{"id":"https://openalex.org/W1990136727","doi":"https://doi.org/10.1371/journal.pmed.1001689","title":"Protective Efficacy and Safety of Three Antimalarial Regimens for the Prevention of Malaria in Young Ugandan Children: A Randomized Controlled Trial","display_name":"Protective Efficacy and Safety of Three Antimalarial Regimens for the Prevention of Malaria in Young Ugandan Children: A Randomized Controlled Trial","publication_year":2014,"publication_date":"2014-08-05","ids":{"openalex":"https://openalex.org/W1990136727","doi":"https://doi.org/10.1371/journal.pmed.1001689","mag":"1990136727","pmid":"https://pubmed.ncbi.nlm.nih.gov/25093754","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4122345"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pmed.1001689","doi":"https://doi.org/10.1371/journal.pmed.1001689","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.1001689","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001689&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001689&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113585088","display_name":"Victor Bigira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118448","display_name":"Infectious Diseases Research Collaboration","ror":"https://ror.org/02f5g3528","country_code":"UG","type":"nonprofit","lineage":["https://openalex.org/I4210118448"]}],"countries":["UG"],"is_corresponding":false,"raw_author_name":"Victor Bigira","raw_affiliation_strings":["Infectious Diseases Research Collaboration, Kampala, Uganda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Research Collaboration, Kampala, Uganda","institution_ids":["https://openalex.org/I4210118448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088905298","display_name":"James Kapisi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118448","display_name":"Infectious Diseases Research Collaboration","ror":"https://ror.org/02f5g3528","country_code":"UG","type":"nonprofit","lineage":["https://openalex.org/I4210118448"]}],"countries":["UG"],"is_corresponding":false,"raw_author_name":"James Kapisi","raw_affiliation_strings":["Infectious Diseases Research Collaboration, Kampala, Uganda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Research Collaboration, Kampala, Uganda","institution_ids":["https://openalex.org/I4210118448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041444021","display_name":"Tamara D. Clark","orcid":"https://orcid.org/0000-0003-1109-6039","observed_orcids":["https://orcid.org/0000-0003-1109-6039"]},"institutions":[{"id":"https://openalex.org/I1295908608","display_name":"San Francisco General Hospital","ror":"https://ror.org/05j8x4n38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295908608"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamara D. Clark","raw_affiliation_strings":["Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1295908608","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033294331","display_name":"Stephen Kinara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118448","display_name":"Infectious Diseases Research Collaboration","ror":"https://ror.org/02f5g3528","country_code":"UG","type":"nonprofit","lineage":["https://openalex.org/I4210118448"]}],"countries":["UG"],"is_corresponding":false,"raw_author_name":"Stephen Kinara","raw_affiliation_strings":["Infectious Diseases Research Collaboration, Kampala, Uganda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Research Collaboration, Kampala, Uganda","institution_ids":["https://openalex.org/I4210118448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003734191","display_name":"Florence Mwangwa","orcid":"https://orcid.org/0000-0001-9467-0950","observed_orcids":["https://orcid.org/0000-0001-9467-0950"]},"institutions":[{"id":"https://openalex.org/I4210118448","display_name":"Infectious Diseases Research Collaboration","ror":"https://ror.org/02f5g3528","country_code":"UG","type":"nonprofit","lineage":["https://openalex.org/I4210118448"]}],"countries":["UG"],"is_corresponding":false,"raw_author_name":"Florence Mwangwa","raw_affiliation_strings":["Infectious Diseases Research Collaboration, Kampala, Uganda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Research Collaboration, Kampala, Uganda","institution_ids":["https://openalex.org/I4210118448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046985054","display_name":"Mary Kakuru Muhindo","orcid":"https://orcid.org/0000-0002-5328-0523","observed_orcids":["https://orcid.org/0000-0002-5328-0523"]},"institutions":[{"id":"https://openalex.org/I4210118448","display_name":"Infectious Diseases