{"id":"https://openalex.org/W1989979780","doi":"https://doi.org/10.1161/01.res.0000014227.76102.5d","title":"A Dominant-Negative p65 PAK Peptide Inhibits Angiogenesis","display_name":"A Dominant-Negative p65 PAK Peptide Inhibits Angiogenesis","publication_year":2002,"publication_date":"2002-04-05","ids":{"openalex":"https://openalex.org/W1989979780","doi":"https://doi.org/10.1161/01.res.0000014227.76102.5d","mag":"1989979780","pmid":"https://pubmed.ncbi.nlm.nih.gov/11934838"},"language":"en","primary_location":{"id":"doi:10.1161/01.res.0000014227.76102.5d","doi":"https://doi.org/10.1161/01.res.0000014227.76102.5d","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.0000014227.76102.5d","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.0000014227.76102.5D","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.0000014227.76102.5D","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030557604","display_name":"William Bill Kiosses","orcid":"https://orcid.org/0000-0003-1832-9050","observed_orcids":["https://orcid.org/0000-0003-1832-9050"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William B. Kiosses","raw_affiliation_strings":["From the Departments of Vascular Biology (W.B.K., D.A.C., N.A., M.A.S.) and Immunology (J.H., D.A.C.), The Scripps Research Institute, La Jolla; and the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Vascular Biology (W.B.K., D.A.C., N.A., M.A.S.) and Immunology (J.H., D.A.C.), The Scripps Research Institute, La Jolla; and the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I183934855"]},{"raw_affiliation_string":"the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109426437","display_name":"John D. Hood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Hood","raw_affiliation_strings":["From the Departments of Vascular Biology (W.B.K., D.A.C., N.A., M.A.S.) and Immunology (J.H., D.A.C.), The Scripps Research Institute, La Jolla; and the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Vascular Biology (W.B.K., D.A.C., N.A., M.A.S.) and Immunology (J.H., D.A.C.), The Scripps Research Institute, La Jolla; and the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I183934855"]},{"raw_affiliation_string":"the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Suya Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suya Yang","raw_affiliation_strings":["From the Departments of Vascular Biology (W.B.K., D.A.C., N.A., M.A.S.) and Immunology (J.H., D.A.C.), The Scripps Research Institute, La Jolla; and the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Vascular Biology (W.B.K., D.A.C., N.A., M.A.S.) and Immunology (J.H., D.A.C.), The Scripps Research Institute, La Jolla; and the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I183934855"]},{"raw_affiliation_string":"the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109920620","display_name":"Mary E. Gerritsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary E. Gerritsen","raw_affiliation_strings":["From the Departments of Vascular Biology (W.B.K., D.A.C., N.A., M.A.S.) and Immunology (J.H., D.A.C.), The Scripps Research Institute, La Jolla; and the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Vascular Biology (W.B.K., D.A.C., N.A., M.A.S.) and Immunology (J.H., D.A.C.), The Scripps Research Institute, La Jolla; and the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I183934855"]},{"raw_affiliation_string":"the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089796560","display_name":"David A. Cheresh","orcid":"https://orcid.org/0000-0002-7193-8595","observed_orcids":["https://orcid.org/0000-0002-7193-8595"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Cheresh","raw_affiliation_strings":["From the Departments of Vascular Biology (W.B.K., D.A.C., N.A., M.A.S.) and Immunology (J.H., D.A.C.), The Scripps Research Institute, La Jolla; and the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Vascular Biology (W.B.K., D.A.C., N.A., M.A.S.) and Immunology (J.H., D.A.C.), The Scripps Research Institute, La Jolla; and the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I183934855"]},{"raw_affiliation_string":"the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063978277","display_name":"Nazilla B. Alderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nazilla Alderson","raw_affiliation_strings":["From the Departments of Vascular Biology (W.B.K., D.A.C., N.A., M.A.S.) and Immunology (J.H., D.A.C.), The Scripps Research Institute, La Jolla; and the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Vascular Biology (W.B.K., D.A.C., N.A., M.A.S.) and Immunology (J.H., D.A.C.), The Scripps Research Institute, La Jolla; and the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I183934855"]},{"raw_affiliation_string":"the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086030901","display_name":"Martin Alexander Schwartz","orcid":"https://orcid.org/0000-0002-2071-1243","observed_orcids":["https://orcid.org/0000-0002-2071-1243"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Alexander Schwartz","raw_affiliation_strings":["From the Departments of Vascular Biology (W.B.K., D.A.C., N.A., M.A.S.) and Immunology (J.H., D.A.C.), The Scripps Research Institute, La Jolla; and the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Vascular Biology (W.B.K., D.A.C., N.A., M.A.S.) and Immunology (J.H., D.A.C.), The Scripps Research Institute, La Jolla; and the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I183934855"]},{"raw_affiliation_string":"the Department of Cardiovascular Research (S.Y., M.E.G.), Genentech, South San Francisco, Calif","institution_ids":["https://openalex.org/I183934855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9287,"has_fulltext":true,"cited_by_count":127,"citation_normalized_percentile":{"value":0.91493106,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"90","issue":"6","first_page":"697","last_page":"702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.12540000677108765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pak1","display_name":"PAK1","score":0.9089999794960022},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.800000011920929},{"id":"https://openalex.org/keywords/nck","display_name":"Nck","score":0.7940000295639038},{"id":"https://openalex.org/keywords/sh3-domain-binding","display_name":"SH3 domain binding","score":0.7960000038146973},{"id":"https://openalex.org/keywords/proline-rich-region","display_name":"proline-rich