{"id":"https://openalex.org/W1990152136","doi":"https://doi.org/10.1074/jbc.m605063200","title":"Mitochondrial Production of Reactive Oxygen Species Mediate Dicumarol-induced Cytotoxicity in Cancer Cells","display_name":"Mitochondrial Production of Reactive Oxygen Species Mediate Dicumarol-induced Cytotoxicity in Cancer Cells","publication_year":2006,"publication_date":"2006-10-15","ids":{"openalex":"https://openalex.org/W1990152136","doi":"https://doi.org/10.1074/jbc.m605063200","mag":"1990152136","pmid":"https://pubmed.ncbi.nlm.nih.gov/17040906"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m605063200","doi":"https://doi.org/10.1074/jbc.m605063200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m605063200","pdf_url":"http://www.jbc.org/article/S0021925820719150/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820719150/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100697923","display_name":"Juan Du","orcid":"https://orcid.org/0000-0003-3444-5043","observed_orcids":["https://orcid.org/0000-0003-3444-5043"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210135841","display_name":"Iowa City VA Medical Center","ror":"https://ror.org/03r9k1585","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210132647","https://openalex.org/I4210135841","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I4390039339","display_name":"University of Iowa Holden Comprehensive Cancer Center","ror":"https://ror.org/01jhe7086","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4390039339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Du","raw_affiliation_strings":["Department of Surgery and University of Iowa College of Medicine, Holden Comprehensive Cancer Center, and Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA","Radiation Oncology, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and University of Iowa College of Medicine, Holden Comprehensive Cancer Center, and Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210135841","https://openalex.org/I4390039339"]},{"raw_affiliation_string":"Radiation Oncology, Iowa City, Iowa 52242","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110495512","display_name":"David H. Daniels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David H. Daniels","raw_affiliation_strings":["University of Iowa College of Medicine, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa College of Medicine, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070285447","display_name":"Carla Asbury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carla Asbury","raw_affiliation_strings":["University of Iowa College of Medicine, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa College of Medicine, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043603281","display_name":"Sujatha Venkataraman","orcid":"https://orcid.org/0000-0002-1512-284X","observed_orcids":["https://orcid.org/0000-0002-1512-284X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sujatha Venkataraman","raw_affiliation_strings":["Radiation Oncology, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology, Iowa City, Iowa 52242","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101984857","display_name":"Jingru Liu","orcid":"https://orcid.org/0000-0001-5626-1216","observed_orcids":["https://orcid.org/0000-0001-5626-1216"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingru Liu","raw_affiliation_strings":["Radiation Oncology, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology, Iowa City, Iowa 52242","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044316011","display_name":"Douglas R. Spitz","orcid":"https://orcid.org/0000-0002-1254-8765","observed_orcids":["https://orcid.org/0000-0002-1254-8765"]},"institutions":[{"id":"https://openalex.org/I4390039339","display_name":"University of Iowa Holden Comprehensive Cancer Center","ror":"https://ror.org/01jhe7086","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4390039339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas R. Spitz","raw_affiliation_strings":["Holden Comprehensive Cancer Center, Iowa City, Iowa 52242","Radiation Oncology, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Holden Comprehensive Cancer Center, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I4390039339"]},{"raw_affiliation_string":"Radiation Oncology, Iowa City, Iowa 52242","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066626887","display_name":"Larry W. Oberley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039339","display_name":"University of Iowa Holden Comprehensive Cancer Center","ror":"https://ror.org/01jhe7086","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4390039339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry W. Oberley","raw_affiliation_strings":["Holden Comprehensive Cancer Center, Iowa City, Iowa 52242","Radiation Oncology, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Holden Comprehensive Cancer Center, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I4390039339"]},{"raw_affiliation_string":"Radiation Oncology, Iowa City, Iowa 52242","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084443904","display_name":"Joseph J. Cullen","orcid":"https://orcid.org/0000-0002-2222-1328","observed_orcids":["https://orcid.org/0000-0002-2222-1328"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210135841","display_name":"Iowa