{"id":"https://openalex.org/W1989797372","doi":"https://doi.org/10.1046/j.1523-1755.2003.00744.x","title":"Anti-inflammatory and immunomodulatory effects of statins","display_name":"Anti-inflammatory and immunomodulatory effects of statins","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W1989797372","doi":"https://doi.org/10.1046/j.1523-1755.2003.00744.x","mag":"1989797372","pmid":"https://pubmed.ncbi.nlm.nih.gov/12472764"},"language":"en","primary_location":{"id":"doi:10.1046/j.1523-1755.2003.00744.x","doi":"https://doi.org/10.1046/j.1523-1755.2003.00744.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1523-1755.2003.00744.x","pdf_url":null,"source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1989797372"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1046/j.1523-1755.2003.00744.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041104466","display_name":"Luis Miguel Blanco\u2010Colio","orcid":"https://orcid.org/0000-0002-1560-6609","observed_orcids":["https://orcid.org/0000-0002-1560-6609"]},"institutions":[{"id":"https://openalex.org/I4210129357","display_name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/049nvyb15","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210129357"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis Miguel Blanco-Colio","raw_affiliation_strings":["Department of Cardiology, Fundaci\u00f3n Jim\u00e9nez D\u00edaz and Autonoma University, Madrid, Spain","Renal and Vascular Research Laboratory and Department of Cardiology, Fundaci\u00f3n Jim\u00e9nez D\u00edaz and Autonoma University, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Fundaci\u00f3n Jim\u00e9nez D\u00edaz and Autonoma University, Madrid, Spain","institution_ids":["https://openalex.org/I4210129357"]},{"raw_affiliation_string":"Renal and Vascular Research Laboratory and Department of Cardiology, Fundaci\u00f3n Jim\u00e9nez D\u00edaz and Autonoma University, Madrid, Spain","institution_ids":["https://openalex.org/I4210129357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066461251","display_name":"Jos\u00e9 Tu\u00f1\u00f3n","orcid":"https://orcid.org/0000-0002-1373-0999","observed_orcids":["https://orcid.org/0000-0002-1373-0999"]},"institutions":[{"id":"https://openalex.org/I4210129357","display_name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/049nvyb15","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210129357"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Tu\u00f1\u00f3n","raw_affiliation_strings":["Renal and Vascular Research Laboratory and Department of Cardiology, Fundaci\u00f3n Jim\u00e9nez D\u00edaz and Autonoma University, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal and Vascular Research Laboratory and Department of Cardiology, Fundaci\u00f3n Jim\u00e9nez D\u00edaz and Autonoma University, Madrid, Spain","institution_ids":["https://openalex.org/I4210129357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062432058","display_name":"Jos\u00e9 Luis Mart\u00edn-Ventura","orcid":"https://orcid.org/0000-0003-2090-8641","observed_orcids":["https://orcid.org/0000-0003-2090-8641","https://orcid.org/0000-0002-5972-8712"]},"institutions":[{"id":"https://openalex.org/I4210129357","display_name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/049nvyb15","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210129357"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose Luis Mart\u00edn-Ventura","raw_affiliation_strings":["Renal and Vascular Research Laboratory and Department of Cardiology, Fundaci\u00f3n Jim\u00e9nez D\u00edaz and Autonoma University, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal and Vascular Research Laboratory and Department of Cardiology, Fundaci\u00f3n Jim\u00e9nez D\u00edaz and Autonoma University, Madrid, Spain","institution_ids":["https://openalex.org/I4210129357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108079533","display_name":"Jes\u00fas Egido","orcid":"https://orcid.org/0000-0001-6321-2666","observed_orcids":["https://orcid.org/0000-0001-6321-2666"]},"institutions":[{"id":"https://openalex.org/I4210129357","display_name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/049nvyb15","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210129357"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jes\u00fas Egido","raw_affiliation_strings":["Renal and Vascular Research Laboratory and Department of Cardiology, Fundaci\u00f3n Jim\u00e9nez D\u00edaz and Autonoma University, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal and Vascular Research Laboratory and Department of