{"id":"https://openalex.org/W1989839710","doi":"https://doi.org/10.1016/s0042-6822(03)00110-7","title":"Extensive immune-mediated hippocampal damage in mice surviving infection with neuroadapted Sindbis virus","display_name":"Extensive immune-mediated hippocampal damage in mice surviving infection with neuroadapted Sindbis virus","publication_year":2003,"publication_date":"2003-05-27","ids":{"openalex":"https://openalex.org/W1989839710","doi":"https://doi.org/10.1016/s0042-6822(03)00110-7","mag":"1989839710","pmid":"https://pubmed.ncbi.nlm.nih.gov/12832200"},"language":"en","primary_location":{"id":"doi:10.1016/s0042-6822(03)00110-7","doi":"https://doi.org/10.1016/s0042-6822(03)00110-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0042-6822(03)00110-7","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0042682203001107/pdf","source":{"id":"https://openalex.org/S6147291","display_name":"Virology","issn_l":"0042-6822","issn":["0042-6822","1089-862X","1096-0341"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S0042682203001107/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101665592","display_name":"Takashi Kimura","orcid":"https://orcid.org/0000-0002-7286-8365","observed_orcids":["https://orcid.org/0000-0002-7286-8365"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takashi Kimura","raw_affiliation_strings":["W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040754947","display_name":"Diane E. Griffin","orcid":"https://orcid.org/0000-0001-6643-2429","observed_orcids":["https://orcid.org/0000-0001-6643-2429"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Diane E Griffin","raw_affiliation_strings":["W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040754947"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":3160,"currency":"USD","value_usd":3160},"apc_paid":null,"fwci":1.5308,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.78875725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"311","issue":"1","first_page":"28","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.6122999787330627,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.6122999787330627,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13201","display_name":"Infectious Encephalopathies and Encephalitis","score":0.11900000274181366,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.10660000145435333,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/encephalomyelitis","display_name":"encephalomyelitis","score":0.8330000042915344},{"id":"https://openalex.org/keywords/hippocampal-lesions","display_name":"hippocampal lesions","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.6990000009536743},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9070000052452087},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7329999804496765},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.7319999933242798},{"id":"https://openalex.org/keywords/pyramidal-neurons","display_name":"pyramidal neurons","score":0.8339999914169312},{"id":"https://openalex.org/keywords/t-cell-immunodeficiency","display_name":"T cell deficiency","score":0.5389999747276306},{"id":"https://openalex.org/keywords/viral-clearance","display_name":"viral clearance","score":0.3330000042915344},{"id":"https://openalex.org/keywords/central-nervous-system-infection","display_name":"central nervous system infection","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7419516444206238},{"id":"https://openalex.org/C2777343345","wikidata":"https://www.wikidata.org/wiki/Q2302993","display_name":"Sindbis virus","level":4,"score":0.6990761160850525},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6108654737472534},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6079473495483398},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4900296926498413},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4865257143974304},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4754756987094879},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.47254395484924316},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.4139624834060669},{"id":"https://openalex.org/C2781313946","wikidata":"https://www.wikidata.org/wiki/Q4735280","display_name":"Alphavirus infection","level":4,"score":0.4104980230331421},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.29621630907058716},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.28355681896209717},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2266470491886139},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.09969180822372437},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07072281837463379},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007116","descriptor_name":"Immunization, Passive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012845","descriptor_name":"Sindbis Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012845","descriptor_name":"Sindbis Virus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018354","descriptor_name":"Alphavirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018354","descriptor_name":"Alphavirus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018354","descriptor_name":"Alphavirus Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0042-6822(03)00110-7","doi":"https://doi.org/10.1016/s0042-6822(03)00110-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0042-6822(03)00110-7","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0042682203001107/pdf","source":{"id":"https://openalex.org/S6147291","display_name":"Virology","issn_l":"0042-6822","issn":["0042-6822","1089-862X","1096-0341"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology","raw_type":"journal-article"},{"id":"pmid:12832200","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12832200","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/s0042-6822(03)00110-7","doi":"https://doi.org/10.1016/s0042-6822(03)00110-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0042-6822(03)00110-7","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0042682203001107/pdf","source":{"id":"https://openalex.org/S6147291","display_name":"Virology","issn_l":"0042-6822","issn":["0042-6822","1089-862X","1096-0341"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6745032928","display_name":"ACUTE ALPHAVIRAL ENCEPHALITIS","funder_award_id":"R01NS018596","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7980193082","display_name":"Control of alphavirous replacation in the nervous system","funder_award_id":"R01NS038932","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320323533","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1989839710.pdf","grobid_xml":"https://content.openalex.org/works/W1989839710.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W26913945","https://openalex.org/W67073985","https://openalex.org/W1483257376","https://openalex.org/W1501367045","https://openalex.org/W1517159675","https://openalex.org/W1525259648","https://openalex.org/W1527726281","https://openalex.org/W1546946747","https://openalex.org/W1558647135","https://openalex.org/W1612135387","https://openalex.org/W1626644585","https://openalex.org/W1830778808","https://openalex.org/W1892799506","https://openalex.org/W1899341523","https://openalex.org/W1904248154","https://openalex.org/W1904492051","https://openalex.org/W1916576520","https://openalex.org/W1933419033","https://openalex.org/W1942126592","https://openalex.org/W1964355702","https://openalex.org/W1968110246","https://openalex.org/W1968486319","https://openalex.org/W1974967271","https://openalex.org/W1986003731","https://openalex.org/W1988256009","https://openalex.org/W1988511536","https://openalex.org/W1989292497","https://openalex.org/W1995407645","https://openalex.org/W2011272195","https://openalex.org/W2011275029","https://openalex.org/W2024285818","https://openalex.org/W2025182790","https://openalex.org/W2025638147","https://openalex.org/W2032072459","https://openalex.org/W2038995612","https://openalex.org/W2039119938","https://openalex.org/W2039664761","https://openalex.org/W2046284937","https://openalex.org/W2049380298","https://openalex.org/W2056631020","https://openalex.org/W2056748099","https://openalex.org/W2057625692","https://openalex.org/W2062843866","https://openalex.org/W2070287513","https://openalex.org/W2074022605","https://openalex.org/W2079177900","https://openalex.org/W2081281197","https://openalex.org/W2084385845","https://openalex.org/W2096428903","https://openalex.org/W2105224367","https://openalex.org/W2124474821","https://openalex.org/W2131043061","https://openalex.org/W2146588462","https://openalex.org/W2147999139","https://openalex.org/W2158364751","https://openalex.org/W2161530562","https://openalex.org/W2164620775","https://openalex.org/W2334174390","https://openalex.org/W2411697459","https://openalex.org/W2419053233"],"related_works":["https://openalex.org/W2146588462","https://openalex.org/W2025182790","https://openalex.org/W9980252","https://openalex.org/W2163166100","https://openalex.org/W2106895889","https://openalex.org/W2523370490","https://openalex.org/W4400180152","https://openalex.org/W2507642282","https://openalex.org/W1973108297","https://openalex.org/W2425802568"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}