{"id":"https://openalex.org/W1990133720","doi":"https://doi.org/10.1016/j.mehy.2009.10.012","title":"How to protect the heart in septic shock: A hypothesis on the pathophysiology and treatment of septic heart failure","display_name":"How to protect the heart in septic shock: A hypothesis on the pathophysiology and treatment of septic heart failure","publication_year":2009,"publication_date":"2009-11-04","ids":{"openalex":"https://openalex.org/W1990133720","doi":"https://doi.org/10.1016/j.mehy.2009.10.012","mag":"1990133720","pmid":"https://pubmed.ncbi.nlm.nih.gov/19889504"},"language":"en","primary_location":{"id":"doi:10.1016/j.mehy.2009.10.012","doi":"https://doi.org/10.1016/j.mehy.2009.10.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mehy.2009.10.012","pdf_url":null,"source":{"id":"https://openalex.org/S27514295","display_name":"Medical Hypotheses","issn_l":"0306-9877","issn":["0306-9877","1532-2777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Hypotheses","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008707725","display_name":"Christian A. Schmittinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christian A. Schmittinger","raw_affiliation_strings":["Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014594180","display_name":"Bettina Wurzinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152535","display_name":"Krankenhaus der Barmherzigen Schwestern Ried","ror":"https://ror.org/03ah74403","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4387152535"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Bettina Wurzinger","raw_affiliation_strings":["Department of Anaesthesiology and Critical Care Medicine, Krankenhaus der Barmherzigen Schwestern, Ried im Innkreis, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology and Critical Care Medicine, Krankenhaus der Barmherzigen Schwestern, Ried im Innkreis, Austria","institution_ids":["https://openalex.org/I4387152535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000868887","display_name":"Martina Deutinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152535","display_name":"Krankenhaus der Barmherzigen Schwestern Ried","ror":"https://ror.org/03ah74403","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4387152535"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Martina Deutinger","raw_affiliation_strings":["Department of Anaesthesiology and Critical Care Medicine, Krankenhaus der Barmherzigen Schwestern, Ried im Innkreis, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology and Critical Care Medicine, Krankenhaus der Barmherzigen Schwestern, Ried im Innkreis, Austria","institution_ids":["https://openalex.org/I4387152535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071707224","display_name":"Christoph Wohlmuth","orcid":"https://orcid.org/0000-0002-3184-0980","observed_orcids":["https://orcid.org/0000-0002-3184-0980"]},"institutions":[{"id":"https://openalex.org/I4387152535","display_name":"Krankenhaus der Barmherzigen Schwestern Ried","ror":"https://ror.org/03ah74403","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4387152535"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christoph Wohlmuth","raw_affiliation_strings":["Department of Anaesthesiology and Critical Care Medicine, Krankenhaus der Barmherzigen Schwestern, Ried im Innkreis, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology and Critical Care Medicine, Krankenhaus der Barmherzigen Schwestern, Ried im Innkreis, Austria","institution_ids":["https://openalex.org/I4387152535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007099379","display_name":"Hans Knotzer","orcid":"https://orcid.org/0000-0003-0132-9994","observed_orcids":["https://orcid.org/0000-0003-0132-9994"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Hans Knotzer","raw_affiliation_strings":["Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113639353","display_name":"Christian Torgersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christian Torgersen","raw_affiliation_strings":["Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113192423","display_name":"Martin W. D\u00fcnser","orcid":"https://orcid.org/0000-0002-6406-0307","observed_orcids":["https://orcid.org/0000-0002-6406-0307"]},"institutions":[{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Martin W. D\u00fcnser","raw_affiliation_strings":["Department of Intensive Care Medicine, Inselspital, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care Medicine, Inselspital, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109967540","display_name":"Walter R. Hasibeder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152535","display_name":"Krankenhaus der Barmherzigen Schwestern Ried","ror":"https://ror.org/03ah74403","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4387152535"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Walter R. Hasibeder","raw_affiliation_strings":["Department of Anaesthesiology and Critical Care Medicine, Krankenhaus der Barmherzigen Schwestern, Ried im Innkreis, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology and Critical Care Medicine, Krankenhaus der Barmherzigen Schwestern, Ried im