Cardiology, Fundaci\u00f3n Jim\u00e9nez D\u00edaz and Autonoma University, Madrid, Spain","institution_ids":["https://openalex.org/I4210129357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108079533"],"corresponding_institution_ids":["https://openalex.org/I4210129357"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.7762,"has_fulltext":false,"cited_by_count":349,"citation_normalized_percentile":{"value":0.85981308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"63","issue":"1","first_page":"12","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.49070000648498535,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.49070000648498535,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.45969998836517334,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.03310000151395798,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":1.0},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9800000190734863},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.984000027179718},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.796999990940094},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8259999752044678},{"id":"https://openalex.org/keywords/thrombogenicity","display_name":"thrombogenicity","score":0.8799999952316284},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/monocyte-recruitment","display_name":"monocyte recruitment","score":0.9589999914169312},{"id":"https://openalex.org/keywords/atherosclerotic-plaque-stability","display_name":"atherosclerotic plaque stability","score":0.8820000290870667},{"id":"https://openalex.org/keywords/small-gtpases","display_name":"small GTPases","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cholesterol-independent-effects","display_name":"cholesterol-independent effects","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C57790582","wikidata":"https://www.wikidata.org/wiki/Q901141","display_name":"Prenylation","level":3,"score":0.7182449698448181},{"id":"https://openalex.org/C2776649359","wikidata":"https://www.wikidata.org/wiki/Q7798338","display_name":"Thrombogenicity","level":3,"score":0.5959705114364624},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.5579786896705627},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.5519921183586121},{"id":"https://openalex.org/C104950815","wikidata":"https://www.wikidata.org/wiki/Q415607","display_name":"HMG-CoA reductase","level":4,"score":0.5455793738365173},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5398814678192139},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5394322276115417},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.511658251285553},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.48296159505844116},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.44934189319610596},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3044254183769226},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2405405342578888},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22984114289283752},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21677741408348083},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20769262313842773},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.18358004093170166}],"mesh":[{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1523-1755.2003.00744.x","doi":"https://doi.org/10.1046/j.1523-1755.2003.00744.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1523-1755.2003.00744.x","pdf_url":null,"source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},{"id":"pmid:12472764","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12472764","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1046/j.1523-1755.2003.00744.x","doi":"https://doi.org/10.1046/j.1523-1755.2003.00744.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1523-1755.2003.00744.x","pdf_url":null,"source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":138,"referenced_works":["https://openalex.org/W15429299","https://openalex.org/W22231678","https://openalex.org/W173700730","https://openalex.org/W190317460","https://openalex.org/W207397168","https://openalex.org/W319674832","https://openalex.org/W1479880028","https://openalex.org/W1486695571","https://openalex.org/W1525331105","https://openalex.org/W1562133246","https://openalex.org/W1963913523","https://openalex.org/W1965418020","https://openalex.org/W1965883902","https://openalex.org/W1967138980","https://openalex.org/W1971585818","https://openalex.org/W1971903720","https://openalex.org/W1972462776","https://openalex.org/W1976694284","https://openalex.org/W1977013336","https://