005,"publication_date":"2005-06-25","ids":{"openalex":"https://openalex.org/W1990155580","doi":"https://doi.org/10.1016/j.jasms.2005.02.005","mag":"1990155580","pmid":"https://pubmed.ncbi.nlm.nih.gov/15979327"},"language":"en","primary_location":{"id":"doi:10.1016/j.jasms.2005.02.005","doi":"https://doi.org/10.1016/j.jasms.2005.02.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jasms.2005.02.005","pdf_url":null,"source":{"id":"https://openalex.org/S60743949","display_name":"Journal of the American Society for Mass Spectrometry","issn_l":"1044-0305","issn":["1044-0305","1879-1123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society for Mass Spectrometry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060699409","display_name":"Brian L. Hood","orcid":"https://orcid.org/0000-0002-2398-487X","observed_orcids":["https://orcid.org/0000-0002-2398-487X"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian L. Hood","raw_affiliation_strings":["Laboratory of Proteomics and Analytical Technologies, National Cancer Institute at Frederick, SAIC-Frederick, Inc., 21702, Frederick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Proteomics and Analytical Technologies, National Cancer Institute at Frederick, SAIC-Frederick, Inc., 21702, Frederick, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111743663","display_name":"David A. Lucas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Lucas","raw_affiliation_strings":["Laboratory of Proteomics and Analytical Technologies, National Cancer Institute at Frederick, SAIC-Frederick, Inc., 21702, Frederick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Proteomics and Analytical Technologies, National Cancer Institute at Frederick, SAIC-Frederick, Inc., 21702, Frederick, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100403875","display_name":"Grace E. Kim","orcid":"https://orcid.org/0000-0002-6044-483X","observed_orcids":["https://orcid.org/0000-0002-6044-483X"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace Kim","raw_affiliation_strings":["Laboratory of Proteomics and Analytical Technologies, National Cancer Institute at Frederick, SAIC-Frederick, Inc., 21702, Frederick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Proteomics and Analytical Technologies, National Cancer Institute at Frederick, SAIC-Frederick, Inc., 21702, Frederick, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030805150","display_name":"King C. Chan","orcid":"https://orcid.org/0000-0002-5355-3501","observed_orcids":["https://orcid.org/0000-0002-5355-3501"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"King C. Chan","raw_affiliation_strings":["Laboratory of Proteomics and Analytical Technologies, National Cancer Institute at Frederick, SAIC-Frederick, Inc., 21702, Frederick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Proteomics and Analytical Technologies, National Cancer Institute at Frederick, SAIC-Frederick, Inc., 21702, Frederick, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039171289","display_name":"Josip Blonder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josip Blonder","raw_affiliation_strings":["Laboratory of Proteomics and Analytical Technologies, National Cancer Institute at Frederick, SAIC-Frederick, Inc., 21702, Frederick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Proteomics and Analytical Technologies, National Cancer Institute at Frederick, SAIC-Frederick, Inc., 21702, Frederick, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111561637","display_name":"Haleem J. Issaq","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haleem J. Issaq","raw_affiliation_strings":["Laboratory of Proteomics and Analytical Technologies, National Cancer Institute at Frederick, SAIC-Frederick, Inc., 21702, Frederick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Proteomics and Analytical Technologies, National Cancer Institute at Frederick, SAIC-Frederick, Inc., 21702, Frederick, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019010663","display_name":"Timothy D. Veenstra","orcid":"https://orcid.org/0000-0003-2941-0225","observed_orcids":["https://orcid.org/0000-0003-2941-0225"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy D. Veenstra","raw_affiliation_strings":["Laboratory of Proteomics and Analytical Technologies, National Cancer Institute at Frederick, SAIC-Frederick, Inc., 21702, Frederick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Proteomics and Analytical Technologies, National Cancer Institute at Frederick, SAIC-Frederick, Inc., 