{"id":"https://openalex.org/W1990100231","doi":"https://doi.org/10.1002/1097-0231(20000930)14:18<1682::aid-rcm78>3.0.co;2-e","title":"Chip-based capillary electrophoresis with an electrodeless nanospray interface","display_name":"Chip-based capillary electrophoresis with an electrodeless nanospray interface","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W1990100231","doi":"https://doi.org/10.1002/1097-0231(20000930)14:18<1682::aid-rcm78>3.0.co;2-e","mag":"1990100231","pmid":"https://pubmed.ncbi.nlm.nih.gov/10962491"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0231(20000930)14:18<1682::aid-rcm78>3.0.co;2-e","doi":"https://doi.org/10.1002/1097-0231(20000930)14:18<1682::aid-rcm78>3.0.co;2-e","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0231(20000930)14:18<1682::aid-rcm78>3.0.co;2-e","pdf_url":null,"source":{"id":"https://openalex.org/S89689683","display_name":"Rapid Communications in Mass Spectrometry","issn_l":"0951-4198","issn":["0951-4198","1097-0231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rapid Communications in Mass Spectrometry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070725681","display_name":"Elwin X. Vrouwe","orcid":"https://orcid.org/0000-0003-3287-3466","observed_orcids":["https://orcid.org/0000-0003-3287-3466"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Elwin X. Vrouwe","raw_affiliation_strings":["Department of Analytical Chemistry, Leiden/Amsterdam Center for Drug Research, Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytical Chemistry, Leiden/Amsterdam Center for Drug Research, Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039683431","display_name":"Jens Gysler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jens Gysler","raw_affiliation_strings":["Department of Analytical Chemistry, Leiden/Amsterdam Center for Drug Research, Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytical Chemistry, Leiden/Amsterdam Center for Drug Research, Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089209206","display_name":"Ubbo R. Tjaden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Ubbo R. Tjaden","raw_affiliation_strings":["Department of Analytical Chemistry, Leiden/Amsterdam Center for Drug Research, Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytical Chemistry, Leiden/Amsterdam Center for Drug Research, Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038766778","display_name":"J. van der Greef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan van der Greef","raw_affiliation_strings":["Department of Analytical Chemistry, Leiden/Amsterdam Center for Drug Research, Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytical Chemistry, Leiden/Amsterdam Center for Drug Research, Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089209206"],"corresponding_institution_ids":["https://openalex.org/I121797337"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":3.8256,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.92731691,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"14","issue":"18","first_page":"1682","last_page":"1688"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.0786999985575676,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12776","display_name":"Electrohydrodynamics and Fluid Dynamics","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ammonium-acetate-buffer","display_name":"ammonium acetate buffer","score":0.7020000219345093},{"id":"https://openalex.org/keywords/beta-adrenergic-agonists","display_name":"beta-adrenergic agonists","score":0.8539999723434448},{"id":"https://openalex.org/keywords/mass-spectrometry-interface","display_name":"mass spectrometry interface","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2900643","wikidata":"https://www.wikidata.org/wiki/Q747468","display_name":"Capillary electrophoresis","level":2,"score":0.8486005067825317},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7993386387825012},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.6599123477935791},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.5438556671142578},{"id":"https://openalex.org/C196806460","wikidata":"https://www.wikidata.org/wiki/Q188603","display_name":"Capillary action","level":2,"score":0.5407947897911072},{"id":"https://openalex.org/C40250595","wikidata":"https://www.wikidata.org/wiki/Q185098","display_name":"Electrophoresis","level":2,"score":0.5359293818473816},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5322824716567993},{"id":"https://openalex.org/C194451485","wikidata":"https://www.wikidata.org/wiki/Q1327575","display_name":"Electrospray","level":3,"score":0.5156899690628052},{"id":"https://openalex.org/C46918542","wikidata":"https://www.wikidata.org/wiki/Q1648344","display_name":"Common