openalex.org/W1977909041","https://openalex.org/W1978644984","https://openalex.org/W1980930513","https://openalex.org/W1984106010","https://openalex.org/W1985720260","https://openalex.org/W1990321264","https://openalex.org/W1992834760","https://openalex.org/W1994527422","https://openalex.org/W1995702870","https://openalex.org/W1997005770","https://openalex.org/W2001626727","https://openalex.org/W2003517508","https://openalex.org/W2004330500","https://openalex.org/W2005529837","https://openalex.org/W2008703761","https://openalex.org/W2008797334","https://openalex.org/W2009414365","https://openalex.org/W2010794512","https://openalex.org/W2011589019","https://openalex.org/W2013958390","https://openalex.org/W2014528583","https://openalex.org/W2014771174","https://openalex.org/W2018905034","https://openalex.org/W2020454682","https://openalex.org/W2021314070","https://openalex.org/W2027244023","https://openalex.org/W2027415701","https://openalex.org/W2028103879","https://openalex.org/W2028560153","https://openalex.org/W2031313044","https://openalex.org/W2033199439","https://openalex.org/W2033968552","https://openalex.org/W2035929496","https://openalex.org/W2037198165","https://openalex.org/W2037571918","https://openalex.org/W2040097840","https://openalex.org/W2040783773","https://openalex.org/W2042469629","https://openalex.org/W2045829491","https://openalex.org/W2046750893","https://openalex.org/W2048512830","https://openalex.org/W2051580480","https://openalex.org/W2056034929","https://openalex.org/W2056809784","https://openalex.org/W2057093252","https://openalex.org/W2057951583","https://openalex.org/W2060320549","https://openalex.org/W2060351304","https://openalex.org/W2060537441","https://openalex.org/W2060774684","https://openalex.org/W2061886045","https://openalex.org/W2061904816","https://openalex.org/W2062605111","https://openalex.org/W2063842926","https://openalex.org/W2064649898","https://openalex.org/W2068730200","https://openalex.org/W2071124826","https://openalex.org/W2072308694","https://openalex.org/W2076110739","https://openalex.org/W2076552301","https://openalex.org/W2077741802","https://openalex.org/W2077792958","https://openalex.org/W2079818105","https://openalex.org/W2080135371","https://openalex.org/W2082372484","https://openalex.org/W2084120431","https://openalex.org/W2084676615","https://openalex.org/W2085728170","https://openalex.org/W2087098935","https://openalex.org/W2087344380","https://openalex.org/W2088865411","https://openalex.org/W2088987957","https://openalex.org/W2089308595","https://openalex.org/W2090467649","https://openalex.org/W2091050865","https://openalex.org/W2093664978","https://openalex.org/W2098946775","https://openalex.org/W2100918102","https://openalex.org/W2106319388","https://openalex.org/W2107867330","https://openalex.org/W2110640974","https://openalex.org/W2111045845","https://openalex.org/W2112098540","https://openalex.org/W2112963353","https://openalex.org/W2113892902","https://openalex.org/W2118667643","https://openalex.org/W2120221873","https://openalex.org/W2122648697","https://openalex.org/W2125053733","https://openalex.org/W2134202905","https://openalex.org/W2138809584","https://openalex.org/W2143330294","https://openalex.org/W2144790761","https://openalex.org/W2147912194","https://openalex.org/W2153390391","https://openalex.org/W2154746915","https://openalex.org/W2159111147","https://openalex.org/W2160152341","https://openalex.org/W2162976988","https://openalex.org/W2164807534","https://openalex.org/W2167474616","https://openalex.org/W2226676844","https://openalex.org/W2315575691","https://openalex.org/W2316243284","https://openalex.org/W2316376271","https://openalex.org/W2323501455","https://openalex.org/W2324489407","https://openalex.org/W2324841714","https://openalex.org/W2331176038","https://openalex.org/W2338977280","https://openalex.org/W2341744705","https://openalex.org/W2569568519","https://openalex.org/W2608539973","https://openalex.org/W2990534548","https://openalex.org/W4246764494","https://openalex.org/W4250102918","https://openalex.org/W4251923414","https://openalex.org/W6607019949","https://openalex.org/W6689415013"],"related_works":["https://openalex.org/W1985246693","https://openalex.org/W2059816227","https://openalex.org/W2088132299","https://openalex.org/W2091019625","https://openalex.org/W2044651570","https://openalex.org/W2764077634","https://openalex.org/W2886968347","https://openalex.org/W277232414","https://openalex.org/W2010515914","https://openalex.org/W2070671835"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