21702, Frederick, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080595928","display_name":"Thomas P. Conrads","orcid":"https://orcid.org/0000-0003-4742-3281","observed_orcids":["https://orcid.org/0000-0003-4742-3281"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas P. Conrads","raw_affiliation_strings":["Laboratory of Proteomics and Analytical Technologies, National Cancer Institute at Frederick, SAIC-Frederick, Inc., 21702, Frederick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Proteomics and Analytical Technologies, National Cancer Institute at Frederick, SAIC-Frederick, Inc., 21702, Frederick, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014878691","display_name":"Ingrid L. Pollet","orcid":"https://orcid.org/0000-0001-7207-8294","observed_orcids":["https://orcid.org/0000-0001-7207-8294"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ingrid Pollet","raw_affiliation_strings":["British Columbia Cancer Research Center, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British Columbia Cancer Research Center, Vancouver, British Columbia, Canada","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083812935","display_name":"Aly Karsan","orcid":"https://orcid.org/0000-0001-6753-892X","observed_orcids":["https://orcid.org/0000-0001-6753-892X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aly Karsan","raw_affiliation_strings":["British Columbia Cancer Research Center, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British Columbia Cancer Research Center, Vancouver, British Columbia, Canada","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.2394,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.95241955,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":"8","first_page":"1221","last_page":"1230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"biomarker discovery","score":0.7170000076293945},{"id":"https://openalex.org/keywords/protein-quantification","display_name":"protein quantification","score":0.5709999799728394},{"id":"https://openalex.org/keywords/strong-cation-exchange-chromatography","display_name":"strong cation exchange chromatography","score":0.7429999709129333},{"id":"https://openalex.org/keywords/tandem-mass-spectrometry","display_name":"tandem mass spectrometry","score":0.9589999914169312},{"id":"https://openalex.org/keywords/animal-disease-models","display_name":"animal disease models","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8360059261322021},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.8169167041778564},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.7282010316848755},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6648688912391663},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.524962842464447},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4992806911468506},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.49375781416893005},{"id":"https://openalex.org/C184185385","wikidata":"https://www.wikidata.org/wiki/Q6085263","display_name":"Isobaric labeling","level":5,"score":0.4815259575843811},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47456032037734985},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.46235379576683044},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.45634493231773376},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.45479822158813477},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31191542744636536},{"id":"https://openalex.org/C202157981","wikidata":"https://www.wikidata.org/wiki/Q7251488","display_name":"Protein mass spectrometry","level":4,"score":0.17933973670005798},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1213492751121521},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010103","descriptor_name":"Oxygen Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jasms.2005.02.005","doi":"https://doi.org/10.1016/j.jasms.2005.02.