{"id":"https://openalex.org/W1989744367","doi":"https://doi.org/10.1097/00006534-199106000-00011","title":"Preparation and Evaluation of a Nonproprietary Bilayer Skin Substitute","display_name":"Preparation and Evaluation of a Nonproprietary Bilayer Skin Substitute","publication_year":1991,"publication_date":"1991-06-01","ids":{"openalex":"https://openalex.org/W1989744367","doi":"https://doi.org/10.1097/00006534-199106000-00011","mag":"1989744367","pmid":"https://pubmed.ncbi.nlm.nih.gov/1852021"},"language":"en","primary_location":{"id":"doi:10.1097/00006534-199106000-00011","doi":"https://doi.org/10.1097/00006534-199106000-00011","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006534-199106000-00011","pdf_url":null,"source":{"id":"https://openalex.org/S100736837","display_name":"Plastic & Reconstructive Surgery","issn_l":"0032-1052","issn":["0032-1052","1076-5751","1529-4242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050986282","display_name":"Charles N. Bertolami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles N. Bertolami","raw_affiliation_strings":["School of Dentistry, Center for the Health Sciences, University of California, Los Angeles","Los Angeles, Calif","the School of Dentistry, Center for the Health Sciences, at the University of California, Los Angeles, and the Shriners Hospitals for Crippled Children, Los Angeles Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Dentistry, Center for the Health Sciences, University of California, Los Angeles","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Los Angeles, Calif","institution_ids":[]},{"raw_affiliation_string":"the School of Dentistry, Center for the Health Sciences, at the University of California, Los Angeles, and the Shriners Hospitals for Crippled Children, Los Angeles Unit","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047665844","display_name":"Vivek Shetty","orcid":"https://orcid.org/0000-0002-3167-3318","observed_orcids":["https://orcid.org/0000-0002-3167-3318"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivek Shetty","raw_affiliation_strings":["Los Angeles, Calif","the School of Dentistry, Center for the Health Sciences, at the University of California, Los Angeles, and the Shriners Hospitals for Crippled Children, Los Angeles Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Los Angeles, Calif","institution_ids":[]},{"raw_affiliation_string":"the School of Dentistry, Center for the Health Sciences, at the University of California, Los Angeles, and the Shriners Hospitals for Crippled Children, Los Angeles Unit","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076615955","display_name":"Joseph E. Milavec","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph E. Milavec","raw_affiliation_strings":["Los Angeles, Calif","the School of Dentistry, Center for the Health Sciences, at the University of California, Los Angeles, and the Shriners Hospitals for Crippled Children, Los Angeles Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Los Angeles, Calif","institution_ids":[]},{"raw_affiliation_string":"the School of Dentistry, Center for the Health Sciences, at the University of California, Los Angeles, and the Shriners Hospitals for Crippled Children, Los Angeles Unit","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064673153","display_name":"Duncan G. Ellis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duncan G. Ellis","raw_affiliation_strings":["Los Angeles, Calif","the School of Dentistry, Center for the Health Sciences, at the University of California, Los Angeles, and the Shriners Hospitals for Crippled Children, Los Angeles Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Los Angeles, Calif","institution_ids":[]},{"raw_affiliation_string":"the School of Dentistry, Center for the Health Sciences, at the University of California, Los Angeles, and the Shriners Hospitals for Crippled Children, Los Angeles Unit","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037348976","display_name":"Henry M. Cherrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry M. Cherrick","raw_affiliation_strings":["Los Angeles, Calif","the School of Dentistry, Center for the Health Sciences, at the University of California, Los Angeles, and the Shriners Hospitals for Crippled Children, Los Angeles Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Los Angeles, Calif","institution_ids":[]},{"raw_affiliation_string":"the School of Dentistry, Center for the Health Sciences, at the University of California, Los Angeles, and the Shriners Hospitals for Crippled Children, Los Angeles Unit","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":1.192,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.78674699,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"87","issue":"6","first_page":"1089","last_page":"1098"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.03009999915957451,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dermal-graft","display_name":"dermal graft","score":0.75},{"id":"https://openalex.org/keywords/full-thickness-skin-wounds","display_name":"full-thickness skin wounds","score":0.9169999957084656},{"id":"https://openalex.org/keywords/graft-incorporation","display_name":"graft