{"id":"https://openalex.org/W1990128362","doi":"https://doi.org/10.1111/j.1365-2249.2008.03679.x","title":"The nexus between atopic disease and autoimmunity: a review of the epidemiological and mechanistic literature","display_name":"The nexus between atopic disease and autoimmunity: a review of the epidemiological and mechanistic literature","publication_year":2008,"publication_date":"2008-05-26","ids":{"openalex":"https://openalex.org/W1990128362","doi":"https://doi.org/10.1111/j.1365-2249.2008.03679.x","mag":"1990128362","pmid":"https://pubmed.ncbi.nlm.nih.gov/18505431"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2249.2008.03679.x","doi":"https://doi.org/10.1111/j.1365-2249.2008.03679.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.2008.03679.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2432093","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029312666","display_name":"Ronald L. Rabin","orcid":"https://orcid.org/0000-0003-3496-0504","observed_orcids":["https://orcid.org/0000-0003-3496-0504"]},"institutions":[{"id":"https://openalex.org/I1318287680","display_name":"Center for Biologics Evaluation and Research","ror":"https://ror.org/02nr3fr97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1318287680","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R L Rabin","raw_affiliation_strings":["Center for Biologics Evaluation and Research, USFDA, Bethesda, MD","Center for Biologics Evaluation and Research, USFDA, Bethesda, MD, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biologics Evaluation and Research, USFDA, Bethesda, MD","institution_ids":["https://openalex.org/I1318287680","https://openalex.org/I1320320070"]},{"raw_affiliation_string":"Center for Biologics Evaluation and Research, USFDA, Bethesda, MD, and","institution_ids":["https://openalex.org/I1318287680","https://openalex.org/I1320320070"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111624052","display_name":"Arnold I. Levinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A I Levinson","raw_affiliation_strings":["Pulmonary Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA","Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2894,"currency":"GBP","value_usd":3816},"apc_paid":null,"fwci":2.4205,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.88504403,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"153","issue":"1","first_page":"19","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.11909999698400497,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.09269999712705612,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atopy","display_name":"atopy","score":0.8679999709129333},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.7149999737739563},{"id":"https://openalex.org/keywords/allergic-diseases","display_name":"allergic diseases","score":0.7799999713897705},{"id":"https://openalex.org/keywords/th1-th2-balance","display_name":"Th1/Th2 balance","score":0.7760000228881836},{"id":"https://openalex.org/keywords/t-helper-cells","display_name":"T helper cells","score":0.7200000286102295},{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.7039999961853027},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":1.0},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":1.0},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9369999766349792},{"id":"https://openalex.org/keywords/immunoglobulin-e","display_name":"immunoglobulin E","score":0.796999990940094},{"id":"https://openalex.org/keywords/endotoxin-exposure","display_name":"endotoxin exposure","score":0.8230000138282776},{"id":"https://openalex.org/keywords/genetic-and-environmental-risk-factors","display_name":"genetic and environmental risk factors","score":0.7609999775886536},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7665451765060425},{"id":"https://openalex.org/C2777697326","wikidata":"https://www.wikidata.org/wiki/Q757678","display_name":"Atopy","level":3,"score":0.741791844367981},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.644349217414856},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.6363787055015564},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.540291965007782},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.5097584128379822},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.45251184701919556},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.45039787888526917},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.42530497908592224},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.42313140630722046},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2729564309120178},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14948517084121704},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.14035364985466003},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2249.2008.03679.x","doi":"https://doi.org/10.1111/j.1365-2249.2008.03679.