{"id":"https://openalex.org/W1990146989","doi":"https://doi.org/10.1021/ol035826v","title":"Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 Urea Leads to Potent Intracellular Inhibitors of Hepatitis C Virus NS3/4A Protease","display_name":"Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 Urea Leads to Potent Intracellular Inhibitors of Hepatitis C Virus NS3/4A Protease","publication_year":2003,"publication_date":"2003-11-01","ids":{"openalex":"https://openalex.org/W1990146989","doi":"https://doi.org/10.1021/ol035826v","mag":"1990146989","pmid":"https://pubmed.ncbi.nlm.nih.gov/14627400"},"language":"en","primary_location":{"id":"doi:10.1021/ol035826v","doi":"https://doi.org/10.1021/ol035826v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ol035826v","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103837161","display_name":"Martin J. Slater","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin J. Slater","raw_affiliation_strings":["GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088285829","display_name":"Elizabeth M. Amphlett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elizabeth M. Amphlett","raw_affiliation_strings":["GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038082731","display_name":"David M. Andrews","orcid":"https://orcid.org/0000-0002-6716-6270","observed_orcids":["https://orcid.org/0000-0002-6716-6270"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David M. Andrews","raw_affiliation_strings":["GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011795002","display_name":"Paul Bamborough","orcid":"https://orcid.org/0000-0001-9479-2894","observed_orcids":["https://orcid.org/0000-0001-9479-2894"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Bamborough","raw_affiliation_strings":["GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005805112","display_name":"Seb J. Carey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Seb J. Carey","raw_affiliation_strings":["GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Martin R. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin R. Johnson","raw_affiliation_strings":["GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103107712","display_name":"Paul S. Jones","orcid":"https://orcid.org/0009-0002-7595-5031","observed_orcids":["https://orcid.org/0009-0002-7595-5031"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul S. Jones","raw_affiliation_strings":["GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110279095","display_name":"Gail Mills","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gail Mills","raw_affiliation_strings":["GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031643532","display_name":"Nigel R. Parry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nigel R. Parry","raw_affiliation_strings":["GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024040683","display_name":"Donald O'N Somers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Donald O'N. Somers,","raw_affiliation_strings":["GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051578001","display_name":"Alan James Stewart","orcid":"https://orcid.org/0000-0003-4580-1840","observed_orcids":["https://orcid.org/0000-0003-4580-1840"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alan J. Stewart","raw_affiliation_strings":["GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068193397","display_name":"Tadeusz J. Skarzynski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tadeusz Skarzynski","raw_affiliation_strings":["GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I188950975"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.8051,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.75799373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"5","issue":"24","first_page":"4627","last_page":"4630"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.7129999995231628},{"id":"https://openalex.org/keywords/ns3-4a-protease","display_name":"NS3/4A protease","score":0.9789999723434448},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.9580000042915344},{"id":"https://openalex.org/keywords/antiviral-drug-design","display_name":"antiviral drug design","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8978989124298096},{"id":"https://openalex.org/C2778851528","wikidata":"https://www.wikidata.org/wiki/Q408898","display_name":"Pyrrolidine","level":2,"score":0.8553411960601807},{"id":"https://openalex.org/C18103114","wikidata":"https://www.wikidata.org/wiki/Q1720369","display_name":"Replicon","level":4,"score":0.838442325592041},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.6536512970924377},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.6335628032684326},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.571186900138855},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4894033968448639},{"id":"https://openalex.org/C132379496","wikidata":"https://www.wikidata.org/wiki/Q83141645","display_name":"NS3","level":4,"score":0.44948089122772217},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3732841908931732},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3418094515800476},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28297245502471924},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.28194764256477356},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2552296221256256},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18420565128326416},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14542469382286072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05969545245170593},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04632404446601868},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000085242","descriptor_name":"Viral Proteases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007769","descriptor_name":"Lactams","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043583","descriptor_name":"Nucleoside-Triphosphatase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ol035826v","doi":"https://doi.org/10.1021/ol035826v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ol035826v","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},{"id":"pmid:14627400","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14627400","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1964993943","https://openalex.org/W1979931682","https://openalex.org/W1983906683","https://openalex.org/W1988248005","https://openalex.org/W1991378085","https://openalex.org/W1993488486","https://openalex.org/W2000104469","https://openalex.org/W2029447838","https://openalex.org/W2030584421","https://openalex.org/W2031225607","https://openalex.org/W2038839676","https://openalex.org/W2045531679","https://openalex.org/W2078887917","https://openalex.org/W2087867836","https://openalex.org/W2101019557","https://openalex.org/W2128055182","https://openalex.org/W2129767605","https://openalex.org/W2139624902","https://openalex.org/W2151898297","https://openalex.org/W2178530792","https://openalex.org/W2181163245","https://openalex.org/W2317554121","https://openalex.org/W2341829866","https://openalex.org/W4236571285"],"related_works":["https://openalex.org/W1993488486","https://openalex.org/W2177229987","https://openalex.org/W2178530792","https://openalex.org/W2181163245","https://openalex.org/W2951620790","https://openalex.org/W2795946247","https://openalex.org/W2064702805","https://openalex.org/W2029704702","https://openalex.org/W2022551878","https://openalex.org/W1966565782"],"abstract_inverted_index":{"[reaction:":[0],"see":[1],"text]":[2],"In":[3],"this,":[4],"the":[5,23,32,43],"first":[6],"of":[7,28],"two":[8],"Letters,":[9],"we":[10],"describe":[11],"how":[12],"a":[13,38],"P3/P4":[14],"urea":[15],"linking":[16],"unit":[17],"was":[18],"used":[19],"to":[20],"greatly":[21],"enhance":[22],"biochemical":[24],"and":[25],"replicon":[26,44],"potency":[27],"inhibitors":[29],"based":[30],"upon":[31],"pyrrolidine-5,5-trans-lactam":[33],"template.":[34],"Compound":[35],"7b":[36],"demonstrated":[37],"100":[39],"nM":[40],"IC(50)":[41],"in":[42],"cell-based":[45],"surrogate":[46],"HCV":[47],"assay.":[48]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