integration","score":0.7400000095367432},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.47200000286102295},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.7749121189117432},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7599416971206665},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.6152896881103516},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.5651044249534607},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4691941440105438},{"id":"https://openalex.org/C2779769944","wikidata":"https://www.wikidata.org/wiki/Q146439","display_name":"Silicone","level":2,"score":0.4663889408111572},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.4643436074256897},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4547301232814789},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.08436578512191772},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0822555422782898},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07930046319961548},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07815706729888916},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.07133254408836365},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0708644688129425},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005069","descriptor_name":"Evaluation Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010330","descriptor_name":"Patents as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012826","descriptor_name":"Silicone Elastomers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012828","descriptor_name":"Silicones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016038","descriptor_name":"Skin Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019736","descriptor_name":"Prostheses and Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00006534-199106000-00011","doi":"https://doi.org/10.1097/00006534-199106000-00011","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006534-199106000-00011","pdf_url":null,"source":{"id":"https://openalex.org/S100736837","display_name":"Plastic & Reconstructive Surgery","issn_l":"0032-1052","issn":["0032-1052","1076-5751","1529-4242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery","raw_type":"journal-article"},{"id":"pmid:1852021","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1852021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and reconstructive surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.766700029373169}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3273622297","display_name":null,"funder_award_id":"DE09178","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G3992806823","display_name":"HYALURONATE CATABOLISM IN OROFACIAL SCARRING                                     ","funder_award_id":"5r01de009178-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2153773363","https://openalex.org/W2500914674","https://openalex.org/W1966301990","https://openalex.org/W2095322019","https://openalex.org/W1590046357","https://openalex.org/W2584377396","https://openalex.org/W3178325773","https://openalex.org/W1976041169","https://openalex.org/W2045635770","https://openalex.org/W2560952256"],"abstract_inverted_index":{"Cross-linked,":[0],"allogeneic,":[1],"telopeptide-depleted":[2],"dermal":[3,140,172],"grafts":[4,173],"were":[5,15,37,69,95,132],"lyophilized":[6],"and":[7,23,79,84,94,101,136,180,189,216],"laminated":[8],"with":[9,50],"silicone":[10],"rubber":[11],"elastomer.":[12],"Resultant":[13],"bilayers":[14],"studied":[16],"for":[17,213],"incorporation":[18],"into":[19],"the":[20,51,55,74,77,137,168],"wound":[21,28,67,82,104,219],"site":[22],"capacity":[24,212],"to":[25,143,153,199],"inhibit":[26],"cutaneous":[27],"contraction":[29,83],"in":[30,39,98,165,208],"experimental":[31,166],"animals.":[32],"Bilateral":[33],"full-thickness":[34],"skin":[35],"wounds":[36,89,111,122],"made":[38],"20":[40],"male":[41],"New":[42],"Zealand":[43],"white":[44],"rabbits.":[45],"One":[46],"side":[47,57],"was":[48],"grafted":[49,110],"processed":[52],"graft,":[53],"while":[54,157],"contralateral":[56],"remained":[58],"ungrafted":[59,120],"as":[60,145,206],"a":[61,146,154,200],"control":[62,121],"wound.":[63],"Over":[64],"63":[65],"days,":[66],"sites":[68],"analyzed":[70],"at":[71],"intervals":[72],"on":[73,177],"basis":[75],"of":[76,81,103,115,127,170,210,218],"extent":[78,102],"rate":[80,100],"by":[85,107],"histologic":[86],"examination.":[87],"Cutaneous":[88],"successfully":[90],"incorporated":[91],"graft":[92,134,214],"matrix":[93],"significantly":[96],"inhibited":[97],"their":[99,116,128],"contraction.":[105,220],"Notably,":[106],"day":[108],"63,":[109],"retained":[112,123],"71":[113],"percent":[114,126],"original":[117,129],"area,":[118],"whereas":[119],"only":[124],"16":[125],"area.":[130],"There":[131],"no":[133],"rejections,":[135],"bilayer":[138,171,201],"graft's":[139],"analogue":[141],"appeared":[142],"function":[144],"biodegradable":[147],"template":[148],"that":[149,190],"physically":[150],"conformed":[151],"neodermis":[152],"preestablished":[155],"pattern":[156],"counteracting":[158],"contractile":[159],"forces.":[160],"This":[161],"investigation":[162],"suggests":[163],"that,":[164],"animals,":[167],"success":[169],"is":[174],"less":[175],"dependent":[176],"highly":[178],"specialized":[179],"complex":[181],"preparative":[182],"techniques":[183],"than":[184],"typically":[185],"has":[186],"been":[187],"presumed":[188],"relatively":[191],"simple,":[192],"previously":[193],"published,":[194],"nonproprietary":[195],"techniques,":[196],"when":[197],"adapted":[198],"format,":[202],"yield":[203],"acceptable":[204],"results":[205],"defined":[207],"terms":[209],"biocompatibility,":[211],"incorporation,":[215],"inhibition":[217]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}