{"id":"https://openalex.org/W1990036471","doi":"https://doi.org/10.1074/jbc.m506348200","title":"p53 Monitors Replication Fork Regression by Binding to \u201cChickenfoot\u201d Intermediates","display_name":"p53 Monitors Replication Fork Regression by Binding to \u201cChickenfoot\u201d Intermediates","publication_year":2005,"publication_date":"2005-10-05","ids":{"openalex":"https://openalex.org/W1990036471","doi":"https://doi.org/10.1074/jbc.m506348200","mag":"1990036471","pmid":"https://pubmed.ncbi.nlm.nih.gov/16204246"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m506348200","doi":"https://doi.org/10.1074/jbc.m506348200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m506348200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m506348200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058282369","display_name":"Deepa Subramanian","orcid":"https://orcid.org/0000-0001-5446-9750","observed_orcids":["https://orcid.org/0000-0001-5446-9750"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepa Subramanian","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061660001","display_name":"Jack D. Griffith","orcid":"https://orcid.org/0000-0002-8357-8689","observed_orcids":["https://orcid.org/0000-0002-8357-8689"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jack D. Griffith","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061660001"],"corresponding_institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.9329,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.69164878,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"280","issue":"52","first_page":"42568","last_page":"42572"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.6518999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.6518999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.3407999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9990000128746033},{"id":"https://openalex.org/keywords/replication-fork-regression","display_name":"replication fork regression","score":0.8629999756813049},{"id":"https://openalex.org/keywords/stalled-replication-forks","display_name":"stalled replication forks","score":0.6430000066757202},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.3230000138282776},{"id":"https://openalex.org/keywords/mutant-p53","display_name":"mutant p53","score":0.7059999704360962},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.8240000009536743},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.5569999814033508},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C40523978","wikidata":"https://www.wikidata.org/wiki/Q14675","display_name":"Fork (system call)","level":2,"score":0.8627636432647705},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.8200992345809937},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.4972992241382599},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4281364977359772},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3284860849380493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2884038984775543},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.2558773159980774},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1826673150062561},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17105108499526978},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.16551998257637024}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007313","descriptor_name":"Insecta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m506348200","doi":"https://doi.org/10.1074/jbc.m506348200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m506348200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:16204246","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16204246","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:ft849157c","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/26yp-4487","pdf_url":"https://doi.org/10.17615/26yp-4487","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Biological Chemistry, 280(52)","raw_type":"Article"},{"id":"doi:10.17615/26yp-4487","doi":"https://doi.org/10.17615/26yp-4487","is_oa":true,"landing_page_url":"https://doi.org/10.17615/26yp-4487","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1074/jbc.m506348200","doi":"https://doi.org/10.1074/jbc.m506348200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m506348200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2774293502","display_name":null,"funder_award_id":"GM-31819","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3518478496","display_name":"DNA-Protein Interactions at the Replication Fork","funder_award_id":"R01GM031819","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7016388848","display_name":null,"funder_award_id":"CA 19014","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000880694","display_name":"Viral Oncogenesis, Latency, and Replication","funder_award_id":"P01CA019014","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306135","display_name":"Ellison Medical Foundation","ror":"https://ror.org/01pqy3846"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990036471.pdf","grobid_xml":"https://content.openalex.org/works/W1990036471.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1559308671","https://openalex.org/W1650797637","https://openalex.org/W1767560565","https://openalex.org/W1849359401","https://openalex.org/W1968373432","https://openalex.org/W1970542601","https://openalex.org/W1976082858","https://openalex.org/W1977694232","https://openalex.org/W1987345634","https://openalex.org/W2001368087","https://openalex.org/W2044134416","https://openalex.org/W2045892846","https://openalex.org/W2046732438","https://openalex.org/W2047191264","https://openalex.org/W2054528125","https://openalex.org/W2060275129","https://openalex.org/W2064795157","https://openalex.org/W2068764175","https://openalex.org/W2080411064","https://openalex.org/W2100287099","https://openalex.org/W2101518009","https://openalex.org/W2107738296","https://openalex.org/W2121813899","https://openalex.org/W2122254308","https://openalex.org/W2127566231","https://openalex.org/W2137926932","https://openalex.org/W2163966230","https://openalex.org/W2165204791","https://openalex.org/W2208690787","https://openalex.org/W2241055366","https://openalex.org/W2313209101","https://openalex.org/W2317412573","https://openalex.org/W2318262155","https://openalex.org/W2318781517","https://openalex.org/W2319779747","https://openalex.org/W2322926939","https://openalex.org/W2323231231","https://openalex.org/W2335538541"],"related_works":["https://openalex.org/W2080411064","https://openalex.org/W2786243851","https://openalex.org/W2042925111","https://openalex.org/W1963699429","https://openalex.org/W2065214188","https://openalex.org/W2046066638","https://openalex.org/W2322926939","https://openalex.org/W2551495011","https://openalex.org/W2000140392","https://openalex.org/W2140041672"],"abstract_inverted_index":{"The":[0],"tumor":[1],"suppressor":[2],"protein,":[3],"p53,":[4],"utilizes":[5],"multiple":[6],"mechanisms":[7],"to":[8,32,53,69,90,104,120],"ensure":[9],"faithful":[10],"transmission":[11],"of":[12,17,30,36,72,85,97,108,131,137],"the":[13,33,70,86,95,117,129],"genome":[14],"including":[15],"regulation":[16],"DNA":[18,34],"replication,":[19],"repair,":[20],"and":[21,49],"recombination.":[22],"Monitoring":[23],"these":[24,37,58,126],"pathways":[25],"may":[26],"involve":[27],"direct":[28],"binding":[29,133],"p53":[31,55,64,78,105],"intermediates":[35,107],"processes.":[38],"In":[39],"this":[40],"study,":[41],"we":[42],"generated":[43],"templates":[44,87],"resembling":[45],"stalled":[46,73],"replication":[47],"forks":[48],"utilized":[50],"electron":[51],"microscopy":[52],"examine":[54],"interactions":[56],"with":[57,66],"substrates.":[59],"Our":[60],"results":[61,127],"show":[62],"that":[63],"bound":[65],"high":[67],"affinity":[68],"junction":[71],"forks,":[74],"whereas":[75],"two":[76],"cancer-derived":[77],"mutants":[79],"showed":[80],"weak":[81],"binding.":[82],"Additionally,":[83],"some":[84],"were":[88,100],"rearranged":[89],"form":[91],"\"chickenfoot\"":[92],"structures":[93],"in":[94,113,134],"presence":[96],"p53.":[98],"These":[99],"mostly":[101],"formed":[102],"due":[103],"trapping":[106],"spontaneous":[109],"fork":[110],"regression;":[111],"however,":[112],"a":[114],"small":[115],"population,":[116],"protein":[118],"appeared":[119],"be":[121],"promoting":[122],"their":[123],"formation.":[124],"Collectively,":[125],"demonstrate":[128],"importance":[130],"sequence-independent":[132],"p53-mediated":[135],"maintenance":[136],"genomic":[138],"integrity.":[139]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}