{"id":"https://openalex.org/W1990133787","doi":"https://doi.org/10.1002/j.1552-4604.1988.tb05725.x","title":"Lack of Effect of Cholestyramine on Phenytoin Bioavailability","display_name":"Lack of Effect of Cholestyramine on Phenytoin Bioavailability","publication_year":1988,"publication_date":"1988-12-01","ids":{"openalex":"https://openalex.org/W1990133787","doi":"https://doi.org/10.1002/j.1552-4604.1988.tb05725.x","mag":"1990133787","pmid":"https://pubmed.ncbi.nlm.nih.gov/3243928"},"language":"en","primary_location":{"id":"doi:10.1002/j.1552-4604.1988.tb05725.x","doi":"https://doi.org/10.1002/j.1552-4604.1988.tb05725.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1552-4604.1988.tb05725.x","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014610079","display_name":"Nicoletta Barzaghi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"N. Barzaghi","raw_affiliation_strings":["Department of Internal Medicine and Therapeutics, University of Pavia, Italy","Department of Internal Medicine and Therapeutics, Division of Pharmacology, University of Pavia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Therapeutics, University of Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"Department of Internal Medicine and Therapeutics, Division of Pharmacology, University of Pavia","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015231246","display_name":"M. Monteleone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Monteleone","raw_affiliation_strings":["Regina Margherita Hospital, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regina Margherita Hospital, Turin, Italy","institution_ids":["https://openalex.org/I4210136185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029104371","display_name":"Cristina Amione","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Amione","raw_affiliation_strings":["Regina Margherita Hospital, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regina Margherita Hospital, Turin, Italy","institution_ids":["https://openalex.org/I4210136185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061549835","display_name":"Sergio Lecchini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Lecchini","raw_affiliation_strings":["Department of Internal Medicine and Therapeutics, Division of Pharmacology, University of Pavia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Therapeutics, Division of Pharmacology, University of Pavia","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040883137","display_name":"Emilio Perucca","orcid":"https://orcid.org/0000-0001-8703-223X","observed_orcids":["https://orcid.org/0000-0001-8703-223X","https://orcid.org/0000-0003-3232-1389"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Perucca","raw_affiliation_strings":["Department of Internal Medicine and Therapeutics, Division of Pharmacology, University of Pavia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Therapeutics, Division of Pharmacology, University of Pavia","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111592697","display_name":"G. M. Frigo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. M. Frigo","raw_affiliation_strings":["Department of Internal Medicine and Therapeutics, Division of Pharmacology, University of Pavia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Therapeutics, Division of Pharmacology, University of Pavia","institution_ids":["https://openalex.org/I25217355"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014610079"],"corresponding_institution_ids":["https://openalex.org/I25217355"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.06784065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"28","issue":"12","first_page":"1112","last_page":"1114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.5526999831199646,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.5526999831199646,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.1453000009059906,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.14339999854564667,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholestyramine","display_name":"cholestyramine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/phenytoin","display_name":"phenytoin","score":1.0},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.7609999775886536},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.9210000038146973},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.6549999713897705},{"id":"https://openalex.org/keywords/bile-acid-sequestrants","display_name":"bile acid sequestrants","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2778697171","wikidata":"https://www.wikidata.org/wiki/Q418006","display_name":"Cholestyramine","level":3,"score":0.9876383543014526},{"id":"https://openalex.org/C2778337148","wikidata":"https://www.wikidata.org/wiki/Q410400","display_name":"Phenytoin","level":3,"score":0.927139163017273},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.9207330346107483},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5682312250137329},{"id":"https://openalex.org/C2779253243","wikidata":"https://www.wikidata.org/wiki/Q410412","display_name":"Carbamazepine","level":3,"score":0.5565052628517151},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5530338287353516},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5256874561309814},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.5192927718162537},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5164446830749512},{"id":"https://openalex.org/C97320921","wikidata":"https://www.wikidata.org/wiki/Q718753","display_name":"Drug interaction","level":3,"score":0.48759761452674866},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.46791011095046997},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.45133405923843384},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.43710020184516907},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2616768479347229},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.11434546113014221},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.11388662457466125},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06473255157470703},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002792","descriptor_name":"Cholestyramine Resin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010672","descriptor_name":"Phenytoin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/j.1552-4604.1988.tb05725.x","doi":"https://doi.org/10.1002/j.1552-4604.1988.tb05725.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1552-4604.1988.tb05725.x","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:3243928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3243928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W565195425","https://openalex.org/W1975404200","https://openalex.org/W2010784054","https://openalex.org/W2013992309","https://openalex.org/W2016625120","https://openalex.org/W2035563311","https://openalex.org/W2044201102","https://openalex.org/W2051427702","https://openalex.org/W2080431921","https://openalex.org/W2082803042","https://openalex.org/W2086956890","https://openalex.org/W2161475611","https://openalex.org/W2165024366","https://openalex.org/W2228414730","https://openalex.org/W2321517118","https://openalex.org/W4254363271","https://openalex.org/W4255166433"],"related_works":["https://openalex.org/W1984463400","https://openalex.org/W2334195474","https://openalex.org/W2060696389","https://openalex.org/W2104797013","https://openalex.org/W93284936","https://openalex.org/W2409757830","https://openalex.org/W2412616125","https://openalex.org/W1992799573","https://openalex.org/W2423300241","https://openalex.org/W2082803042"],"abstract_inverted_index":{"The":[0],"effect":[1],"of":[2,13,35,76,80],"cholestyramine":[3,40,69],"(4":[4],"g":[5],"qid":[6],"for":[7],"5":[8],"days)":[9],"on":[10],"the":[11,31,36,53,62,74],"kinetics":[12],"phenytoin":[14,29,55],"(400":[15],"mg":[16],"orally)":[17],"was":[18,42],"investigated":[19],"in":[20,47,61],"normal":[21],"subjects.":[22],"Apart":[23],"from":[24],"a":[25,48,77],"trend":[26],"toward":[27],"faster":[28],"absorption,":[30],"serum":[32,54],"level":[33],"profile":[34],"drug":[37],"during":[38],"concurrent":[39],"coadministration":[41],"similar":[43],"to":[44],"that":[45,68],"observed":[46],"control":[49],"session.":[50],"Areas":[51],"under":[52],"concentration":[56],"curves":[57],"were":[58],"virtually":[59],"identical":[60],"two":[63],"occasions.":[64],"It":[65],"is":[66],"concluded":[67],"does":[70],"not":[71],"significantly":[72],"affect":[73],"bioavailability":[75],"single":[78],"dose":[79],"phenytoin.":[81]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
