{"id":"https://openalex.org/W1989851136","doi":"https://doi.org/10.1213/ane.0b013e3181f6da34","title":"Prolonged High-Dose Isoflurane for Refractory Status Epilepticus","display_name":"Prolonged High-Dose Isoflurane for Refractory Status Epilepticus","publication_year":2010,"publication_date":"2010-09-15","ids":{"openalex":"https://openalex.org/W1989851136","doi":"https://doi.org/10.1213/ane.0b013e3181f6da34","mag":"1989851136","pmid":"https://pubmed.ncbi.nlm.nih.gov/20841413"},"language":"en","primary_location":{"id":"doi:10.1213/ane.0b013e3181f6da34","doi":"https://doi.org/10.1213/ane.0b013e3181f6da34","is_oa":false,"landing_page_url":"https://doi.org/10.1213/ane.0b013e3181f6da34","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia & Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082626550","display_name":"Jennifer E. Fugate","orcid":"https://orcid.org/0000-0001-7479-6732","observed_orcids":["https://orcid.org/0000-0001-7479-6732"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jennifer E. Fugate","raw_affiliation_strings":["Department of Neurology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA","Neurology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Neurology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049516627","display_name":"Joseph D. Burns","orcid":"https://orcid.org/0000-0002-8583-2599","observed_orcids":["https://orcid.org/0000-0002-8583-2599"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joseph D. Burns","raw_affiliation_strings":["Neurology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029488636","display_name":"Eelco F. M. Wijdicks","orcid":"https://orcid.org/0000-0001-9807-9172","observed_orcids":["https://orcid.org/0000-0001-9807-9172"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Eelco F. M. Wijdicks","raw_affiliation_strings":["Neurology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067856866","display_name":"David O. Warner","orcid":"https://orcid.org/0000-0002-0365-2536","observed_orcids":["https://orcid.org/0000-0002-0365-2536"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David O. Warner","raw_affiliation_strings":["Anesthesiology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057179364","display_name":"Christopher J. Jankowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Jankowski","raw_affiliation_strings":["Anesthesiology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031713672","display_name":"Alejandro A. Rabinstein","orcid":"https://orcid.org/0000-0001-8359-2838","observed_orcids":["https://orcid.org/0000-0001-8359-2838"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alejandro A. Rabinstein","raw_affiliation_strings":["Neurology and","and reprint requests to Alejandro A. Rabinstein, MD, Department of Neurology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905. Address e-mail to [email\u00a0protected]","reprint requests to Alejandro A. Rabinstein, MD, Department of Neurology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905. Address e-mail to [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology and","institution_ids":[]},{"raw_affiliation_string":"and reprint requests to Alejandro A. Rabinstein, MD, Department of Neurology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905. Address e-mail to [email\u00a0protected]","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"reprint requests to Alejandro A. Rabinstein, MD, Department of Neurology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905. Address e-mail to [email\u00a0protected]","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029488636","https://openalex.org/A5031713672","https://openalex.org/A5049516627","https://openalex.org/A5082626550"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":5.4928,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.94860499,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"111","issue":"6","first_page":"1520","last_page":"1524"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.7085000276565552,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.7085000276565552,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.15230000019073486,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.08969999849796295,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isoflurane","display_name":"isoflurane","score":0.9980000257492065},{"id":"https://openalex.org/keywords/refractory-status-epilepticus","display_name":"refractory status epilepticus","score":0.984000027179718},{"id":"https://openalex.org/keywords/t2-hyperintensity","display_name":"T2 hyperintensity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/thalamus","display_name":"thalamus","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":1.0},{"id":"https://openalex.org/keywords/brain-mri-abnormalities","display_name":"brain MRI abnormalities","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C2776359302","wikidata":"https://www.wikidata.org/wiki/Q413918","display_name":"Isoflurane","level":2,"score":0.9622942805290222},{"id":"https://openalex.org/C2777341932","wikidata":"https://www.wikidata.org/wiki/Q980709","display_name":"Status epilepticus","level":3,"score":0.9383578300476074},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.893787145614624},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7135708332061768},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.7124789953231812},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6504251956939697},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.604738175868988},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.4875335395336151},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.32745110988616943},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.28591662645339966},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.1383293867111206},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007530","descriptor_name":"Isoflurane","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007530","descriptor_name":"Isoflurane","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013226","descriptor_name":"Status Epilepticus","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D013226","descriptor_name":"Status Epilepticus","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018458","descriptor_name":"Persistent Vegetative State","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1213/ane.0b013e3181f6da34","doi":"https://doi.org/10.1213/ane.0b013e3181f6da34","is_oa":false,"landing_page_url":"https://doi.org/10.1213/ane.0b013e3181f6da34","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia & Analgesia","raw_type":"journal-article"},{"id":"pmid:20841413","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20841413","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7900000214576721,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1484549515","https://openalex.org/W1533969500","https://openalex.org/W1966694379","https://openalex.org/W1981354581","https://openalex.org/W1981391377","https://openalex.org/W1988358928","https://openalex.org/W1994372868","https://openalex.org/W2013758610","https://openalex.org/W2016486532","https://openalex.org/W2024970451","https://openalex.org/W2025939685","https://openalex.org/W2035181561","https://openalex.org/W2091191244","https://openalex.org/W2092211150","https://openalex.org/W2100569554","https://openalex.org/W2123500560","https://openalex.org/W2137124394","https://openalex.org/W2140594985","https://openalex.org/W2143031359","https://openalex.org/W2145736239","https://openalex.org/W2158825577","https://openalex.org/W2170926970","https://openalex.org/W2342071350","https://openalex.org/W4297904988"],"related_works":["https://openalex.org/W2564220915","https://openalex.org/W3186247719","https://openalex.org/W2138925621","https://openalex.org/W2601446026","https://openalex.org/W2016486532","https://openalex.org/W2137124394","https://openalex.org/W2412426031","https://openalex.org/W90688524","https://openalex.org/W4254449643","https://openalex.org/W2419378936"],"abstract_inverted_index":{"Isoflurane":[0],"is":[1,10],"an":[2],"alternative":[3],"treatment":[4],"for":[5,47,59,100],"refractory":[6,24],"status":[7,25],"epilepticus.":[8],"Little":[9],"known":[11],"regarding":[12],"human":[13],"toxicities":[14],"caused":[15],"by":[16],"isoflurane.":[17,86],"We":[18],"present":[19],"2":[20,54],"patients":[21],"with":[22,28,45,50,57,62],"prolonged":[23],"epilepticus":[26],"treated":[27,44,56],"high":[29,98],"concentrations":[30],"of":[31,85],"isoflurane":[32,46,58,91],"who":[33],"developed":[34],"signal":[35,75],"abnormalities":[36],"on":[37],"magnetic":[38,67],"resonance":[39,68],"imaging.":[40],"Patient":[41,53],"1":[42],"was":[43,55],"85":[48],"days":[49,61],"1975.2%":[51],"concentration-hours.":[52,64],"34":[60],"1382.4%":[63],"Serial":[65],"brain":[66],"images":[69],"in":[70,97],"both":[71],"showed":[72],"progressive":[73],"T2":[74],"hyperintensity":[76],"involving":[77],"thalamus":[78],"and":[79],"cerebellum,":[80],"which":[81],"improved":[82],"after":[83],"discontinuation":[84],"These":[87],"cases":[88],"suggest":[89],"that":[90],"may":[92],"be":[93],"neurotoxic":[94],"when":[95],"used":[96],"doses":[99],"long":[101],"time":[102],"periods.":[103]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}