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.2008.03679.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},{"id":"pmid:18505431","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18505431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2432093","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2432093","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2432093","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2432093","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":132,"referenced_works":["https://openalex.org/W47366420","https://openalex.org/W59631671","https://openalex.org/W160934395","https://openalex.org/W1487475526","https://openalex.org/W1492298001","https://openalex.org/W1499666021","https://openalex.org/W1568496347","https://openalex.org/W1598608638","https://openalex.org/W1598899303","https://openalex.org/W1644006106","https://openalex.org/W1677381867","https://openalex.org/W1773724118","https://openalex.org/W1967261754","https://openalex.org/W1968204922","https://openalex.org/W1968918322","https://openalex.org/W1971359978","https://openalex.org/W1974666828","https://openalex.org/W1975438745","https://openalex.org/W1976038358","https://openalex.org/W1978278739","https://openalex.org/W1980516444","https://openalex.org/W1981182186","https://openalex.org/W1984562943","https://openalex.org/W1985340642","https://openalex.org/W1990877529","https://openalex.org/W1997192647","https://openalex.org/W1997832617","https://openalex.org/W1998021069","https://openalex.org/W1999944301","https://openalex.org/W2001681412","https://openalex.org/W2004446552","https://openalex.org/W2006660236","https://openalex.org/W2007286155","https://openalex.org/W2008975391","https://openalex.org/W2011312724","https://openalex.org/W2011652507","https://openalex.org/W2014217048","https://openalex.org/W2015085911","https://openalex.org/W2020403641","https://openalex.org/W2022455780","https://openalex.org/W2029836713","https://openalex.org/W2032137791","https://openalex.org/W2035313919","https://openalex.org/W2037615827","https://openalex.org/W2037621319","https://openalex.org/W2037667024","https://openalex.org/W2040302922","https://openalex.org/W2041712515","https://openalex.org/W2042944593","https://openalex.org/W2042952724","https://openalex.org/W2045200013","https://openalex.org/W2046212715","https://openalex.org/W2046319977","https://openalex.org/W2048114019","https://openalex.org/W2048292780","https://openalex.org/W2048424415","https://openalex.org/W2051469534","https://openalex.org/W2052438488","https://openalex.org/W2057037962","https://openalex.org/W2057450814","https://openalex.org/W2058593261","https://openalex.org/W2059359671","https://openalex.org/W2061343675","https://openalex.org/W2063711312","https://openalex.org/W2065805602","https://openalex.org/W2068537045","https://openalex.org/W2068870295","https://openalex.org/W2072480829","https://openalex.org/W2074384884","https://openalex.org/W2076651424","https://openalex.org/W2081041392","https://openalex.org/W2081521873","https://openalex.org/W2082615180","https://openalex.org/W2085412596","https://openalex.org/W2089121737","https://openalex.org/W2092599690","https://openalex.org/W2095962660","https://openalex.org/W2099027783","https://openalex.org/W2103122550","https://openalex.org/W2104206929","https://openalex.org/W2107860814","https://openalex.org/W2108615089","https://openalex.org/W2109506765","https://openalex.org/W2110483876","https://openalex.org/W2112866067","https://openalex.org/W2114877336","https://openalex.org/W2119927797","https://openalex.org/W2120760544","https://openalex.org/W2122128999","https://openalex.org/W2125324778","https://openalex.org/W2126073991","https://openalex.org/W2128338782","https://openalex.org/W2128712834","https://openalex.org/W2130445686","https://openalex.org/W2131678280","https://openalex.org/W2134303810","https://openalex.org/W2135790224","https://