emitter","level":2,"score":0.44079434871673584},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.38614344596862793},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.2174813151359558},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.11328154802322388},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.09269058704376221},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0629701018333435},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005280","descriptor_name":"Fenoterol","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008904","descriptor_name":"Miniaturization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009388","descriptor_name":"Neostigmine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019075","descriptor_name":"Electrophoresis, Capillary","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/1097-0231(20000930)14:18<1682::aid-rcm78>3.0.co;2-e","doi":"https://doi.org/10.1002/1097-0231(20000930)14:18<1682::aid-rcm78>3.0.co;2-e","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0231(20000930)14:18<1682::aid-rcm78>3.0.co;2-e","pdf_url":null,"source":{"id":"https://openalex.org/S89689683","display_name":"Rapid Communications in Mass Spectrometry","issn_l":"0951-4198","issn":["0951-4198","1097-0231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rapid Communications in Mass Spectrometry","raw_type":"journal-article"},{"id":"doi:10.1002/1097-0231(20000930)14:18<1682::aid-rcm78>3.3.co;2-5","doi":"https://doi.org/10.1002/1097-0231(20000930)14:18<1682::aid-rcm78>3.3.co;2-5","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0231(20000930)14:18<1682::aid-rcm78>3.3.co;2-5","pdf_url":null,"source":{"id":"https://openalex.org/S89689683","display_name":"Rapid Communications in Mass Spectrometry","issn_l":"0951-4198","issn":["0951-4198","1097-0231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rapid Communications in Mass Spectrometry","raw_type":"journal-article"},{"id":"pmid:10962491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10962491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rapid communications in mass spectrometry : RCM","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1973097651","https://openalex.org/W1977946292","https://openalex.org/W1989045329","https://openalex.org/W1991876570","https://openalex.org/W2008546104","https://openalex.org/W2008842530","https://openalex.org/W2010397145","https://openalex.org/W2019670420","https://openalex.org/W2027849535","https://openalex.org/W2039676199","https://openalex.org/W2039838252","https://openalex.org/W2047430074","https://openalex.org/W2054874583","https://openalex.org/W2057954468","https://openalex.org/W2060790346","https://openalex.org/W2061650403","https://openalex.org/W2076464687","https://openalex.org/W2077877779","https://openalex.org/W2080501907","https://openalex.org/W2093819702","https://openalex.org/W4245104830"],"related_works":["https://openalex.org/W7222917678","https://openalex.org/W2090855680","https://openalex.org/W1972511164","https://openalex.org/W2031674280","https://openalex.org/W7132259310","https://openalex.org/W2069650171","https://openalex.org/W1975333644","https://openalex.org/W2614710890","https://openalex.org/W2008546104","https://openalex.org/W2475265417"],"abstract_inverted_index":{"A":[0,50,112,161],"sheathless":[1],"and":[2,159],"electrodeless":[3,68],"nanospray":[4,62,86],"interface":[5,10,69],"has":[6],"been":[7],"used":[8,59,106,125],"to":[9,17,55,76,81,94,101,107,126,174,181,206],"a":[11,18,47,78,128,145,169,182,187,195],"polycarbonate":[12,29],"capillary":[13,53,190],"electrophoresis":[14],"(CE)":[15],"chip":[16,23,57,83],"mass":[19],"spectrometer":[20],"(MS).":[21],"The":[22,64,136],"was":[24,58,73,105,124,141,200],"made":[25],"of":[26,40,66,116,138,147,164,172,198,209],"two":[27],"flat":[28],"plates":[30,42],"which":[31,202],"were":[32,36,156],"bolted":[33],"together.":[34],"Channels":[35],"imprinted":[37],"in":[38,121,168,186],"one":[39],"the":[41,56,61,82,85,89,95,99,103,109,133,139,177,207,210],"with":[43,191],"metal":[44],"wires,":[45],"using":[46],"hydraulic":[48],"press.":[49],"short":[51],"tapered":[52],"connected":[54],"as":[60],"emitter.":[63,87],"advantage":[65],"this":[67],"is":[70],"that":[71],"it":[72],"not":[74],"necessary":[75],"apply":[77],"electrospray":[79],"voltage":[80,91],"or":[84],"Instead,":[88],"CE":[90,184],"already":[92],"applied":[93],"buffer":[96,115,134],"compartment":[97],"on":[98],"chip,":[100],"drive":[102],"electrophoresis,":[104],"generate":[108],"spray":[110],"also.":[111],"low":[113],"conductivity":[114],"1.25":[117],"mmol/L":[118],"ammonium":[119],"acetate":[120],"80%":[122],"methanol":[123],"obtain":[127],"large":[129],"electric":[130],"field":[131],"across":[132],"channel.":[135],"performance":[137],"device":[140],"evaluated":[142],"by":[143],"analyzing":[144],"mixture":[146],"three":[148],"beta-agonists":[149],"Relative":[150],"standard":[151],"deviation":[152],"(RSD)":[153],"values":[154],"obtained":[155],"between":[157],"4.8":[158],"5.0%.":[160],"sample":[162],"concentration":[163],"40":[165],"nmol/L":[166],"resulted":[167],"signal-to-noise":[170],"ratio":[171],"2":[173],"5":[175],"for":[176],"different":[178],"components.":[179],"Compared":[180],"conventional":[183],"analysis":[185],"fused":[188],"silica":[189],"UV":[192],"detection,":[193],"only":[194],"minor":[196],"loss":[197],"resolution":[199],"observed,":[201],"can":[203],"be":[204],"attributed":[205],"design":[208],"chip.":[211]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}