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jasms.2005.02.005","pdf_url":null,"source":{"id":"https://openalex.org/S60743949","display_name":"Journal of the American Society for Mass Spectrometry","issn_l":"1044-0305","issn":["1044-0305","1879-1123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society for Mass Spectrometry","raw_type":"journal-article"},{"id":"pmid:15979327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15979327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society for Mass Spectrometry","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.cedarville.edu:pharmaceutical_sciences_publications-1423","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/432","pdf_url":null,"source":{"id":"https://openalex.org/S4377196552","display_name":"DigitalCommons-Cedarville (Cedarville University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169138485","host_organization_name":"Cedarville University","host_organization_lineage":["https://openalex.org/I169138485"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutical Sciences Faculty Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1356092923","display_name":null,"funder_award_id":"N01CO12400","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G174812244","display_name":"DCTD Computer Support","funder_award_id":"n01co12400-79-0-22","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W312568510","https://openalex.org/W1597678601","https://openalex.org/W1979283760","https://openalex.org/W1981322456","https://openalex.org/W1988812826","https://openalex.org/W2006419756","https://openalex.org/W2010715204","https://openalex.org/W2016707540","https://openalex.org/W2024141877","https://openalex.org/W2029316471","https://openalex.org/W2037483846","https://openalex.org/W2043256631","https://openalex.org/W2044970750","https://openalex.org/W2062594120","https://openalex.org/W2062999949","https://openalex.org/W2080237681","https://openalex.org/W2080463438","https://openalex.org/W2087746647","https://openalex.org/W2097286385","https://openalex.org/W2134389439","https://openalex.org/W2138482047","https://openalex.org/W2139927267","https://openalex.org/W2144979640","https://openalex.org/W2172116519","https://openalex.org/W2440090833"],"related_works":["https://openalex.org/W2086386755","https://openalex.org/W2090089390","https://openalex.org/W2007843519","https://openalex.org/W2114329163","https://openalex.org/W2469758145","https://openalex.org/W3039120330","https://openalex.org/W2525241054","https://openalex.org/W2144979640","https://openalex.org/W1991531886","https://openalex.org/W2070466113"],"abstract_inverted_index":{"With":[0],"advancements":[1],"in":[2,8,14,17,72,154,186,196,203],"the":[3,28,68,82,104,124,155,190],"analytical":[4],"technologies":[5],"and":[6,22,40,60,114,140,174,202],"methodologies":[7],"proteomics,":[9],"there":[10],"is":[11],"great":[12],"interest":[13],"biomarker":[15],"discovery":[16],"biofluids":[18,53],"such":[19],"as":[20],"serum":[21,33,106],"plasma.":[23],"Current":[24],"hypotheses":[25],"suggest":[26],"that":[27,44],"low":[29],"molecular":[30],"weight":[31],"(LMW)":[32],"proteome":[34,107],"possesses":[35],"an":[36],"archive":[37],"of":[38,81,123,127,157,200],"clipped":[39],"cleaved":[41],"protein":[42],"fragments":[43],"may":[45,65],"provide":[46],"insight":[47],"into":[48],"disease":[49,63,91,201,205],"development.":[50],"Though":[51],"these":[52,73],"represent":[54,94],"attractive":[55],"samples":[56,74],"from":[57],"which":[58],"new":[59],"more":[61,179],"accurate":[62],"biomarkers":[64],"be":[66],"found,":[67],"intrinsic":[69],"person-to-person":[70],"variability":[71],"complicates":[75],"their":[76],"discovery.":[77],"Mice":[78],"are":[79],"one":[80],"most":[83],"extensively":[84],"used":[85],"animal":[86,198],"models":[87,199],"for":[88,192],"studying":[89],"human":[90,204],"because":[92],"they":[93],"a":[95,164],"highly":[96],"controllable":[97],"experimental":[98],"model":[99],"system.":[100],"In":[101],"this":[102,187],"study,":[103],"LMW":[105],"was":[108],"compared":[109],"between":[110],"xenografted":[111],"tumor-bearing":[112],"mice":[113,116],"control":[115],"by":[117,135,142,161,176],"differential":[118],"labeling":[119],"utilizing":[120],"trypsin-mediated":[121],"incorporation":[122],"stable":[125],"isotope":[126],"oxygen,":[128],"18O.":[129],"The":[130,183],"digestates":[131],"were":[132,172],"combined,":[133],"fractionated":[134],"strong":[136],"cation":[137],"exchange":[138],"chromatography,":[139],"analyzed":[141],"nanoflow":[143],"reversed-phase":[144],"liquid":[145],"chromatography":[146],"coupled":[147],"online":[148],"with":[149],"tandem":[150],"mass":[151],"spectrometry,":[152],"resulting":[153],"identification":[156],"6003":[158],"proteins":[159,171],"identified":[160,173],"at":[162],"least":[163],"single,":[165],"fully":[166,180],"tryptic":[167,181],"peptide.":[168],"Almost":[169],"1650":[170],"quantitated":[175],"two":[177],"or":[178],"peptides.":[182],"methodology":[184],"adopted":[185],"work":[188],"provides":[189],"means":[191],"future":[193],"quantitative":[194],"measurements":[195],"comparative":[197],"cohorts.":[206]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}