{"id":"https://openalex.org/W1989791192","doi":"https://doi.org/10.1073/pnas.81.15.4864","title":"Protein differentiation: a comparison of aspartate transcarbamoylase and ornithine transcarbamoylase from Escherichia coli K-12.","display_name":"Protein differentiation: a comparison of aspartate transcarbamoylase and ornithine transcarbamoylase from Escherichia coli K-12.","publication_year":1984,"publication_date":"1984-08-01","ids":{"openalex":"https://openalex.org/W1989791192","doi":"https://doi.org/10.1073/pnas.81.15.4864","mag":"1989791192","pmid":"https://pubmed.ncbi.nlm.nih.gov/6379651","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/391592"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.81.15.4864","doi":"https://doi.org/10.1073/pnas.81.15.4864","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.81.15.4864","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/391592","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014912999","display_name":"John E. Houghton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J E Houghton","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Texas A & M University, College Station, TX 77843","Department of Chemistry, Harvard University, Cambridge, MA 02138"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A & M University, College Station, TX 77843","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Chemistry, Harvard University, Cambridge, MA 02138","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055810280","display_name":"David A. Bencini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D A Bencini","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Texas A & M University, College Station, TX 77843","Department of Chemistry, Harvard University, Cambridge, MA 02138"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A & M University, College Station, TX 77843","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Chemistry, Harvard University, Cambridge, MA 02138","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073637856","display_name":"Gerard A. O\u2019Donovan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G A O'Donovan","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Texas A & M University, College Station, TX 77843","Department of Chemistry, Harvard University, Cambridge, MA 02138"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A & M University, College Station, TX 77843","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Chemistry, Harvard University, Cambridge, MA 02138","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057518595","display_name":"James R. Wild","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J R Wild","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Texas A & M University, College Station, TX 77843","Department of Chemistry, Harvard University, Cambridge, MA 02138"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A & M University, College Station, TX 77843","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Chemistry, Harvard University, Cambridge, MA 02138","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.759,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.67931898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"81","issue":"15","first_page":"4864","last_page":"4868"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspartate-transcarbamoylase","display_name":"aspartate transcarbamylase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ornithine-transcarbamylase","display_name":"ornithine transcarbamylase","score":1.0},{"id":"https://openalex.org/keywords/carbamoyl-phosphate","display_name":"carbamoyl phosphate","score":0.7300000190734863},{"id":"https://openalex.org/keywords/amino-acid-sequence-homology","display_name":"amino acid sequence homology","score":0.8519999980926514},{"id":"https://openalex.org/keywords/protein-evolution","display_name":"protein evolution","score":0.7279999852180481},{"id":"https://openalex.org/keywords/secondary-structure-conservation","display_name":"secondary structure conservation","score":0.6930000185966492},{"id":"https://openalex.org/keywords/escherichia-coli-k-12","display_name":"Escherichia coli K-12","score":0.9139999747276306},{"id":"https://openalex.org/keywords/urea-cycle-enzymes","display_name":"urea cycle enzymes","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C197248121","wikidata":"https://www.wikidata.org/wiki/Q24724427","display_name":"Aspartate carbamoyltransferase","level":4,"score":0.9923877716064453},{"id":"https://openalex.org/C2909874926","wikidata":"https://www.wikidata.org/wiki/Q420678","display_name":"Ornithine Carbamoyltransferase","level":5,"score":0.9500035643577576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.542378306388855},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5217224359512329},{"id":"https://openalex.org/C74539022","wikidata":"https://www.wikidata.org/wiki/Q5037840","display_name":"Carbamoyl phosphate