{"id":"https://openalex.org/W1990108113","doi":"https://doi.org/10.1055/s-1999-14060","title":"Hypotensive, Hypoglycaemic and Toxicological Studies on the Flavonol C-Glycoside Shamimin from Bombax ceiba","display_name":"Hypotensive, Hypoglycaemic and Toxicological Studies on the Flavonol C-Glycoside Shamimin from Bombax ceiba","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W1990108113","doi":"https://doi.org/10.1055/s-1999-14060","mag":"1990108113","pmid":"https://pubmed.ncbi.nlm.nih.gov/10364838"},"language":"en","primary_location":{"id":"doi:10.1055/s-1999-14060","doi":"https://doi.org/10.1055/s-1999-14060","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-1999-14060","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001413544","display_name":"Rubeena Saleem","orcid":"https://orcid.org/0000-0002-8531-0387","observed_orcids":["https://orcid.org/0000-0002-8531-0387"]},"institutions":[{"id":"https://openalex.org/I191365509","display_name":"Hamdard University","ror":"https://ror.org/01zrv0z61","country_code":"PK","type":"education","lineage":["https://openalex.org/I191365509"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Rubeena Saleem","raw_affiliation_strings":["Dr. H. M. I. Institute of Pharmacology and Herbal Sciences, Hamdard University, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. H. M. I. Institute of Pharmacology and Herbal Sciences, Hamdard University, Karachi, Pakistan","institution_ids":["https://openalex.org/I191365509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028019186","display_name":"Mohammad Ahmad","orcid":"https://orcid.org/0000-0003-1228-4445","observed_orcids":["https://orcid.org/0000-0003-1228-4445","https://orcid.org/0000-0002-4714-0102"]},"institutions":[{"id":"https://openalex.org/I191365509","display_name":"Hamdard University","ror":"https://ror.org/01zrv0z61","country_code":"PK","type":"education","lineage":["https://openalex.org/I191365509"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Mohammad Ahmad","raw_affiliation_strings":["Dr. H. M. I. Institute of Pharmacology and Herbal Sciences, \nHamdard University, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. H. M. I. Institute of Pharmacology and Herbal Sciences, \nHamdard University, Karachi, Pakistan","institution_ids":["https://openalex.org/I191365509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033963863","display_name":"Syed Ahmed Hussain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191365509","display_name":"Hamdard University","ror":"https://ror.org/01zrv0z61","country_code":"PK","type":"education","lineage":["https://openalex.org/I191365509"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Syed Ahmed Hussain","raw_affiliation_strings":["Dr. H. M. I. Institute of Pharmacology and Herbal Sciences, \nHamdard University, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. H. M. I. Institute of Pharmacology and Herbal Sciences, \nHamdard University, Karachi, Pakistan","institution_ids":["https://openalex.org/I191365509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042015193","display_name":"Aamer Mahmood Qazi","orcid":"https://orcid.org/0000-0003-0425-4246","observed_orcids":["https://orcid.org/0000-0003-0425-4246"]},"institutions":[{"id":"https://openalex.org/I191365509","display_name":"Hamdard University","ror":"https://ror.org/01zrv0z61","country_code":"PK","type":"education","lineage":["https://openalex.org/I191365509"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Aamer Mahmood Qazi","raw_affiliation_strings":["Dr. H. M. I. Institute of Pharmacology and Herbal Sciences, \nHamdard University, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. H. M. I. Institute of Pharmacology and Herbal Sciences, \nHamdard University, Karachi, Pakistan","institution_ids":["https://openalex.org/I191365509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113853670","display_name":"Syed Iqbal Ahmad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191365509","display_name":"Hamdard University","ror":"https://ror.org/01zrv0z61","country_code":"PK","type":"education","lineage":["https://openalex.org/I191365509"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Syed Iqbal Ahmad","raw_affiliation_strings":["Dr. H. M. I. Institute of Pharmacology and Herbal Sciences, \nHamdard University, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. H. M. I. Institute of Pharmacology and Herbal Sciences, \nHamdard University, Karachi, Pakistan","institution_ids":["https://openalex.org/I191365509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109142462","display_name":"Mahmood Husain Qazi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191365509","display_name":"Hamdard University","ror":"https://ror.org/01zrv0z61","country_code":"PK","type":"education","lineage":["https://openalex.org/I191365509"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Mahmood Hussain Qazi","raw_affiliation_strings":["Dr. H. M. I. Institute of Pharmacology and Herbal Sciences, \nHamdard University, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. H. M. I. Institute of Pharmacology and Herbal Sciences, \nHamdard University, Karachi, Pakistan","institution_ids":["https://openalex.org/I191365509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023048006","display_name":"Muhammad Ali","orcid":"https://orcid.org/0000-0002-5861-1993","observed_orcids":["https://orcid.org/0000-0002-5861-1993","https://orcid.org/0000-0002-2339-2364","https://orcid.org/0009-0002-7593-0395","https://orcid.org/0009-0007-9635-6341"]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Ali","raw_affiliation_strings":["H.E.J. Research Institute of Chemistry, University of Karachi, \nKarachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H.E.J. Research Institute of Chemistry, University of Karachi, \nKarachi, Pakistan","institution_ids":["https://openalex.org/I193670377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079121543","display_name":"Shaheen