Innkreis, Austria","institution_ids":["https://openalex.org/I4387152535"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5109967540"],"corresponding_institution_ids":["https://openalex.org/I4387152535"],"apc_list":{"value":2820,"currency":"USD","value_usd":2820},"apc_paid":null,"fwci":2.3425,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.88378315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"74","issue":"3","first_page":"460","last_page":"465"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.5238999724388123,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.5238999724388123,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12082","display_name":"Takotsubo Cardiomyopathy and Associated Phenomena","score":0.4722000062465668,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.9860000014305115},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.9269999861717224},{"id":"https://openalex.org/keywords/myocardial-stunning","display_name":"myocardial stunning","score":0.8740000128746033},{"id":"https://openalex.org/keywords/left-ventricular-apical-ballooning","display_name":"left ventricular apical ballooning","score":0.8330000042915344},{"id":"https://openalex.org/keywords/takotsubo-cardiomyopathy","display_name":"takotsubo cardiomyopathy","score":0.9409999847412109},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9649999737739563},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6700000166893005},{"id":"https://openalex.org/keywords/calcium-handling","display_name":"calcium handling","score":0.878000020980835},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6800000071525574},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.5630000233650208},{"id":"https://openalex.org/keywords/circulatory-collapse","display_name":"cardiovascular collapse","score":0.5049999952316284},{"id":"https://openalex.org/keywords/sepsis-pathophysiology","display_name":"sepsis pathophysiology","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.9221341609954834},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.8028178811073303},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6381216049194336},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5761973261833191},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.5652884244918823},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.535769522190094},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.40634655952453613},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3696785867214203},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2414259910583496}],"mesh":[{"descriptor_ui":"D002316","descriptor_name":"Cardiotonic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.mehy.2009.10.012","doi":"https://doi.org/10.1016/j.mehy.2009.10.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mehy.2009.10.012","pdf_url":null,"source":{"id":"https://openalex.org/S27514295","display_name":"Medical Hypotheses","issn_l":"0306-9877","issn":["0306-9877","1532-2777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Hypotheses","raw_type":"journal-article"},{"id":"pmid:19889504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19889504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical hypotheses","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W63292209","https://openalex.org/W95901626","https://openalex.org/W1481030511","https://openalex.org/W1538681874","https://openalex.org/W1820594263","https://openalex.org/W1964171066","https://openalex.org/W1966738422","https://openalex.org/W1967069173","https://openalex.org/W1967522850","https://openalex.org/W1976880615","https://openalex.org/W1980037442","https://openalex.org/W1982654319","https://openalex.org/W1988397850","https://openalex.org/W1988555414","https://openalex.org/W1994053845","https://openalex.org/W1997195556","https://openalex.org/W1999092336","https://openalex.org/W2006287148","https://openalex.org/W2018524773","https://openalex.org/W2019606224","https://openalex.org/W2023582801","https://openalex.org/W2027694078","https://openalex.org/W2039096112","https://openalex.org/W2043513395","https://openalex.org/W2044606549","https://openalex.org/W2046425814","https://openalex.org/W2050266484","https://openalex.org/W2051476972","https://openalex.org/W2059130611","https://openalex.org/W2060858675","https://openalex.org/W2060924206","https://openalex.org/W2065334177","https://openalex.org/W2066551756","https://openalex.org/W2069398444","https://openalex.org/W2071882984","https://openalex.org/W2080591927","https://openalex.org/W2080744981","https://openalex.org/W2082439271","https://openalex.org/W2086076030","https://openalex.org/W2098518710","https://openalex.org/W2100683801","https://openalex.org/W2102662967","https://openalex.org/W2103053257","https://openalex.org/W2120872485","https://openalex.org/W2139813235","https://openalex.org/W2140486985","https://openalex.org/W2142798193","https://openalex.org/W2144400515","https://openalex.org/W2146592576","https://openalex.org/W2148740377","https://openalex.org/W2161607654","https://openalex.org/W2169682503","https://openalex.org/W2170438288","https://openalex.org/W2262126354","https://openalex.org/W2370305224","https://openalex.org/W2410519949","https://openalex.org/W4210974702"],"related_works":["https://openalex.org/W3031304433","https://openalex.org/W2038109494","https://openalex.org/W4401335133","https://openalex.org/W2072974485","https://openalex.org/W2995085325","https://openalex.org/W2104978347","https://openalex.org/W2136119774","https://openalex.org/W167683701","https://openalex.org/W2087246147","https://openalex.org/W3048701248"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}