synthetase","level":3,"score":0.4719749391078949},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4549599885940552},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4035303592681885},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.37926769256591797},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.3751637637615204},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.34998583793640137},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3343907594680786},{"id":"https://openalex.org/C2776796294","wikidata":"https://www.wikidata.org/wiki/Q410198","display_name":"Ornithine","level":4,"score":0.2695090174674988},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.10408687591552734},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0852205753326416}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001221","descriptor_name":"Aspartate Carbamoyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009954","descriptor_name":"Ornithine Carbamoyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.81.15.4864","doi":"https://doi.org/10.1073/pnas.81.15.4864","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.81.15.4864","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:391592","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/391592","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:6379651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6379651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/182631","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1969.1/182631","pdf_url":null,"source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:391592","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/391592","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Life on land","score":0.6499999761581421,"id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W22542678","https://openalex.org/W197740357","https://openalex.org/W1490395002","https://openalex.org/W1538493401","https://openalex.org/W1548933099","https://openalex.org/W1575696732","https://openalex.org/W1606086820","https://openalex.org/W1963550288","https://openalex.org/W1974303276","https://openalex.org/W1983519083","https://openalex.org/W2018225090","https://openalex.org/W2019212822","https://openalex.org/W2020498566","https://openalex.org/W2023881865","https://openalex.org/W2023996824","https://openalex.org/W2026046929","https://openalex.org/W2028686506","https://openalex.org/W2042807617","https://openalex.org/W2048947819","https://openalex.org/W2049695588","https://openalex.org/W2060932108","https://openalex.org/W2067746226","https://openalex.org/W2075170510","https://openalex.org/W2090672707","https://openalex.org/W2099579830","https://openalex.org/W2117751300","https://openalex.org/W2135846862","https://openalex.org/W2138315172","https://openalex.org/W2317388273","https://openalex.org/W2916217134","https://openalex.org/W4205669956"],"related_works":["https://openalex.org/W2006859343","https://openalex.org/W2097671472","https://openalex.org/W2021508720","https://openalex.org/W2075388874","https://openalex.org/W1481483781","https://openalex.org/W2562401796","https://openalex.org/W2052706948","https://openalex.org/W1592091487","https://openalex.org/W7100290406","https://openalex.org/W2921819841"],"abstract_inverted_index":{"The":[0,23,36,51,104],"amino":[1],"acid":[2],"sequence":[3,25,100],"of":[4,16,33,48,63,87],"aspartate":[5,113],"transcarbamoylase":[6,18,114],"(carbamoylphosphate:L-aspartate":[7],"carbamoyltransferase,":[8,20],"EC":[9,21],"2.1.3.2)":[10],"has":[11],"been":[12],"compared":[13],"with":[14],"that":[15,109],"ornithine":[17,116],"(carbamoylphosphate:L-ornithine":[19],"2.1.3.3).":[22],"primary":[24,99],"homology":[26],"is":[27,101],"25-40%,":[28],"depending":[29],"upon":[30],"the":[31,61,64,92,110],"alignment":[32],"homologous":[34],"residues.":[35],"homologies":[37,54],"are":[38,44],"incorporated":[39],"into":[40],"discrete":[41],"clusters":[42],"and":[43,115,123],"interrupted":[45],"by":[46],"regions":[47,57,97],"length":[49],"polymorphism.":[50],"most":[52],"striking":[53],"correspond":[55],"to":[56,125],"putatively":[58],"involved":[59],"in":[60,96],"binding":[62],"common":[65,120],"substrate,":[66],"carbamoyl":[67],"phosphate.":[68],"Chou-Fasman":[69],"predictive":[70],"analysis":[71],"[Chou,":[72],"P.":[73],"Y.":[74],"&":[75],"Fasman,":[76],"G.":[77],"D.":[78],"(1974)":[79],"Biochemistry":[80],"13,":[81],"211-222;":[82],"222-245]":[83],"indicates":[84],"substantial":[85],"conservation":[86],"secondary":[88],"structural":[89,129],"elements":[90],"within":[91],"two":[93,111],"enzymes,":[94,112],"even":[95],"whose":[98],"quite":[102],"divergent.":[103],"results":[105],"reported":[106],"herein":[107],"demonstrate":[108],"transcarbamoylase,":[117],"share":[118],"a":[119],"evolutionary":[121,133],"origin":[122],"appear":[124],"have":[126],"retained":[127],"similar":[128],"conformations":[130],"throughout":[131],"their":[132],"development.":[134]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