Faizi","orcid":"https://orcid.org/0000-0003-1743-051X","observed_orcids":["https://orcid.org/0000-0003-1743-051X"]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Shaheen Faizi","raw_affiliation_strings":["H.E.J. Research Institute of Chemistry, University of Karachi, \nKarachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H.E.J. Research Institute of Chemistry, University of Karachi, \nKarachi, Pakistan","institution_ids":["https://openalex.org/I193670377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049737290","display_name":"Shamim Akhtar","orcid":"https://orcid.org/0000-0002-3014-6030","observed_orcids":["https://orcid.org/0000-0002-3014-6030"]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Shamim Akhtar","raw_affiliation_strings":["VGV;Department of Biochemistry, University of Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VGV;Department of Biochemistry, University of Karachi, Pakistan","institution_ids":["https://openalex.org/I193670377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001344616","display_name":"Syed Nazrul Husnain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Syed Nazrul Husnain","raw_affiliation_strings":["VGV;Department of Biochemistry, University of Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VGV;Department of Biochemistry, University of Karachi, Pakistan","institution_ids":["https://openalex.org/I193670377"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.977,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.79200363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"65","issue":"4","first_page":"331","last_page":"334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.23849999904632568,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.23849999904632568,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.20020000636577606,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.16040000319480896,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bombax-ceiba","display_name":"Bombax ceiba","score":0.9620000123977661},{"id":"https://openalex.org/keywords/antihypertensive-effect","display_name":"antihypertensive effect","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hypoglycemic-activity","display_name":"hypoglycemic activity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/toxicity","display_name":"toxicity","score":0.5820000171661377},{"id":"https://openalex.org/keywords/leaf-extract","display_name":"leaf extract","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2778228072","wikidata":"https://www.wikidata.org/wiki/Q284019","display_name":"Ceiba","level":2,"score":0.8213411569595337},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.7530406713485718},{"id":"https://openalex.org/C194671627","wikidata":"https://www.wikidata.org/wiki/Q192639","display_name":"Glycoside","level":2,"score":0.743197500705719},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.6035172939300537},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.4638547897338867},{"id":"https://openalex.org/C167552308","wikidata":"https://www.wikidata.org/wiki/Q711849","display_name":"Median lethal dose","level":3,"score":0.46165525913238525},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4278397560119629},{"id":"https://openalex.org/C2993907526","wikidata":"https://www.wikidata.org/wiki/Q1259977","display_name":"Aqueous extract","level":2,"score":0.42723405361175537},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41766947507858276},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4065616726875305},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.3772585391998291},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.3060968518257141},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2727632224559784},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18277552723884583},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.125300794839859},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.09063926339149475},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08951833844184875},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010944","descriptor_name":"Plants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-1999-14060","doi":"https://doi.org/10.1055/s-1999-14060","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-1999-14060","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},{"id":"pmid:10364838","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10364838","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta medica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1981405504","https://openalex.org/W2336588081","https://openalex.org/W2122744265","https://openalex.org/W4304890266","https://openalex.org/W7217226311","https://openalex.org/W4401155044","https://openalex.org/W2776594254","https://openalex.org/W4396782641","https://openalex.org/W2965405530","https://openalex.org/W204474539"],"abstract_inverted_index":{"Shamimin,":[0],"a":[1,12,59],"C-flavonol":[2],"glucoside":[3],"from":[4],"Bombax":[5,67],"ceiba":[6,68],"leaves":[7,69],"showed":[8],"significant":[9,26],"potency":[10],"as":[11],"hypotensive":[13],"agent":[14],"at":[15,29,47],"the":[16,48],"doses":[17],"of":[18,50,66,72],"15":[19],"mg/kg,":[20,22],"3":[21],"1":[23,51],"mg/kg":[24,31,57],"and":[25,63,70,80],"hypoglycaemic":[27],"activity":[28],"500":[30,56],"in":[32,45,54],"Sprague-Dawley":[33],"rats.":[34],"Further":[35],"studies":[36],"revealed":[37],"that":[38],"it":[39],"did":[40],"not":[41],"cause":[42],"any":[43],"mortality":[44],"mice":[46],"dose":[49],"g/kg":[52],"but":[53],"rats":[55],"is":[58],"lethal":[60],"dose.":[61],"Aqueous":[62],"methanolic":[64],"extracts":[65],"one":[71],"its":[73],"fractions":[74],"were":[75],"also":[76],"subjected":[77],"to":[78],"pharmacological":[79],"toxicological":[81],"screening.":[82]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}