region","score":0.8840000033378601},{"id":"https://openalex.org/keywords/endothelial-cell-migration","display_name":"endothelial cell migration","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cell-contractility","display_name":"cell contractility","score":0.8690000176429749},{"id":"https://openalex.org/keywords/tube-formation","display_name":"tube formation","score":0.7139999866485596},{"id":"https://openalex.org/keywords/chick-chorioallantoic-membrane","display_name":"chick chorioallantoic membrane","score":0.824999988079071},{"id":"https://openalex.org/keywords/rac","display_name":"Rac","score":0.5329999923706055},{"id":"https://openalex.org/keywords/cdc42","display_name":"Cdc42","score":1.0}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8295501470565796},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.666343092918396},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6601952910423279},{"id":"https://openalex.org/C2780040266","wikidata":"https://www.wikidata.org/wiki/Q15311701","display_name":"CDC42","level":3,"score":0.6043612957000732},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47884559631347656},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4308190941810608},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.41832396388053894},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3684285879135132},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.33331120014190674},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.294009268283844},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.25771671533584595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2267528474330902},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.14561545848846436}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015696","descriptor_name":"Gene Products, tat","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015696","descriptor_name":"Gene Products, tat","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054462","descriptor_name":"p21-Activated Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.res.0000014227.76102.5d","doi":"https://doi.org/10.1161/01.res.0000014227.76102.5d","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.0000014227.76102.5d","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.0000014227.76102.5D","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.547.7259","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.547.7259","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"http://circres.ahajournals.org/content/90/6/697.full.pdf","raw_type":"text"},{"id":"pmid:11934838","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11934838","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1161/01.res.0000014227.76102.5d","doi":"https://doi.org/10.1161/01.res.0000014227.76102.5d","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.0000014227.76102.5d","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.0000014227.76102.5D","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1648785187","display_name":null,"funder_award_id":"CA-50286","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G243309107","display_name":"Integrin alpha v beta 3 promotes resistance to EGF receptor inhibitors","funder_award_id":"R01CA045726","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6189164895","display_name":"Combinatorial Chemistry and Cancer Target","funder_award_id":"P01CA078045","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8931877706","display_name":"Integrin Signaling in Hemostasis and Blood Diseases","funder_award_id":"P01HL057900","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1989979780.pdf","grobid_xml":"https://content.openalex.org/works/W1989979780.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1578332600","https://openalex.org/W1826215572","https://openalex.org/W1994076220","https://openalex.org/W2001753204","https://openalex.org/W2009461629","https://openalex.org/W2028972436","https://openalex.org/W2034825883","https://openalex.org/W2070190928","https://openalex.org/W2074190587","https://openalex.org/W2076647477","https://openalex.org/W2078875435","https://openalex.org/W2105668301","https://openalex.org/W2109197670","https://openalex.org/W2142714350","https://openalex.org/W2144240811","https://openalex.org/W2150172003"],"related_works":["https://openalex.org/W2069826577","https://openalex.org/W2144240811","https://openalex.org/W2276184075","https://openalex.org/W2075404997","https://openalex.org/W3215618521","https://openalex.org/W2022067714","https://openalex.org/W2055718746","https://openalex.org/W2158978595","https://openalex.org/W2047458615","https://openalex.org/W2528402917"],"abstract_inverted_index":{"PAK1":[0],"is":[1],"a":[2,60,93,161],"protein":[3,42,77],"kinase":[4],"downstream":[5],"of":[6,24,31,54,99,112,140],"the":[7,40,52,64,70,74,86,102,107,134,151],"small":[8],"GTPases":[9],"Rac":[10],"and":[11,121],"Cdc42":[12],"that":[13,33,85],"previous":[14],"work":[15],"has":[16],"implicated":[17],"in":[18,56,62,130,145,165],"endothelial":[19,118],"cell":[20,25,119],"migration":[21,120],"via":[22],"modulation":[23],"contraction.":[26],"The":[27],"first":[28],"proline-rich":[29,65],"region":[30,66],"PAK":[32,55,103,135,152,164],"binds":[34,90],"to":[35,69,78,124],"an":[36,129,144],"SH3":[37],"domain":[38],"from":[39,73],"adapter":[41],"NCK":[43],"was":[44,67],"responsible":[45],"for":[46,163],"these":[47],"dominant-negative":[48,126],"effects.":[49],"To":[50],"test":[51],"role":[53,162],"angiogenesis,":[57],"we":[58],"prepared":[59],"peptide":[61,88,95,104,109,115,136,153],"which":[63],"fused":[68],"polybasic":[71],"sequence":[72],"HIV":[75],"Tat":[76],"facilitate":[79],"entry":[80],"into":[81],"cells.":[82],"We":[83],"show":[84],"short":[87],"selectively":[89],"NCK,":[91],"whereas":[92],"mutant":[94],"does":[96],"not.":[97],"Treatment":[98],"cells":[100],"with":[101],"but":[105],"not":[106],"control":[108],"disrupts":[110],"localization":[111],"PAK.":[113,127],"This":[114],"specifically":[116,137,154],"inhibited":[117],"contractility":[122],"similarly":[123],"full-length":[125],"In":[128,143],"vitro":[131],"tube-forming":[132],"assay,":[133,150],"blocked":[138,155],"formation":[139],"multicellular":[141],"networks.":[142],"vivo":[146],"chick":[147],"chorioallantoic":[148],"membrane":[149],"angiogenesis.":[156,166],"These":[157],"results,":[158],"therefore,":[159],"suggest":[160]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}