Research Collaboration","ror":"https://ror.org/02f5g3528","country_code":"UG","type":"nonprofit","lineage":["https://openalex.org/I4210118448"]}],"countries":["UG"],"is_corresponding":false,"raw_author_name":"Mary K. Muhindo","raw_affiliation_strings":["Infectious Diseases Research Collaboration, Kampala, Uganda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Research Collaboration, Kampala, Uganda","institution_ids":["https://openalex.org/I4210118448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056803741","display_name":"Beth Osterbauer","orcid":"https://orcid.org/0000-0003-2774-3229","observed_orcids":["https://orcid.org/0000-0003-2774-3229"]},"institutions":[{"id":"https://openalex.org/I1295908608","display_name":"San Francisco General Hospital","ror":"https://ror.org/05j8x4n38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295908608"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth Osterbauer","raw_affiliation_strings":["Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1295908608","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063298724","display_name":"Francesca  T. Aweeka","orcid":"https://orcid.org/0000-0002-6005-6124","observed_orcids":["https://orcid.org/0000-0002-6005-6124"]},"institutions":[{"id":"https://openalex.org/I1295908608","display_name":"San Francisco General Hospital","ror":"https://ror.org/05j8x4n38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295908608"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francesca T. Aweeka","raw_affiliation_strings":["Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1295908608","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076124051","display_name":"Liusheng Huang","orcid":"https://orcid.org/0000-0003-2702-4486","observed_orcids":["https://orcid.org/0000-0003-2702-4486"]},"institutions":[{"id":"https://openalex.org/I1295908608","display_name":"San Francisco General Hospital","ror":"https://ror.org/05j8x4n38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295908608"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liusheng Huang","raw_affiliation_strings":["Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1295908608","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045699932","display_name":"Jane Achan","orcid":"https://orcid.org/0000-0001-8111-025X","observed_orcids":["https://orcid.org/0000-0001-8111-025X"]},"institutions":[{"id":"https://openalex.org/I72227227","display_name":"Makerere University","ror":"https://ror.org/03dmz0111","country_code":"UG","type":"education","lineage":["https://openalex.org/I72227227"]}],"countries":["UG"],"is_corresponding":false,"raw_author_name":"Jane Achan","raw_affiliation_strings":["Department of Pediatrics, Makerere University College of Health Sciences, Kampala, Uganda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Makerere University College of Health Sciences, Kampala, Uganda","institution_ids":["https://openalex.org/I72227227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069551580","display_name":"Diane V. Havlir","orcid":"https://orcid.org/0000-0003-0761-3136","observed_orcids":["https://orcid.org/0000-0003-0761-3136"]},"institutions":[{"id":"https://openalex.org/I1295908608","display_name":"San Francisco General Hospital","ror":"https://ror.org/05j8x4n38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295908608"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane V. Havlir","raw_affiliation_strings":["Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1295908608","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077631479","display_name":"Philip Jon Rosenthal","orcid":"https://orcid.org/0000-0002-7953-7622","observed_orcids":["https://orcid.org/0000-0002-7953-7622","https://orcid.org/0000-0001-7840-5401"]},"institutions":[{"id":"https://openalex.org/I1295908608","display_name":"San Francisco General Hospital","ror":"https://ror.org/05j8x4n38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295908608"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip J. Rosenthal","raw_affiliation_strings":["Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1295908608","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083823135","display_name":"Moses Robert Kamya","orcid":"https://orcid.org/0000-0001-9106-4234","observed_orcids":["https://orcid.org/0000-0001-9106-4234"]},"institutions":[{"id":"https://openalex.org/I72227227","display_name":"Makerere University","ror":"https://ror.org/03dmz0111","country_code":"UG","type":"education","lineage":["https://openalex.org/I72227227"]}],"countries":["UG"],"is_corresponding":false,"raw_author_name":"Moses