{"id":"https://openalex.org/W1989851328","doi":"https://doi.org/10.1002/lsm.1900040104","title":"Photoradiation therapy of endobronchial lung cancers employing the photodynamic action of hematoporphvrin derivative","display_name":"Photoradiation therapy of endobronchial lung cancers employing the photodynamic action of hematoporphvrin derivative","publication_year":1984,"publication_date":"1984-01-01","ids":{"openalex":"https://openalex.org/W1989851328","doi":"https://doi.org/10.1002/lsm.1900040104","mag":"1989851328","pmid":"https://pubmed.ncbi.nlm.nih.gov/6235412"},"language":"en","primary_location":{"id":"doi:10.1002/lsm.1900040104","doi":"https://doi.org/10.1002/lsm.1900040104","is_oa":false,"landing_page_url":"https://doi.org/10.1002/lsm.1900040104","pdf_url":null,"source":{"id":"https://openalex.org/S155721155","display_name":"Lasers in Surgery and Medicine","issn_l":"0196-8092","issn":["0196-8092","1096-9101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lasers in Surgery and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052815878","display_name":"Oscar J. Balchum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1342924430","display_name":"LAC+USC Medical Center","ror":"https://ror.org/04xzj3x20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I1342924430"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Oscar J. Balchum","raw_affiliation_strings":["University of Southern California Medical School and The Los Angeles County/USC Medical Center, Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southern California Medical School and The Los Angeles County/USC Medical Center, Los Angeles","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1342924430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110037428","display_name":"Daniel R. Doiron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I1342924430","display_name":"LAC+USC Medical Center","ror":"https://ror.org/04xzj3x20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I1342924430"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel R. Doiron","raw_affiliation_strings":["Ocular Oncology Program, Childrens Hospital of Los Angeles, Los Angeles","University of Southern California Medical School and The Los Angeles County/USC Medical Center, Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ocular Oncology Program, Childrens Hospital of Los Angeles, Los Angeles","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"University of Southern California Medical School and The Los Angeles County/USC Medical Center, Los Angeles","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1342924430"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060854345","display_name":"Gerald C. Huth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1342924430","display_name":"LAC+USC Medical Center","ror":"https://ror.org/04xzj3x20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I1342924430"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald C. Huth","raw_affiliation_strings":["University of Southern California Medical School and The Los Angeles County/USC Medical Center, Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southern California Medical School and The Los Angeles County/USC Medical Center, Los Angeles","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1342924430"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052815878"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1342924430"],"apc_list":{"value":4620,"currency":"USD","value_usd":4620},"apc_paid":null,"fwci":7.9945,"has_fulltext":false,"cited_by_count":137,"citation_normalized_percentile":{"value":0.98533782,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"4","issue":"1","first_page":"13","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.8529999852180481},{"id":"https://openalex.org/keywords/hematoporphyrin-derivative","display_name":"hematoporphyrin derivative","score":0.9049999713897705},{"id":"https://openalex.org/keywords/argon-pumped-dye-laser","display_name":"argon-pumped dye laser","score":0.878000020980835},{"id":"https://openalex.org/keywords/tumor-resection","display_name":"tumor resection","score":0.37400001287460327},{"id":"https://openalex.org/keywords/metastatic-lung-cancer","display_name":"metastatic lung cancer","score":0.6539999842643738},{"id":"https://openalex.org/keywords/bronchial-obstruction","display_name":"bronchial