{"id":"https://openalex.org/W1990124144","doi":"https://doi.org/10.1186/1471-213x-8-86","title":"An in vivo reporter of BMP signaling in organogenesis reveals targets in the developing kidney","display_name":"An in vivo reporter of BMP signaling in organogenesis reveals targets in the developing kidney","publication_year":2008,"publication_date":"2008-09-18","ids":{"openalex":"https://openalex.org/W1990124144","doi":"https://doi.org/10.1186/1471-213x-8-86","mag":"1990124144","pmid":"https://pubmed.ncbi.nlm.nih.gov/18801194","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2561030"},"language":"en","primary_location":{"id":"doi:10.1186/1471-213x-8-86","doi":"https://doi.org/10.1186/1471-213x-8-86","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-213x-8-86","pdf_url":"https://bmcdevbiol.biomedcentral.com/counter/pdf/10.1186/1471-213X-8-86","source":{"id":"https://openalex.org/S179646348","display_name":"BMC Developmental Biology","issn_l":"1471-213X","issn":["1471-213X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://bmcdevbiol.biomedcentral.com/counter/pdf/10.1186/1471-213X-8-86","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082609586","display_name":"Ulrika Blank","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146345","display_name":"Maine Medical Center Research Institute","ror":"https://ror.org/03d1wq758","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774","https://openalex.org/I4210146345"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ulrika Blank","raw_affiliation_strings":["Department of Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA. Blanku@mmc.org","Department of Molecular Medicine, Maine Medical Center Research Institute, Scarborough, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA. Blanku@mmc.org","institution_ids":["https://openalex.org/I4210146345"]},{"raw_affiliation_string":"Department of Molecular Medicine, Maine Medical Center Research Institute, Scarborough, USA","institution_ids":["https://openalex.org/I4210146345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014354186","display_name":"Marianne L. Seto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146345","display_name":"Maine Medical Center Research Institute","ror":"https://ror.org/03d1wq758","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774","https://openalex.org/I4210146345"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marianne L Seto","raw_affiliation_strings":["Department of Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME, 04074, USA","Department of Molecular Medicine, Maine Medical Center Research Institute, Scarborough, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME, 04074, USA","institution_ids":["https://openalex.org/I4210146345"]},{"raw_affiliation_string":"Department of Molecular Medicine, Maine Medical Center Research Institute, Scarborough, USA","institution_ids":["https://openalex.org/I4210146345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058929947","display_name":"Derek C. Adams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146345","display_name":"Maine Medical Center Research Institute","ror":"https://ror.org/03d1wq758","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774","https://openalex.org/I4210146345"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek C Adams","raw_affiliation_strings":["Department of Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME, 04074, USA","Department of Molecular Medicine, Maine Medical Center Research Institute, Scarborough, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME, 04074, USA","institution_ids":["https://openalex.org/I4210146345"]},{"raw_affiliation_string":"Department of Molecular Medicine, Maine Medical Center Research Institute, Scarborough, USA","institution_ids":["https://openalex.org/I4210146345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020130202","display_name":"Don M. Wojchowski","orcid":"https://orcid.org/0000-0002-0385-0284","observed_orcids":["https://orcid.org/0000-0002-0385-0284"]},"institutions":[{"id":"https://openalex.org/I4210146345","display_name":"Maine Medical Center Research Institute","ror":"https://ror.org/03d1wq758","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774","https://openalex.org/I4210146345"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Don M Wojchowski","raw_affiliation_strings":["Department of Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME, 04074, USA","Department of Molecular Medicine, Maine Medical Center Research Institute, Scarborough, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME, 04074, USA","institution_ids":["https://openalex.org/I4210146345"]},{"raw_affiliation_string":"Department