{"id":"https://openalex.org/W1990123939","doi":"https://doi.org/10.1074/jbc.273.37.23837","title":"Hypoxia-inducible Mammalian Gene Expression Analyzed in Vivo at a TATA-driven Promoter and at an Initiator-driven Promoter","display_name":"Hypoxia-inducible Mammalian Gene Expression Analyzed in Vivo at a TATA-driven Promoter and at an Initiator-driven Promoter","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W1990123939","doi":"https://doi.org/10.1074/jbc.273.37.23837","mag":"1990123939","pmid":"https://pubmed.ncbi.nlm.nih.gov/9726995"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.273.37.23837","doi":"https://doi.org/10.1074/jbc.273.37.23837","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.37.23837","pdf_url":"http://www.jbc.org/article/S0021925819602139/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819602139/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027705783","display_name":"Steven T. Okino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven T. Okino","raw_affiliation_strings":["Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305-5332, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305-5332, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083060099","display_name":"Christine H. Chichester","orcid":"https://orcid.org/0000-0001-6818-334X","observed_orcids":["https://orcid.org/0000-0001-6818-334X"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine H. Chichester","raw_affiliation_strings":["Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305-5332","From the Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305-5332"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305-5332","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"From the Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305-5332","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112727836","display_name":"James P. Whitlock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James P. Whitlock","raw_affiliation_strings":["Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305-5332","From the Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305-5332"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305-5332","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"From the Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305-5332","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112727836"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.5449,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.62743956,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"273","issue":"37","first_page":"23837","last_page":"23843"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.6470000147819519,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.6470000147819519,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.32010000944137573,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia-inducible-genes","display_name":"hypoxia-responsive genes","score":0.8550000190734863},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1","display_name":"HIF-1","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tata-box","display_name":"TATA box","score":0.7580000162124634},{"id":"https://openalex.org/keywords/initiator-element","display_name":"initiator element","score":0.9259999990463257},{"id":"https://openalex.org/keywords/pgk1","display_name":"PGK1","score":0.8180000185966492},{"id":"https://openalex.org/keywords/glucose-transporter-1","display_name":"glucose transporter 1","score":0.8820000290870667},{"id":"https://openalex.org/keywords/protein-dna-interactions","display_name":"protein-DNA interactions","score":0.7599999904632568},{"id":"https://openalex.org/keywords/transcription-factor-binding-sites","display_name":"transcription factor binding sites","score":0.628000020980835},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.8700000047683716},{"id":"https://openalex.org/keywords/tfiid","display_name":"TFIID","score":0.828000009059906},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor-nuclear-translocator","display_name":"ARNT","score":0.6299999952316284},{"id":"https://openalex.org/keywords/hepatoma-cells","display_name":"hepatoma cells","score":0.8100000023841858},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.6552332639694214},{"id":"https://openalex.org/C65888428","wikidata":"https://www.wikidata.org/wiki/Q1413955","display_name":"TATA box","level":5,"score":0.6457242369651794},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5448760986328125},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5317584276199341},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5165061354637146},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.49750879406929016},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.49460622668266296},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.47880277037620544},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4489249885082245},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39257538318634033},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3725852370262146},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3107583224773407},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.13769951462745667},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009004","descriptor_name":"Monosaccharide Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010735","descriptor_name":"Phosphoglycerate Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016385","descriptor_name":"TATA Box","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051272","descriptor_name":"Glucose Transporter Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051784","descriptor_name":"Aryl Hydrocarbon Receptor Nuclear