{"id":"https://openalex.org/W1990144221","doi":"https://doi.org/10.1002/1097-0142(19930101)71:1<117::aid-cncr2820710119>3.0.co;2-k","title":"Acute neurotoxicity after intrathecal cytosine arabinoside in two adolescents with acute lymphoblastic leukemia of B-cell type","display_name":"Acute neurotoxicity after intrathecal cytosine arabinoside in two adolescents with acute lymphoblastic leukemia of B-cell type","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W1990144221","doi":"https://doi.org/10.1002/1097-0142(19930101)71:1<117::aid-cncr2820710119>3.0.co;2-k","mag":"1990144221","pmid":"https://pubmed.ncbi.nlm.nih.gov/8416707"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(19930101)71:1<117::aid-cncr2820710119>3.0.co;2-k","doi":"https://doi.org/10.1002/1097-0142(19930101)71:1<117::aid-cncr2820710119>3.0.co;2-k","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19930101)71:1<117::aid-cncr2820710119>3.0.co;2-k","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819930101%2971%3A1%3C117%3A%3AAID-CNCR2820710119%3E3.0.CO%3B2-K","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819930101%2971%3A1%3C117%3A%3AAID-CNCR2820710119%3E3.0.CO%3B2-K","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061685890","display_name":"Linda M S Resar","orcid":"https://orcid.org/0000-0002-4004-7060","observed_orcids":["https://orcid.org/0000-0002-4004-7060"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda M. S. Resar","raw_affiliation_strings":["Department of Oncology, Johns Hopkins Hospital, Baltimore, Maryland","Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland","Department of Pediatrics, The Johns Hopkins Hospital, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Johns Hopkins Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]},{"raw_affiliation_string":"Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]},{"raw_affiliation_string":"Department of Pediatrics, The Johns Hopkins Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101920170","display_name":"Peter C. Phillips\u2225","orcid":"https://orcid.org/0000-0001-5565-8326","observed_orcids":["https://orcid.org/0000-0001-5565-8326"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter C. Phillips","raw_affiliation_strings":["Department of Neurology, The Johns Hopkins Hospital, Baltimore, Maryland","Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland","Department of Pediatrics, The Johns Hopkins Hospital, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Johns Hopkins Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]},{"raw_affiliation_string":"Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]},{"raw_affiliation_string":"Department of Pediatrics, The Johns Hopkins Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021559507","display_name":"Michael B. Kastan","orcid":"https://orcid.org/0000-0002-1719-7562","observed_orcids":["https://orcid.org/0000-0002-1719-7562"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael B. Kastan","raw_affiliation_strings":["Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland","Department of Pediatrics, The Johns Hopkins Hospital, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]},{"raw_affiliation_string":"Department of Pediatrics, The Johns Hopkins Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108556590","display_name":"Brigid G. Leventhal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brigid G. Leventhal","raw_affiliation_strings":["Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland","Department of Pediatrics, The Johns Hopkins Hospital, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]},{"raw_affiliation_string":"Department of Pediatrics, The Johns Hopkins Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087999923","display_name":"Paul Bowman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090149","display_name":"Cook Children's Medical Center","ror":"https://ror.org/009z5t729","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210090149","https://openalex.org/I4210102753"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul W. Bowman","raw_affiliation_strings":["Department of Hematology and Oncology, Cook-Fort Worth Children's Medical Center, Fort Worth, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Cook-Fort Worth Children's Medical Center, Fort Worth, Texas","institution_ids":["https://openalex.org/I4210090149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047214928","display_name":"Curt I. Civin","orcid":"https://orcid.org/0000-0002-9555-4895","observed_orcids":["https://orcid.org/0000-0002-9555-4895"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Curt I. Civin","raw_affiliation_strings":["Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland","Department of Pediatrics, The Johns Hopkins Hospital, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]},{"raw_affiliation_string":"Department of Pediatrics, The Johns Hopkins Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101920170"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":2.5488,"has_fulltext":true,"cited_by_count":55,"citation_normalized_percentile":{"value":0.88433454,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"71","issue":"1","first_page":"117","last_page":"123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-neurotoxicity","display_name":"acute neurotoxicity","score":0.8809999823570251},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.8410000205039978},{"id":"https://openalex.org/keywords/b-cell-acute-lymphoblastic-leukemia","display_name":"B-cell acute lymphoblastic leukemia","score":0.8949999809265137},{"id":"https://openalex.org/keywords/burkitt-leukemia","display_name":"Burkitt leukemia","score":0.972000002861023},{"id":"https://openalex.org/keywords/myelopathy","display_name":"myelopathy","score":0.7940000295639038},{"id":"https://openalex.org/keywords/encephalopathy","display_name":"encephalopathy","score":0.9769999980926514},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.7639999985694885},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.5830000042915344},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.937056303024292},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.7851055860519409},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.6531448364257812},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.6048505306243896},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.5709245800971985},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.4956263303756714},{"id":"https://openalex.org/C2781107101","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Acute