R. Kamya","raw_affiliation_strings":["Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda","institution_ids":["https://openalex.org/I72227227"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033897984","display_name":"Grant Dorsey","orcid":"https://orcid.org/0000-0003-0740-0317","observed_orcids":["https://orcid.org/0000-0003-0740-0317"]},"institutions":[{"id":"https://openalex.org/I1295908608","display_name":"San Francisco General Hospital","ror":"https://ror.org/05j8x4n38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295908608"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Grant Dorsey","raw_affiliation_strings":["Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1295908608","https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5033897984"],"corresponding_institution_ids":["https://openalex.org/I1295908608","https://openalex.org/I180670191"],"apc_list":{"value":6460,"currency":"USD","value_usd":6460},"apc_paid":{"value":6460,"currency":"USD","value_usd":6460},"fwci":11.9603,"has_fulltext":true,"cited_by_count":109,"citation_normalized_percentile":{"value":0.9898326,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"11","issue":"8","first_page":"e1001689","last_page":"e1001689"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12402","display_name":"Travel-related health issues","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malaria-prophylaxis","display_name":"malaria prophylaxis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/sulfadoxine-pyrimethamine","display_name":"sulfadoxine-pyrimethamine","score":0.9380000233650208},{"id":"https://openalex.org/keywords/trimethoprim-sulfamethoxazole","display_name":"trimethoprim-sulfamethoxazole","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dihydroartemisinin-piperaquine","display_name":"dihydroartemisinin-piperaquine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.753000020980835},{"id":"https://openalex.org/keywords/protective-efficacy","display_name":"protective efficacy","score":0.6589999794960022},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6850000023841858},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.3889999985694885},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.4860000014305115},{"id":"https://openalex.org/keywords/antifolate-resistance","display_name":"antifolate resistance","score":0.9459999799728394},{"id":"https://openalex.org/keywords/insecticide-treated-bednets","display_name":"insecticide-treated bednets","score":0.8740000128746033},{"id":"https://openalex.org/keywords/uganda","display_name":"Uganda","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8907292485237122},{"id":"https://openalex.org/C2777616469","wikidata":"https://www.wikidata.org/wiki/Q7197338","display_name":"Piperaquine","level":5,"score":0.7607226967811584},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.68837571144104},{"id":"https://openalex.org/C2778301690","wikidata":"https://www.wikidata.org/wiki/Q411557","display_name":"Sulfadoxine","level":5,"score":0.5827971696853638},{"id":"https://openalex.org/C2778059366","wikidata":"https://www.wikidata.org/wiki/Q707939","display_name":"Artesunate","level":4,"score":0.5556134581565857},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5338168144226074},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5199407339096069},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5131211876869202},{"id":"https://openalex.org/C2777035104","wikidata":"https://www.wikidata.org/wiki/Q421072","display_name":"Pyrimethamine","level":4,"score":0.4817104935646057},{"id":"https://openalex.org/C2780441369","wikidata":"https://www.wikidata.org/wiki/Q421072","display_name":"Sulfadoxine/pyrimethamine","level":5,"score":0.4345112144947052},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3947688639163971},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36314675211906433},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.2628825008869171},{"id":"https://openalex.org/C2776120307","wikidata":"https://www.wikidata.org/wiki/Q426921","display_name":"Artemisinin","level":4,"score":0.26005038619041443},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.16632720828056335},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1503869891166687},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011739","descriptor_name":"Pyrimethamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013413","descriptor_name":"Sulfadoxine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014454","descriptor_name":"Uganda","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015662","descriptor_name":"Trimethoprim, Sulfamethoxazole