Translocator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.273.37.23837","doi":"https://doi.org/10.1074/jbc.273.37.23837","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.37.23837","pdf_url":"http://www.jbc.org/article/S0021925819602139/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9726995","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9726995","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.273.37.23837","doi":"https://doi.org/10.1074/jbc.273.37.23837","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.37.23837","pdf_url":"http://www.jbc.org/article/S0021925819602139/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5810157261","display_name":null,"funder_award_id":"ES 05677","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G5873118749","display_name":"DIFFERENTIAL RESPONSIVENESS TO DIOXIN--ALDH VS CYP1A1","funder_award_id":"F32ES005677","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6216579798","display_name":null,"funder_award_id":"ES 08655","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6362790579","display_name":"ADAPTATION TO ENVIRONMENTAL STRESS--MECHANISTIC ANALYSES","funder_award_id":"R01ES008655","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990123939.pdf","grobid_xml":"https://content.openalex.org/works/W1990123939.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1264979566","https://openalex.org/W1483725891","https://openalex.org/W1485553398","https://openalex.org/W1486593521","https://openalex.org/W1503667331","https://openalex.org/W1542868541","https://openalex.org/W1598551221","https://openalex.org/W1721827275","https://openalex.org/W1826000501","https://openalex.org/W1860035717","https://openalex.org/W1876406296","https://openalex.org/W1884481283","https://openalex.org/W1917226777","https://openalex.org/W1968087152","https://openalex.org/W1972805802","https://openalex.org/W1973912514","https://openalex.org/W1975545468","https://openalex.org/W1978198515","https://openalex.org/W1984604224","https://openalex.org/W1990260467","https://openalex.org/W1991843895","https://openalex.org/W1996454474","https://openalex.org/W2000699462","https://openalex.org/W2005233776","https://openalex.org/W2006322387","https://openalex.org/W2010394923","https://openalex.org/W2017133589","https://openalex.org/W2032864324","https://openalex.org/W2034822725","https://openalex.org/W2035797443","https://openalex.org/W2043625689","https://openalex.org/W2056103475","https://openalex.org/W2070216704","https://openalex.org/W2075570601","https://openalex.org/W2075763636","https://openalex.org/W2077714606","https://openalex.org/W2078281286","https://openalex.org/W2082584138","https://openalex.org/W2090641061","https://openalex.org/W2090939833","https://openalex.org/W2098919421","https://openalex.org/W2098972920","https://openalex.org/W2100326496","https://openalex.org/W2107867483","https://openalex.org/W2126180229","https://openalex.org/W2129185784","https://openalex.org/W2133972226","https://openalex.org/W2138033100","https://openalex.org/W2138214907","https://openalex.org/W2144515939","https://openalex.org/W2146909058","https://openalex.org/W2149751735","https://openalex.org/W2158196806","https://openalex.org/W2160806267","https://openalex.org/W2165426283","https://openalex.org/W2166010700","https://openalex.org/W2169539585","https://openalex.org/W2314225431"],"related_works":["https://openalex.org/W2000699462","https://openalex.org/W2940119820","https://openalex.org/W2057559671","https://openalex.org/W2037034010","https://openalex.org/W2030384820","https://openalex.org/W2786306330","https://openalex.org/W2183702354","https://openalex.org/W2111983416","https://openalex.org/W4200182500","https://openalex.org/W2050442786"],"abstract_inverted_index":{"We":[0,140],"have":[1],"analyzed":[2],"protein-DNA":[3,103],"interactions":[4],"in":[5,15,109,123,131,147],"vivo":[6],"at":[7,105,203],"transcriptional":[8],"control":[9],"elements":[10],"for":[11,21,39,64,95,144,178],"two":[12],"hypoxia-inducible":[13,65],"genes":[14,181],"mouse":[16],"hepatoma":[17],"cells.":[18,114],"The":[19,74,85,115],"promoter":[20,38,87,117],"the":[22,37,40,79,106,125,156,176],"phosphoglycerate":[23],"kinase":[24],"1":[25,43,67],"(PGK1)":[26],"gene":[27,45,158],"contains":[28,46],"an":[29,96,184],"initiator":[30,52,107],"element,":[31,108],"but":[32,50],"no":[33,51,102,142],"TATA":[34,48,126,169],"sequence,":[35],"whereas":[36],"glucose":[41],"transporter":[42],"(Glut1)":[44],"a":[47,92,160,197],"element":[49,127,170],"sequence.":[53],"Our":[54,172],"findings":[55,173],"reveal":[56,159],"hypoxia-inducible,":[57],"Arnt-dependent":[58],"occupancy":[59,90,130,136,164],"of":[60,70,91,150,155,165],"DNA":[61],"recognition":[62,76,81],"sites":[63,82,167],"factor":[66],"(HIF-1)":[68],"upstream":[69],"both":[71,179,204],"target":[72],"genes.":[73],"conserved":[75],"motif":[77],"among":[78],"five":[80],"is":[83],"5'-CGTG-3'.":[84],"PGK1":[86],"exhibits":[88,119,128],"constitutive":[89,120],"binding":[93],"site":[94],"unknown":[97],"protein(s);":[98],"however,":[99],"we":[100],"detect":[101],"interaction":[104],"either":[110,151],"uninduced":[111,132],"or":[112],"induced":[113],"Glut1":[116,157],"also":[118],"protein":[121],"binding;":[122],"addition,":[124],"partial":[129],"cells":[133],"and":[134,168,188],"increased":[135],"under":[137],"hypoxic":[138],"conditions.":[139],"find":[141],"evidence":[143],"hypoxia-induced":[145],"changes":[146],"chromatin":[148,186],"structure":[149],"gene.":[152],"Time-course":[153],"analyses":[154],"temporal":[161],"relationship":[162],"between":[163],"HIF-1":[166,190],"occupancy.":[171],"suggest":[174],"that":[175,189],"promoters":[177],"hypoxia-responsive":[180],"constitutively":[182],"maintain":[183],"accessible":[185],"configuration":[187],"facilitates":[191],"transcription":[192,198],"by":[193],"recruiting":[194],"and/or":[195],"stabilizing":[196],"factor(s),":[199],"such":[200],"as":[201],"TFIID,":[202],"promoters.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}