obstruction","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.7864769697189331},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6691374778747559},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5728805065155029},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.46026402711868286},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.326171875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29885655641555786},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22753939032554626},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001999","descriptor_name":"Bronchoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006415","descriptor_name":"Hematoporphyrins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017324","descriptor_name":"Hematoporphyrin Derivative","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053685","descriptor_name":"Laser Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/lsm.1900040104","doi":"https://doi.org/10.1002/lsm.1900040104","is_oa":false,"landing_page_url":"https://doi.org/10.1002/lsm.1900040104","pdf_url":null,"source":{"id":"https://openalex.org/S155721155","display_name":"Lasers in Surgery and Medicine","issn_l":"0196-8092","issn":["0196-8092","1096-9101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lasers in Surgery and Medicine","raw_type":"journal-article"},{"id":"pmid:6235412","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6235412","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lasers in surgery and medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310693","display_name":"Deutsches Krebsforschungszentrum","ror":"https://ror.org/04cdgtt98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W2398867","https://openalex.org/W1954387510","https://openalex.org/W1966550851","https://openalex.org/W2089054799","https://openalex.org/W2124378074","https://openalex.org/W2138227433","https://openalex.org/W2479135807"],"related_works":["https://openalex.org/W2413377034","https://openalex.org/W2098525289","https://openalex.org/W2036596556","https://openalex.org/W2056258266","https://openalex.org/W2401778701","https://openalex.org/W2160029055","https://openalex.org/W2338071537","https://openalex.org/W4252343154","https://openalex.org/W2035079174","https://openalex.org/W2330406969"],"abstract_inverted_index":{"Thirty-five":[0],"patients":[1],"with":[2,10,47],"tumors":[3,113],"within":[4,130],"the":[5,15,39,43,131,153,170,175,178,214],"tracheobronchial":[6],"tree":[7],"were":[8,60,82,92,163,192],"treated":[9],"photoradiation":[11],"therapy":[12],"(PRT)":[13],"employing":[14],"photodynamic":[16],"action":[17],"of":[18,29,42,70,76,121,138,156,174,222],"hematoporphyrin":[19],"derivative":[20],"(HPD).":[21],"An":[22],"effective":[23],"protocol":[24],"has":[25],"been":[26],"developed":[27,61],"consisting":[28],"3.0":[30],"mg/kg":[31],"HPD":[32],"given":[33],"intravenously":[34],"72":[35],"hours":[36],"prior":[37],"to":[38,146,152,177,205,216],"bronchoscopic":[40],"illumination":[41,69],"endobronchial":[44,112],"tumor":[45,71,129],"sites":[46,162],"red":[48],"light":[49,74],"(630":[50],"nm)":[51],"from":[52],"an":[53],"argon":[54],"pumped":[55],"dye":[56],"laser.":[57],"Light":[58],"applicators":[59],"that":[62,168],"provided":[63],"surface":[64,85],"(area)":[65],"and":[66,79,86,95,118,194,197,213],"insertion":[67,87],"(volume)":[68],"masses.":[72],"Average":[73],"dosages":[75],"100":[77],"J/cm2":[78],"200":[80,93],"J/cm":[81],"used":[83],"for":[84,128],"illumination,":[88],"respectively.":[89],"Delivery":[90],"rates":[91],"mW/cm2":[94],"400":[96],"mW/cm.":[97],"There":[98],"was":[99,126,181],"no":[100],"immediate":[101],"visible":[102],"effect":[103],"such":[104],"as":[105],"coagulation":[106],"or":[107,159,190],"charring":[108],"noted.":[109],"All":[110],"malignant":[111],"responded.":[114],"Tumors":[115],"included":[116],"primary":[117],"metastatic":[119],"lesions":[120],"various":[122],"histologic":[123],"types.":[124],"Response":[125],"complete":[127,149,166],"bronchus":[132,157],"after":[133],"one":[134,186],"treatment":[135],"in":[136,183,209,218],"80%":[137],"instances.":[139],"The":[140,202],"remaining":[141],"cases":[142],"required":[143],"two":[144],"treatments":[145],"obtain":[147],"a":[148,219],"response":[150],"due":[151],"extensive":[154],"length":[155],"involved":[158],"because":[160],"multiple":[161],"present.":[164],"A":[165],"response,":[167],"is,":[169],"full":[171],"opening":[172],"up":[173],"lumen":[176],"bronchial":[179],"wall,":[180],"accomplished":[182],"all":[184],"but":[185],"instance.":[187],"Atelectatic":[188],"lungs":[189],"lobes":[191],"re-expanded":[193],"reaerated.":[195],"Dyspnea":[196],"cough":[198],"became":[199],"significantly":[200],"less.":[201],"follow-up":[203],"achieved":[204],"date":[206],"indicates":[207],"improvement":[208],"symptoms,":[210],"activity":[211],"level,":[212],"return":[215],"work":[217],"significant":[220],"number":[221],"cases.":[223]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