of Molecular Medicine, Maine Medical Center Research Institute, Scarborough, USA","institution_ids":["https://openalex.org/I4210146345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055739299","display_name":"Michele J. Karolak","orcid":"https://orcid.org/0000-0001-8974-8215","observed_orcids":["https://orcid.org/0000-0001-8974-8215"]},"institutions":[{"id":"https://openalex.org/I4210146345","display_name":"Maine Medical Center Research Institute","ror":"https://ror.org/03d1wq758","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774","https://openalex.org/I4210146345"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michele J Karolak","raw_affiliation_strings":["Department of Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME, 04074, USA","Department of Molecular Medicine, Maine Medical Center Research Institute, Scarborough, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME, 04074, USA","institution_ids":["https://openalex.org/I4210146345"]},{"raw_affiliation_string":"Department of Molecular Medicine, Maine Medical Center Research Institute, Scarborough, USA","institution_ids":["https://openalex.org/I4210146345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014318244","display_name":"Leif H. Oxburgh","orcid":"https://orcid.org/0000-0002-2825-7663","observed_orcids":["https://orcid.org/0000-0002-2825-7663"]},"institutions":[{"id":"https://openalex.org/I4210146345","display_name":"Maine Medical Center Research Institute","ror":"https://ror.org/03d1wq758","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774","https://openalex.org/I4210146345"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leif Oxburgh","raw_affiliation_strings":["Department of Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME, 04074, USA","Department of Molecular Medicine, Maine Medical Center Research Institute, Scarborough, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME, 04074, USA","institution_ids":["https://openalex.org/I4210146345"]},{"raw_affiliation_string":"Department of Molecular Medicine, Maine Medical Center Research Institute, Scarborough, USA","institution_ids":["https://openalex.org/I4210146345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014318244"],"corresponding_institution_ids":["https://openalex.org/I4210146345"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":2.0262,"has_fulltext":true,"cited_by_count":65,"citation_normalized_percentile":{"value":0.85797944,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"86","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.5996000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.5996000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.22619999945163727,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.13729999959468842,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.8999999761581421},{"id":"https://openalex.org/keywords/kidney-development","display_name":"kidney development","score":0.6349999904632568},{"id":"https://openalex.org/keywords/transgenic-reporter","display_name":"transgenic reporter","score":0.8349999785423279},{"id":"https://openalex.org/keywords/id1","display_name":"Id1","score":0.8450000286102295},{"id":"https://openalex.org/keywords/nephron-progenitor-cells","display_name":"nephron progenitor cells","score":0.8479999899864197},{"id":"https://openalex.org/keywords/collecting-duct","display_name":"collecting duct","score":0.8090000152587891},{"id":"https://openalex.org/keywords/glomerular-endothelial-cells","display_name":"glomerular endothelial cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/nephrogenic-zone","display_name":"nephrogenic zone","score":0.828000009059906},{"id":"https://openalex.org/keywords/organogenesis","display_name":"organogenesis","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7415886521339417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7242042422294617},{"id":"https://openalex.org/C2781231759","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Nephron","level":3,"score":0.6051365733146667},{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.5825462341308594},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.5736067891120911},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.49342647194862366},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.45182132720947266},{"id":"https://openalex.org/C30503417","wikidata":"https://www.wikidata.org/wiki/Q958938","display_name":"Organogenesis","level":3,"score":0.41079920530319214},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.34868326783180237},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3328237533569336},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16948023438453674},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07362726330757141},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D038081","descriptor_name":"Organogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051898","descriptor_name":"Smad1 Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051898","descriptor_name":"Smad1 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051902","descriptor_name":"Smad5 Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051902","descriptor_name":"Smad5 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051904","descriptor_name":"Smad8 Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051904","descriptor_name":"Smad8 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-213x-8-86","doi":"https://doi.org/10.1186/1471-213x-8-86","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-213x-8-86","pdf_url":"https://bmcdevbiol.biomedcentral.com/counter/pdf/10.1186/1471-213X-8-86","source":{"id":"https://openalex.org/S179646348","display_name":"BMC Developmental Biology","issn_l":"1471-213X","issn":["1471-213X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Developmental Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2561030","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2561030","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Dev Biol","raw_type":"Text"},{"id":"pmid:18801194","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18801194","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC developmental biology","raw_type":"Comparative Study"},{"id":"pmh:oai:doaj.org/article:6471201667b147cfa0418ea561232042","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6471201667b147cfa0418ea561232042","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Developmental Biology, Vol 8, Iss 1, p 86 (2008)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-213x-8-86","doi":"https://doi.org/10.1186/1471-213x-8-86","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-213x-8-86","pdf_url":"https://bmcdevbiol.biomedcentral.com/counter/pdf/10.1186/1471-213X-8-86","source":{"id":"https://openalex.org/S179646348","display_name":"BMC Developmental Biology","issn_l":"1471-213X","issn":["1471-213X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3972990261","display_name":"Defining the progenitor cell niche of the developing kidney","funder_award_id":"R01DK078161","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4359693856","display_name":"Helicobacter hepaticus induced typhlitis","funder_award_id":"K01RR018798","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G65068198","display_name":null,"funder_award_id":"2P20 RR18798-06","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320310896","display_name":"Maine Medical Center Research Institute","ror":"https://ror.org/03d1wq758"},{"id":"https://openalex.org/F4320315060","display_name":"Wenner-Gren Stiftelserna","ror":"https://ror.org/033b0v780"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990124144.pdf","grobid_xml":"https://content.openalex.org/works/W1990124144.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W1851488602","https://openalex.org/W1937940610","https://openalex.org/W1967051300","https://openalex.org/W1970122794","https://openalex.org/W1975792673","https://openalex.org/W1976213734","https://openalex.org/W1976529648","https://openalex.org/W1980989951","https://openalex.org/W1981702146","https://openalex.org/W1983091844","https://openalex.org/W1986595328","https://openalex.org/W1989794180","https://openalex.org/W1991156103","https://openalex.org/W1992618022","https://openalex.org/W1992949513","https://openalex.org/W1994678646","https://openalex.org/W1995060691","https://openalex.org/W1996760543","https://openalex.org/W1998911240","https://openalex.org/W2003561988","https://openalex.org/W2005740605","https://openalex.org/W2005883936","https://openalex.org/W2010011163","https://openalex.org/W2011002905","https://openalex.org/W2016637403","https://openalex.org/W2017685034","https://openalex.org/W2024215958","https://openalex.org/W2025087506","https://openalex.org/W2025921655","https://openalex.org/W2026436579","https://openalex.org/W2033759169","https://openalex.org/W2036401671","https://openalex.org/W2038629624","https://openalex.org/W2041745288","https://openalex.org/W2045308252","https://openalex.org/W2047244839","https://openalex.org/W2052128821","https://openalex.org/W2053682193","https://openalex.org/W2056731837","https://openalex.org/W2067595882","https://openalex.org/W2069879597","https://openalex.org/W2074892771","https://openalex.org/W2076754935","https://openalex.org/W2081153570","https://openalex.org/W2089953630","