City VA Medical Center","ror":"https://ror.org/03r9k1585","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210132647","https://openalex.org/I4210135841","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I4390039339","display_name":"University of Iowa Holden Comprehensive Cancer Center","ror":"https://ror.org/01jhe7086","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4390039339"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph J. Cullen","raw_affiliation_strings":["Departments of Surgery, Iowa City, Iowa 52242","Holden Comprehensive Cancer Center, Iowa City, Iowa 52242","Radiation Oncology, Iowa City, Iowa 52242","Veterans Affairs Medical Center, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Holden Comprehensive Cancer Center, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I4390039339"]},{"raw_affiliation_string":"Radiation Oncology, Iowa City, Iowa 52242","institution_ids":[]},{"raw_affiliation_string":"Veterans Affairs Medical Center, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I4210135841"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5084443904"],"corresponding_institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210135841","https://openalex.org/I4390039339"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":7.3521,"has_fulltext":true,"cited_by_count":70,"citation_normalized_percentile":{"value":0.96774896,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"281","issue":"49","first_page":"37416","last_page":"37426"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dicoumarol","display_name":"dicumarol","score":1.0},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mitochondrial-superoxide","display_name":"mitochondrial superoxide","score":0.7720000147819519},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.878000020980835},{"id":"https://openalex.org/keywords/nqo1","display_name":"NQO1","score":0.8069999814033508},{"id":"https://openalex.org/keywords/pancreatic-cancer-cells","display_name":"pancreatic cancer cells","score":0.699999988079071},{"id":"https://openalex.org/keywords/breast-cancer-cells","display_name":"breast cancer cells","score":0.7129999995231628},{"id":"https://openalex.org/keywords/antimycin-a","display_name":"antimycin A","score":0.7549999952316284},{"id":"https://openalex.org/keywords/mitochondrial-electron-transport-chain","display_name":"mitochondrial electron transport chain","score":0.9120000004768372},{"id":"https://openalex.org/keywords/manganese-superoxide-dismutase","display_name":"manganese superoxide dismutase","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7319999933242798},{"id":"https://openalex.org/keywords/clonogenic-survival","display_name":"clonogenic survival","score":0.7670000195503235},{"id":"https://openalex.org/keywords/coumarin-anticoagulants","display_name":"coumarin anticoagulants","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.8728065490722656},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.8278688192367554},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.553517758846283},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5358719825744629},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4520235061645508},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.42944642901420593},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4078027009963989},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4002341628074646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3425073027610779},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2513798475265503},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16505840420722961},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07753929495811462},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001728","descriptor_name":"Dicumarol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014410","descriptor_name":"Tumor Stem Cell Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014475","descriptor_name":"Uncoupling Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016660","descriptor_name":"NAD(P)H Dehydrogenase (Quinone)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m605063200","doi":"https://doi.org/10.1074/jbc.m605063200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m605063200","pdf_url":"http://www.jbc.org/article/S0021925820719150/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:17040906","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17040906","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m605063200","doi":"https://doi.org/10.1074/jbc.m605063200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m605063200","pdf_url":"http://www.jbc.org/article/S0021925820719150/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3343448652","display_name":"Short-Term Training for Students in the Health Professions","funder_award_id":"T35HL007485","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3406692104","display_name":"Metabolic Oxidative Stress in Human Cancer Cells","funder_award_id":"R01CA100045","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3734021424","display_name":"Mechanisms of Dicumarol-Induced