Drug Combination","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":12,"locations":[{"id":"doi:10.1371/journal.pmed.1001689","doi":"https://doi.org/10.1371/journal.pmed.1001689","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.1001689","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001689&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4122345","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4122345","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Med","raw_type":"Text"},{"id":"pmid:25093754","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25093754","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS medicine","raw_type":"Journal Article"},{"id":"pmh:oai:researchonline.lshtm.ac.uk:4651980","doi":null,"is_oa":false,"landing_page_url":"https://researchonline.lshtm.ac.uk/view/creators/lshja1.html>;","pdf_url":null,"source":{"id":"https://openalex.org/S4306402527","display_name":"LSHTM Research Online (London School of Hygiene and Tropical Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210089966","host_organization_name":"London School of Hygiene & Tropical Medicine","host_organization_lineage":["https://openalex.org/I4210089966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.810.1499","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.810.1499","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/9e/26/pmed.1001689.PMC4122345.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pmed00:1001689","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001689","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:962cb667668946d18dad8a18d96013f6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/962cb667668946d18dad8a18d96013f6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Medicine, Vol 11, Iss 8, p e1001689 (2014)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt1725r5zr","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/1725r5zr","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1129956","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Protective_Efficacy_and_Safety_of_Three_Antimalarial_Regimens_for_the_Prevention_of_Malaria_in_Young_Ugandan_Children_A_Randomized_Controlled_Trial_/1129956","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:qt1725r5zr","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/1725r5zr","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rosenthal, Philip; Aweeka, Francesca; Havlir, Diane; Bigira, V; Kapisi, J; Clark, TD; \u00c2\u00a0et al.(2015). Protective efficacy and safety of three antimalarial regimens for the prevention of malaria in young Ugandan children: A randomized controlled trial. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1725r5zr","raw_type":"article"},{"id":"doi:10.60692/7s2pk-vqt81","doi":"https://doi.org/10.60692/7s2pk-vqt81","is_oa":true,"landing_page_url":"https://doi.org/10.60692/7s2pk-vqt81","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/we1e5-0hq93","doi":"https://doi.org/10.60692/we1e5-0hq93","is_oa":true,"landing_page_url":"https://doi.org/10.60692/we1e5-0hq93","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pmed.1001689","doi":"https://doi.org/10.1371/journal.pmed.1001689","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pmed.1001689","pdf_url":"https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001689&type=printable","source":{"id":"https://openalex.org/S197939330","display_name":"PLoS Medicine","issn_l":"1549-1277","issn":["1549-1277","1549-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G8583638391","display_name":"Novel Strategies to Prevent Malaria and Improve Maternal-Child Health in Africa","funder_award_id":"P01HD059454","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000898530","display_name":"San Francisco Bay Clinical Trials Unit (CTU)","funder_award_id":"UM1AI069496","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000898549","display_name":"UCSF-Bay Area Center for AIDS Research","funder_award_id":"P30AI027763","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990136727.pdf","grobid_xml":"https://content.openalex.org/works/W1990136727.