https://openalex.org/W2093316809","https://openalex.org/W2098278242","https://openalex.org/W2098944834","https://openalex.org/W2099471848","https://openalex.org/W2102636621","https://openalex.org/W2103031848","https://openalex.org/W2106384420","https://openalex.org/W2107394952","https://openalex.org/W2113631993","https://openalex.org/W2114245705","https://openalex.org/W2120045068","https://openalex.org/W2124415162","https://openalex.org/W2124938985","https://openalex.org/W2138562294","https://openalex.org/W2139470337","https://openalex.org/W2142325605","https://openalex.org/W2144634347","https://openalex.org/W2151214732","https://openalex.org/W2151349025","https://openalex.org/W2158847377","https://openalex.org/W2162238950","https://openalex.org/W2165213969","https://openalex.org/W2165857084","https://openalex.org/W2166012778","https://openalex.org/W2166792046","https://openalex.org/W2166920557","https://openalex.org/W2167589429","https://openalex.org/W2171539702","https://openalex.org/W2189624263","https://openalex.org/W2314225431","https://openalex.org/W4235438234"],"related_works":["https://openalex.org/W2070562593","https://openalex.org/W4232171333","https://openalex.org/W2076381257","https://openalex.org/W2437953044","https://openalex.org/W2001097889","https://openalex.org/W2222593384","https://openalex.org/W3028941627","https://openalex.org/W1971144486","https://openalex.org/W1985007684","https://openalex.org/W2166792046"],"abstract_inverted_index":{"BACKGROUND:":[0],"Bone":[1],"morphogenetic":[2],"proteins":[3,17],"(BMPs)":[4],"regulate":[5],"essential":[6],"processes":[7],"during":[8],"organogenesis,":[9],"and":[10,126,151,197,218,245,297],"a":[11,30,93,228,283],"functional":[12],"understanding":[13],"of":[14,21,65,96,99,148,203,213,290],"these":[15,88,247],"secreted":[16],"depends":[18],"on":[19,52,293],"identification":[20],"their":[22],"target":[23],"cells.":[24,167],"In":[25,168],"this":[26],"study,":[27],"we":[28,37,90,230,258],"generate":[29],"transgenic":[31],"reporter":[32],"for":[33,77,201,211,286],"organogenesis":[34],"studies":[35,202],"that":[36,108,235,246,260,273],"use":[38],"to":[39,158,223,251],"define":[40],"BMP":[41,53,66,100,111,155,162,186,204,214,238,262,280,291],"pathway":[42,54,78,137,205,263],"activation":[43,55,79,141,252],"in":[44,80,102,115,144,152,164,174,195,216,242,268],"the":[45,63,85,103,131,145,149,232,261,287],"developing":[46,104],"kidney.":[47,105],"RESULTS:":[48],"Mouse":[49],"strains":[50],"reporting":[51],"were":[56],"generated":[57,92],"by":[58,182,253,279],"transgenically":[59],"expressing":[60],"beta-galactosidase":[61],"under":[62],"control":[64,183],"responsive":[67,187],"elements":[68,184],"from":[69,130,185],"Id1.":[70],"Reporter":[71],"expression":[72],"corresponds":[73],"well":[74],"with":[75],"immunoassays":[76],"all":[81],"organs":[82],"studied,":[83],"validating":[84],"model.":[86],"Using":[87,226],"reporters":[89,180],"have":[91],"detailed":[94],"map":[95],"cellular":[97],"targets":[98],"signaling":[101,112,163,170,215,239],"We":[106],"find":[107,259],"SMAD":[109,160,236],"dependent":[110,161,237],"is":[113,142,171,240,264],"active":[114,267],"collecting":[116,175,269,294],"duct":[117,176,270,295],"trunks,":[118],"but":[119,272],"not":[120,265],"tips.":[121,177],"Furthermore,":[122,257],"glomerular":[123],"endothelial":[124],"cells,":[125],"proximal":[127],"nephron":[128,165,243],"tubules":[129],"renal":[132],"vesicle":[133],"stage":[134],"onward":[135],"show":[136],"activation.":[138,206],"Surprisingly,":[139],"little":[140],"detected":[143],"nephrogenic":[146],"zone":[147],"kidney,":[150],"organ":[153,217],"culture":[154],"treatment":[156,292],"fails":[157],"activate":[159],"progenitor":[166],"contrast,":[169],"efficiently":[172],"induced":[173],"CONCLUSION:":[178],"Transgenic":[179],"driven":[181],"genes":[188],"such":[189,227],"as":[190],"Id1":[191],"offer":[192],"significant":[193],"advantages":[194],"sensitivity":[196],"consistency":[198],"over":[199],"immunostaining":[200],"They":[207],"also":[208],"provide":[209],"opportunities":[210],"analysis":[212],"primary":[219],"cell":[220],"cultures":[221],"subjected":[222],"experimental":[224],"manipulation.":[225],"reporter,":[229],"made":[231],"surprising":[233],"finding":[234],"inactive":[241],"progenitors,":[244],"cells":[248],"are":[249],"refractory":[250],"applied":[254],"growth":[255,296],"factors.":[256],"normally":[266],"tips,":[271],"it":[274],"can":[275],"be":[276],"ectopically":[277],"activated":[278],"treatment,":[281],"offering":[282],"possible":[284],"explanation":[285],"inhibitory":[288],"effects":[289],"branching.":[298]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