Cytotoxicity","funder_award_id":"R21CA115785","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5503516424","display_name":null,"funder_award_id":"CA66081","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5824403655","display_name":null,"funder_award_id":"HL07485-24","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6484522286","display_name":null,"funder_award_id":"CA100045","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8704817102","display_name":null,"funder_award_id":"CA115785","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8718735108","display_name":"Oxidative Events in Cancer Therapy","funder_award_id":"P01CA066081","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000340569","display_name":null,"funder_award_id":"CA66081","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320310581","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990152136.pdf","grobid_xml":"https://content.openalex.org/works/W1990152136.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W191793640","https://openalex.org/W1480951384","https://openalex.org/W1503552721","https://openalex.org/W1508395055","https://openalex.org/W1531856321","https://openalex.org/W1555526039","https://openalex.org/W1562677986","https://openalex.org/W1768247331","https://openalex.org/W1775749144","https://openalex.org/W1809723326","https://openalex.org/W1943243678","https://openalex.org/W1966072897","https://openalex.org/W1967467994","https://openalex.org/W1990283519","https://openalex.org/W1991102140","https://openalex.org/W1996844781","https://openalex.org/W2016681598","https://openalex.org/W2021883819","https://openalex.org/W2038658212","https://openalex.org/W2056701503","https://openalex.org/W2060363769","https://openalex.org/W2072080593","https://openalex.org/W2075023632","https://openalex.org/W2085569151","https://openalex.org/W2086415396","https://openalex.org/W2096094438","https://openalex.org/W2102955022","https://openalex.org/W2105892074","https://openalex.org/W2106160859","https://openalex.org/W2111303550","https://openalex.org/W2124361666","https://openalex.org/W2124413979","https://openalex.org/W2153677362","https://openalex.org/W2154339406","https://openalex.org/W2284561719","https://openalex.org/W2519916497","https://openalex.org/W4242413941"],"related_works":["https://openalex.org/W2118547420","https://openalex.org/W2007095665","https://openalex.org/W2123679904","https://openalex.org/W1974528131","https://openalex.org/W1983521123","https://openalex.org/W2005917635","https://openalex.org/W2034148229","https://openalex.org/W2248282128","https://openalex.org/W7096523599","https://openalex.org/W1669763518"],"abstract_inverted_index":{"Dicumarol":[0,112,127,167],"is":[1,67],"a":[2],"naturally":[3],"occurring":[4],"anticoagulant":[5],"derived":[6],"from":[7],"coumarin":[8],"that":[9,92],"induces":[10],"cytotoxicity":[11,213],"and":[12,42,86,121,163,180,204,214],"oxidative":[13,110],"stress":[14],"in":[15,76,117,131,158,184],"human":[16,159],"pancreatic":[17,104,160],"cancer":[18,105,125,161,194,234],"cells":[19,106,162,185,195,235],"(Cullen,":[20],"J.":[21,37],"J.,":[22,32],"Hinkhouse,":[23],"M.":[24],"M.,":[25,27],"Grady,":[26],"Gaut,":[28],"A.":[29],"W.,":[30],"Liu,":[31],"Zhang,":[33],"Y.,":[34],"Weydert,":[35],"C.":[36],"D.,":[38],"Domann,":[39],"F.":[40],"E.,":[41],"Oberley,":[43],"L.":[44],"W.":[45],"(2003)":[46],"Cancer":[47],"Res.":[48],"63,":[49],"5513-5520).":[50],"Although":[51],"dicumarol":[52,66],"has":[53],"been":[54],"used":[55],"as":[56],"an":[57],"inhibitor":[58],"of":[59,83,95,103,148,200,217,225,233],"the":[60,77,81,100,132,140,146,169,211,218,230],"two-electron":[61],"reductase":[62],"NAD(P)H:quinone":[63],"oxidoreductase":[64],"(NQO1),":[65],"also":[68],"thought":[69],"to":[70,80,107,236],"affect":[71],"quinone-mediated":[72],"electron":[73,150,171],"transfer":[74],"reactions":[75],"mitochondria,":[78],"leading":[79],"production":[82,94,224],"superoxide":[84,165,182,202],"(O2*-)":[85],"hydrogen":[87],"peroxide":[88],"(H(2)O(2)).":[89],"We":[90,221],"hypothesized":[91],"mitochondrial":[93,149,170,223],"reactive":[96,226],"oxygen":[97,227],"species":[98,228],"mediates":[99,229],"increased":[101,164,181,231],"susceptibility":[102,232],"dicumarol-induced":[108,212,237],"metabolic":[109],"stress.":[111],"decreased":[113,128,154,177],"clonogenic":[114,129,155,178],"survival":[115,130,157,179],"equally":[116],"both":[118],"MDA-MB-468":[119,122],"NQO1(-)":[120],"NQO1+":[123],"breast":[124],"cells.":[126],"transformed":[133],"fibroblast":[134],"cell":[135,142,156],"line":[136],"IMRSV-90":[137],"compared":[138],"with":[139,145,168,186,207],"IMR-90":[141],"line.":[143],"Dicumarol,":[144],"addition":[147],"transport":[151,172],"chain":[152,173],"blockers,":[153],"levels.":[166],"blocker":[174],"antimycin":[175],"A":[176],"levels":[183],"functional":[187,197],"mitochondria":[188],"but":[189],"had":[190],"little":[191],"effect":[192],"on":[193],"without":[196],"mitochondria.":[198],"Overexpression":[199],"manganese":[201],"dismutase":[203],"mitochondrial-targeted":[205],"catalase":[206],"adenoviral":[208],"vectors":[209],"reversed":[210,215],"fluorescence":[216],"oxidation-sensitive":[219],"probe.":[220],"conclude":[222],"cytotoxicity.":[238]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}