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1275343739","https://openalex.org/W1501895899","https://openalex.org/W1969763842","https://openalex.org/W1973192869","https://openalex.org/W1992510231","https://openalex.org/W1993749542","https://openalex.org/W2021725162","https://openalex.org/W2025539135","https://openalex.org/W2026989910","https://openalex.org/W2042372663","https://openalex.org/W2052262611","https://openalex.org/W2070197127","https://openalex.org/W2075937258","https://openalex.org/W2077559715","https://openalex.org/W2095934992","https://openalex.org/W2096883543","https://openalex.org/W2104697202","https://openalex.org/W2109832371","https://openalex.org/W2117002553","https://openalex.org/W2120009689","https://openalex.org/W2133866137","https://openalex.org/W2138888301","https://openalex.org/W2139863681","https://openalex.org/W2141917084","https://openalex.org/W2145891164","https://openalex.org/W2155737651","https://openalex.org/W2163934961","https://openalex.org/W2168604498"],"related_works":["https://openalex.org/W7098808759","https://openalex.org/W2145282983","https://openalex.org/W2131067205","https://openalex.org/W2334186750","https://openalex.org/W3172944297","https://openalex.org/W6938949745","https://openalex.org/W2036003931","https://openalex.org/W4304086171","https://openalex.org/W7169517307","https://openalex.org/W4386561931"],"abstract_inverted_index":{"BACKGROUND:":[0],"Chemoprevention":[1,134],"offers":[2],"a":[3,105,127,288],"promising":[4],"strategy":[5,20],"for":[6,186,195,199,320],"prevention":[7],"of":[8,25,46,76,107,140,153,164,217,241,251,272],"malaria":[9,154,165,221,252,265],"in":[10,23,48,109,166,224,238,266,269,299,317],"African":[11],"children.":[12,50],"However,":[13],"the":[14,110,151,156,160,162,167,213,218,225,235,239,246,249,254,258,279,318,321],"optimal":[15],"chemoprevention":[16,47,169],"drug":[17],"and":[18,28,62,70,118,142,197,248,282,292,305],"dosing":[19],"is":[21],"unclear":[22],"areas":[24,300],"year-round":[26],"transmission":[27,274,303],"resistance":[29,307],"to":[30,78,122,126,204,308],"many":[31],"antimalarial":[32],"drugs.":[33],"To":[34],"compare":[35],"three":[36],"available":[37],"regimens,":[38],"we":[39],"conducted":[40,57],"an":[41,145,270],"open-label":[42],"randomized":[43,72],"controlled":[44],"trial":[45],"Ugandan":[49],"METHODS":[51],"AND":[52],"FINDINGS:":[53],"This":[54],"study":[55,128,236],"was":[56,135,150,171,180,222,260,278],"between":[58,234],"June":[59],"28,":[60],"2010,":[61],"September":[63],"25,":[64],"2013.":[65],"400":[66],"infants":[67],"were":[68,93,102,114,120,132,211,231],"enrolled":[69],"393":[71],"at":[73,95,137,176],"6":[74],"mo":[75,139],"age":[77],"no":[79,168,232],"chemoprevention,":[80],"monthly":[81,88,276],"sulfadoxine-pyrimethamine":[82],"(SP),":[83],"daily":[84,293],"trimethoprim-sulfamethoxazole":[85],"(TS),":[86],"or":[87],"dihydroartemisinin-piperaquine":[89],"(DP).":[90],"Study":[91],"drugs":[92],"administered":[94],"home":[96],"without":[97],"supervision.":[98],"Piperaquine":[99],"(PQ)":[100],"levels":[101,210],"used":[103],"as":[104],"measure":[106],"compliance":[108],"DP":[111,226,277],"arm.":[112],"Participants":[113],"given":[115],"insecticide-treated":[116],"bednets,":[117],"caregivers":[119],"encouraged":[121],"bring":[123],"their":[124],"child":[125],"clinic":[129],"whenever":[130],"they":[131],"ill.":[133],"stopped":[136],"24":[138],"age,":[141],"participants":[143],"followed-up":[144],"additional":[146],"year.":[147],"Primary":[148],"outcome":[149],"incidence":[152,163,240,250],"during":[155,245,253],"intervention":[157,247,259],"period.":[158],"During":[159],"intervention,":[161],"arm":[170],"6.95":[172],"episodes":[173],"per":[174],"person-year":[175],"risk.":[177],"Protective":[178],"efficacy":[179],"58%":[181],"(95%":[182,189,201],"CI,":[183,190,202],"45%-67%,":[184],"p<0.001)":[185],"DP,":[187],"28%":[188],"7%-44%,":[191],"p":[192,206],"=":[193,207],"0.01)":[194],"TS,":[196],"7%":[198],"SP":[200,291],"-19%":[203],"28%,":[205],"0.57).":[208],"PQ":[209],"below":[212],"detection":[214],"limit":[215],"52%":[216],"time":[219],"when":[220],"diagnosed":[223],"arm,":[227],"suggesting":[228],"non-adherence.":[229],"There":[230],"differences":[233],"arms":[237],"serious":[242],"adverse":[243],"events":[244],"1-y":[255],"period":[256],"after":[257],"stopped.":[261],"CONCLUSIONS:":[262],"For":[263],"preventing":[264],"children":[267],"living":[268],"area":[271],"high":[273,302],"intensity,":[275],"most":[280],"efficacious":[281],"safe,":[283],"although":[284],"adherence":[285],"may":[286,295],"pose":[287],"problem.":[289],"Monthly":[290],"TS":[294],"not":[296],"be":[297],"appropriate":[298],"with":[301],"intensity":[304],"frequent":[306],"antifolates.":[309],"TRIAL":[310],"REGISTRATION:":[311],"www.ClinicalTrials.gov":[312],"NCT00948896":[313],"Please":[314],"see":[315],"later":[316],"article":[319],"Editors'":[322],"Summary.":[323]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}