lymphocytic leukemia","level":4,"score":0.4813721776008606},{"id":"https://openalex.org/C2777604421","wikidata":"https://www.wikidata.org/wiki/Q2303951","display_name":"Myelopathy","level":3,"score":0.4263274371623993},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4238797426223755},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.42101845145225525},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3948850929737091},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.3430384397506714},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3367927074432373},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.29285216331481934},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.1760883331298828},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D002051","descriptor_name":"Burkitt Lymphoma","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D002051","descriptor_name":"Burkitt Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003561","descriptor_name":"Cytarabine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003561","descriptor_name":"Cytarabine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007278","descriptor_name":"Injections, Spinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009460","descriptor_name":"Neurologic Examination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013118","descriptor_name":"Spinal Cord Diseases","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D013118","descriptor_name":"Spinal Cord Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(19930101)71:1<117::aid-cncr2820710119>3.0.co;2-k","doi":"https://doi.org/10.1002/1097-0142(19930101)71:1<117::aid-cncr2820710119>3.0.co;2-k","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19930101)71:1<117::aid-cncr2820710119>3.0.co;2-k","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819930101%2971%3A1%3C117%3A%3AAID-CNCR2820710119%3E3.0.CO%3B2-K","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:8416707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8416707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1002/1097-0142(19930101)71:1<117::aid-cncr2820710119>3.0.co;2-k","doi":"https://doi.org/10.1002/1097-0142(19930101)71:1<117::aid-cncr2820710119>3.0.co;2-k","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19930101)71:1<117::aid-cncr2820710119>3.0.co;2-k","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819930101%2971%3A1%3C117%3A%3AAID-CNCR2820710119%3E3.0.CO%3B2-K","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990144221.pdf","grobid_xml":"https://content.openalex.org/works/W1990144221.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W172130653","https://openalex.org/W1485026327","https://openalex.org/W1850094271","https://openalex.org/W1854667071","https://openalex.org/W1897993962","https://openalex.org/W1972274967","https://openalex.org/W1972548264","https://openalex.org/W1974265038","https://openalex.org/W1990019551","https://openalex.org/W1998810356","https://openalex.org/W2011685655","https://openalex.org/W2038856601","https://openalex.org/W2044414819","https://openalex.org/W2047201850","https://openalex.org/W2054306115","https://openalex.org/W2054472820","https://openalex.org/W2054722364","https://openalex.org/W2065532732","https://openalex.org/W2075971850","https://openalex.org/W2081343731","https://openalex.org/W2082923659","https://openalex.org/W2091679619","https://openalex.org/W2092907033","https://openalex.org/W2118440167","https://openalex.org/W2133176740","https://openalex.org/W2164051062","https://openalex.org/W2211072972","https://openalex.org/W2328743736","https://openalex.org/W2412338107","https://openalex.org/W2414855633","https://openalex.org/W2415945522","https://openalex.org/W2462779651","https://openalex.org/W2992354837","https://openalex.org/W4233999131","https://openalex.org/W6712343624"],"related_works":["https://openalex.org/W1989807339","https://openalex.org/W2075971850","https://openalex.org/W2007912934","https://openalex.org/W6988645918","https://openalex.org/W2066323806","https://openalex.org/W2099191228","https://openalex.org/W2089796448","https://openalex.org/W2076898573","https://openalex.org/W1964728709","https://openalex.org/W2081343731"],"abstract_inverted_index":{"BACKGROUND:":[0],"Two":[1],"adolescents":[2],"with":[3,15],"acute":[4,10,72,122],"B-cell":[5],"leukemia":[6],"(Burkitt":[7],"leukemia)":[8],"had":[9,35,71],"severe":[11,123],"neurotoxicity":[12,124,138],"after":[13,44,96,125],"treatment":[14],"intrathecal":[16],"(IT)":[17],"cytosine":[18],"arabinoside":[19],"(AraC)":[20],"at":[21],"a":[22,36],"dose":[23,48,92,146],"of":[24,49,88,121,147,168],"50":[25],"mg/day":[26],"for":[27,59,153],"three":[28],"consecutive":[29,157],"days.":[30],"RESULTS:":[31],"A":[32,68],"16-year-old":[33],"boy":[34],"rapidly":[37],"ascending":[38],"myelopathy":[39],"and":[40,55,75,82,93,165],"encephalopathy":[41],"20":[42],"hours":[43,87,95],"receiving":[45],"the":[46,80,89,108,114,118,129,144],"third":[47,90],"IT":[50,97,131,136,150],"AraC.":[51],"He":[52],"remained":[53],"quadriplegic":[54],"required":[56],"ventilatory":[57],"assistance":[58],"10":[60],"months":[61],"until":[62],"his":[63],"death":[64],"from":[65],"progressive":[66],"tumor.":[67],"12-year-old":[69],"girl":[70],"encephalopathy,":[73],"seizures,":[74],"focal":[76],"neuroimaging":[77],"abnormalities":[78],"in":[79],"cerebellum":[81],"brain":[83],"stem":[84],"within":[85],"32":[86],"AraC":[91,126,137,151],"8":[94],"methotrexate":[98],"(MTX,":[99],"12":[100],"mg).":[101],"Her":[102],"clinical":[103],"neurologic":[104,163],"deficits":[105],"resolved":[106],"during":[107],"ensuing":[109],"month.":[110],"Patient":[111,134],"1":[112],"represents":[113],"first":[115],"report":[116],"to":[117,161],"authors'":[119],"knowledge":[120],"administered":[127,152],"as":[128],"only":[130],"drug.":[132],"In":[133],"2,":[135],"may":[139,159],"have":[140],"been":[141],"potentiated":[142],"by":[143],"single":[145],"MTX.":[148],"CONCLUSION:":[149],"3":[154],"or":[155],"more":[156],"days":[158],"lead":[160],"profound":[162],"dysfunction":[164],"require":[166],"discontinuation":[167],"therapy.":[169]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