openalex.org/W2136272619","https://openalex.org/W2136325849","https://openalex.org/W2138290476","https://openalex.org/W2140627356","https://openalex.org/W2140831471","https://openalex.org/W2141583404","https://openalex.org/W2142177598","https://openalex.org/W2143728771","https://openalex.org/W2144281476","https://openalex.org/W2145042499","https://openalex.org/W2152913934","https://openalex.org/W2155779547","https://openalex.org/W2156451877","https://openalex.org/W2160373918","https://openalex.org/W2161232010","https://openalex.org/W2162834686","https://openalex.org/W2166037275","https://openalex.org/W2166522697","https://openalex.org/W2168581900","https://openalex.org/W2169084332","https://openalex.org/W2182431289","https://openalex.org/W2332724447","https://openalex.org/W2396792352","https://openalex.org/W2411933722","https://openalex.org/W2412496605","https://openalex.org/W2412876320","https://openalex.org/W2416355830","https://openalex.org/W2594272597","https://openalex.org/W3145246212","https://openalex.org/W3208442724","https://openalex.org/W4229932900","https://openalex.org/W4313342416","https://openalex.org/W6629364244","https://openalex.org/W6638046866","https://openalex.org/W6685625336"],"related_works":["https://openalex.org/W2052261014","https://openalex.org/W2407394122","https://openalex.org/W2060792731","https://openalex.org/W804050744","https://openalex.org/W1970667451","https://openalex.org/W4381052852","https://openalex.org/W2142244649","https://openalex.org/W2129546463","https://openalex.org/W2089485974","https://openalex.org/W2059428590"],"abstract_inverted_index":{"There":[0],"has":[1,78],"been":[2],"considerable":[3],"interest":[4],"in":[5,17,61,181],"defining":[6],"the":[7,10,34,41,44,74,99,159,167,172,182,193,197],"relationship":[8],"between":[9,101],"expression":[11],"of":[12,19,36,43,47,63,73,121,129,161,174,184,186,217],"allergic":[13,29],"and":[14,89,98,103,140,163,176],"autoimmune":[15,24,48,133,224],"diseases":[16],"populations":[18],"patients.":[20],"Are":[21],"patients":[22],"with":[23,131,189],"disease":[25],"'protected'":[26],"from":[27],"developing":[28],"(immunoglobulin":[30],"E-mediated)":[31],"diseases?":[32,49],"Does":[33],"establishment":[35],"an":[37,70],"atopic":[38,64,226],"phenotype":[39],"reduce":[40],"risk":[42],"subsequent":[45],"development":[46,160],"Although":[50],"there":[51],"are":[52],"clinical":[53,122],"studies":[54],"addressing":[55],"this":[56,115],"question,":[57,116],"methodological":[58],"problems,":[59],"particularly":[60],"identification":[62],"subjects,":[65],"limits":[66],"their":[67],"usefulness.":[68],"Moreover,":[69],"immune-based":[71],"explanation":[72],"observed":[75],"epidemiological":[76],"findings":[77],"relied":[79],"on":[80],"a":[81,119,147],"paradigm":[82],"that":[83,124],"is":[84,200],"currently":[85],"undergoing":[86],"increased":[87],"scrutiny":[88],"modification":[90],"to":[91,192,201,211,222],"include":[92],"newly":[93],"defined":[94],"effector":[95],"cell":[96],"subsets":[97],"interaction":[100],"genetic":[102],"environmental":[104],"factors,":[105],"such":[106],"as":[107],"early":[108],"endotoxin":[109],"or":[110,127,203,213,225],"mycobacterial":[111],"exposure.":[112],"To":[113],"address":[114],"we":[117],"reviewed":[118],"series":[120],"reports":[123],"addressed":[125],"coincidence":[126],"co-prevalence":[128],"atopy":[130,164],"four":[132],"diseases:":[134],"psoriasis,":[135],"rheumatoid":[136],"arthritis,":[137],"multiple":[138],"sclerosis":[139],"type":[141,153],"I":[142],"diabetes":[143],"mellitus.":[144],"We":[145],"present":[146],"model":[148,180],"whereby":[149],"active":[150],"T":[151],"helper":[152],"1":[154],"(Th1)":[155],"inflammation":[156],"may":[157,165,209],"suppress":[158,166],"atopy,":[162],"severity":[168],"but":[169],"not":[170],"necessarily":[171],"onset":[173],"autoimmunity,":[175],"then":[177],"discuss":[178],"our":[179,207],"context":[183],"mechanisms":[185],"adaptive":[187],"immunity":[188],"particular":[190],"reference":[191],"Th1/Th2":[194],"paradigms.":[195],"Because":[196],"ultimate":[198],"goal":[199],"ameliorate":[202],"cure":[204],"these":[205],"diseases,":[206],"discussion":[208],"help":[210],"predict":[212],"interpret":[214],"unexpected":[215],"consequences":[216],"novel":[218],"therapeutic":[219],"agents":[220],"used":[221],"target":[223],"diseases.":[227]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
